Nick Norwitz MD PhD - Metabolic Health & Longevity https://www.youtube.com/@nicknorwitzMDPhD en MD, Harvard | PhD, Oxford | Motto: StayCurious | Thanks for Learning with Me!About: Dr. Nick Norwitz graduated valedictorian from Dartmouth College, where he majored in cell biology and biochemistry. He earned his PhD in Human Metabolism from the University of Oxford and completed his MD at Harvard Medical School.During his training, a personal battle with inflammatory bowel disease ignited a deep passion for metabolic health and a mission to empower others on their individual health journeys. Nick has since become a leading voice in the metabolic health space, best known for the intellectual rigor and clarity of his educational content, which reaches millions worldwide. He also authors a best-selling newsletter at StayCuriousMetabolism.com.Disclaimer: While I am an MD PhD, this channel is intended to educate. It is not intended to provide clinical recommendations for any individual. Please contact your doctor or other clinical provider if you have questions about your care.Links:Newsletter: https://staycuriousmetabolism.comInstagram: https://www.instagram.com/nicknorwitz/My Website: https://www.nicknorwitz.comTwitter: https://twitter.com/nicknorwitzLinkedIn: https://www.linkedin.com/in/nicknorwitz/ Unofficial fan audio feed — not affiliated with or endorsed by the original creator. All content belongs to its respective owner. https://megaphone.imgix.net/podcasts/378b340e-b8c7-11f1-8b5f-e3296f6f73da/image/9cc5f05651aa13bcc28f71ee1ccaec1f.jpg?ixlib=rails-4.3.1&max-w=3000&max-h=3000&fit=crop&auto=format,compress Nick Norwitz MD PhD - Metabolic Health & Longevity https://www.youtube.com/@nicknorwitzMDPhD no episodic Nick Norwitz MD PhD MD, Harvard | PhD, Oxford | Motto: StayCurious | Thanks for Learning with Me!About: Dr. Nick Norwitz graduated valedictorian from Dartmouth College, where he majored in cell biology and biochemistry. He earned his PhD in Human Metabolism from the University of Oxford and completed his MD at Harvard Medical School.During his training, a personal battle with inflammatory bowel disease ignited a deep passion for metabolic health and a mission to empower others on their individual health journeys. Nick has since become a leading voice in the metabolic health space, best known for the intellectual rigor and clarity of his educational content, which reaches millions worldwide. He also authors a best-selling newsletter at StayCuriousMetabolism.com.Disclaimer: While I am an MD PhD, this channel is intended to educate. It is not intended to provide clinical recommendations for any individual. Please contact your doctor or other clinical provider if you have questions about your care.Links:Newsletter: https://staycuriousmetabolism.comInstagram: https://www.instagram.com/nicknorwitz/My Website: https://www.nicknorwitz.comTwitter: https://twitter.com/nicknorwitzLinkedIn: https://www.linkedin.com/in/nicknorwitz/ Unofficial fan audio feed — not affiliated with or endorsed by the original creator. All content belongs to its respective owner. MD, Harvard | PhD, Oxford | Motto: StayCurious | Thanks for Learning with Me!

About: Dr. Nick Norwitz graduated valedictorian from Dartmouth College, where he majored in cell biology and biochemistry. He earned his PhD in Human Metabolism from the University of Oxford and completed his MD at Harvard Medical School.

During his training, a personal battle with inflammatory bowel disease ignited a deep passion for metabolic health and a mission to empower others on their individual health journeys. Nick has since become a leading voice in the metabolic health space, best known for the intellectual rigor and clarity of his educational content, which reaches millions worldwide. He also authors a best-selling newsletter at StayCuriousMetabolism.com.

Disclaimer: While I am an MD PhD, this channel is intended to educate. It is not intended to provide clinical recommendations for any individual. Please contact your doctor or other clinical provider if you have questions about your care.

Links:
Newsletter: https://staycuriousmetabolism.com
Instagram: https://www.instagram.com/nicknorwitz/
My Website: https://www.nicknorwitz.com
Twitter: https://twitter.com/nicknorwitz
LinkedIn: https://www.linkedin.com/in/nicknorwitz/

Unofficial fan audio feed — not affiliated with or endorsed by the original creator. All content belongs to its respective owner.

]]> Nick Norwitz MD PhD rogue007c@gmail.com The Hidden Toxin that Causes Insulin Resistance For more nuances and references, see the associated Newsletter: https://staycuriousmetabolism.substack.com/p/can-we-trap-a-microbial-toxin-to?r=40ekz2 Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSMicroplastics and Cardiovascular Disease, Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 A new study has uncovered a surprising metabolic villain — D-lactate, the molecular twin of the lactate that fuels your muscles. Unlike L-lactate, D-lactate builds up in people with obesity and contributes to insulin resistance, fatty liver, and metabolic dysfunction. But scientists have now found a way to trap this molecule in the gut, potentially opening the door to a brand-new class of metabolic therapies. In this video, Nick Norwitz MD PhD explains the study, its implications for human health, and how certain probiotics and homemade yogurts could help reduce D-lactate levels naturally.Chapters:0:00 – The Evil Twin of Lactate: New Research Explained1:18 – L-Lactate vs D-Lactate: Why the Difference Matters2:43 – Elevated D-Lactate in Obesity: The Hidden Connection3:18 – How D-Lactate Worsens Blood Sugar and Metabolic Health4:00 – Gut Microbes: The Source of D-Lactate6:30 – The D-Lactate Trap: How Scientists Made Mice Poop It Out9:11 – What This Discovery Means for Metabolic Research9:42 – Practical Takeaways: What You Can Do Right Now#Lactate # microbiome #metabolichealth #fatloss #insulinsensitivity #diabetes #obesity #weightloss #educationa #staycurious #inflammation #yogurt #guthealth #biochemistry #metabolism #glucosecontrol #bloodsugar #fattyliver #insulinresistance #healthscience #nutritionresearch #probiotics #gutmicrobiome #scienceexplained #wellnessscience #hormones #metabolicsyndrome Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 03 Nov 2026 04:46:00 -0000 full Nick Norwitz MD PhD For more nuances and references, see the associated Newsletter: https://staycuriousmetabolism.substack.com/p/can-we-trap-a-microbial-toxin-to?r=40ekz2 Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSMicroplastics and Cardiovascular Disease, Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 A new study has uncovered a surprising metabolic villain — D-lactate, the molecular twin of the lactate that fuels your muscles. Unlike L-lactate, D-lactate builds up in people with obesity and contributes to insulin resistance, fatty liver, and metabolic dysfunction. But scientists have now found a way to trap this molecule in the gut, potentially opening the door to a brand-new class of metabolic therapies. In this video, Nick Norwitz MD PhD explains the study, its implications for human health, and how certain probiotics and homemade yogurts could help reduce D-lactate levels naturally.Chapters:0:00 – The Evil Twin of Lactate: New Research Explained1:18 – L-Lactate vs D-Lactate: Why the Difference Matters2:43 – Elevated D-Lactate in Obesity: The Hidden Connection3:18 – How D-Lactate Worsens Blood Sugar and Metabolic Health4:00 – Gut Microbes: The Source of D-Lactate6:30 – The D-Lactate Trap: How Scientists Made Mice Poop It Out9:11 – What This Discovery Means for Metabolic Research9:42 – Practical Takeaways: What You Can Do Right Now#Lactate # microbiome #metabolichealth #fatloss #insulinsensitivity #diabetes #obesity #weightloss #educationa #staycurious #inflammation #yogurt #guthealth #biochemistry #metabolism #glucosecontrol #bloodsugar #fattyliver #insulinresistance #healthscience #nutritionresearch #probiotics #gutmicrobiome #scienceexplained #wellnessscience #hormones #metabolicsyndrome Learn more about your ad choices. Visit megaphone.fm/adchoices For more nuances and references, see the associated Newsletter: https://staycuriousmetabolism.substack.com/p/can-we-trap-a-microbial-toxin-to?r=40ekz2

Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUS

Microplastics and Cardiovascular Disease, Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2

A new study has uncovered a surprising metabolic villain — D-lactate, the molecular twin of the lactate that fuels your muscles. Unlike L-lactate, D-lactate builds up in people with obesity and contributes to insulin resistance, fatty liver, and metabolic dysfunction. But scientists have now found a way to trap this molecule in the gut, potentially opening the door to a brand-new class of metabolic therapies. In this video, Nick Norwitz MD PhD explains the study, its implications for human health, and how certain probiotics and homemade yogurts could help reduce D-lactate levels naturally.

Chapters:
0:00 – The Evil Twin of Lactate: New Research Explained
1:18 – L-Lactate vs D-Lactate: Why the Difference Matters
2:43 – Elevated D-Lactate in Obesity: The Hidden Connection
3:18 – How D-Lactate Worsens Blood Sugar and Metabolic Health
4:00 – Gut Microbes: The Source of D-Lactate
6:30 – The D-Lactate Trap: How Scientists Made Mice Poop It Out
9:11 – What This Discovery Means for Metabolic Research
9:42 – Practical Takeaways: What You Can Do Right Now

#Lactate # microbiome #metabolichealth #fatloss #insulinsensitivity #diabetes #obesity #weightloss #educationa #staycurious #inflammation #yogurt #guthealth #biochemistry #metabolism #glucosecontrol #bloodsugar #fattyliver #insulinresistance #healthscience #nutritionresearch #probiotics #gutmicrobiome #scienceexplained #wellnessscience #hormones #metabolicsyndrome

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1060 no Allulose: Nature's Sweet Ozempic? Link: https://pubmed.ncbi.nlm.nih.gov/29317623/Newer Video (April 2024): https://youtu.be/pr93EsEV2bM?si=AEcnv1jlUoEWF-e1 Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 02 Nov 2026 10:46:00 -0000 full Nick Norwitz MD PhD Link: https://pubmed.ncbi.nlm.nih.gov/29317623/Newer Video (April 2024): https://youtu.be/pr93EsEV2bM?si=AEcnv1jlUoEWF-e1 Learn more about your ad choices. Visit megaphone.fm/adchoices Link: https://pubmed.ncbi.nlm.nih.gov/29317623/

Newer Video (April 2024): https://youtu.be/pr93EsEV2bM?si=AEcnv1jlUoEWF-e1

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1210 no How a $1 Trillion Drug Got It Wrong For references and a written breakdown, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/weve-been-prescribing-statins-wrong?r=40ekz2 For a consolidated resource on prior StayCurious Heart Health Content, check out our Heart Health Map! https://open.substack.com/pub/staycuriousmetabolism/p/the-intricate-metabolic-web-of-heart?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=trueStatins are among the most prescribed and profitable drugs in the world, but new research is forcing us to rethink what they actually do — and for whom. In this video, Dr. Nick Norwitz MD PhD breaks down the latest data showing that statins only reduce cardiovascular risk in people with existing heart disease, while showing little or no benefit for those without.Nick walks through, not one, but 4 major studies and explains why LDL cholesterol and ApoB aren’t the whole story, how coronary imaging (CAC or CTA scans) provide better risk prediction, and why the real root causes — like insulin resistance and mitochondrial dysfunction — often get ignored. This isn’t about conspiracy or fear — it’s about context. Good medicine isn’t black or white — it’s nuanced, transparent, and collaborative.Chapters0:00 – Intro: Statins as a Misunderstood Tool1:46 – Paper 1, Statins Don’t Benefit Those Without Heart Disease3:43 – Imaging Beats LDL and ApoB for Risk Stratification4:26 – Paper 2, If Your Heart is Clear, Does LDL Cholesterol Matter?5:33 – Reviewing the Pros and Cons of Statins6:43 – Paper 3, Statins Harm Mitochondria and Muscles7:55 – Paper 4, Statins Slash GLP-1 Levels9:00 – The Essential Social Dynamics of Statins You Need to Know11:15 – Conclusion, The Right Tool for the Right Job#Statins #HeartHealth #Cholesterol #LDL #ApoB #InsulinResistance #MetabolicHealth #Mitochondria #Type2Diabetes #CardiovascularHealth #Medicine #Pharmaceuticals #GLP1 #CoQ10 #StayCurious #NickNorwitz #Educational #ScienceCommunication #CriticalThinking #HealthResearch #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 01 Nov 2026 16:46:00 -0000 full Nick Norwitz MD PhD For references and a written breakdown, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/weve-been-prescribing-statins-wrong?r=40ekz2 For a consolidated resource on prior StayCurious Heart Health Content, check out our Heart Health Map! https://open.substack.com/pub/staycuriousmetabolism/p/the-intricate-metabolic-web-of-heart?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=trueStatins are among the most prescribed and profitable drugs in the world, but new research is forcing us to rethink what they actually do — and for whom. In this video, Dr. Nick Norwitz MD PhD breaks down the latest data showing that statins only reduce cardiovascular risk in people with existing heart disease, while showing little or no benefit for those without.Nick walks through, not one, but 4 major studies and explains why LDL cholesterol and ApoB aren’t the whole story, how coronary imaging (CAC or CTA scans) provide better risk prediction, and why the real root causes — like insulin resistance and mitochondrial dysfunction — often get ignored. This isn’t about conspiracy or fear — it’s about context. Good medicine isn’t black or white — it’s nuanced, transparent, and collaborative.Chapters0:00 – Intro: Statins as a Misunderstood Tool1:46 – Paper 1, Statins Don’t Benefit Those Without Heart Disease3:43 – Imaging Beats LDL and ApoB for Risk Stratification4:26 – Paper 2, If Your Heart is Clear, Does LDL Cholesterol Matter?5:33 – Reviewing the Pros and Cons of Statins6:43 – Paper 3, Statins Harm Mitochondria and Muscles7:55 – Paper 4, Statins Slash GLP-1 Levels9:00 – The Essential Social Dynamics of Statins You Need to Know11:15 – Conclusion, The Right Tool for the Right Job#Statins #HeartHealth #Cholesterol #LDL #ApoB #InsulinResistance #MetabolicHealth #Mitochondria #Type2Diabetes #CardiovascularHealth #Medicine #Pharmaceuticals #GLP1 #CoQ10 #StayCurious #NickNorwitz #Educational #ScienceCommunication #CriticalThinking #HealthResearch #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For references and a written breakdown, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/weve-been-prescribing-statins-wrong?r=40ekz2

For a consolidated resource on prior StayCurious Heart Health Content, check out our Heart Health Map! https://open.substack.com/pub/staycuriousmetabolism/p/the-intricate-metabolic-web-of-heart?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Statins are among the most prescribed and profitable drugs in the world, but new research is forcing us to rethink what they actually do — and for whom. In this video, Dr. Nick Norwitz MD PhD breaks down the latest data showing that statins only reduce cardiovascular risk in people with existing heart disease, while showing little or no benefit for those without.

Nick walks through, not one, but 4 major studies and explains why LDL cholesterol and ApoB aren’t the whole story, how coronary imaging (CAC or CTA scans) provide better risk prediction, and why the real root causes — like insulin resistance and mitochondrial dysfunction — often get ignored. This isn’t about conspiracy or fear — it’s about context. Good medicine isn’t black or white — it’s nuanced, transparent, and collaborative.

Chapters
0:00 – Intro: Statins as a Misunderstood Tool
1:46 – Paper 1, Statins Don’t Benefit Those Without Heart Disease
3:43 – Imaging Beats LDL and ApoB for Risk Stratification
4:26 – Paper 2, If Your Heart is Clear, Does LDL Cholesterol Matter?
5:33 – Reviewing the Pros and Cons of Statins
6:43 – Paper 3, Statins Harm Mitochondria and Muscles
7:55 – Paper 4, Statins Slash GLP-1 Levels
9:00 – The Essential Social Dynamics of Statins You Need to Know
11:15 – Conclusion, The Right Tool for the Right Job

#Statins #HeartHealth #Cholesterol #LDL #ApoB #InsulinResistance #MetabolicHealth #Mitochondria #Type2Diabetes #CardiovascularHealth #Medicine #Pharmaceuticals #GLP1 #CoQ10 #StayCurious #NickNorwitz #Educational #ScienceCommunication #CriticalThinking #HealthResearch #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 989 no Oreo Statin Data LEAK! Shawn Baker Tweet: https://x.com/SBakerMD/status/1728878646793003085?s=20Nick Tweet: https://x.com/nicknorwitz/status/1729122883564171274?s=200:12: Data “leak”0:50: Who am I? (For those who don’t know me)1:54: Lean Mass Hyper-Responders2:56: What (design and hypothesis)5:15: Why am I doing this?7:13 – 9:40: “How” (Lipid Energy Model)Other details and Final commentsLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/LMHR, first paper: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext JCL LMHR editorial: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltextLMHR, low saturated fat case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/ Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 31 Oct 2026 22:46:00 -0000 full Nick Norwitz MD PhD Shawn Baker Tweet: https://x.com/SBakerMD/status/1728878646793003085?s=20Nick Tweet: https://x.com/nicknorwitz/status/1729122883564171274?s=200:12: Data “leak”0:50: Who am I? (For those who don’t know me)1:54: Lean Mass Hyper-Responders2:56: What (design and hypothesis)5:15: Why am I doing this?7:13 – 9:40: “How” (Lipid Energy Model)Other details and Final commentsLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/LMHR, first paper: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext JCL LMHR editorial: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltextLMHR, low saturated fat case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/ Learn more about your ad choices. Visit megaphone.fm/adchoices Shawn Baker Tweet: https://x.com/SBakerMD/status/1728878646793003085?s=20

Nick Tweet: https://x.com/nicknorwitz/status/1729122883564171274?s=20

0:12: Data “leak”

0:50: Who am I? (For those who don’t know me)

1:54: Lean Mass Hyper-Responders

2:56: What (design and hypothesis)

5:15: Why am I doing this?

7:13 – 9:40: “How” (Lipid Energy Model)

Other details and Final comments

Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/
LMHR, first paper: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext
JCL LMHR editorial: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltext
LMHR, low saturated fat case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 983 no The Coolest Fiber Paper and Biggest Keto Lie! Microplastics and Cardiovascular Disease Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Winnow Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSWinnow is a first-in-class probiotic that binds microplastics to provide a microplastic shield from your inside. See the letter above for more details.Inulin StayCurious Newsletter: https://staycuriousmetabolism.substack.com/p/the-fiber-that-fights-fat-how-inulin?r=40ekz2 Inulin Video: https://youtu.be/blNLHsww_Qs Andrew Koutnik, Interview 1: https://youtu.be/2doAS18X9kA Andrew Koutnik, Interview 2: https://youtu.be/-vdol1TSxoc Andrew Koutnik, Interview 3: https://youtu.be/NrZlvtWIgBAIn this episode, Dr Andrew Koutnik and I dive deep into the science of fiber, keto, and more – focusing on two influential 2025 papers. First, we unpack the a new study revealing how a specific type of fiber can “immunize” the body against fructose by reshaping the microbiome, protecting the liver, reducing de novo lipogenesis, and boosting glutathione production. This isn’t “more fiber is better”—it’s precision nutrition.Then we break down the keto mouse study that was widely discuss for claiming ketogenic diets cause fatty liver and glucose intolerance. We explain why this particular mouse model leads to misleading results, and how diet design specifics dramatically change outcomes. When viewed through these lenses, the scare headlines collapse.We also explore how to think critically about nutrition science, why animal studies can both illuminate and mislead, how individuals can apply evidence with nuance, and why personal experimentation—combined with skepticism and curiosity—leads to better metabolic outcomes. If you're trying to understand fiber, fructose, ketogenic diets, diabetes, or simply want to make better decisions about your own metabolic health, this conversation provides clarity and actionable insight.Chapters:0:00 – Intro: Welcome Back Dr Andrew Koutnik PhD1:40 – The Coolest Fiber Paper Ever!21:19 – Probiotic That Binds Plastics22:52 – Keto Mouse Myths: A Shady Study Skews the Truth30:01 – Andrew Reflects on his Diary of a CEO Appearance 43:01 – Do Credentials Teach Curiosity, or Crush Them?#NickNorwitz #AndrewKoutnik #MetabolicHealth #NutritionScience #Inulin #FiberScience #Microbiome #GutHealth #Fructose #HFCS #LiverHealth #NAFLD #Metabolism #InsulinResistance #KetogenicDiet #KetoScience #LowCarb #Type1Diabetes #PrecisionNutrition #LongevityScience #Healthspan #ScientificDebunk #DietStudies #EvidenceBasedNutrition #ScienceExplainer #StayCurious #Glutathione #Mitochondria #DeNovoLipogenesis #MicrobiomeResearch Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 31 Oct 2026 04:46:00 -0000 full Nick Norwitz MD PhD Microplastics and Cardiovascular Disease Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Winnow Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSWinnow is a first-in-class probiotic that binds microplastics to provide a microplastic shield from your inside. See the letter above for more details.Inulin StayCurious Newsletter: https://staycuriousmetabolism.substack.com/p/the-fiber-that-fights-fat-how-inulin?r=40ekz2 Inulin Video: https://youtu.be/blNLHsww_Qs Andrew Koutnik, Interview 1: https://youtu.be/2doAS18X9kA Andrew Koutnik, Interview 2: https://youtu.be/-vdol1TSxoc Andrew Koutnik, Interview 3: https://youtu.be/NrZlvtWIgBAIn this episode, Dr Andrew Koutnik and I dive deep into the science of fiber, keto, and more – focusing on two influential 2025 papers. First, we unpack the a new study revealing how a specific type of fiber can “immunize” the body against fructose by reshaping the microbiome, protecting the liver, reducing de novo lipogenesis, and boosting glutathione production. This isn’t “more fiber is better”—it’s precision nutrition.Then we break down the keto mouse study that was widely discuss for claiming ketogenic diets cause fatty liver and glucose intolerance. We explain why this particular mouse model leads to misleading results, and how diet design specifics dramatically change outcomes. When viewed through these lenses, the scare headlines collapse.We also explore how to think critically about nutrition science, why animal studies can both illuminate and mislead, how individuals can apply evidence with nuance, and why personal experimentation—combined with skepticism and curiosity—leads to better metabolic outcomes. If you're trying to understand fiber, fructose, ketogenic diets, diabetes, or simply want to make better decisions about your own metabolic health, this conversation provides clarity and actionable insight.Chapters:0:00 – Intro: Welcome Back Dr Andrew Koutnik PhD1:40 – The Coolest Fiber Paper Ever!21:19 – Probiotic That Binds Plastics22:52 – Keto Mouse Myths: A Shady Study Skews the Truth30:01 – Andrew Reflects on his Diary of a CEO Appearance 43:01 – Do Credentials Teach Curiosity, or Crush Them?#NickNorwitz #AndrewKoutnik #MetabolicHealth #NutritionScience #Inulin #FiberScience #Microbiome #GutHealth #Fructose #HFCS #LiverHealth #NAFLD #Metabolism #InsulinResistance #KetogenicDiet #KetoScience #LowCarb #Type1Diabetes #PrecisionNutrition #LongevityScience #Healthspan #ScientificDebunk #DietStudies #EvidenceBasedNutrition #ScienceExplainer #StayCurious #Glutathione #Mitochondria #DeNovoLipogenesis #MicrobiomeResearch Learn more about your ad choices. Visit megaphone.fm/adchoices Microplastics and Cardiovascular Disease Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2

Winnow Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUS
Winnow is a first-in-class probiotic that binds microplastics to provide a microplastic shield from your inside. See the letter above for more details.

Inulin StayCurious Newsletter: https://staycuriousmetabolism.substack.com/p/the-fiber-that-fights-fat-how-inulin?r=40ekz2

Inulin Video: https://youtu.be/blNLHsww_Qs

Andrew Koutnik, Interview 1: https://youtu.be/2doAS18X9kA
Andrew Koutnik, Interview 2: https://youtu.be/-vdol1TSxoc
Andrew Koutnik, Interview 3: https://youtu.be/NrZlvtWIgBA

In this episode, Dr Andrew Koutnik and I dive deep into the science of fiber, keto, and more – focusing on two influential 2025 papers. First, we unpack the a new study revealing how a specific type of fiber can “immunize” the body against fructose by reshaping the microbiome, protecting the liver, reducing de novo lipogenesis, and boosting glutathione production. This isn’t “more fiber is better”—it’s precision nutrition.

Then we break down the keto mouse study that was widely discuss for claiming ketogenic diets cause fatty liver and glucose intolerance. We explain why this particular mouse model leads to misleading results, and how diet design specifics dramatically change outcomes. When viewed through these lenses, the scare headlines collapse.

We also explore how to think critically about nutrition science, why animal studies can both illuminate and mislead, how individuals can apply evidence with nuance, and why personal experimentation—combined with skepticism and curiosity—leads to better metabolic outcomes. If you're trying to understand fiber, fructose, ketogenic diets, diabetes, or simply want to make better decisions about your own metabolic health, this conversation provides clarity and actionable insight.

Chapters:
0:00 – Intro: Welcome Back Dr Andrew Koutnik PhD
1:40 – The Coolest Fiber Paper Ever!
21:19 – Probiotic That Binds Plastics
22:52 – Keto Mouse Myths: A Shady Study Skews the Truth
30:01 – Andrew Reflects on his Diary of a CEO Appearance
43:01 – Do Credentials Teach Curiosity, or Crush Them?

#NickNorwitz #AndrewKoutnik #MetabolicHealth #NutritionScience #Inulin #FiberScience #Microbiome #GutHealth #Fructose #HFCS #LiverHealth #NAFLD #Metabolism #InsulinResistance #KetogenicDiet #KetoScience #LowCarb #Type1Diabetes #PrecisionNutrition #LongevityScience #Healthspan #ScientificDebunk #DietStudies #EvidenceBasedNutrition #ScienceExplainer #StayCurious #Glutathione #Mitochondria #DeNovoLipogenesis #MicrobiomeResearch

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 3419 no Oreo Joe Rogan! JRE #2069, Spotify: https://open.spotify.com/episode/6BVcDMKLN820nNXYSPcbwvOreo experiment, Video: https://youtu.be/GHALacs44I8?si=Oec-0YqamBj5dO1XOreo experiment, Tweet: https://x.com/nicknorwitz/status/1729122883564171274?s=20Carnivore, Harvard Study: https://pubmed.ncbi.nlm.nih.gov/34934897/LMHR study: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltextLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/ Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 30 Oct 2026 10:46:00 -0000 full Nick Norwitz MD PhD JRE #2069, Spotify: https://open.spotify.com/episode/6BVcDMKLN820nNXYSPcbwvOreo experiment, Video: https://youtu.be/GHALacs44I8?si=Oec-0YqamBj5dO1XOreo experiment, Tweet: https://x.com/nicknorwitz/status/1729122883564171274?s=20Carnivore, Harvard Study: https://pubmed.ncbi.nlm.nih.gov/34934897/LMHR study: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltextLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/ Learn more about your ad choices. Visit megaphone.fm/adchoices JRE #2069, Spotify: https://open.spotify.com/episode/6BVcDMKLN820nNXYSPcbwv

Oreo experiment, Video: https://youtu.be/GHALacs44I8?si=Oec-0YqamBj5dO1X
Oreo experiment, Tweet: https://x.com/nicknorwitz/status/1729122883564171274?s=20

Carnivore, Harvard Study: https://pubmed.ncbi.nlm.nih.gov/34934897/
LMHR study: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext
Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/

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]]> 388 no The New Skinny on Lp(a) For references, extra nuances and my Lp(a) protocol, see this letter: https://staycuriousmetabolism.substack.com/p/why-lpa-may-not-be-as-dangerous-as?r=40ekz2 Relevant Prior VideosLp(a) Background Video: https://youtu.be/iVwDJqJiTEY Lp(a) and Vitamin C Video: https://youtu.be/3rbJnKnhg3s MPO Video: https://youtu.be/inTK-9DCxf0 Lipoprotein(a), or Lp(a), is one of the most feared genetic risk factors for heart disease. But new 2025 data tell a far more hopeful story.In this video, I break down a large, long-term study showing that Lp(a)-related cardiovascular risk depends heavily on metabolic context, especially waist-to-hip ratio — a simple marker of visceral fat. Shockingly, in people with low waist-to-hip ratios, even high Lp(a) levels were not associated with increased heart disease risk.We walk through the data, the graphs, the mechanisms (clotting, inflammation, oxidative stress), and the practical takeaways.Genes are not destiny. Metabolic health changes the story.Chapters0:00 – I Have Lp(a)… Oh No!1:47 – New Study on Waist-to-Hip Ratio and Lp(a)2:47 – High Lp(a) But Low WHR… Low Risk!3:31 – Look At This Graph! 4:28 – And Now Look at These Graphs!5:45 – Your Waist-to-Hip Ratio Goals7:23 – Mechanisms: Why Would Waist-to-Hip Ratio Matter for Lp(a) Risk?10:11 – Teasing the Protocol… See More at StayCurious Metabolism11:00 – Summarizing Key Points#LpA #HeartHealth #CardiovascularDisease #Genetics #MetabolicHealth #VisceralFat#WaistToHipRatio #Atherosclerosis #Inflammation #OxidativeStress #PrecisionHealth#Longevity #HealthScience #PreventiveCardiology #NickNorwitz #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 29 Oct 2026 16:46:00 -0000 full Nick Norwitz MD PhD For references, extra nuances and my Lp(a) protocol, see this letter: https://staycuriousmetabolism.substack.com/p/why-lpa-may-not-be-as-dangerous-as?r=40ekz2 Relevant Prior VideosLp(a) Background Video: https://youtu.be/iVwDJqJiTEY Lp(a) and Vitamin C Video: https://youtu.be/3rbJnKnhg3s MPO Video: https://youtu.be/inTK-9DCxf0 Lipoprotein(a), or Lp(a), is one of the most feared genetic risk factors for heart disease. But new 2025 data tell a far more hopeful story.In this video, I break down a large, long-term study showing that Lp(a)-related cardiovascular risk depends heavily on metabolic context, especially waist-to-hip ratio — a simple marker of visceral fat. Shockingly, in people with low waist-to-hip ratios, even high Lp(a) levels were not associated with increased heart disease risk.We walk through the data, the graphs, the mechanisms (clotting, inflammation, oxidative stress), and the practical takeaways.Genes are not destiny. Metabolic health changes the story.Chapters0:00 – I Have Lp(a)… Oh No!1:47 – New Study on Waist-to-Hip Ratio and Lp(a)2:47 – High Lp(a) But Low WHR… Low Risk!3:31 – Look At This Graph! 4:28 – And Now Look at These Graphs!5:45 – Your Waist-to-Hip Ratio Goals7:23 – Mechanisms: Why Would Waist-to-Hip Ratio Matter for Lp(a) Risk?10:11 – Teasing the Protocol… See More at StayCurious Metabolism11:00 – Summarizing Key Points#LpA #HeartHealth #CardiovascularDisease #Genetics #MetabolicHealth #VisceralFat#WaistToHipRatio #Atherosclerosis #Inflammation #OxidativeStress #PrecisionHealth#Longevity #HealthScience #PreventiveCardiology #NickNorwitz #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For references, extra nuances and my Lp(a) protocol, see this letter: https://staycuriousmetabolism.substack.com/p/why-lpa-may-not-be-as-dangerous-as?r=40ekz2

Relevant Prior Videos
Lp(a) Background Video: https://youtu.be/iVwDJqJiTEY
Lp(a) and Vitamin C Video: https://youtu.be/3rbJnKnhg3s
MPO Video: https://youtu.be/inTK-9DCxf0

Lipoprotein(a), or Lp(a), is one of the most feared genetic risk factors for heart disease. But new 2025 data tell a far more hopeful story.

In this video, I break down a large, long-term study showing that Lp(a)-related cardiovascular risk depends heavily on metabolic context, especially waist-to-hip ratio — a simple marker of visceral fat. Shockingly, in people with low waist-to-hip ratios, even high Lp(a) levels were not associated with increased heart disease risk.

We walk through the data, the graphs, the mechanisms (clotting, inflammation, oxidative stress), and the practical takeaways.

Genes are not destiny. Metabolic health changes the story.

Chapters
0:00 – I Have Lp(a)… Oh No!
1:47 – New Study on Waist-to-Hip Ratio and Lp(a)
2:47 – High Lp(a) But Low WHR… Low Risk!
3:31 – Look At This Graph!
4:28 – And Now Look at These Graphs!
5:45 – Your Waist-to-Hip Ratio Goals
7:23 – Mechanisms: Why Would Waist-to-Hip Ratio Matter for Lp(a) Risk?
10:11 – Teasing the Protocol… See More at StayCurious Metabolism
11:00 – Summarizing Key Points

#LpA #HeartHealth #CardiovascularDisease #Genetics #MetabolicHealth #VisceralFat
#WaistToHipRatio #Atherosclerosis #Inflammation #OxidativeStress #PrecisionHealth
#Longevity #HealthScience #PreventiveCardiology #NickNorwitz #StayCurious

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]]> 962 no Nuanced Response to Peter Attia about LDL on Keto Peter and Derek: https://www.youtube.com/watch?v=sl0LrPYZoTYLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/LMHR, first paper: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext JCL LMHR editorial: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltextLMHR, low saturated fat case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/ Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 28 Oct 2026 22:46:00 -0000 full Nick Norwitz MD PhD Peter and Derek: https://www.youtube.com/watch?v=sl0LrPYZoTYLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/LMHR, first paper: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext JCL LMHR editorial: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltextLMHR, low saturated fat case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/ Learn more about your ad choices. Visit megaphone.fm/adchoices Peter and Derek: https://www.youtube.com/watch?v=sl0LrPYZoTY

Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/
LMHR, first paper: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext
JCL LMHR editorial: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltext
LMHR, low saturated fat case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/

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]]> 1720 no Belly Fat is Destroying Your Mental Health For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/can-visceral-fat-cause-depression?r=40ekz2 Chapter*Call our service line at 815-STAY-CUR (815-782-9287) *Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2 Visceral Fat Randomized Controlled Trial Video: https://youtu.be/lDeegZ1wtAIDescription:Most people think of fat as extra weight—something cosmetic or something to “burn off.” But new science is showing something far more profound: visceral fat is an endocrine organ that sends biochemical messages across the entire body, including directly into the brain. And those messages can change mood, increase stress sensitivity, and even promote depression.In this video, we break down a brand-new study revealing how visceral fat releases tiny molecular packages called extracellular vesicles. Inside those vesicles is a specific microRNA—a signal that can cross the blood-brain barrier, impair neurons in the hippocampus, lower BDNF, and induce depression-like behavior in animal models. This emerging research provides a mechanistic explanation for why obesity and depression are so tightly linked, why mood disorders often worsen with metabolic disease, and why improving metabolic health may improve mental health. Finally, we explore what you can do today—how reducing visceral fat may lower miR-145-5p, improve brain resilience, and break the vicious metabolic–mood loop. Your metabolism and your mind are not separate systems. They are one.Chapters:0:00 – Visceral Fat: More Than Storage1:03 – Can Fat Cause Depression? New Biology2:26 – The Obesity–Depression Loop3:32 – Mechanism: How Visceral Fat Sends Signals to the Brain5:07 – miR-145-5p: The Molecular “Letter” Driving Depression9:19 – What You Can Do: Reducing Visceral Fat to Protect Brain Health#visceralfat #depression #metabolichealth #extracellularvesicles #microRNA #brainhealth #inflammation #mentalhealth #obesityresearch #healthscience #NickNorwitz #StayCuriousMetabolism*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 28 Oct 2026 04:46:00 -0000 full Nick Norwitz MD PhD For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/can-visceral-fat-cause-depression?r=40ekz2 Chapter*Call our service line at 815-STAY-CUR (815-782-9287) *Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2 Visceral Fat Randomized Controlled Trial Video: https://youtu.be/lDeegZ1wtAIDescription:Most people think of fat as extra weight—something cosmetic or something to “burn off.” But new science is showing something far more profound: visceral fat is an endocrine organ that sends biochemical messages across the entire body, including directly into the brain. And those messages can change mood, increase stress sensitivity, and even promote depression.In this video, we break down a brand-new study revealing how visceral fat releases tiny molecular packages called extracellular vesicles. Inside those vesicles is a specific microRNA—a signal that can cross the blood-brain barrier, impair neurons in the hippocampus, lower BDNF, and induce depression-like behavior in animal models. This emerging research provides a mechanistic explanation for why obesity and depression are so tightly linked, why mood disorders often worsen with metabolic disease, and why improving metabolic health may improve mental health. Finally, we explore what you can do today—how reducing visceral fat may lower miR-145-5p, improve brain resilience, and break the vicious metabolic–mood loop. Your metabolism and your mind are not separate systems. They are one.Chapters:0:00 – Visceral Fat: More Than Storage1:03 – Can Fat Cause Depression? New Biology2:26 – The Obesity–Depression Loop3:32 – Mechanism: How Visceral Fat Sends Signals to the Brain5:07 – miR-145-5p: The Molecular “Letter” Driving Depression9:19 – What You Can Do: Reducing Visceral Fat to Protect Brain Health#visceralfat #depression #metabolichealth #extracellularvesicles #microRNA #brainhealth #inflammation #mentalhealth #obesityresearch #healthscience #NickNorwitz #StayCuriousMetabolism*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. Learn more about your ad choices. Visit megaphone.fm/adchoices For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/can-visceral-fat-cause-depression?r=40ekz2

Chapter
*Call our service line at 815-STAY-CUR (815-782-9287)
*Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2

Visceral Fat Randomized Controlled Trial Video: https://youtu.be/lDeegZ1wtAI

Description:
Most people think of fat as extra weight—something cosmetic or something to “burn off.” But new science is showing something far more profound: visceral fat is an endocrine organ that sends biochemical messages across the entire body, including directly into the brain. And those messages can change mood, increase stress sensitivity, and even promote depression.

In this video, we break down a brand-new study revealing how visceral fat releases tiny molecular packages called extracellular vesicles. Inside those vesicles is a specific microRNA—a signal that can cross the blood-brain barrier, impair neurons in the hippocampus, lower BDNF, and induce depression-like behavior in animal models.

This emerging research provides a mechanistic explanation for why obesity and depression are so tightly linked, why mood disorders often worsen with metabolic disease, and why improving metabolic health may improve mental health.

Finally, we explore what you can do today—how reducing visceral fat may lower miR-145-5p, improve brain resilience, and break the vicious metabolic–mood loop. Your metabolism and your mind are not separate systems. They are one.

Chapters:
0:00 – Visceral Fat: More Than Storage
1:03 – Can Fat Cause Depression? New Biology
2:26 – The Obesity–Depression Loop
3:32 – Mechanism: How Visceral Fat Sends Signals to the Brain
5:07 – miR-145-5p: The Molecular “Letter” Driving Depression
9:19 – What You Can Do: Reducing Visceral Fat to Protect Brain Health

#visceralfat #depression #metabolichealth #extracellularvesicles #microRNA #brainhealth #inflammation #mentalhealth #obesityresearch #healthscience #NickNorwitz #StayCuriousMetabolism

*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options.

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]]> 1167 no Plant-Based Low-Fat Study was Wrong Link: https://jn.nutrition.org/article/S0022-3166(23)72806-X/fulltexthttps://authors.elsevier.com/sd/article/S0022-3166(23)72806-X Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 27 Oct 2026 10:46:00 -0000 full Nick Norwitz MD PhD Link: https://jn.nutrition.org/article/S0022-3166(23)72806-X/fulltexthttps://authors.elsevier.com/sd/article/S0022-3166(23)72806-X Learn more about your ad choices. Visit megaphone.fm/adchoices Link: https://jn.nutrition.org/article/S0022-3166(23)72806-X/fulltext
https://authors.elsevier.com/sd/article/S0022-3166(23)72806-X

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 620 no Sardines, Sleep and Super-Longevity | ft' Professor Dominic D’Agostino Dom D’Agostino Part 1 Interview: https://youtu.be/ksV9f4jSbLQ Creatine Letter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2 Sardine Diet Letter: https://staycuriousmetabolism.substack.com/p/sardine-fasting-the-ultimate-health?r=40ekz2 Sardine Diet Video: https://youtu.be/_Th54GWd8WY Lived to 117 Letter: https://staycuriousmetabolism.substack.com/p/the-oldest-woman-117-had-high-cholesterol?r=40ekz2 Lived to 117 Video: https://youtu.be/U7UY8ZPKNlM Stress Makes Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2 Stress Makes Sugar Video: https://youtu.be/7ekVEYlKFfE This interview with Professor Dom D’Agostino is one of the most information-dense conversations I’ve had on the channel. We dive into the real science behind melatonin — why it doesn’t suppress your hormones and why its neuroprotective effects might matter more than its sleep benefits. We explore creatine far beyond muscle performance, including its impact on brain energy and cognitive resilience, and how to take it without the GI issues many people experience.We also break down the surprising biology of a verified 117-year-old woman, what her data reveals about longevity, and why factors like mindset, mitochondria, and microbiome may matter more than any single biomarker. And finally, we tackle sardine fasting — why it may be the most elite, nutrient-dense, muscle-sparing fasting protocol available. If you want cutting-edge science translated into practical strategies for metabolic health, brain health, and longevity, this is the episode to watch.Chapters 0:00 – Welcome Back Professor D’Agostino 1:34 – Does Melatonin Suppress Your Hormones?6:27 – Real Benefits of Melatonin8:00 – Creatine for Brain Health10:24 – How to Reduce GI Upset from Creatine14:04 – How Did This Woman Live to 117?30:00 – Sardine Fasting: The Most Elite Form of Fasting#melatonin #creatine #sardines #sardinediet #fasting #longevity #brainhealth #metabolichealth #neuroprotection #omega3 #NickNorwitz #DomDAgostino #StayCurious #nutritionresearch #healthscience #biohacking #antiaging #ketodiet #ketosis #healthoptimization #supplements #exercisephysiology #functionalnutrition #lowcarb #cholesterol #labresults #epigenetics #mitochondria #inflammation #mentalclarity #superfoods #metabolismboost #wellnessjourney #lifespan #healthylonglife Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 26 Oct 2026 16:46:00 -0000 full Nick Norwitz MD PhD Dom D’Agostino Part 1 Interview: https://youtu.be/ksV9f4jSbLQ Creatine Letter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2 Sardine Diet Letter: https://staycuriousmetabolism.substack.com/p/sardine-fasting-the-ultimate-health?r=40ekz2 Sardine Diet Video: https://youtu.be/_Th54GWd8WY Lived to 117 Letter: https://staycuriousmetabolism.substack.com/p/the-oldest-woman-117-had-high-cholesterol?r=40ekz2 Lived to 117 Video: https://youtu.be/U7UY8ZPKNlM Stress Makes Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2 Stress Makes Sugar Video: https://youtu.be/7ekVEYlKFfE This interview with Professor Dom D’Agostino is one of the most information-dense conversations I’ve had on the channel. We dive into the real science behind melatonin — why it doesn’t suppress your hormones and why its neuroprotective effects might matter more than its sleep benefits. We explore creatine far beyond muscle performance, including its impact on brain energy and cognitive resilience, and how to take it without the GI issues many people experience.We also break down the surprising biology of a verified 117-year-old woman, what her data reveals about longevity, and why factors like mindset, mitochondria, and microbiome may matter more than any single biomarker. And finally, we tackle sardine fasting — why it may be the most elite, nutrient-dense, muscle-sparing fasting protocol available. If you want cutting-edge science translated into practical strategies for metabolic health, brain health, and longevity, this is the episode to watch.Chapters 0:00 – Welcome Back Professor D’Agostino 1:34 – Does Melatonin Suppress Your Hormones?6:27 – Real Benefits of Melatonin8:00 – Creatine for Brain Health10:24 – How to Reduce GI Upset from Creatine14:04 – How Did This Woman Live to 117?30:00 – Sardine Fasting: The Most Elite Form of Fasting#melatonin #creatine #sardines #sardinediet #fasting #longevity #brainhealth #metabolichealth #neuroprotection #omega3 #NickNorwitz #DomDAgostino #StayCurious #nutritionresearch #healthscience #biohacking #antiaging #ketodiet #ketosis #healthoptimization #supplements #exercisephysiology #functionalnutrition #lowcarb #cholesterol #labresults #epigenetics #mitochondria #inflammation #mentalclarity #superfoods #metabolismboost #wellnessjourney #lifespan #healthylonglife Learn more about your ad choices. Visit megaphone.fm/adchoices Dom D’Agostino Part 1 Interview: https://youtu.be/ksV9f4jSbLQ

Creatine Letter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2

Sardine Diet Letter: https://staycuriousmetabolism.substack.com/p/sardine-fasting-the-ultimate-health?r=40ekz2
Sardine Diet Video: https://youtu.be/_Th54GWd8WY

Lived to 117 Letter: https://staycuriousmetabolism.substack.com/p/the-oldest-woman-117-had-high-cholesterol?r=40ekz2
Lived to 117 Video: https://youtu.be/U7UY8ZPKNlM

Stress Makes Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2
Stress Makes Sugar Video: https://youtu.be/7ekVEYlKFfE

This interview with Professor Dom D’Agostino is one of the most information-dense conversations I’ve had on the channel. We dive into the real science behind melatonin — why it doesn’t suppress your hormones and why its neuroprotective effects might matter more than its sleep benefits.

We explore creatine far beyond muscle performance, including its impact on brain energy and cognitive resilience, and how to take it without the GI issues many people experience.

We also break down the surprising biology of a verified 117-year-old woman, what her data reveals about longevity, and why factors like mindset, mitochondria, and microbiome may matter more than any single biomarker.

And finally, we tackle sardine fasting — why it may be the most elite, nutrient-dense, muscle-sparing fasting protocol available. If you want cutting-edge science translated into practical strategies for metabolic health, brain health, and longevity, this is the episode to watch.

Chapters
0:00 – Welcome Back Professor D’Agostino
1:34 – Does Melatonin Suppress Your Hormones?
6:27 – Real Benefits of Melatonin
8:00 – Creatine for Brain Health
10:24 – How to Reduce GI Upset from Creatine
14:04 – How Did This Woman Live to 117?
30:00 – Sardine Fasting: The Most Elite Form of Fasting

#melatonin #creatine #sardines #sardinediet #fasting #longevity #brainhealth #metabolichealth #neuroprotection #omega3 #NickNorwitz #DomDAgostino #StayCurious #nutritionresearch #healthscience #biohacking #antiaging #ketodiet #ketosis #healthoptimization #supplements #exercisephysiology #functionalnutrition #lowcarb #cholesterol #labresults #epigenetics #mitochondria #inflammation #mentalclarity #superfoods #metabolismboost #wellnessjourney #lifespan #healthylonglife

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 2854 no Cholesterol Manipulation in 10 Keto Women Link to paper: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/fullAdrian Soto Mota MD PhD Tweet: https://x.com/AdrianSotoMota/status/1737733204734579062?s=20 Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 25 Oct 2026 22:46:00 -0000 full Nick Norwitz MD PhD Link to paper: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/fullAdrian Soto Mota MD PhD Tweet: https://x.com/AdrianSotoMota/status/1737733204734579062?s=20 Learn more about your ad choices. Visit megaphone.fm/adchoices Link to paper: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full

Adrian Soto Mota MD PhD Tweet: https://x.com/AdrianSotoMota/status/1737733204734579062?s=20

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]]> 848 no The Harvard Cookie Study That Broke Cholesterol Science For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/the-true-story-of-the-cookie-that?r=40ekz2 Oreo vs Statin Paper: https://pubmed.ncbi.nlm.nih.gov/38276308/Lipid Energy Model Paper: https://pubmed.ncbi.nlm.nih.gov/35629964/ What if Oreo cookies could lower cholesterol faster — and more powerfully — than a multi-billion-dollar statin drug? That’s the question I set out to test in a 5-month controlled self-experiment I ran as a Harvard Medical School student. And the results were so shocking they were eventually published in peer-reviewed literature.This video shares the full story — why my LDL cholesterol skyrocketed into the 500s after going ketogenic, the physiology behind the lean-mass hyper-responder phenomenon, and how adding 12 Oreo cookies per day dropped my LDL twice as much as high-dose statin therapy and in one-third of the time.But this isn’t just about cookies…This is a video about challenging assumptions, testing mechanisms, provoking curiosity, and using a viral headline to shine light on a deeply misunderstood physiological phenomenon.Chapters0:00 – I Used Oreo Cookies to Lower My LDL 1:06 – Why My Cholesterol Skyrocketed in the First Place 4:43 – The True Mechanism Behind the LDL Rocket ship7:53 – Why Oreos vs Statin Worked So Well11:00 – What Does this Oreo Cookie Cholesterol Drop Really Mean?12:33 – What is the Risk of High Cholesterol in People Like Me?14:08 – What We Now Know#cholesterol #LDL #hearthealth #metabolism #LMHR #lipidenergymodel #LEM #exercise #ApoB #cardiovasculardisease #obesity #staycurious #VLDL #triglycerides #metabolichealth #educational #metabolichealth #cholesterol #LDL #statins #ketodiet #lipidenergymodel #leanmasshyperresponder #metabolichealth #healthscience #ApoB #nutritionresearch #NickNorwitz #StayCurious #cardiovascularhealth #scienceeducation #cholesterolmyth Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 25 Oct 2026 04:46:00 -0000 full Nick Norwitz MD PhD For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/the-true-story-of-the-cookie-that?r=40ekz2 Oreo vs Statin Paper: https://pubmed.ncbi.nlm.nih.gov/38276308/Lipid Energy Model Paper: https://pubmed.ncbi.nlm.nih.gov/35629964/ What if Oreo cookies could lower cholesterol faster — and more powerfully — than a multi-billion-dollar statin drug? That’s the question I set out to test in a 5-month controlled self-experiment I ran as a Harvard Medical School student. And the results were so shocking they were eventually published in peer-reviewed literature.This video shares the full story — why my LDL cholesterol skyrocketed into the 500s after going ketogenic, the physiology behind the lean-mass hyper-responder phenomenon, and how adding 12 Oreo cookies per day dropped my LDL twice as much as high-dose statin therapy and in one-third of the time.But this isn’t just about cookies…This is a video about challenging assumptions, testing mechanisms, provoking curiosity, and using a viral headline to shine light on a deeply misunderstood physiological phenomenon.Chapters0:00 – I Used Oreo Cookies to Lower My LDL 1:06 – Why My Cholesterol Skyrocketed in the First Place 4:43 – The True Mechanism Behind the LDL Rocket ship7:53 – Why Oreos vs Statin Worked So Well11:00 – What Does this Oreo Cookie Cholesterol Drop Really Mean?12:33 – What is the Risk of High Cholesterol in People Like Me?14:08 – What We Now Know#cholesterol #LDL #hearthealth #metabolism #LMHR #lipidenergymodel #LEM #exercise #ApoB #cardiovasculardisease #obesity #staycurious #VLDL #triglycerides #metabolichealth #educational #metabolichealth #cholesterol #LDL #statins #ketodiet #lipidenergymodel #leanmasshyperresponder #metabolichealth #healthscience #ApoB #nutritionresearch #NickNorwitz #StayCurious #cardiovascularhealth #scienceeducation #cholesterolmyth Learn more about your ad choices. Visit megaphone.fm/adchoices For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/the-true-story-of-the-cookie-that?r=40ekz2

Oreo vs Statin Paper: https://pubmed.ncbi.nlm.nih.gov/38276308/
Lipid Energy Model Paper: https://pubmed.ncbi.nlm.nih.gov/35629964/

What if Oreo cookies could lower cholesterol faster — and more powerfully — than a multi-billion-dollar statin drug? That’s the question I set out to test in a 5-month controlled self-experiment I ran as a Harvard Medical School student. And the results were so shocking they were eventually published in peer-reviewed literature.

This video shares the full story — why my LDL cholesterol skyrocketed into the 500s after going ketogenic, the physiology behind the lean-mass hyper-responder phenomenon, and how adding 12 Oreo cookies per day dropped my LDL twice as much as high-dose statin therapy and in one-third of the time.

But this isn’t just about cookies…This is a video about challenging assumptions, testing mechanisms, provoking curiosity, and using a viral headline to shine light on a deeply misunderstood physiological phenomenon.

Chapters
0:00 – I Used Oreo Cookies to Lower My LDL
1:06 – Why My Cholesterol Skyrocketed in the First Place
4:43 – The True Mechanism Behind the LDL Rocket ship
7:53 – Why Oreos vs Statin Worked So Well
11:00 – What Does this Oreo Cookie Cholesterol Drop Really Mean?
12:33 – What is the Risk of High Cholesterol in People Like Me?
14:08 – What We Now Know

#cholesterol #LDL #hearthealth #metabolism #LMHR #lipidenergymodel #LEM #exercise #ApoB #cardiovasculardisease #obesity #staycurious #VLDL #triglycerides #metabolichealth #educational #metabolichealth #cholesterol #LDL #statins #ketodiet #lipidenergymodel #leanmasshyperresponder #metabolichealth #healthscience #ApoB #nutritionresearch #NickNorwitz #StayCurious #cardiovascularhealth #scienceeducation #cholesterolmyth

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]]> 1322 no Nutrition versus The Lipid Problem: Response Video Prior Response video: https://youtu.be/ILuEO7Jc8TY?si=RCPFWtRDC09Pst5sLMHR CCTA study drop: https://youtu.be/IMkDwtJVeB0?si=yx-zbFnfkLNtZeuLOreovsStatin leak video: https://youtu.be/GHALacs44I8?si=9IOAgZTl3sMnVg6LPeter Libby Review: https://www.nature.com/articles/s41586-021-03392-8Norwitz et al 2021: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltextCooper et al 2023: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 24 Oct 2026 10:46:00 -0000 full Nick Norwitz MD PhD Prior Response video: https://youtu.be/ILuEO7Jc8TY?si=RCPFWtRDC09Pst5sLMHR CCTA study drop: https://youtu.be/IMkDwtJVeB0?si=yx-zbFnfkLNtZeuLOreovsStatin leak video: https://youtu.be/GHALacs44I8?si=9IOAgZTl3sMnVg6LPeter Libby Review: https://www.nature.com/articles/s41586-021-03392-8Norwitz et al 2021: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltextCooper et al 2023: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full Learn more about your ad choices. Visit megaphone.fm/adchoices Prior Response video: https://youtu.be/ILuEO7Jc8TY?si=RCPFWtRDC09Pst5s

LMHR CCTA study drop: https://youtu.be/IMkDwtJVeB0?si=yx-zbFnfkLNtZeuL

OreovsStatin leak video: https://youtu.be/GHALacs44I8?si=9IOAgZTl3sMnVg6L

Peter Libby Review: https://www.nature.com/articles/s41586-021-03392-8

Norwitz et al 2021: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext

Cooper et al 2023: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full

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]]> 624 no Why I’m Not Afraid of Alzheimer’s Anymore For references and a written breakdown, see the associated Stay Curious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/new-hope-for-alzheimers-can-apoe2?r=40ekz2 Lithium for Brain Health: https://staycuriousmetabolism.substack.com/p/lithium-and-alzheimers-the-harvard?r=40ekz2 Ketone Cleans the Brain, Video: https://youtu.be/oRaNzfHF_do Chapter*Call our service line at 815-STAY-CUR (815-782-9287) *Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2 I carry two copies of APOE4 — the gene variant that increases Alzheimer’s risk 10–15-fold. For years, that terrified me. But emerging research provides hope. The study we will review suggests that adding APOE2 might quiet brain inflammation, reduce plaques, and help save neurons. In today’s video, I break down the research in simple terms and what this could mean for the future of Alzheimer’s therapy. Then I’ll share the evidence-based strategies that I personally use to protect my brain while we wait for next-generation gene therapies: lithium orotate, ketosis, omega-3s, and more.Chapters0:00 – Why I’m Determined to Prevent Alzheimer’s1:28 – An Incredible Picture of Neuroinflammation 2:06 – APOE2, APOE3, APOE4: What These Genes Really Mean3:54 – The Big Question: Is There an Antidote to APOE4?5:36 – APOE2 Therapy: Reduced Plaques and Silenced Neuroinflammation7:19 – Chapter: The Right Insurance Saves Money and Life-Years8:33 – My 3 Neuroprotection Essentials: Lithium, Ketosis and Omega-3s#alzheimersdisease #apoe4 #brainhealth #longevity #dementia #neuroscience #educational #staycurious #Alzheimers #BrainHealth #Neuroinflammation #CognitiveHealth #DementiaPrevention #APOE2 #Genetics #Longevity #Neuroscience #Metabolism #Ketosis #LithiumOrotate #Omega3 #HealthyBrainAging #StayCurious #Neuroprotection #Microglia #Amyloid #BrainOptimization*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 23 Oct 2026 16:46:00 -0000 full Nick Norwitz MD PhD For references and a written breakdown, see the associated Stay Curious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/new-hope-for-alzheimers-can-apoe2?r=40ekz2 Lithium for Brain Health: https://staycuriousmetabolism.substack.com/p/lithium-and-alzheimers-the-harvard?r=40ekz2 Ketone Cleans the Brain, Video: https://youtu.be/oRaNzfHF_do Chapter*Call our service line at 815-STAY-CUR (815-782-9287) *Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2 I carry two copies of APOE4 — the gene variant that increases Alzheimer’s risk 10–15-fold. For years, that terrified me. But emerging research provides hope. The study we will review suggests that adding APOE2 might quiet brain inflammation, reduce plaques, and help save neurons. In today’s video, I break down the research in simple terms and what this could mean for the future of Alzheimer’s therapy. Then I’ll share the evidence-based strategies that I personally use to protect my brain while we wait for next-generation gene therapies: lithium orotate, ketosis, omega-3s, and more.Chapters0:00 – Why I’m Determined to Prevent Alzheimer’s1:28 – An Incredible Picture of Neuroinflammation 2:06 – APOE2, APOE3, APOE4: What These Genes Really Mean3:54 – The Big Question: Is There an Antidote to APOE4?5:36 – APOE2 Therapy: Reduced Plaques and Silenced Neuroinflammation7:19 – Chapter: The Right Insurance Saves Money and Life-Years8:33 – My 3 Neuroprotection Essentials: Lithium, Ketosis and Omega-3s#alzheimersdisease #apoe4 #brainhealth #longevity #dementia #neuroscience #educational #staycurious #Alzheimers #BrainHealth #Neuroinflammation #CognitiveHealth #DementiaPrevention #APOE2 #Genetics #Longevity #Neuroscience #Metabolism #Ketosis #LithiumOrotate #Omega3 #HealthyBrainAging #StayCurious #Neuroprotection #Microglia #Amyloid #BrainOptimization*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. Learn more about your ad choices. Visit megaphone.fm/adchoices For references and a written breakdown, see the associated Stay Curious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/new-hope-for-alzheimers-can-apoe2?r=40ekz2

Lithium for Brain Health: https://staycuriousmetabolism.substack.com/p/lithium-and-alzheimers-the-harvard?r=40ekz2

Ketone Cleans the Brain, Video: https://youtu.be/oRaNzfHF_do

Chapter
*Call our service line at 815-STAY-CUR (815-782-9287)
*Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2

I carry two copies of APOE4 — the gene variant that increases Alzheimer’s risk 10–15-fold. For years, that terrified me. But emerging research provides hope. The study we will review suggests that adding APOE2 might quiet brain inflammation, reduce plaques, and help save neurons. In today’s video, I break down the research in simple terms and what this could mean for the future of Alzheimer’s therapy. Then I’ll share the evidence-based strategies that I personally use to protect my brain while we wait for next-generation gene therapies: lithium orotate, ketosis, omega-3s, and more.

Chapters
0:00 – Why I’m Determined to Prevent Alzheimer’s
1:28 – An Incredible Picture of Neuroinflammation
2:06 – APOE2, APOE3, APOE4: What These Genes Really Mean
3:54 – The Big Question: Is There an Antidote to APOE4?
5:36 – APOE2 Therapy: Reduced Plaques and Silenced Neuroinflammation
7:19 – Chapter: The Right Insurance Saves Money and Life-Years
8:33 – My 3 Neuroprotection Essentials: Lithium, Ketosis and Omega-3s

#alzheimersdisease #apoe4 #brainhealth #longevity #dementia #neuroscience #educational #staycurious #Alzheimers #BrainHealth #Neuroinflammation #CognitiveHealth #DementiaPrevention #APOE2 #Genetics #Longevity #Neuroscience #Metabolism #Ketosis #LithiumOrotate #Omega3 #HealthyBrainAging #StayCurious #Neuroprotection #Microglia #Amyloid #BrainOptimization

*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options.

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]]> 930 no This Vegan Documentary is a Bait and Switch What I liked: I like the concept of 'bringing the viewer along with the science.' I agree with the fact that the SAD eating pattern is problematic and that it would be an improvement to eat a whole food-based diet. I also (very much) acknowledge there are non-health related issues about food that we should have adult discussions about.What I didn't like: (1) This series wasn't really about the twin study. Data were only presented, a bit, in the last of the 4 episodes. (2) The advertised foods (fake meat, fake cheese, fake eggs) are cast as similar/identical, but simply aren't, nor were they the basis of the participant's diets.(3) The data presented were, I think, not all that impressive. And some data presented in the documentary could not be found in the paper, e.g. body composition.For more on the topic of Data Misrepresentation, see our new paper: https://www.sciencedirect.com/science/article/pii/S002231662372806X?via%3Dihub Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 22 Oct 2026 22:46:00 -0000 full Nick Norwitz MD PhD What I liked: I like the concept of 'bringing the viewer along with the science.' I agree with the fact that the SAD eating pattern is problematic and that it would be an improvement to eat a whole food-based diet. I also (very much) acknowledge there are non-health related issues about food that we should have adult discussions about.What I didn't like: (1) This series wasn't really about the twin study. Data were only presented, a bit, in the last of the 4 episodes. (2) The advertised foods (fake meat, fake cheese, fake eggs) are cast as similar/identical, but simply aren't, nor were they the basis of the participant's diets.(3) The data presented were, I think, not all that impressive. And some data presented in the documentary could not be found in the paper, e.g. body composition.For more on the topic of Data Misrepresentation, see our new paper: https://www.sciencedirect.com/science/article/pii/S002231662372806X?via%3Dihub Learn more about your ad choices. Visit megaphone.fm/adchoices What I liked: I like the concept of 'bringing the viewer along with the science.' I agree with the fact that the SAD eating pattern is problematic and that it would be an improvement to eat a whole food-based diet. I also (very much) acknowledge there are non-health related issues about food that we should have adult discussions about.

What I didn't like:
(1) This series wasn't really about the twin study. Data were only presented, a bit, in the last of the 4 episodes.
(2) The advertised foods (fake meat, fake cheese, fake eggs) are cast as similar/identical, but simply aren't, nor were they the basis of the participant's diets.
(3) The data presented were, I think, not all that impressive. And some data presented in the documentary could not be found in the paper, e.g. body composition.

For more on the topic of Data Misrepresentation, see our new paper: https://www.sciencedirect.com/science/article/pii/S002231662372806X?via%3Dihub

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1448 no This Sugar Science Blew Our Minds! (ft’ Dr. Andrew Koutnik) For a mini-masterclass in blood sugar control, see: https://staycuriousmetabolism.substack.com/p/7-ways-to-lower-blood-sugar-without?r=40ekz2 For the Stress Creates Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2 Statin Slash GLP-1 Video: https://youtu.be/6NomrgjK1yQIn this interview, Dr. Nick Norwitz MD PhD sits down once again with Dr. Andrew Koutnik PhD to unpack several groundbreaking research papers, including how psychological stress can cause your liver to make sugar from scratch, how different carbs and fibers impact bodies differently depending on metabolic health, how potatoes can tell you if you’re insulin sensitive, and more. If you’ve ever wondered how stress, nutrition, and biology collide to shape your health, this conversation might change the way you think about your body—and your mind.Chapters:00:00 — The new stress-sugar discovery01:10 — How your brain signals your liver to make glucose04:30 — The real mechanism behind “stress-induced sugar spikes”07:00 — Andrew’s story: TED Talk stress sent glucose up 100 mg/dL10:20 — How sprinting saved him from a glucose crash12:00 — What this means for diabetics and the general population14:30 — Why meditation changes your biology (not just mindset)16:00 — How obesity amplifies stress’s metabolic effects17:00 — The ‘semi-myth’ of fiber protection in insulin resistance21:30 — Personalized nutrition and CGM insights24:00 — Potatoes vs Grapes test for insulin resistance27:00 — GLP-1 dysfunction, statins, and “new species of diabetes”38:00 — The future of metabolic precision medicine#Cortisol #Glucose #BrainHealth #LiverHealth #Type1Diabetes #Type2Diabetes #Hormones #NutritionScience #Mitochondria #HealthOptimization #Neuroscience #Endocrinology #MetabolicFlexibility #LowCarb #KetogenicDiet #FunctionalMedicine #ChronicStress #Biohacking #HealthResearch #ScienceCommunication #Educational #Informative #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 22 Oct 2026 04:46:00 -0000 full Nick Norwitz MD PhD For a mini-masterclass in blood sugar control, see: https://staycuriousmetabolism.substack.com/p/7-ways-to-lower-blood-sugar-without?r=40ekz2 For the Stress Creates Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2 Statin Slash GLP-1 Video: https://youtu.be/6NomrgjK1yQIn this interview, Dr. Nick Norwitz MD PhD sits down once again with Dr. Andrew Koutnik PhD to unpack several groundbreaking research papers, including how psychological stress can cause your liver to make sugar from scratch, how different carbs and fibers impact bodies differently depending on metabolic health, how potatoes can tell you if you’re insulin sensitive, and more. If you’ve ever wondered how stress, nutrition, and biology collide to shape your health, this conversation might change the way you think about your body—and your mind.Chapters:00:00 — The new stress-sugar discovery01:10 — How your brain signals your liver to make glucose04:30 — The real mechanism behind “stress-induced sugar spikes”07:00 — Andrew’s story: TED Talk stress sent glucose up 100 mg/dL10:20 — How sprinting saved him from a glucose crash12:00 — What this means for diabetics and the general population14:30 — Why meditation changes your biology (not just mindset)16:00 — How obesity amplifies stress’s metabolic effects17:00 — The ‘semi-myth’ of fiber protection in insulin resistance21:30 — Personalized nutrition and CGM insights24:00 — Potatoes vs Grapes test for insulin resistance27:00 — GLP-1 dysfunction, statins, and “new species of diabetes”38:00 — The future of metabolic precision medicine#Cortisol #Glucose #BrainHealth #LiverHealth #Type1Diabetes #Type2Diabetes #Hormones #NutritionScience #Mitochondria #HealthOptimization #Neuroscience #Endocrinology #MetabolicFlexibility #LowCarb #KetogenicDiet #FunctionalMedicine #ChronicStress #Biohacking #HealthResearch #ScienceCommunication #Educational #Informative #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For a mini-masterclass in blood sugar control, see: https://staycuriousmetabolism.substack.com/p/7-ways-to-lower-blood-sugar-without?r=40ekz2
For the Stress Creates Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2
Statin Slash GLP-1 Video: https://youtu.be/6NomrgjK1yQ

In this interview, Dr. Nick Norwitz MD PhD sits down once again with Dr. Andrew Koutnik PhD to unpack several groundbreaking research papers, including how psychological stress can cause your liver to make sugar from scratch, how different carbs and fibers impact bodies differently depending on metabolic health, how potatoes can tell you if you’re insulin sensitive, and more. If you’ve ever wondered how stress, nutrition, and biology collide to shape your health, this conversation might change the way you think about your body—and your mind.

Chapters:
00:00 — The new stress-sugar discovery
01:10 — How your brain signals your liver to make glucose
04:30 — The real mechanism behind “stress-induced sugar spikes”
07:00 — Andrew’s story: TED Talk stress sent glucose up 100 mg/dL
10:20 — How sprinting saved him from a glucose crash
12:00 — What this means for diabetics and the general population
14:30 — Why meditation changes your biology (not just mindset)
16:00 — How obesity amplifies stress’s metabolic effects
17:00 — The ‘semi-myth’ of fiber protection in insulin resistance
21:30 — Personalized nutrition and CGM insights
24:00 — Potatoes vs Grapes test for insulin resistance
27:00 — GLP-1 dysfunction, statins, and “new species of diabetes”
38:00 — The future of metabolic precision medicine


#Cortisol #Glucose #BrainHealth #LiverHealth #Type1Diabetes #Type2Diabetes #Hormones #NutritionScience #Mitochondria #HealthOptimization #Neuroscience #Endocrinology #MetabolicFlexibility #LowCarb #KetogenicDiet #FunctionalMedicine #ChronicStress #Biohacking #HealthResearch #ScienceCommunication #Educational #Informative #StayCurious

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]]> 2719 no NEW STUDY Proves it's BMI not Butter that increases Cholesterol on Low-Carb Diets Link: https://pubmed.ncbi.nlm.nih.gov/38237807/0:00: intro 0:15: NEW paper!0:38: Low-Carb for various diseases0:57: LDL boogeyman1:17: Lean Mass Hyper-Responder #LMHR1:35: The BIG question2:11: Intro to NEW study, meta-analysis of RCTs2:46: BMI Results!4:43: Not the Saturated Fat!5:58: Lipid Energy Model 6:56: Conclusion Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 21 Oct 2026 10:46:00 -0000 full Nick Norwitz MD PhD Link: https://pubmed.ncbi.nlm.nih.gov/38237807/0:00: intro 0:15: NEW paper!0:38: Low-Carb for various diseases0:57: LDL boogeyman1:17: Lean Mass Hyper-Responder #LMHR1:35: The BIG question2:11: Intro to NEW study, meta-analysis of RCTs2:46: BMI Results!4:43: Not the Saturated Fat!5:58: Lipid Energy Model 6:56: Conclusion Learn more about your ad choices. Visit megaphone.fm/adchoices Link: https://pubmed.ncbi.nlm.nih.gov/38237807/

0:00: intro
0:15: NEW paper!
0:38: Low-Carb for various diseases
0:57: LDL boogeyman
1:17: Lean Mass Hyper-Responder #LMHR
1:35: The BIG question
2:11: Intro to NEW study, meta-analysis of RCTs
2:46: BMI Results!
4:43: Not the Saturated Fat!
5:58: Lipid Energy Model
6:56: Conclusion

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]]> 588 no 350% Increase in Heart Attacks! For more nuances and references, see the associated Newsletter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSMost people think of plastic as an environmental problem—something that harms oceans, wildlife, and ecosystems. But emerging science is revealing something far more personal: microplastics don’t just pollute the planet— they may be poisoning your heart.A landmark study published in the New England Journal of Medicine found microplastics and nanoplastics embedded inside human arterial plaque. Even more alarming, patients with these particles inside their arteries had a 350% higher risk of heart attack, stroke, or death.This research suggests microplastics may drive cardiovascular disease through oxidative stress, inflammation, immune activation, and vascular damage. Under the microscope, jagged plastic fragments were found lodged inside macrophages—immune cells that normally clear debris—triggering inflammation and accelerating plaque instability.We also explore what you can do today—from reducing heat-exposed plastics, filtering water, and improving air quality, to emerging research on internal defense strategies aimed at binding microplastics before they’re absorbed. This isn’t fear. It’s empowerment. Knowledge isn’t meant to panic us—it’s meant to protect us. Stay curious.Chapters0:00 – Plastic Poisons the Heart. But There’s Good News!1:15 – Find More Information at StayCurious Metabolism 1:41 – A Landmark NEJM Study 2:42 – 350% Increased Risk of Heart Attack, Stroke and Death!4:15 – Microplastics Associate with Inflammation 5:02 – Microplastics Lodged in Macrophage Immune Cells6:41 – Comparison to LDL Cholesterol 8:15 – How to Reduce Your Exposure to Microplastics9:54 – A Probiotic That Shields You from Microplastics#microplastics #cardiovasculardisease #microbiome #hearthealth #heartdisease #NEJM #microplastics #hearthealth #cardiovasculardisease #nanoplastics #inflammation #science #longevity #metabolichealth #heartattack #stroke #healthscience #NickNorwitz #StayCuriousMetabolism Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 20 Oct 2026 16:46:00 -0000 full Nick Norwitz MD PhD For more nuances and references, see the associated Newsletter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSMost people think of plastic as an environmental problem—something that harms oceans, wildlife, and ecosystems. But emerging science is revealing something far more personal: microplastics don’t just pollute the planet— they may be poisoning your heart.A landmark study published in the New England Journal of Medicine found microplastics and nanoplastics embedded inside human arterial plaque. Even more alarming, patients with these particles inside their arteries had a 350% higher risk of heart attack, stroke, or death.This research suggests microplastics may drive cardiovascular disease through oxidative stress, inflammation, immune activation, and vascular damage. Under the microscope, jagged plastic fragments were found lodged inside macrophages—immune cells that normally clear debris—triggering inflammation and accelerating plaque instability.We also explore what you can do today—from reducing heat-exposed plastics, filtering water, and improving air quality, to emerging research on internal defense strategies aimed at binding microplastics before they’re absorbed. This isn’t fear. It’s empowerment. Knowledge isn’t meant to panic us—it’s meant to protect us. Stay curious.Chapters0:00 – Plastic Poisons the Heart. But There’s Good News!1:15 – Find More Information at StayCurious Metabolism 1:41 – A Landmark NEJM Study 2:42 – 350% Increased Risk of Heart Attack, Stroke and Death!4:15 – Microplastics Associate with Inflammation 5:02 – Microplastics Lodged in Macrophage Immune Cells6:41 – Comparison to LDL Cholesterol 8:15 – How to Reduce Your Exposure to Microplastics9:54 – A Probiotic That Shields You from Microplastics#microplastics #cardiovasculardisease #microbiome #hearthealth #heartdisease #NEJM #microplastics #hearthealth #cardiovasculardisease #nanoplastics #inflammation #science #longevity #metabolichealth #heartattack #stroke #healthscience #NickNorwitz #StayCuriousMetabolism Learn more about your ad choices. Visit megaphone.fm/adchoices For more nuances and references, see the associated Newsletter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2

Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUS

Most people think of plastic as an environmental problem—something that harms oceans, wildlife, and ecosystems. But emerging science is revealing something far more personal: microplastics don’t just pollute the planet— they may be poisoning your heart.

A landmark study published in the New England Journal of Medicine found microplastics and nanoplastics embedded inside human arterial plaque. Even more alarming, patients with these particles inside their arteries had a 350% higher risk of heart attack, stroke, or death.

This research suggests microplastics may drive cardiovascular disease through oxidative stress, inflammation, immune activation, and vascular damage. Under the microscope, jagged plastic fragments were found lodged inside macrophages—immune cells that normally clear debris—triggering inflammation and accelerating plaque instability.

We also explore what you can do today—from reducing heat-exposed plastics, filtering water, and improving air quality, to emerging research on internal defense strategies aimed at binding microplastics before they’re absorbed. This isn’t fear. It’s empowerment. Knowledge isn’t meant to panic us—it’s meant to protect us. Stay curious.

Chapters
0:00 – Plastic Poisons the Heart. But There’s Good News!
1:15 – Find More Information at StayCurious Metabolism
1:41 – A Landmark NEJM Study
2:42 – 350% Increased Risk of Heart Attack, Stroke and Death!
4:15 – Microplastics Associate with Inflammation
5:02 – Microplastics Lodged in Macrophage Immune Cells
6:41 – Comparison to LDL Cholesterol
8:15 – How to Reduce Your Exposure to Microplastics
9:54 – A Probiotic That Shields You from Microplastics

#microplastics #cardiovasculardisease #microbiome #hearthealth #heartdisease #NEJM #microplastics #hearthealth #cardiovasculardisease #nanoplastics #inflammation #science #longevity #metabolichealth #heartattack #stroke #healthscience #NickNorwitz #StayCuriousMetabolism

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1036 no Oreos are the Most Potent Drug for LDL Cholesterol Paper link: https://www.mdpi.com/2218-1989/14/1/73Chapters0:00 – Intro0:28 – metabolic demonstration0:43 – Part I, the idea1:30 – LMHR triad 1:58 – Lipid Energy Model3:06 – Part II, the experimental design4:19 – Part III, results 6:00 – results summary 6:40 – Part IV, What’s Next? 7:37 – Thanks and Call to ActionAim: To tested the prediction -- consistent with the Lipid Energy Model (below) -- that adding carbohydrates (in the form of Oreo cookies) to an LMHR on a ketogenic diet would reduce LDL-C levels by a similar, or greater, magnitude than high-intensity statin therapy. Findings: Oreo supplementation (12 cookies/d) lowered LDL-C by 71% (273 mg/dl) in just 16 days. Rosuvastatin (20 mg/d) lowered LDL-C by 32.5% (137 mg/dl). Thus, Oreos were ~2X as potent as high-intensity statin therapy for LDL cholesterol lowering in this LMHR subject.The Why: The LMHR phenotype has much to teach us about human metabolism, and cardiovascular disease pathophysiology. It's a new frontier that deserves further study, for the sake of the patients with this phenotype and for pure scientific curiosity! This experiment will serve as 'productive provocation,' a form of 'legit-bait' that will hopefully help prompt discussions and larger-scale experiments that need to happen.6 select Prior publications1/ META of RCTs (new, 1/16/24)Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis. Amer J of Clin Nutr. 2024; doi: 10.1016/j.ajcnut.2024.01.009 **LINK: https://www.sciencedirect.com/science/article/pii/S0002916524000091**VIDEO: https://youtu.be/FcUUqGJBXFM2/ n = 10 lean healthy women Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, Sota-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Frontiers in Endocrinology. 2023; doi: 10.3389/fendo.2023.1326768 LINK: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/fullVIDEO: https://youtu.be/OpOkeXVUotU?si=vHmfywr3CH27B2w53/ JCL editorialNorwitz NG, Mindrum M, Giral P, Kontush A, Soto-Mota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyper-responders on low-carbohydrate diets deserve urgent clinical attention and further research. Journal of Clinical Lipidology. 2022; doi:10.1016/j.jacl.2022.10.010 Link: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltext4/ Lipid Energy ModelNorwitz NG, Soto-Mota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets. Metabolites. 2022; doi: 10.3390/metabo12050460 Link: https://pubmed.ncbi.nlm.nih.gov/35629964/Video: https://youtu.be/AkzxESsTJyM?si=A8lfhLXp_U1wPRdx5/ LMHR, first paperNorwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype. Current Developments in Nutrition. 2022; doi: 10.1093/cdn/nzab144 Link: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext6/ Low Sat Fat LMHR case reportNorwitz NG, Soto-Mota A, Feldman D, Parpos S, Budoff M. Case report: hypercholesterolemia “lean mass hyper-responder” phenotype presents in the context of a low saturated fat carbohydrate restricted diet. Frontiers in Endocrinology. 2022; doi: 10.3389/fendo.2022.830325Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/Video: https://youtu.be/JSEqIsYBZxU?si=lJ0_dnDYlDzvNyjt Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 19 Oct 2026 22:46:00 -0000 full Nick Norwitz MD PhD Paper link: https://www.mdpi.com/2218-1989/14/1/73Chapters0:00 – Intro0:28 – metabolic demonstration0:43 – Part I, the idea1:30 – LMHR triad 1:58 – Lipid Energy Model3:06 – Part II, the experimental design4:19 – Part III, results 6:00 – results summary 6:40 – Part IV, What’s Next? 7:37 – Thanks and Call to ActionAim: To tested the prediction -- consistent with the Lipid Energy Model (below) -- that adding carbohydrates (in the form of Oreo cookies) to an LMHR on a ketogenic diet would reduce LDL-C levels by a similar, or greater, magnitude than high-intensity statin therapy. Findings: Oreo supplementation (12 cookies/d) lowered LDL-C by 71% (273 mg/dl) in just 16 days. Rosuvastatin (20 mg/d) lowered LDL-C by 32.5% (137 mg/dl). Thus, Oreos were ~2X as potent as high-intensity statin therapy for LDL cholesterol lowering in this LMHR subject.The Why: The LMHR phenotype has much to teach us about human metabolism, and cardiovascular disease pathophysiology. It's a new frontier that deserves further study, for the sake of the patients with this phenotype and for pure scientific curiosity! This experiment will serve as 'productive provocation,' a form of 'legit-bait' that will hopefully help prompt discussions and larger-scale experiments that need to happen.6 select Prior publications1/ META of RCTs (new, 1/16/24)Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis. Amer J of Clin Nutr. 2024; doi: 10.1016/j.ajcnut.2024.01.009 **LINK: https://www.sciencedirect.com/science/article/pii/S0002916524000091**VIDEO: https://youtu.be/FcUUqGJBXFM2/ n = 10 lean healthy women Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, Sota-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Frontiers in Endocrinology. 2023; doi: 10.3389/fendo.2023.1326768 LINK: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/fullVIDEO: https://youtu.be/OpOkeXVUotU?si=vHmfywr3CH27B2w53/ JCL editorialNorwitz NG, Mindrum M, Giral P, Kontush A, Soto-Mota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyper-responders on low-carbohydrate diets deserve urgent clinical attention and further research. Journal of Clinical Lipidology. 2022; doi:10.1016/j.jacl.2022.10.010 Link: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltext4/ Lipid Energy ModelNorwitz NG, Soto-Mota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets. Metabolites. 2022; doi: 10.3390/metabo12050460 Link: https://pubmed.ncbi.nlm.nih.gov/35629964/Video: https://youtu.be/AkzxESsTJyM?si=A8lfhLXp_U1wPRdx5/ LMHR, first paperNorwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype. Current Developments in Nutrition. 2022; doi: 10.1093/cdn/nzab144 Link: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext6/ Low Sat Fat LMHR case reportNorwitz NG, Soto-Mota A, Feldman D, Parpos S, Budoff M. Case report: hypercholesterolemia “lean mass hyper-responder” phenotype presents in the context of a low saturated fat carbohydrate restricted diet. Frontiers in Endocrinology. 2022; doi: 10.3389/fendo.2022.830325Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/Video: https://youtu.be/JSEqIsYBZxU?si=lJ0_dnDYlDzvNyjt Learn more about your ad choices. Visit megaphone.fm/adchoices Paper link: https://www.mdpi.com/2218-1989/14/1/73

Chapters
0:00 – Intro
0:28 – metabolic demonstration
0:43 – Part I, the idea
1:30 – LMHR triad
1:58 – Lipid Energy Model
3:06 – Part II, the experimental design
4:19 – Part III, results
6:00 – results summary
6:40 – Part IV, What’s Next?
7:37 – Thanks and Call to Action


Aim: To tested the prediction -- consistent with the Lipid Energy Model (below) -- that adding carbohydrates (in the form of Oreo cookies) to an LMHR on a ketogenic diet would reduce LDL-C levels by a similar, or greater, magnitude than high-intensity statin therapy.

Findings: Oreo supplementation (12 cookies/d) lowered LDL-C by 71% (273 mg/dl) in just 16 days. Rosuvastatin (20 mg/d) lowered LDL-C by 32.5% (137 mg/dl). Thus, Oreos were ~2X as potent as high-intensity statin therapy for LDL cholesterol lowering in this LMHR subject.

The Why: The LMHR phenotype has much to teach us about human metabolism, and cardiovascular disease pathophysiology. It's a new frontier that deserves further study, for the sake of the patients with this phenotype and for pure scientific curiosity! This experiment will serve as 'productive provocation,' a form of 'legit-bait' that will hopefully help prompt discussions and larger-scale experiments that need to happen.

6 select Prior publications
1/ META of RCTs (new, 1/16/24)
Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis. Amer J of Clin Nutr. 2024; doi: 10.1016/j.ajcnut.2024.01.009
**LINK: https://www.sciencedirect.com/science/article/pii/S0002916524000091**
VIDEO: https://youtu.be/FcUUqGJBXFM

2/ n = 10 lean healthy women
Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, Sota-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Frontiers in Endocrinology. 2023; doi: 10.3389/fendo.2023.1326768
LINK: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full
VIDEO: https://youtu.be/OpOkeXVUotU?si=vHmfywr3CH27B2w5

3/ JCL editorial
Norwitz NG, Mindrum M, Giral P, Kontush A, Soto-Mota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyper-responders on low-carbohydrate diets deserve urgent clinical attention and further research. Journal of Clinical Lipidology. 2022; doi:10.1016/j.jacl.2022.10.010
Link: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltext

4/ Lipid Energy Model
Norwitz NG, Soto-Mota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets. Metabolites. 2022; doi: 10.3390/metabo12050460
Link: https://pubmed.ncbi.nlm.nih.gov/35629964/
Video: https://youtu.be/AkzxESsTJyM?si=A8lfhLXp_U1wPRdx

5/ LMHR, first paper
Norwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype. Current Developments in Nutrition. 2022; doi: 10.1093/cdn/nzab144
Link: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext

6/ Low Sat Fat LMHR case report
Norwitz NG, Soto-Mota A, Feldman D, Parpos S, Budoff M. Case report: hypercholesterolemia “lean mass hyper-responder” phenotype presents in the context of a low saturated fat carbohydrate restricted diet. Frontiers in Endocrinology. 2022; doi: 10.3389/fendo.2022.830325
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/
Video: https://youtu.be/JSEqIsYBZxU?si=lJ0_dnDYlDzvNyjt

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]]> 628 no This Study Redefines Fatherhood For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/this-study-redefines-fatherhood?r=40ekz2 Aspartame and Anxiety Video: https://youtu.be/VpCFdumr5rw What if exercise could rewire your sperm and change the destiny of your future children? Not just the number of sperm or how fast they swim — but the biological code you pass on being altered by your workouts.A recent Cell Metabolism study found that when male mice trained, their offspring — who never exercised — had more lean mass, stronger bones, better endurance, and healthier mitochondria. Even more surprising, they were more resilient to a junk-food diet. The mechanism is incredible: exercise changes microRNAs inside sperm, tiny molecular instructions that help shape how early cells build muscle, manage energy, and respond to metabolic stress. And when researchers looked at human males, most of these same microRNAs were present — suggesting this mechanism may operate in humans too. Exercise doesn’t just sculpt your body. It may sculpt who comes after you. Stay curious.Chapters:0:00 – How Exercise Rewrites Your Children’s Biology1:13 – Extra Insights in the StayCurious Newsletter1:50 – The New Cell Metabolism Study2:41 – Offspring of Exercising Fathers: Leaner, Faster, Stronger4:49 – The Mechanism: microRNA Reprogramming in Sperm6:32 – Mouse to Human: Is the Effect Conserved?7:49 – The Future of Engineered Health Inheritance9:35 – Functional Fitness: Targets That Actually Matter10:41 – Why I Avoid Aspartame (The Evidence)12:20 – Final Thought: Your Molecular Momentum#epigenetics #exercise #metabolichealth #microRNA #inheritance #longevity #fathershealth #fitnessscience #cellmetabolism #healthscience #NickNorwitz #StayCuriousMetabolism #biology #offspringhealth #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 19 Oct 2026 04:46:00 -0000 full Nick Norwitz MD PhD For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/this-study-redefines-fatherhood?r=40ekz2 Aspartame and Anxiety Video: https://youtu.be/VpCFdumr5rw What if exercise could rewire your sperm and change the destiny of your future children? Not just the number of sperm or how fast they swim — but the biological code you pass on being altered by your workouts.A recent Cell Metabolism study found that when male mice trained, their offspring — who never exercised — had more lean mass, stronger bones, better endurance, and healthier mitochondria. Even more surprising, they were more resilient to a junk-food diet. The mechanism is incredible: exercise changes microRNAs inside sperm, tiny molecular instructions that help shape how early cells build muscle, manage energy, and respond to metabolic stress. And when researchers looked at human males, most of these same microRNAs were present — suggesting this mechanism may operate in humans too. Exercise doesn’t just sculpt your body. It may sculpt who comes after you. Stay curious.Chapters:0:00 – How Exercise Rewrites Your Children’s Biology1:13 – Extra Insights in the StayCurious Newsletter1:50 – The New Cell Metabolism Study2:41 – Offspring of Exercising Fathers: Leaner, Faster, Stronger4:49 – The Mechanism: microRNA Reprogramming in Sperm6:32 – Mouse to Human: Is the Effect Conserved?7:49 – The Future of Engineered Health Inheritance9:35 – Functional Fitness: Targets That Actually Matter10:41 – Why I Avoid Aspartame (The Evidence)12:20 – Final Thought: Your Molecular Momentum#epigenetics #exercise #metabolichealth #microRNA #inheritance #longevity #fathershealth #fitnessscience #cellmetabolism #healthscience #NickNorwitz #StayCuriousMetabolism #biology #offspringhealth #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/this-study-redefines-fatherhood?r=40ekz2

Aspartame and Anxiety Video: https://youtu.be/VpCFdumr5rw

What if exercise could rewire your sperm and change the destiny of your future children? Not just the number of sperm or how fast they swim — but the biological code you pass on being altered by your workouts.

A recent Cell Metabolism study found that when male mice trained, their offspring — who never exercised — had more lean mass, stronger bones, better endurance, and healthier mitochondria. Even more surprising, they were more resilient to a junk-food diet. The mechanism is incredible: exercise changes microRNAs inside sperm, tiny molecular instructions that help shape how early cells build muscle, manage energy, and respond to metabolic stress. And when researchers looked at human males, most of these same microRNAs were present — suggesting this mechanism may operate in humans too. Exercise doesn’t just sculpt your body. It may sculpt who comes after you. Stay curious.

Chapters:
0:00 – How Exercise Rewrites Your Children’s Biology
1:13 – Extra Insights in the StayCurious Newsletter
1:50 – The New Cell Metabolism Study
2:41 – Offspring of Exercising Fathers: Leaner, Faster, Stronger
4:49 – The Mechanism: microRNA Reprogramming in Sperm
6:32 – Mouse to Human: Is the Effect Conserved?
7:49 – The Future of Engineered Health Inheritance
9:35 – Functional Fitness: Targets That Actually Matter
10:41 – Why I Avoid Aspartame (The Evidence)
12:20 – Final Thought: Your Molecular Momentum

#epigenetics #exercise #metabolichealth #microRNA #inheritance #longevity #fathershealth #fitnessscience #cellmetabolism #healthscience #NickNorwitz #StayCuriousMetabolism #biology #offspringhealth #staycurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 991 no Response to Peter Attia Insulting Low-Carbers Prior Response Video: https://youtu.be/ILuEO7Jc8TY?si=x2nN2zHM0O1jFj9AOreoVsStatin video: https://youtu.be/L1mMnnyJrgk?si=yWjXiftfoN4Mg5az OreoVsStatin paper: https://www.mdpi.com/2218-1989/14/1/73 Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 18 Oct 2026 10:46:00 -0000 full Nick Norwitz MD PhD Prior Response Video: https://youtu.be/ILuEO7Jc8TY?si=x2nN2zHM0O1jFj9AOreoVsStatin video: https://youtu.be/L1mMnnyJrgk?si=yWjXiftfoN4Mg5az OreoVsStatin paper: https://www.mdpi.com/2218-1989/14/1/73 Learn more about your ad choices. Visit megaphone.fm/adchoices Prior Response Video: https://youtu.be/ILuEO7Jc8TY?si=x2nN2zHM0O1jFj9A
OreoVsStatin video: https://youtu.be/L1mMnnyJrgk?si=yWjXiftfoN4Mg5az
OreoVsStatin paper: https://www.mdpi.com/2218-1989/14/1/73

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 694 no A Pinch of Truth: Rethinking Salt | ft. Robb Wolf Robb Wolf Interview Part 1: https://youtu.be/Wi-6KttZ54g LMNT “Scandal” Video: https://youtu.be/uI2ewgimH3g Salt, Leptin and Blood Pressure: https://staycuriousmetabolism.substack.com/p/salt-vs-fat-rethinking-the-root-causes?r=40ekz2 Oleuropein and Calcium Signaling: https://youtu.be/ljuimrT2a1s In Part 2 of my conversation with Robb Wolf, we dig into one of the most misunderstood aspects of nutrition and metabolic health: electrolytes. Most people think electrolytes simply matter for athletes or hot summer workouts, but the reality is far more complex. We also get into the science behind sodium, why the old fear of salt never made sense mechanistically, and how obesity and leptin signaling influence salt sensitivity, and more. Chapters0:00 – Why Electrolytes Matter More Than You Think3:12 – Low-Carb, Insulin and Hidden Electrolyte Loss7:38 – How to Know If You’re Sodium Deficient11:25 – The Truth About Sodium, Obesity and Blood Pressure21:59 – How Much Sodium You Really Need29:13 – LMNT Transparency, Controversy and What’s Next#Electrolytes #Sodium #LMNT #RobbWolf #MetabolicHealth #KetoDiet #LowCarb #AncestralHealth #BloodPressure #Hypertension #InsulinResistance #Performance #Hydration #NutritionScience #PodcastInterview #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 17 Oct 2026 16:46:00 -0000 full Nick Norwitz MD PhD Robb Wolf Interview Part 1: https://youtu.be/Wi-6KttZ54g LMNT “Scandal” Video: https://youtu.be/uI2ewgimH3g Salt, Leptin and Blood Pressure: https://staycuriousmetabolism.substack.com/p/salt-vs-fat-rethinking-the-root-causes?r=40ekz2 Oleuropein and Calcium Signaling: https://youtu.be/ljuimrT2a1s In Part 2 of my conversation with Robb Wolf, we dig into one of the most misunderstood aspects of nutrition and metabolic health: electrolytes. Most people think electrolytes simply matter for athletes or hot summer workouts, but the reality is far more complex. We also get into the science behind sodium, why the old fear of salt never made sense mechanistically, and how obesity and leptin signaling influence salt sensitivity, and more. Chapters0:00 – Why Electrolytes Matter More Than You Think3:12 – Low-Carb, Insulin and Hidden Electrolyte Loss7:38 – How to Know If You’re Sodium Deficient11:25 – The Truth About Sodium, Obesity and Blood Pressure21:59 – How Much Sodium You Really Need29:13 – LMNT Transparency, Controversy and What’s Next#Electrolytes #Sodium #LMNT #RobbWolf #MetabolicHealth #KetoDiet #LowCarb #AncestralHealth #BloodPressure #Hypertension #InsulinResistance #Performance #Hydration #NutritionScience #PodcastInterview #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Robb Wolf Interview Part 1: https://youtu.be/Wi-6KttZ54g

LMNT “Scandal” Video: https://youtu.be/uI2ewgimH3g

Salt, Leptin and Blood Pressure: https://staycuriousmetabolism.substack.com/p/salt-vs-fat-rethinking-the-root-causes?r=40ekz2

Oleuropein and Calcium Signaling: https://youtu.be/ljuimrT2a1s


In Part 2 of my conversation with Robb Wolf, we dig into one of the most misunderstood aspects of nutrition and metabolic health: electrolytes. Most people think electrolytes simply matter for athletes or hot summer workouts, but the reality is far more complex. We also get into the science behind sodium, why the old fear of salt never made sense mechanistically, and how obesity and leptin signaling influence salt sensitivity, and more.

Chapters
0:00 – Why Electrolytes Matter More Than You Think
3:12 – Low-Carb, Insulin and Hidden Electrolyte Loss
7:38 – How to Know If You’re Sodium Deficient
11:25 – The Truth About Sodium, Obesity and Blood Pressure
21:59 – How Much Sodium You Really Need
29:13 – LMNT Transparency, Controversy and What’s Next

#Electrolytes #Sodium #LMNT #RobbWolf #MetabolicHealth #KetoDiet #LowCarb #AncestralHealth #BloodPressure #Hypertension #InsulinResistance #Performance #Hydration #NutritionScience #PodcastInterview #StayCurious

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]]> 3068 no No more myths. Saturated fat and keto diet 0:00 – What Saturated Fat Myth?0:24 – 1) Effect Magnitude 1:16 – 2) The low-carb lipid ‘triad’1:37 – 3) Inverse association between BMI and LDL-C on low-carb2:13 – 4) High LDL-C on low sat fat diets, and the converse3:46 – 5) Meta-analysis of RCTsOreoVsStatin video: https://youtu.be/L1mMnnyJrgkOreoVsStatin paper: https://www.mdpi.com/2218-1989/14/1/73Meta-analysis video: https://youtu.be/FcUUqGJBXFMMeta-analysis, Soto-Mota et al: https://www.sciencedirect.com/science/article/pii/S0002916524000091Interventional Trial, Cooper et al: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 16 Oct 2026 22:46:00 -0000 full Nick Norwitz MD PhD 0:00 – What Saturated Fat Myth?0:24 – 1) Effect Magnitude 1:16 – 2) The low-carb lipid ‘triad’1:37 – 3) Inverse association between BMI and LDL-C on low-carb2:13 – 4) High LDL-C on low sat fat diets, and the converse3:46 – 5) Meta-analysis of RCTsOreoVsStatin video: https://youtu.be/L1mMnnyJrgkOreoVsStatin paper: https://www.mdpi.com/2218-1989/14/1/73Meta-analysis video: https://youtu.be/FcUUqGJBXFMMeta-analysis, Soto-Mota et al: https://www.sciencedirect.com/science/article/pii/S0002916524000091Interventional Trial, Cooper et al: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full Learn more about your ad choices. Visit megaphone.fm/adchoices 0:00 – What Saturated Fat Myth?
0:24 – 1) Effect Magnitude
1:16 – 2) The low-carb lipid ‘triad’
1:37 – 3) Inverse association between BMI and LDL-C on low-carb
2:13 – 4) High LDL-C on low sat fat diets, and the converse
3:46 – 5) Meta-analysis of RCTs

OreoVsStatin video: https://youtu.be/L1mMnnyJrgk
OreoVsStatin paper: https://www.mdpi.com/2218-1989/14/1/73

Meta-analysis video: https://youtu.be/FcUUqGJBXFM
Meta-analysis, Soto-Mota et al: https://www.sciencedirect.com/science/article/pii/S0002916524000091

Interventional Trial, Cooper et al: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full

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]]> 400 no Lowering Cholesterol Killed: A Study Buried for 40 Years For the references, extra details and early access to context, see the newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/lowering-cholesterol-killed-a-study?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Description:What if lowering cholesterol didn’t save lives—but actually increased the risk of death?In this video, I break down a forgotten ‘gold-standard’ randomized controlled trial from the late 1960s and early 1970s: the Minnesota Coronary Experiment. This uniquely rigorous study tested whether replacing saturated fat (butter, beef) with vegetable oils rich in linoleic acid would reduce heart disease and mortality.The results were shocking. Cholesterol dropped—but deaths increased. Even more unsettling, the greater the cholesterol reduction, the higher the risk of death. Cardiovascular outcomes didn’t improve either. The cholesterol reducing diet was even associated with a trend towards increased atherosclerosis on autopsy. So why were these results buried for decades? Were they inconvenient? Misunderstood? Or simply too complex for a simple narrative?We’ll walk through the study design, the actual outcomes, and the major criticisms—then evaluate whether those critiques really hold up.Chapters:0:00 – The Trial That Vanished for 40 Years1:37 – Inside the Minnesota Coronary Experiment (Study Design)4:54 – Cholesterol Fell… Mortality Rose7:03 – Worse Arteries Despite Lower Cholesterol8:20 – What Other RCTs Show: The Meta-Analysis9:25 – Why These Results Never Changed the Guidelines10:10 – Major Criticisms of the Minnesota Coronary Experiment11:33 – The “Hidden Trans Fat” Explanation Examined13:19 – Does the Dropout Rate Undermine the Data?14:47 – When Cholesterol Lowering Became a Catastrophe16:11 – The One-Word Takeaway: Humility#seedoils #saturated fat #cholesterol #cholesterol #nutritionscience #hearthealth #dietaryfat #saturatedfat #seedoils #linoleicacid #cardiovascularhealth #metabolichealth #evidencebasednutrition #medicalhistory #nutritionmyths #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 16 Oct 2026 04:46:00 -0000 full Nick Norwitz MD PhD For the references, extra details and early access to context, see the newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/lowering-cholesterol-killed-a-study?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Description:What if lowering cholesterol didn’t save lives—but actually increased the risk of death?In this video, I break down a forgotten ‘gold-standard’ randomized controlled trial from the late 1960s and early 1970s: the Minnesota Coronary Experiment. This uniquely rigorous study tested whether replacing saturated fat (butter, beef) with vegetable oils rich in linoleic acid would reduce heart disease and mortality.The results were shocking. Cholesterol dropped—but deaths increased. Even more unsettling, the greater the cholesterol reduction, the higher the risk of death. Cardiovascular outcomes didn’t improve either. The cholesterol reducing diet was even associated with a trend towards increased atherosclerosis on autopsy. So why were these results buried for decades? Were they inconvenient? Misunderstood? Or simply too complex for a simple narrative?We’ll walk through the study design, the actual outcomes, and the major criticisms—then evaluate whether those critiques really hold up.Chapters:0:00 – The Trial That Vanished for 40 Years1:37 – Inside the Minnesota Coronary Experiment (Study Design)4:54 – Cholesterol Fell… Mortality Rose7:03 – Worse Arteries Despite Lower Cholesterol8:20 – What Other RCTs Show: The Meta-Analysis9:25 – Why These Results Never Changed the Guidelines10:10 – Major Criticisms of the Minnesota Coronary Experiment11:33 – The “Hidden Trans Fat” Explanation Examined13:19 – Does the Dropout Rate Undermine the Data?14:47 – When Cholesterol Lowering Became a Catastrophe16:11 – The One-Word Takeaway: Humility#seedoils #saturated fat #cholesterol #cholesterol #nutritionscience #hearthealth #dietaryfat #saturatedfat #seedoils #linoleicacid #cardiovascularhealth #metabolichealth #evidencebasednutrition #medicalhistory #nutritionmyths #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices For the references, extra details and early access to context, see the newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/lowering-cholesterol-killed-a-study?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Description:
What if lowering cholesterol didn’t save lives—but actually increased the risk of death?
In this video, I break down a forgotten ‘gold-standard’ randomized controlled trial from the late 1960s and early 1970s: the Minnesota Coronary Experiment. This uniquely rigorous study tested whether replacing saturated fat (butter, beef) with vegetable oils rich in linoleic acid would reduce heart disease and mortality.

The results were shocking. Cholesterol dropped—but deaths increased. Even more unsettling, the greater the cholesterol reduction, the higher the risk of death. Cardiovascular outcomes didn’t improve either. The cholesterol reducing diet was even associated with a trend towards increased atherosclerosis on autopsy.

So why were these results buried for decades? Were they inconvenient? Misunderstood? Or simply too complex for a simple narrative?

We’ll walk through the study design, the actual outcomes, and the major criticisms—then evaluate whether those critiques really hold up.

Chapters:
0:00 – The Trial That Vanished for 40 Years
1:37 – Inside the Minnesota Coronary Experiment (Study Design)
4:54 – Cholesterol Fell… Mortality Rose
7:03 – Worse Arteries Despite Lower Cholesterol
8:20 – What Other RCTs Show: The Meta-Analysis
9:25 – Why These Results Never Changed the Guidelines
10:10 – Major Criticisms of the Minnesota Coronary Experiment
11:33 – The “Hidden Trans Fat” Explanation Examined
13:19 – Does the Dropout Rate Undermine the Data?
14:47 – When Cholesterol Lowering Became a Catastrophe
16:11 – The One-Word Takeaway: Humility

#seedoils #saturated fat #cholesterol #cholesterol #nutritionscience #hearthealth #dietaryfat #saturatedfat #seedoils #linoleicacid #cardiovascularhealth #metabolichealth #evidencebasednutrition #medicalhistory #nutritionmyths #staycurious

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]]> 1368 no Keto is "bad" for cholesterol. When is it true? Meta of RCTs: https://youtu.be/FcUUqGJBXFM?si=Z2qQH85PNr2XagIEPaper: https://www.sciencedirect.com/science/article/pii/S0002916524000091OreoVsStatin: https://youtu.be/L1mMnnyJrgk?si=R6vWZSK5bD9CcrvNPaper: https://www.mdpi.com/2218-1989/14/1/73Lipid Energy Model: https://youtu.be/AkzxESsTJyM?si=bKrkR0Tc_any_eUgPaper: https://www.mdpi.com/2218-1989/12/5/460LMHR CCTA study data drop: https://youtu.be/IMkDwtJVeB0?si=o4WGsw82JBYLlyxE Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 15 Oct 2026 10:46:00 -0000 full Nick Norwitz MD PhD Meta of RCTs: https://youtu.be/FcUUqGJBXFM?si=Z2qQH85PNr2XagIEPaper: https://www.sciencedirect.com/science/article/pii/S0002916524000091OreoVsStatin: https://youtu.be/L1mMnnyJrgk?si=R6vWZSK5bD9CcrvNPaper: https://www.mdpi.com/2218-1989/14/1/73Lipid Energy Model: https://youtu.be/AkzxESsTJyM?si=bKrkR0Tc_any_eUgPaper: https://www.mdpi.com/2218-1989/12/5/460LMHR CCTA study data drop: https://youtu.be/IMkDwtJVeB0?si=o4WGsw82JBYLlyxE Learn more about your ad choices. Visit megaphone.fm/adchoices Meta of RCTs: https://youtu.be/FcUUqGJBXFM?si=Z2qQH85PNr2XagIE
Paper: https://www.sciencedirect.com/science/article/pii/S0002916524000091

OreoVsStatin: https://youtu.be/L1mMnnyJrgk?si=R6vWZSK5bD9CcrvN
Paper: https://www.mdpi.com/2218-1989/14/1/73

Lipid Energy Model: https://youtu.be/AkzxESsTJyM?si=bKrkR0Tc_any_eUg
Paper: https://www.mdpi.com/2218-1989/12/5/460

LMHR CCTA study data drop: https://youtu.be/IMkDwtJVeB0?si=o4WGsw82JBYLlyxE

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]]> 391 no Is the New Food Pyramid Science-Based? A Dietary Guidelines Scientist Weighs In For a written digest on the guidelines, see the StayCurious Metabolism Letter: https://staycuriousmetabolism.substack.com/p/the-new-dietary-guidelines-actually?r=40ekz2 The 2025–2030 Dietary Guidelines are being marketed as a major reset with a simple message: put “real food” back at the center of the American diet. And in a lot of ways, they do represent progress. But when you actually read what’s written, some of the most important details raise real questions. For example, the document still states that saturated fat should not exceed 10% of total daily calories.To separate signal from spin, I’m joined by Dr. Ty Beal PhD, who worked on the evidence review side of the Guidelines process, to explain what the scientific background documents actually say, what happens after scientists submit reviews, and why the final public-facing document can end up with compromises, inconsistencies, or imprecise terminology. If you want a clear, good-faith breakdown—what’s genuinely better, what still doesn’t add up, and what needs to be fixed next—this is the conversation.Professor William Harris Omega-3 Interview, Part 1: https://youtu.be/rZT4Y6T_0Vc Guidelines PDF: https://cdn.realfood.gov/DGA_508.pdf CHAPTERS:0:00 – 2025–2030 Dietary Guidelines: The “Biggest Reset” Explained1:10 – Meet Ty Beal, PhD (Scientific Review Author)2:06 – “Ending the War on Saturated Fat”… But the 10% Cap Stayed7:27 – Who Actually Writes the Guidelines? Science vs Bureaucracy9:05 – “Essential Fats” Confusion: Olive Oil, Butter, Beef Tallow12:22 – Real-World Impact: School Meals, SNAP, and Policy Levers16:34 – Key Takeaway So Far: Progress, But Messaging Still Conflicts18:11 – The “Pink Elephant” Problem: Bad Logic in Nutrition Policy18:56 – Sodium Limits + Whole Grains: Context Matters23:20 – “Empty Calories” Is a Myth (Metabolic Effects Still Count)24:16 – The Biggest Wins: Sugar, Protein Targets, Omega-3 for Pregnancy31:42 – What “Real Food” Means (and Why Definitions Get Messy)37:12 – What Needs to Happen Next (Policy + Research + Clarity)#dietaryguidelines #saturatedfat #MAHA #dairy #metabolichealth #processedfoods #butter #meat #steak #omega3 #realfood #vegetables #foodpolitics #essentialfats #tallow #seedoil #oliveoil #staycurious #SNAP #refinedgrains #NOVA #RealFood #NutritionScience #FullFatDairy #ProteinIntake #UltraProcessedFoods #AddedSugar #HeartHealth #NutritionPolicy #TyBeal #NickNorwitz #USDA #HHS Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 14 Oct 2026 16:46:00 -0000 full Nick Norwitz MD PhD For a written digest on the guidelines, see the StayCurious Metabolism Letter: https://staycuriousmetabolism.substack.com/p/the-new-dietary-guidelines-actually?r=40ekz2 The 2025–2030 Dietary Guidelines are being marketed as a major reset with a simple message: put “real food” back at the center of the American diet. And in a lot of ways, they do represent progress. But when you actually read what’s written, some of the most important details raise real questions. For example, the document still states that saturated fat should not exceed 10% of total daily calories.To separate signal from spin, I’m joined by Dr. Ty Beal PhD, who worked on the evidence review side of the Guidelines process, to explain what the scientific background documents actually say, what happens after scientists submit reviews, and why the final public-facing document can end up with compromises, inconsistencies, or imprecise terminology. If you want a clear, good-faith breakdown—what’s genuinely better, what still doesn’t add up, and what needs to be fixed next—this is the conversation.Professor William Harris Omega-3 Interview, Part 1: https://youtu.be/rZT4Y6T_0Vc Guidelines PDF: https://cdn.realfood.gov/DGA_508.pdf CHAPTERS:0:00 – 2025–2030 Dietary Guidelines: The “Biggest Reset” Explained1:10 – Meet Ty Beal, PhD (Scientific Review Author)2:06 – “Ending the War on Saturated Fat”… But the 10% Cap Stayed7:27 – Who Actually Writes the Guidelines? Science vs Bureaucracy9:05 – “Essential Fats” Confusion: Olive Oil, Butter, Beef Tallow12:22 – Real-World Impact: School Meals, SNAP, and Policy Levers16:34 – Key Takeaway So Far: Progress, But Messaging Still Conflicts18:11 – The “Pink Elephant” Problem: Bad Logic in Nutrition Policy18:56 – Sodium Limits + Whole Grains: Context Matters23:20 – “Empty Calories” Is a Myth (Metabolic Effects Still Count)24:16 – The Biggest Wins: Sugar, Protein Targets, Omega-3 for Pregnancy31:42 – What “Real Food” Means (and Why Definitions Get Messy)37:12 – What Needs to Happen Next (Policy + Research + Clarity)#dietaryguidelines #saturatedfat #MAHA #dairy #metabolichealth #processedfoods #butter #meat #steak #omega3 #realfood #vegetables #foodpolitics #essentialfats #tallow #seedoil #oliveoil #staycurious #SNAP #refinedgrains #NOVA #RealFood #NutritionScience #FullFatDairy #ProteinIntake #UltraProcessedFoods #AddedSugar #HeartHealth #NutritionPolicy #TyBeal #NickNorwitz #USDA #HHS Learn more about your ad choices. Visit megaphone.fm/adchoices For a written digest on the guidelines, see the StayCurious Metabolism Letter: https://staycuriousmetabolism.substack.com/p/the-new-dietary-guidelines-actually?r=40ekz2

The 2025–2030 Dietary Guidelines are being marketed as a major reset with a simple message: put “real food” back at the center of the American diet. And in a lot of ways, they do represent progress. But when you actually read what’s written, some of the most important details raise real questions. For example, the document still states that saturated fat should not exceed 10% of total daily calories.

To separate signal from spin, I’m joined by Dr. Ty Beal PhD, who worked on the evidence review side of the Guidelines process, to explain what the scientific background documents actually say, what happens after scientists submit reviews, and why the final public-facing document can end up with compromises, inconsistencies, or imprecise terminology.

If you want a clear, good-faith breakdown—what’s genuinely better, what still doesn’t add up, and what needs to be fixed next—this is the conversation.

Professor William Harris Omega-3 Interview, Part 1: https://youtu.be/rZT4Y6T_0Vc

Guidelines PDF: https://cdn.realfood.gov/DGA_508.pdf

CHAPTERS:
0:00 – 2025–2030 Dietary Guidelines: The “Biggest Reset” Explained
1:10 – Meet Ty Beal, PhD (Scientific Review Author)
2:06 – “Ending the War on Saturated Fat”… But the 10% Cap Stayed
7:27 – Who Actually Writes the Guidelines? Science vs Bureaucracy
9:05 – “Essential Fats” Confusion: Olive Oil, Butter, Beef Tallow
12:22 – Real-World Impact: School Meals, SNAP, and Policy Levers
16:34 – Key Takeaway So Far: Progress, But Messaging Still Conflicts
18:11 – The “Pink Elephant” Problem: Bad Logic in Nutrition Policy
18:56 – Sodium Limits + Whole Grains: Context Matters
23:20 – “Empty Calories” Is a Myth (Metabolic Effects Still Count)
24:16 – The Biggest Wins: Sugar, Protein Targets, Omega-3 for Pregnancy
31:42 – What “Real Food” Means (and Why Definitions Get Messy)
37:12 – What Needs to Happen Next (Policy + Research + Clarity)

#dietaryguidelines #saturatedfat #MAHA #dairy #metabolichealth #processedfoods #butter #meat #steak #omega3 #realfood #vegetables #foodpolitics #essentialfats #tallow #seedoil #oliveoil #staycurious #SNAP #refinedgrains #NOVA #RealFood #NutritionScience #FullFatDairy #ProteinIntake #UltraProcessedFoods #AddedSugar #HeartHealth #NutritionPolicy #TyBeal #NickNorwitz #USDA #HHS

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]]> 2796 no ALS Experimental Treatment Link: https://www.frontiersin.org/articles/10.3389/fneur.2023.1329541/full Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 13 Oct 2026 22:46:00 -0000 full Nick Norwitz MD PhD Link: https://www.frontiersin.org/articles/10.3389/fneur.2023.1329541/full Learn more about your ad choices. Visit megaphone.fm/adchoices Link: https://www.frontiersin.org/articles/10.3389/fneur.2023.1329541/full

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 373 no The Ketogenic Cure: They Don't Teach This in Medical School For extra details and all references, see this newsletter: https://staycuriousmetabolism.substack.com/p/a-keto-diet-cured-my-inflammatory?r=40ekz2Description:There was a time when I was dying from inflammatory bowel disease. It was my rock bottom. Out of desperation, I tried a ketogenic diet—and within a week, everything changed. My symptoms stopped, inflammation markers dropped, and follow-up testing showed no active disease. In this video, I unpack what may have happened biologically. We walk through human and animal data showing how a ketogenic diet reshapes the gut microbiome, suppresses inflammatory TH17 immune cells, and reduces inflammation not just in the intestines, but system-wide. We even look at fecal transplant experiments demonstrating that the ketogenic microbiome itself can transfer anti-inflammatory effects.This isn’t a promise or a prescription. It’s a personal story, grounded in real data, that explores the tension between lived biology and what medicine has—or hasn’t—caught up to yet.Sometimes biology doesn’t wait for peer review.Chapters:0:00 – How a Ketogenic Diet Put My Inflammatory Bowel Disease into Remission1:36 – Human Trial: Keto Rapidly Reshapes the Gut Microbiome3:20 – Ketosis Suppresses Gut Inflammation and TH17 Immune Cells4:35 – Fecal Transplants Prove the Ketogenic Microbiome Is Causal6:50 – When Evidence-Based Medicine Lags Behind Biology8:37 – Real Patient Remissions from a Ketogenic IBD Case Series9:14 – Biology Doesn’t Wait for Peer Review — Stay Curious#keto #ketogenicdiet #guthealth #IBD #crohnsdisease #ulcerativecolitis #microbiome #inflammation #metabolichealth #nutritionscience #staycurious #ketoscience #lowcarblifestyle #healingwithfood #foodasmedicine #autoimmunedisease #gutbrainaxis #intestinalhealth #digestivehealth #chronicillness #functionalmedicine #nutritionresearch #humanbiology #immunehealth #microbiomesupport #inflammationscience #personalhealth #metabolicreset #clinicalnutrition #lifesavingnutrition #healthjourney Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 13 Oct 2026 04:46:00 -0000 full Nick Norwitz MD PhD For extra details and all references, see this newsletter: https://staycuriousmetabolism.substack.com/p/a-keto-diet-cured-my-inflammatory?r=40ekz2Description:There was a time when I was dying from inflammatory bowel disease. It was my rock bottom. Out of desperation, I tried a ketogenic diet—and within a week, everything changed. My symptoms stopped, inflammation markers dropped, and follow-up testing showed no active disease. In this video, I unpack what may have happened biologically. We walk through human and animal data showing how a ketogenic diet reshapes the gut microbiome, suppresses inflammatory TH17 immune cells, and reduces inflammation not just in the intestines, but system-wide. We even look at fecal transplant experiments demonstrating that the ketogenic microbiome itself can transfer anti-inflammatory effects.This isn’t a promise or a prescription. It’s a personal story, grounded in real data, that explores the tension between lived biology and what medicine has—or hasn’t—caught up to yet.Sometimes biology doesn’t wait for peer review.Chapters:0:00 – How a Ketogenic Diet Put My Inflammatory Bowel Disease into Remission1:36 – Human Trial: Keto Rapidly Reshapes the Gut Microbiome3:20 – Ketosis Suppresses Gut Inflammation and TH17 Immune Cells4:35 – Fecal Transplants Prove the Ketogenic Microbiome Is Causal6:50 – When Evidence-Based Medicine Lags Behind Biology8:37 – Real Patient Remissions from a Ketogenic IBD Case Series9:14 – Biology Doesn’t Wait for Peer Review — Stay Curious#keto #ketogenicdiet #guthealth #IBD #crohnsdisease #ulcerativecolitis #microbiome #inflammation #metabolichealth #nutritionscience #staycurious #ketoscience #lowcarblifestyle #healingwithfood #foodasmedicine #autoimmunedisease #gutbrainaxis #intestinalhealth #digestivehealth #chronicillness #functionalmedicine #nutritionresearch #humanbiology #immunehealth #microbiomesupport #inflammationscience #personalhealth #metabolicreset #clinicalnutrition #lifesavingnutrition #healthjourney Learn more about your ad choices. Visit megaphone.fm/adchoices For extra details and all references, see this newsletter: https://staycuriousmetabolism.substack.com/p/a-keto-diet-cured-my-inflammatory?r=40ekz2

Description:
There was a time when I was dying from inflammatory bowel disease. It was my rock bottom. Out of desperation, I tried a ketogenic diet—and within a week, everything changed. My symptoms stopped, inflammation markers dropped, and follow-up testing showed no active disease.

In this video, I unpack what may have happened biologically. We walk through human and animal data showing how a ketogenic diet reshapes the gut microbiome, suppresses inflammatory TH17 immune cells, and reduces inflammation not just in the intestines, but system-wide. We even look at fecal transplant experiments demonstrating that the ketogenic microbiome itself can transfer anti-inflammatory effects.

This isn’t a promise or a prescription. It’s a personal story, grounded in real data, that explores the tension between lived biology and what medicine has—or hasn’t—caught up to yet.
Sometimes biology doesn’t wait for peer review.

Chapters:
0:00 – How a Ketogenic Diet Put My Inflammatory Bowel Disease into Remission
1:36 – Human Trial: Keto Rapidly Reshapes the Gut Microbiome
3:20 – Ketosis Suppresses Gut Inflammation and TH17 Immune Cells
4:35 – Fecal Transplants Prove the Ketogenic Microbiome Is Causal
6:50 – When Evidence-Based Medicine Lags Behind Biology
8:37 – Real Patient Remissions from a Ketogenic IBD Case Series
9:14 – Biology Doesn’t Wait for Peer Review — Stay Curious

#keto #ketogenicdiet #guthealth #IBD #crohnsdisease #ulcerativecolitis #microbiome #inflammation #metabolichealth #nutritionscience #staycurious #ketoscience #lowcarblifestyle #healingwithfood #foodasmedicine #autoimmunedisease #gutbrainaxis #intestinalhealth #digestivehealth #chronicillness #functionalmedicine
#nutritionresearch #humanbiology #immunehealth #microbiomesupport #inflammationscience #personalhealth #metabolicreset #clinicalnutrition #lifesavingnutrition #healthjourney

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]]> 764 no Dr Layne Norton gets a "D" in Lipid Energy Meta of RCTs paper: https://www.sciencedirect.com/science/article/pii/S0002916524000091Meta of RCTs video: https://youtu.be/FcUUqGJBXFM?si=tzcIwgBCDV-kx1k_OreoVsStatin paper: https://www.mdpi.com/2218-1989/14/1/73OreoVsStatin video: https://youtu.be/L1mMnnyJrgk?si=EfNbfFxQTwxLhJaTLayne's video: https://youtu.be/2v7bk6c7o7s?si=unL2SZMCLK4WNHARA BIG thank you to Mr. Andrew Degryse for his amazing work on my new thumbnails. Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 12 Oct 2026 10:46:00 -0000 full Nick Norwitz MD PhD Meta of RCTs paper: https://www.sciencedirect.com/science/article/pii/S0002916524000091Meta of RCTs video: https://youtu.be/FcUUqGJBXFM?si=tzcIwgBCDV-kx1k_OreoVsStatin paper: https://www.mdpi.com/2218-1989/14/1/73OreoVsStatin video: https://youtu.be/L1mMnnyJrgk?si=EfNbfFxQTwxLhJaTLayne's video: https://youtu.be/2v7bk6c7o7s?si=unL2SZMCLK4WNHARA BIG thank you to Mr. Andrew Degryse for his amazing work on my new thumbnails. Learn more about your ad choices. Visit megaphone.fm/adchoices Meta of RCTs paper: https://www.sciencedirect.com/science/article/pii/S0002916524000091
Meta of RCTs video: https://youtu.be/FcUUqGJBXFM?si=tzcIwgBCDV-kx1k_
OreoVsStatin paper: https://www.mdpi.com/2218-1989/14/1/73
OreoVsStatin video: https://youtu.be/L1mMnnyJrgk?si=EfNbfFxQTwxLhJaT
Layne's video: https://youtu.be/2v7bk6c7o7s?si=unL2SZMCLK4WNHAR

A BIG thank you to Mr. Andrew Degryse for his amazing work on my new thumbnails.

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 828 no Salt Isn’t the Problem — THIS IS For references and a written breakdown, see the associated Stay Curious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/salt-vs-fat-rethinking-the-root-causes?r=40ekz2 We’ve been told to restrict salt because it increases blood pressure, but what does the science actually say? In today’s video, we dive into the fascinating biology of salt sensitivity and salt resistance. It’s not simply about your genes, but rather your fat cells. I’m going to reveal the secret of salt sensitivity, backed by data from top journals like Cell Metabolism and NEJM. Get ready to learn how fat impacts your blood pressure, and why understanding this can challenge conventional advice from your cardiologist and nephrologist. Whether you're dealing with high blood pressure or curious about metabolic health, this breakthrough science could change the way you think about your health and your diet. Chapters:0:00 – Why I’m Salt Resistant: Breaking Myths on Salt Sensitivity1:33 – The Status Quo on Salt: The Old Wisdom vs. New Science2:34 – Fat as an Endocrine Organ: The Role of Leptin 3:59 – The Hypothalamus: Mission Control for the Endocrine System5:12 – Leptin from Fat: How It Impacts the Blood-Brain Barrier and Blood Pressure6:46 – The Mechanistic Cascade: From Fat Cells to Increased Blood Pressure10:09 – Body Fat, Leptin, and Salt Sensitivity: The Human Data #saltsensitivity #bloodpressure #saltintake #fatcells #leptin #endocrinology #metabolichealth #bloodpressurecontrol #saltresistance #highbloodpressure #saltmyths #fatburning #healthytips #metabolicdisorders #endocrinehealth #nephrology #fatandhealth #cardiovascularhealth #saltandfat #nutritionfacts #bodyfat #scientificresearch #healthscience #saltmyths #healthoptimization #hearthealth #saltandhealth #saltmythsbusted #healthfacts #fatandhealth #leptinandbloodpressure #saltintakecontrol #endocrinefunction #cardiovascularresearch #metabolicinsights #saltfacts #bodyfatandhealth #bloodpressuremyths #saltintolerance #saltstudies #endocrinesystem #metabolichealthjourney #healthyhabits #metabolismscience #nutritionalhealth #bloodpressurerelief #saltcontrol #saltandfat #healthytipsandtricks #healthscientist #lifestylemedicine #stayhealthy #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 11 Oct 2026 16:46:00 -0000 full Nick Norwitz MD PhD For references and a written breakdown, see the associated Stay Curious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/salt-vs-fat-rethinking-the-root-causes?r=40ekz2 We’ve been told to restrict salt because it increases blood pressure, but what does the science actually say? In today’s video, we dive into the fascinating biology of salt sensitivity and salt resistance. It’s not simply about your genes, but rather your fat cells. I’m going to reveal the secret of salt sensitivity, backed by data from top journals like Cell Metabolism and NEJM. Get ready to learn how fat impacts your blood pressure, and why understanding this can challenge conventional advice from your cardiologist and nephrologist. Whether you're dealing with high blood pressure or curious about metabolic health, this breakthrough science could change the way you think about your health and your diet. Chapters:0:00 – Why I’m Salt Resistant: Breaking Myths on Salt Sensitivity1:33 – The Status Quo on Salt: The Old Wisdom vs. New Science2:34 – Fat as an Endocrine Organ: The Role of Leptin 3:59 – The Hypothalamus: Mission Control for the Endocrine System5:12 – Leptin from Fat: How It Impacts the Blood-Brain Barrier and Blood Pressure6:46 – The Mechanistic Cascade: From Fat Cells to Increased Blood Pressure10:09 – Body Fat, Leptin, and Salt Sensitivity: The Human Data #saltsensitivity #bloodpressure #saltintake #fatcells #leptin #endocrinology #metabolichealth #bloodpressurecontrol #saltresistance #highbloodpressure #saltmyths #fatburning #healthytips #metabolicdisorders #endocrinehealth #nephrology #fatandhealth #cardiovascularhealth #saltandfat #nutritionfacts #bodyfat #scientificresearch #healthscience #saltmyths #healthoptimization #hearthealth #saltandhealth #saltmythsbusted #healthfacts #fatandhealth #leptinandbloodpressure #saltintakecontrol #endocrinefunction #cardiovascularresearch #metabolicinsights #saltfacts #bodyfatandhealth #bloodpressuremyths #saltintolerance #saltstudies #endocrinesystem #metabolichealthjourney #healthyhabits #metabolismscience #nutritionalhealth #bloodpressurerelief #saltcontrol #saltandfat #healthytipsandtricks #healthscientist #lifestylemedicine #stayhealthy #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices For references and a written breakdown, see the associated Stay Curious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/salt-vs-fat-rethinking-the-root-causes?r=40ekz2

We’ve been told to restrict salt because it increases blood pressure, but what does the science actually say? In today’s video, we dive into the fascinating biology of salt sensitivity and salt resistance. It’s not simply about your genes, but rather your fat cells. I’m going to reveal the secret of salt sensitivity, backed by data from top journals like Cell Metabolism and NEJM. Get ready to learn how fat impacts your blood pressure, and why understanding this can challenge conventional advice from your cardiologist and nephrologist. Whether you're dealing with high blood pressure or curious about metabolic health, this breakthrough science could change the way you think about your health and your diet.

Chapters:
0:00 – Why I’m Salt Resistant: Breaking Myths on Salt Sensitivity
1:33 – The Status Quo on Salt: The Old Wisdom vs. New Science
2:34 – Fat as an Endocrine Organ: The Role of Leptin
3:59 – The Hypothalamus: Mission Control for the Endocrine System
5:12 – Leptin from Fat: How It Impacts the Blood-Brain Barrier and Blood Pressure
6:46 – The Mechanistic Cascade: From Fat Cells to Increased Blood Pressure
10:09 – Body Fat, Leptin, and Salt Sensitivity: The Human Data

#saltsensitivity #bloodpressure #saltintake #fatcells #leptin #endocrinology #metabolichealth #bloodpressurecontrol #saltresistance #highbloodpressure #saltmyths #fatburning #healthytips #metabolicdisorders #endocrinehealth #nephrology #fatandhealth #cardiovascularhealth #saltandfat #nutritionfacts #bodyfat #scientificresearch #healthscience #saltmyths #healthoptimization #hearthealth #saltandhealth #saltmythsbusted #healthfacts #fatandhealth #leptinandbloodpressure #saltintakecontrol #endocrinefunction #cardiovascularresearch #metabolicinsights #saltfacts #bodyfatandhealth #bloodpressuremyths #saltintolerance #saltstudies #endocrinesystem #metabolichealthjourney #healthyhabits #metabolismscience #nutritionalhealth #bloodpressurerelief #saltcontrol #saltandfat #healthytipsandtricks #healthscientist #lifestylemedicine #stayhealthy #staycurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1047 no Could New Drug Lower Cholesterol in lean people on a Keto diet? Cooper et al. Thyroid in LMHR Women: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1326768/full NEJM, New Drug for NASH: https://www.nejm.org/doi/full/10.1056/NEJMoa2309000 OreoVsStatin: https://www.mdpi.com/2218-1989/14/1/73 0:00 - New Drug for Fatty Liver and Overview 0:50 - T3 predicts LDL cholesterol on Keto 1:20 - Lipid Energy Model tie in 2:14 - Thyroid Hormone Receptor Beta 2:50 - NEW trial 3:50 - But LMHR don't have fatty liver 4:10 - The question? 4:48 - Provocative alternative possibility 6:18 - Why does this matter? CONTEXT!A BIG thank you to Mr. Andrew Degryse for his amazing work on my new thumbnails. Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 10 Oct 2026 22:46:00 -0000 full Nick Norwitz MD PhD Cooper et al. Thyroid in LMHR Women: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1326768/full NEJM, New Drug for NASH: https://www.nejm.org/doi/full/10.1056/NEJMoa2309000 OreoVsStatin: https://www.mdpi.com/2218-1989/14/1/73 0:00 - New Drug for Fatty Liver and Overview 0:50 - T3 predicts LDL cholesterol on Keto 1:20 - Lipid Energy Model tie in 2:14 - Thyroid Hormone Receptor Beta 2:50 - NEW trial 3:50 - But LMHR don't have fatty liver 4:10 - The question? 4:48 - Provocative alternative possibility 6:18 - Why does this matter? CONTEXT!A BIG thank you to Mr. Andrew Degryse for his amazing work on my new thumbnails. Learn more about your ad choices. Visit megaphone.fm/adchoices Cooper et al. Thyroid in LMHR Women: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1326768/full

NEJM, New Drug for NASH: https://www.nejm.org/doi/full/10.1056/NEJMoa2309000

OreoVsStatin: https://www.mdpi.com/2218-1989/14/1/73

0:00 - New Drug for Fatty Liver and Overview
0:50 - T3 predicts LDL cholesterol on Keto
1:20 - Lipid Energy Model tie in
2:14 - Thyroid Hormone Receptor Beta
2:50 - NEW trial
3:50 - But LMHR don't have fatty liver
4:10 - The question?
4:48 - Provocative alternative possibility
6:18 - Why does this matter? CONTEXT!

A BIG thank you to Mr. Andrew Degryse for his amazing work on my new thumbnails.

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 601 no Top Omega-3s Research Explains What You Need to Know I Ate 1000 Sardines in a Month, Video: https://youtu.be/_Th54GWd8WY How Sardines Supercharged my Metabolism, Letter: https://staycuriousmetabolism.substack.com/p/the-weird-anti-insulin-hormone-that?r=40ekz2 Omega-6/3 Ratio Can Be Misleading, Letter: https://staycuriousmetabolism.substack.com/p/how-we-got-omega-fat-wrong-this-will?r=40ekz2 Best Omega-3 for the Brain, Letter: https://staycuriousmetabolism.substack.com/p/why-omega-3-supplements-dont-work?r=40ekz2 If you want to get your Omega-3 via Omega Quant, click on this link: https://omegaquant.com/ref/864Discount Code: NickNorwitz for 10% offFatty Acid Research Institute: https://www.faresinst.org Description:In this conversation, I sit down with Professor William Harris, one of the world’s leading experts on omega-3 and omega-6 fatty acids, to cut through confusion around fish oil, seed oils, cardiovascular health, and brain health.We break down what omega-3 and omega-6 fats actually are, why their chemistry matters, and how they’re converted into powerful signaling molecules that influence inflammation, metabolism, heart disease, and neurological health. We also discuss the omega-6:3 ratio and the omega-3 index—why the ratio can be misleading, why higher omega-6 levels are not inherently harmful, and why low EPA and DHA are the real problem for most people. We discuss optimal omega-3 index targets, whether there’s a ceiling to benefits, how omega-3s relate to Alzheimer’s risk and brain aging, and what the data actually say about long-term outcomes.This is a nuanced, evidence-driven discussion meant to replace fear-based nutrition narratives with clarity, context, and better questions to ask about your own health.Chapters0:00 – Meet Omega-3 Expert: Professor Bill Harris1:21 – A High-Level Overview of Omega-3 and Omega-65:10 – Do Omega-3 Help Cardiovascular Health?9:19 – Limitations of Randomized Controlled Trials11:11 – Omega-6/3 Ratio vs Omega-3 Index12:12 – Optimal Levels on the Omega-3 Index15:28 – Why the Omega-6/3 Ratio Can be Misleading 21:20 – Seed Oils vs Omega-6. What Should we Do?22:20 – Practical Dietary Tips from Professor Harris25:11 – Omega-3 and Neuropsychological Health27:45 – Nuance about Navigating Personal Choices 29:30 – Professor Harris’s Personal Routine30:50 – What Really Matters for Longevity #omega3 #metabolichealth #sardinediet #omega6 #linoleicacid #PUFA #saturatedfat #hearthealth #brainhealth #staycurious #omegaquant #mitochondria #hormones #brainhealth #brainaging #dementia #EPA #DHA #ALA #salmon #seedoils #mitochondria #atherosclerosis #Apoe4 #Apoe #cholesterol #apoB #fishoil Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 10 Oct 2026 04:46:00 -0000 full Nick Norwitz MD PhD I Ate 1000 Sardines in a Month, Video: https://youtu.be/_Th54GWd8WY How Sardines Supercharged my Metabolism, Letter: https://staycuriousmetabolism.substack.com/p/the-weird-anti-insulin-hormone-that?r=40ekz2 Omega-6/3 Ratio Can Be Misleading, Letter: https://staycuriousmetabolism.substack.com/p/how-we-got-omega-fat-wrong-this-will?r=40ekz2 Best Omega-3 for the Brain, Letter: https://staycuriousmetabolism.substack.com/p/why-omega-3-supplements-dont-work?r=40ekz2 If you want to get your Omega-3 via Omega Quant, click on this link: https://omegaquant.com/ref/864Discount Code: NickNorwitz for 10% offFatty Acid Research Institute: https://www.faresinst.org Description:In this conversation, I sit down with Professor William Harris, one of the world’s leading experts on omega-3 and omega-6 fatty acids, to cut through confusion around fish oil, seed oils, cardiovascular health, and brain health.We break down what omega-3 and omega-6 fats actually are, why their chemistry matters, and how they’re converted into powerful signaling molecules that influence inflammation, metabolism, heart disease, and neurological health. We also discuss the omega-6:3 ratio and the omega-3 index—why the ratio can be misleading, why higher omega-6 levels are not inherently harmful, and why low EPA and DHA are the real problem for most people. We discuss optimal omega-3 index targets, whether there’s a ceiling to benefits, how omega-3s relate to Alzheimer’s risk and brain aging, and what the data actually say about long-term outcomes.This is a nuanced, evidence-driven discussion meant to replace fear-based nutrition narratives with clarity, context, and better questions to ask about your own health.Chapters0:00 – Meet Omega-3 Expert: Professor Bill Harris1:21 – A High-Level Overview of Omega-3 and Omega-65:10 – Do Omega-3 Help Cardiovascular Health?9:19 – Limitations of Randomized Controlled Trials11:11 – Omega-6/3 Ratio vs Omega-3 Index12:12 – Optimal Levels on the Omega-3 Index15:28 – Why the Omega-6/3 Ratio Can be Misleading 21:20 – Seed Oils vs Omega-6. What Should we Do?22:20 – Practical Dietary Tips from Professor Harris25:11 – Omega-3 and Neuropsychological Health27:45 – Nuance about Navigating Personal Choices 29:30 – Professor Harris’s Personal Routine30:50 – What Really Matters for Longevity #omega3 #metabolichealth #sardinediet #omega6 #linoleicacid #PUFA #saturatedfat #hearthealth #brainhealth #staycurious #omegaquant #mitochondria #hormones #brainhealth #brainaging #dementia #EPA #DHA #ALA #salmon #seedoils #mitochondria #atherosclerosis #Apoe4 #Apoe #cholesterol #apoB #fishoil Learn more about your ad choices. Visit megaphone.fm/adchoices I Ate 1000 Sardines in a Month, Video: https://youtu.be/_Th54GWd8WY

How Sardines Supercharged my Metabolism, Letter: https://staycuriousmetabolism.substack.com/p/the-weird-anti-insulin-hormone-that?r=40ekz2

Omega-6/3 Ratio Can Be Misleading, Letter: https://staycuriousmetabolism.substack.com/p/how-we-got-omega-fat-wrong-this-will?r=40ekz2

Best Omega-3 for the Brain, Letter: https://staycuriousmetabolism.substack.com/p/why-omega-3-supplements-dont-work?r=40ekz2

If you want to get your Omega-3 via Omega Quant, click on this link: https://omegaquant.com/ref/864
Discount Code: NickNorwitz for 10% off

Fatty Acid Research Institute: https://www.faresinst.org

Description:
In this conversation, I sit down with Professor William Harris, one of the world’s leading experts on omega-3 and omega-6 fatty acids, to cut through confusion around fish oil, seed oils, cardiovascular health, and brain health.

We break down what omega-3 and omega-6 fats actually are, why their chemistry matters, and how they’re converted into powerful signaling molecules that influence inflammation, metabolism, heart disease, and neurological health.

We also discuss the omega-6:3 ratio and the omega-3 index—why the ratio can be misleading, why higher omega-6 levels are not inherently harmful, and why low EPA and DHA are the real problem for most people. We discuss optimal omega-3 index targets, whether there’s a ceiling to benefits, how omega-3s relate to Alzheimer’s risk and brain aging, and what the data actually say about long-term outcomes.

This is a nuanced, evidence-driven discussion meant to replace fear-based nutrition narratives with clarity, context, and better questions to ask about your own health.

Chapters
0:00 – Meet Omega-3 Expert: Professor Bill Harris
1:21 – A High-Level Overview of Omega-3 and Omega-6
5:10 – Do Omega-3 Help Cardiovascular Health?
9:19 – Limitations of Randomized Controlled Trials
11:11 – Omega-6/3 Ratio vs Omega-3 Index
12:12 – Optimal Levels on the Omega-3 Index
15:28 – Why the Omega-6/3 Ratio Can be Misleading
21:20 – Seed Oils vs Omega-6. What Should we Do?
22:20 – Practical Dietary Tips from Professor Harris
25:11 – Omega-3 and Neuropsychological Health
27:45 – Nuance about Navigating Personal Choices
29:30 – Professor Harris’s Personal Routine
30:50 – What Really Matters for Longevity

#omega3 #metabolichealth #sardinediet #omega6 #linoleicacid #PUFA #saturatedfat #hearthealth #brainhealth #staycurious #omegaquant #mitochondria #hormones #brainhealth #brainaging #dementia #EPA #DHA #ALA #salmon #seedoils #mitochondria #atherosclerosis #Apoe4 #Apoe #cholesterol #apoB #fishoil

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 2420 no Bonehead! Hormone from Bone Causes Cognitive Decline Nature paper: https://www.nature.com/articles/s42255-024-00989-xHouse Of Macadamia Landing Page: partner.houseofmacadamias.com/nick-norwitz**15% OFF All Bundles! "Clean and Simple" and "Mac-nificent"10% off any item (non-bundle) with code "NICK10"My Blog on Macadamia: https://ketodietapp.com/Blog/lchf/macadamia-nuts-king-of-keto-nutsWnt, Alzheimer's: https://www.frontiersin.org/articles/10.3389/fnagi.2019.00184/fullCase Report: https://pubmed.ncbi.nlm.nih.gov/30972028/0:00 – New Study!0:30 – Channel Intro 0:40 – Wnt Signaling Background 1:37 – Sclerostin increases with age2:44 – Sclerostin crosses BBB3:20 – Sclerostin impairs cognition and synaptic plasticity4:56 – Sclerostin increases pathological Amyloid-Beta processing5:42 – Sclerostin negatively associated with cognition 6:09 – Blocking Sclerostin improves amyloid, plaque, and cognition6:47 – Bone Drug for Brain?7:15 – Surprising personal disclosure 8:28 – My first media partner: House of Macadamia (20% off)A BIG thank you to Mr. Andrew Degryse for his amazing work on my new thumbnails. Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 09 Oct 2026 10:46:00 -0000 full Nick Norwitz MD PhD Nature paper: https://www.nature.com/articles/s42255-024-00989-xHouse Of Macadamia Landing Page: partner.houseofmacadamias.com/nick-norwitz**15% OFF All Bundles! "Clean and Simple" and "Mac-nificent"10% off any item (non-bundle) with code "NICK10"My Blog on Macadamia: https://ketodietapp.com/Blog/lchf/macadamia-nuts-king-of-keto-nutsWnt, Alzheimer's: https://www.frontiersin.org/articles/10.3389/fnagi.2019.00184/fullCase Report: https://pubmed.ncbi.nlm.nih.gov/30972028/0:00 – New Study!0:30 – Channel Intro 0:40 – Wnt Signaling Background 1:37 – Sclerostin increases with age2:44 – Sclerostin crosses BBB3:20 – Sclerostin impairs cognition and synaptic plasticity4:56 – Sclerostin increases pathological Amyloid-Beta processing5:42 – Sclerostin negatively associated with cognition 6:09 – Blocking Sclerostin improves amyloid, plaque, and cognition6:47 – Bone Drug for Brain?7:15 – Surprising personal disclosure 8:28 – My first media partner: House of Macadamia (20% off)A BIG thank you to Mr. Andrew Degryse for his amazing work on my new thumbnails. Learn more about your ad choices. Visit megaphone.fm/adchoices Nature paper: https://www.nature.com/articles/s42255-024-00989-x

House Of Macadamia Landing Page: partner.houseofmacadamias.com/nick-norwitz
**15% OFF All Bundles! "Clean and Simple" and "Mac-nificent"
10% off any item (non-bundle) with code "NICK10"
My Blog on Macadamia: https://ketodietapp.com/Blog/lchf/macadamia-nuts-king-of-keto-nuts

Wnt, Alzheimer's: https://www.frontiersin.org/articles/10.3389/fnagi.2019.00184/full
Case Report: https://pubmed.ncbi.nlm.nih.gov/30972028/

0:00 – New Study!
0:30 – Channel Intro
0:40 – Wnt Signaling Background
1:37 – Sclerostin increases with age
2:44 – Sclerostin crosses BBB
3:20 – Sclerostin impairs cognition and synaptic plasticity
4:56 – Sclerostin increases pathological Amyloid-Beta processing
5:42 – Sclerostin negatively associated with cognition
6:09 – Blocking Sclerostin improves amyloid, plaque, and cognition
6:47 – Bone Drug for Brain?
7:15 – Surprising personal disclosure
8:28 – My first media partner: House of Macadamia (20% off)

A BIG thank you to Mr. Andrew Degryse for his amazing work on my new thumbnails.

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 738 no The Unexpected Omega-3 Your Brain Really Wants For the written breakdown with all the references and extra details, see: https://staycuriousmetabolism.substack.com/p/why-omega-3-supplements-dont-work?r=40ekz2 To try the Accentrate Omega Max supplement containing Lysoveta, click HERE: https://www.fenixhealthscience.com/staycuriousUse code StayCurious for 20% off.NAD+ for Alzheimer’s Prevention Letter:https://staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2Omega-3 Brain Metabolism Letter: Coming soon to https://staycuroiusmetabolism.com ... sorry, we changed the calendar orderCreatine Letter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2 Most omega-3 supplements fail to protect the brain—not because DHA is useless, but because it’s delivered in the wrong biochemical “package.” In this video, I break down the omega-3 paradox: fatty fish is consistently linked with better brain aging, yet many trials of DHA supplements show disappointing results.The key is transport. A specific form—lysophospholipid DHA (lysoDHA)—can use a dedicated brain transporter (MSFD2A). In animal studies, lysoDHA dramatically increases brain DHA, boosts BDNF (a major brain growth signal), and improves memory performance compared to conventional DHA forms that often end up in fat tissue instead.I’ll walk you through the evidence, explain why “DHA” isn’t one thing, and give an action plan: food strategies (fatty fish, roe, krill) and supplement considerations—especially if you carry ApoE4 and may break down DHA faster in the brain. We’ll also cover additional high-yield neuroprotective moves: exercise, creatine, and more.References + extra nuance are in the newsletter linked above.Chapters0:00 – Most Omega-3 Supplements Don’t Work1:38 – Video Roadmap: What We’re Going to Cover2:46 – Chapter 1. The Omega-3 Paradox: Why Omega-3 Supplements Fail4:40 – Chapter 2. Lyso-DHA is The Express Courier to the Brain5:51 – Lyso-DHA Boosts Brain DHA Levels Better 8:47 – Translating the Animal Data to Humans9:42 – Chapter 3. The Action Plan 10:28 – The Omega-3 Supplement I Use and Why12:45 – Chapter 4. Other Neuroprotective Strategies#Omega3 #DHA #BrainHealth #AlzheimersPrevention #APOE4 #FishOil #CognitiveHealth #Neuroprotection #BDNF #Longevity #NutritionScience #Supplements #StayCurious #MetabolicHealth #Omega3Index #Sardines #Salmon #KrillOil #Neuroscience #EvidenceBased Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 08 Oct 2026 16:46:00 -0000 full Nick Norwitz MD PhD For the written breakdown with all the references and extra details, see: https://staycuriousmetabolism.substack.com/p/why-omega-3-supplements-dont-work?r=40ekz2 To try the Accentrate Omega Max supplement containing Lysoveta, click HERE: https://www.fenixhealthscience.com/staycuriousUse code StayCurious for 20% off.NAD+ for Alzheimer’s Prevention Letter:https://staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2Omega-3 Brain Metabolism Letter: Coming soon to https://staycuroiusmetabolism.com ... sorry, we changed the calendar orderCreatine Letter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2 Most omega-3 supplements fail to protect the brain—not because DHA is useless, but because it’s delivered in the wrong biochemical “package.” In this video, I break down the omega-3 paradox: fatty fish is consistently linked with better brain aging, yet many trials of DHA supplements show disappointing results.The key is transport. A specific form—lysophospholipid DHA (lysoDHA)—can use a dedicated brain transporter (MSFD2A). In animal studies, lysoDHA dramatically increases brain DHA, boosts BDNF (a major brain growth signal), and improves memory performance compared to conventional DHA forms that often end up in fat tissue instead.I’ll walk you through the evidence, explain why “DHA” isn’t one thing, and give an action plan: food strategies (fatty fish, roe, krill) and supplement considerations—especially if you carry ApoE4 and may break down DHA faster in the brain. We’ll also cover additional high-yield neuroprotective moves: exercise, creatine, and more.References + extra nuance are in the newsletter linked above.Chapters0:00 – Most Omega-3 Supplements Don’t Work1:38 – Video Roadmap: What We’re Going to Cover2:46 – Chapter 1. The Omega-3 Paradox: Why Omega-3 Supplements Fail4:40 – Chapter 2. Lyso-DHA is The Express Courier to the Brain5:51 – Lyso-DHA Boosts Brain DHA Levels Better 8:47 – Translating the Animal Data to Humans9:42 – Chapter 3. The Action Plan 10:28 – The Omega-3 Supplement I Use and Why12:45 – Chapter 4. Other Neuroprotective Strategies#Omega3 #DHA #BrainHealth #AlzheimersPrevention #APOE4 #FishOil #CognitiveHealth #Neuroprotection #BDNF #Longevity #NutritionScience #Supplements #StayCurious #MetabolicHealth #Omega3Index #Sardines #Salmon #KrillOil #Neuroscience #EvidenceBased Learn more about your ad choices. Visit megaphone.fm/adchoices For the written breakdown with all the references and extra details, see: https://staycuriousmetabolism.substack.com/p/why-omega-3-supplements-dont-work?r=40ekz2

To try the Accentrate Omega Max supplement containing Lysoveta, click HERE: https://www.fenixhealthscience.com/staycurious

Use code StayCurious for 20% off.

NAD+ for Alzheimer’s Prevention Letter:
https://staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2

Omega-3 Brain Metabolism Letter: Coming soon to https://staycuroiusmetabolism.com ... sorry, we changed the calendar order

Creatine Letter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2

Most omega-3 supplements fail to protect the brain—not because DHA is useless, but because it’s delivered in the wrong biochemical “package.” In this video, I break down the omega-3 paradox: fatty fish is consistently linked with better brain aging, yet many trials of DHA supplements show disappointing results.

The key is transport. A specific form—lysophospholipid DHA (lysoDHA)—can use a dedicated brain transporter (MSFD2A). In animal studies, lysoDHA dramatically increases brain DHA, boosts BDNF (a major brain growth signal), and improves memory performance compared to conventional DHA forms that often end up in fat tissue instead.

I’ll walk you through the evidence, explain why “DHA” isn’t one thing, and give an action plan: food strategies (fatty fish, roe, krill) and supplement considerations—especially if you carry ApoE4 and may break down DHA faster in the brain. We’ll also cover additional high-yield neuroprotective moves: exercise, creatine, and more.

References + extra nuance are in the newsletter linked above.

Chapters
0:00 – Most Omega-3 Supplements Don’t Work
1:38 – Video Roadmap: What We’re Going to Cover
2:46 – Chapter 1. The Omega-3 Paradox: Why Omega-3 Supplements Fail
4:40 – Chapter 2. Lyso-DHA is The Express Courier to the Brain
5:51 – Lyso-DHA Boosts Brain DHA Levels Better
8:47 – Translating the Animal Data to Humans
9:42 – Chapter 3. The Action Plan
10:28 – The Omega-3 Supplement I Use and Why
12:45 – Chapter 4. Other Neuroprotective Strategies

#Omega3 #DHA #BrainHealth #AlzheimersPrevention #APOE4 #FishOil #CognitiveHealth #Neuroprotection #BDNF #Longevity #NutritionScience #Supplements #StayCurious #MetabolicHealth #Omega3Index #Sardines #Salmon #KrillOil #Neuroscience #EvidenceBased

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1105 no How to LOWER LDL on Keto. No meds! DISCLAIMER: This is NOT a "You Should" video. I am also NOT making claims about the dangers, or lack thereof, of high LDL is particular metabolic contexts (e.g. LMHR). However, I believe that when it comes to health more OPTIONS/TOOLS are generally better. Therefore, take this for what it's worth: information for you to act on (or ignore) as you see fit. House Of Macadamia Landing Page: partner.houseofmacadamias.com/nick-norwitz**15% OFF All Bundles! "Clean and Simple" and "Mac-nificent"10% off any item (non-bundle) with code "NICK10"My Blog on Macadamia: https://ketodietapp.com/Blog/lchf/macadamia-nuts-king-of-keto-nuts0:00 -- Overview0:49 -- 2 phases1:20 -- Part Ia: Specific fibers4:10 -- Part Ib: Fatty acid profile8:30 -- Macadamia9:51 -- Part II 4 Levers for LMHR14:05 -- Ranking the 4 Levers14:29 -- "rock and hard place" patients16:50 -- Not Tribal, a collaboration Saturated Fat Meta-analysis: https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltextOreoVsStatin: https://www.mdpi.com/2218-1989/14/1/73Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/Arabinoxylan paper: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00166-4Tahini dressing: https://ketodietapp.com/Blog/lchf/easy-keto-tahini-dressingTahini: https://amzn.to/42JFSai (Amazon)Icelandic Cod Liver: https://amzn.to/3I5j0bW (Amazon)Tazo Dark Chocolate with Ginger: https://amzn.to/49jMCOK (Amazon) Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 07 Oct 2026 22:46:00 -0000 full Nick Norwitz MD PhD DISCLAIMER: This is NOT a "You Should" video. I am also NOT making claims about the dangers, or lack thereof, of high LDL is particular metabolic contexts (e.g. LMHR). However, I believe that when it comes to health more OPTIONS/TOOLS are generally better. Therefore, take this for what it's worth: information for you to act on (or ignore) as you see fit. House Of Macadamia Landing Page: partner.houseofmacadamias.com/nick-norwitz**15% OFF All Bundles! "Clean and Simple" and "Mac-nificent"10% off any item (non-bundle) with code "NICK10"My Blog on Macadamia: https://ketodietapp.com/Blog/lchf/macadamia-nuts-king-of-keto-nuts0:00 -- Overview0:49 -- 2 phases1:20 -- Part Ia: Specific fibers4:10 -- Part Ib: Fatty acid profile8:30 -- Macadamia9:51 -- Part II 4 Levers for LMHR14:05 -- Ranking the 4 Levers14:29 -- "rock and hard place" patients16:50 -- Not Tribal, a collaboration Saturated Fat Meta-analysis: https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltextOreoVsStatin: https://www.mdpi.com/2218-1989/14/1/73Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/Arabinoxylan paper: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00166-4Tahini dressing: https://ketodietapp.com/Blog/lchf/easy-keto-tahini-dressingTahini: https://amzn.to/42JFSai (Amazon)Icelandic Cod Liver: https://amzn.to/3I5j0bW (Amazon)Tazo Dark Chocolate with Ginger: https://amzn.to/49jMCOK (Amazon) Learn more about your ad choices. Visit megaphone.fm/adchoices DISCLAIMER: This is NOT a "You Should" video. I am also NOT making claims about the dangers, or lack thereof, of high LDL is particular metabolic contexts (e.g. LMHR). However, I believe that when it comes to health more OPTIONS/TOOLS are generally better. Therefore, take this for what it's worth: information for you to act on (or ignore) as you see fit.

House Of Macadamia Landing Page: partner.houseofmacadamias.com/nick-norwitz
**15% OFF All Bundles! "Clean and Simple" and "Mac-nificent"
10% off any item (non-bundle) with code "NICK10"
My Blog on Macadamia: https://ketodietapp.com/Blog/lchf/macadamia-nuts-king-of-keto-nuts

0:00 -- Overview
0:49 -- 2 phases
1:20 -- Part Ia: Specific fibers
4:10 -- Part Ib: Fatty acid profile
8:30 -- Macadamia
9:51 -- Part II 4 Levers for LMHR
14:05 -- Ranking the 4 Levers
14:29 -- "rock and hard place" patients
16:50 -- Not Tribal, a collaboration

Saturated Fat Meta-analysis: https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltext
OreoVsStatin: https://www.mdpi.com/2218-1989/14/1/73
Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/
Arabinoxylan paper: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00166-4

Tahini dressing: https://ketodietapp.com/Blog/lchf/easy-keto-tahini-dressing
Tahini: https://amzn.to/42JFSai (Amazon)
Icelandic Cod Liver: https://amzn.to/3I5j0bW (Amazon)
Tazo Dark Chocolate with Ginger: https://amzn.to/49jMCOK (Amazon)

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1348 no "That's Terrible!" | What Statin Trials Really Show For more nuances, references and a written breakdown, join the StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/the-ldl-illusion-what-statin-trials?r=40ekz2 Statins and Mitochondrial Health: https://youtu.be/qHXMI3DudEc Breaking Statins (with a Hammer): https://youtu.be/cX7qzj4qazg Description:What if the number your doctor focuses on most isn’t actually predicting what matters? LDL cholesterol has become the central metric in cardiovascular medicine because it’s easy to measure and easy to change, and easy to standardize. But large-scale analyses suggest that reductions in LDL cholesterol may be a surprisingly weak predictor of real cardiovascular outcomes.In this video, I break down a major umbrella review published in the European Heart Journal covering nearly 200,000 patients across 20 randomized controlled trials. The core question is simple but uncomfortable: does lowering LDL cholesterol reliably predict fewer heart attacks, strokes, or deaths? The answer, based on the data, is not what most people expect.We also look at replication data from JAMA Internal Medicine, explore why statins may still help certain patients despite LDL being a poor surrogate marker, and explain the concept of pleiotropy—how drugs can work through multiple biological pathways unrelated to cholesterol.Chapter:0:00 – Why LDL Cholesterol Can Be Misleading (The Hot Chocolate Analogy)1:37 – New Meta-Analysis: 20 Randomized Controlled Trials Reviewed3:17 – Why LDL Reductions Failed to Predict Heart Outcomes4:37 – Replication Matters: Independent Trials Show the Same Pattern5:54 – One Pill, Many Effects: How Statins Work Beyond LDL9:45 – Final Takeaway: Why Surrogate Markers Can Mislead in Medicine#LDL #Cholesterol #HeartDisease #Statins #CardiovascularHealth #MetabolicHealth #Inflammation #ApoB #PrecisionMedicine #EvidenceBasedMedicine #HealthScience #MedicalEducation #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 07 Oct 2026 04:46:00 -0000 full Nick Norwitz MD PhD For more nuances, references and a written breakdown, join the StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/the-ldl-illusion-what-statin-trials?r=40ekz2 Statins and Mitochondrial Health: https://youtu.be/qHXMI3DudEc Breaking Statins (with a Hammer): https://youtu.be/cX7qzj4qazg Description:What if the number your doctor focuses on most isn’t actually predicting what matters? LDL cholesterol has become the central metric in cardiovascular medicine because it’s easy to measure and easy to change, and easy to standardize. But large-scale analyses suggest that reductions in LDL cholesterol may be a surprisingly weak predictor of real cardiovascular outcomes.In this video, I break down a major umbrella review published in the European Heart Journal covering nearly 200,000 patients across 20 randomized controlled trials. The core question is simple but uncomfortable: does lowering LDL cholesterol reliably predict fewer heart attacks, strokes, or deaths? The answer, based on the data, is not what most people expect.We also look at replication data from JAMA Internal Medicine, explore why statins may still help certain patients despite LDL being a poor surrogate marker, and explain the concept of pleiotropy—how drugs can work through multiple biological pathways unrelated to cholesterol.Chapter:0:00 – Why LDL Cholesterol Can Be Misleading (The Hot Chocolate Analogy)1:37 – New Meta-Analysis: 20 Randomized Controlled Trials Reviewed3:17 – Why LDL Reductions Failed to Predict Heart Outcomes4:37 – Replication Matters: Independent Trials Show the Same Pattern5:54 – One Pill, Many Effects: How Statins Work Beyond LDL9:45 – Final Takeaway: Why Surrogate Markers Can Mislead in Medicine#LDL #Cholesterol #HeartDisease #Statins #CardiovascularHealth #MetabolicHealth #Inflammation #ApoB #PrecisionMedicine #EvidenceBasedMedicine #HealthScience #MedicalEducation #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For more nuances, references and a written breakdown, join the StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/the-ldl-illusion-what-statin-trials?r=40ekz2
Statins and Mitochondrial Health: https://youtu.be/qHXMI3DudEc
Breaking Statins (with a Hammer): https://youtu.be/cX7qzj4qazg

Description:
What if the number your doctor focuses on most isn’t actually predicting what matters? LDL cholesterol has become the central metric in cardiovascular medicine because it’s easy to measure and easy to change, and easy to standardize. But large-scale analyses suggest that reductions in LDL cholesterol may be a surprisingly weak predictor of real cardiovascular outcomes.

In this video, I break down a major umbrella review published in the European Heart Journal covering nearly 200,000 patients across 20 randomized controlled trials. The core question is simple but uncomfortable: does lowering LDL cholesterol reliably predict fewer heart attacks, strokes, or deaths? The answer, based on the data, is not what most people expect.

We also look at replication data from JAMA Internal Medicine, explore why statins may still help certain patients despite LDL being a poor surrogate marker, and explain the concept of pleiotropy—how drugs can work through multiple biological pathways unrelated to cholesterol.

Chapter:
0:00 – Why LDL Cholesterol Can Be Misleading (The Hot Chocolate Analogy)
1:37 – New Meta-Analysis: 20 Randomized Controlled Trials Reviewed
3:17 – Why LDL Reductions Failed to Predict Heart Outcomes
4:37 – Replication Matters: Independent Trials Show the Same Pattern
5:54 – One Pill, Many Effects: How Statins Work Beyond LDL
9:45 – Final Takeaway: Why Surrogate Markers Can Mislead in Medicine

#LDL #Cholesterol #HeartDisease #Statins #CardiovascularHealth #MetabolicHealth #Inflammation #ApoB #PrecisionMedicine #EvidenceBasedMedicine #HealthScience #MedicalEducation #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 824 no Microplastics may be Poisoning You! 11 Solutions Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2309822 0:00 - New Microplastics Paper in NEJM! 0:47 - Methods 1:15 - Results 3:08 - 11 Solutions to reduce exposure *A criticism of the data in this paper will be that they are "associative." This was an "observational" trial, not an RCT. Technically, causality isn't proven. However, it's important to keep in mind that (1) You can't do an RCT on this topic with hard outcomes... you can't randomize a group a humans to microplastics exposure and then monitor for the outcomes of heart attack, stroke and death. (2) These data are consistent with prior work and have biological plausibility, i.e. there are data that microplastics can induce an inflammatory and immune response, signs of which we also see in this paper with the increase in immune cell activation markers and inflammatory cytokines (3) In general, the "cost" to reducing microplastics is inconvenience at most. If you choose to drink filtered tap water out of your own stainless steel bottle, rather than bottled, at absolute worst you get negligible health benefit and that water bottle doesn't end up in the ocean as pollution. Beat the microbead: https://www.beatthemicrobead.org/guide-to-microplastics/PFAS free: https://pfascentral.org/pfas-free-products/My favorite plastic-free tea company: https://yogiproducts.com/all-teas/ Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 06 Oct 2026 10:46:00 -0000 full Nick Norwitz MD PhD Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2309822 0:00 - New Microplastics Paper in NEJM! 0:47 - Methods 1:15 - Results 3:08 - 11 Solutions to reduce exposure *A criticism of the data in this paper will be that they are "associative." This was an "observational" trial, not an RCT. Technically, causality isn't proven. However, it's important to keep in mind that (1) You can't do an RCT on this topic with hard outcomes... you can't randomize a group a humans to microplastics exposure and then monitor for the outcomes of heart attack, stroke and death. (2) These data are consistent with prior work and have biological plausibility, i.e. there are data that microplastics can induce an inflammatory and immune response, signs of which we also see in this paper with the increase in immune cell activation markers and inflammatory cytokines (3) In general, the "cost" to reducing microplastics is inconvenience at most. If you choose to drink filtered tap water out of your own stainless steel bottle, rather than bottled, at absolute worst you get negligible health benefit and that water bottle doesn't end up in the ocean as pollution. Beat the microbead: https://www.beatthemicrobead.org/guide-to-microplastics/PFAS free: https://pfascentral.org/pfas-free-products/My favorite plastic-free tea company: https://yogiproducts.com/all-teas/ Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2309822

0:00 - New Microplastics Paper in NEJM!
0:47 - Methods
1:15 - Results
3:08 - 11 Solutions to reduce exposure

*A criticism of the data in this paper will be that they are "associative." This was an "observational" trial, not an RCT. Technically, causality isn't proven. However, it's important to keep in mind that (1) You can't do an RCT on this topic with hard outcomes... you can't randomize a group a humans to microplastics exposure and then monitor for the outcomes of heart attack, stroke and death. (2) These data are consistent with prior work and have biological plausibility, i.e. there are data that microplastics can induce an inflammatory and immune response, signs of which we also see in this paper with the increase in immune cell activation markers and inflammatory cytokines (3) In general, the "cost" to reducing microplastics is inconvenience at most. If you choose to drink filtered tap water out of your own stainless steel bottle, rather than bottled, at absolute worst you get negligible health benefit and that water bottle doesn't end up in the ocean as pollution.


Beat the microbead: https://www.beatthemicrobead.org/guide-to-microplastics/
PFAS free: https://pfascentral.org/pfas-free-products/
My favorite plastic-free tea company: https://yogiproducts.com/all-teas/

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 652 no Top Stanford Professor Weighs in on How Exercise Changes Your Metabolism For written details on this paper, see the StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/the-art-of-a-heartbeat-one-of-the?r=40ekz2 Snyder Interview 1: https://youtu.be/mCrc4gfbK2o Snyder Interview 2: https://youtu.be/kMpGkg4zMOU Snyder Interview 3: This one!Snyder Interview 4: Coming Soon…Leptin Resistance Letter: https://staycuriousmetabolism.substack.com/p/obesitys-secret-letters-the-hidden?r=40ekz2 Gift Guide: https://staycuriousmetabolism.substack.com/p/saint-dr-nicks-holiday-gift-guide?r=40ekz2 This conversation with Stanford’s Professor Michael Snyder breaks down one of the most important exercise studies ever published — a deep, molecular look at what really happens inside your body when you work out. We explore how thousands of molecules shift in real time, why inflammation during exercise is actually a good thing, how omega-3 signaling, mitochondrial remodeling, nitric oxide pathways, and metabolic flexibility all come together in a coordinated “molecular choreography,” and why your insulin sensitivity can completely change how your body responds to the same workout. We also discuss VO₂ max, the difference between sprinting and steady-state cardio, how to think about recovery, and why exercise affects every organ in your body, from muscles to brain. If you want a deeper understanding of the biology behind fitness — and why personalized exercise matters — this interview is a must-watch. Stay Curious.Chapters0:00 – A Workout for Your Brain0:30 – Re-Introducing Professor Snyder1:30 – The Exercise Study That Changed Everything6:29 – The Four Molecular Response Clusters8:53 – The “Fitness Inflammatory Signature” Explained12:20 – Omega-3 Surges, Saturated Fats Drop16:30 – Why I Keep Re-Reading This Study17:40 – The Discovery of Lac-Phe (A New Appetite Signal)20:07 – Sprinting vs. Steady State: What Wins?25:40 – How Insulin Resistance Changes Your Exercise Response28:53 – The Exercise Graph That Blows People’s Minds34:40 – Exercise Isn’t About Calories — Here’s Why37:30 – Morning vs. Afternoon Exercise: What’s Best?40:53 – Post-Meal Walks and “Exercise Snacks”#ExerciseScience #MetabolicHealth #InsulinResistance #VO2max #MolecularFitness #StanfordResearch #MichaelSnyder #NickNorwitz #LongevityScience #FitnessMotivation #HealthOptimization #Omega3 #Inflammation #Metabolism #StrengthTraining #Sprinting #EnduranceTraining #Wearables #PersonalizedHealth #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 05 Oct 2026 16:46:00 -0000 full Nick Norwitz MD PhD For written details on this paper, see the StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/the-art-of-a-heartbeat-one-of-the?r=40ekz2 Snyder Interview 1: https://youtu.be/mCrc4gfbK2o Snyder Interview 2: https://youtu.be/kMpGkg4zMOU Snyder Interview 3: This one!Snyder Interview 4: Coming Soon…Leptin Resistance Letter: https://staycuriousmetabolism.substack.com/p/obesitys-secret-letters-the-hidden?r=40ekz2 Gift Guide: https://staycuriousmetabolism.substack.com/p/saint-dr-nicks-holiday-gift-guide?r=40ekz2 This conversation with Stanford’s Professor Michael Snyder breaks down one of the most important exercise studies ever published — a deep, molecular look at what really happens inside your body when you work out. We explore how thousands of molecules shift in real time, why inflammation during exercise is actually a good thing, how omega-3 signaling, mitochondrial remodeling, nitric oxide pathways, and metabolic flexibility all come together in a coordinated “molecular choreography,” and why your insulin sensitivity can completely change how your body responds to the same workout. We also discuss VO₂ max, the difference between sprinting and steady-state cardio, how to think about recovery, and why exercise affects every organ in your body, from muscles to brain. If you want a deeper understanding of the biology behind fitness — and why personalized exercise matters — this interview is a must-watch. Stay Curious.Chapters0:00 – A Workout for Your Brain0:30 – Re-Introducing Professor Snyder1:30 – The Exercise Study That Changed Everything6:29 – The Four Molecular Response Clusters8:53 – The “Fitness Inflammatory Signature” Explained12:20 – Omega-3 Surges, Saturated Fats Drop16:30 – Why I Keep Re-Reading This Study17:40 – The Discovery of Lac-Phe (A New Appetite Signal)20:07 – Sprinting vs. Steady State: What Wins?25:40 – How Insulin Resistance Changes Your Exercise Response28:53 – The Exercise Graph That Blows People’s Minds34:40 – Exercise Isn’t About Calories — Here’s Why37:30 – Morning vs. Afternoon Exercise: What’s Best?40:53 – Post-Meal Walks and “Exercise Snacks”#ExerciseScience #MetabolicHealth #InsulinResistance #VO2max #MolecularFitness #StanfordResearch #MichaelSnyder #NickNorwitz #LongevityScience #FitnessMotivation #HealthOptimization #Omega3 #Inflammation #Metabolism #StrengthTraining #Sprinting #EnduranceTraining #Wearables #PersonalizedHealth #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For written details on this paper, see the StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/the-art-of-a-heartbeat-one-of-the?r=40ekz2

Snyder Interview 1: https://youtu.be/mCrc4gfbK2o
Snyder Interview 2: https://youtu.be/kMpGkg4zMOU
Snyder Interview 3: This one!
Snyder Interview 4: Coming Soon…

Leptin Resistance Letter: https://staycuriousmetabolism.substack.com/p/obesitys-secret-letters-the-hidden?r=40ekz2

Gift Guide: https://staycuriousmetabolism.substack.com/p/saint-dr-nicks-holiday-gift-guide?r=40ekz2

This conversation with Stanford’s Professor Michael Snyder breaks down one of the most important exercise studies ever published — a deep, molecular look at what really happens inside your body when you work out.

We explore how thousands of molecules shift in real time, why inflammation during exercise is actually a good thing, how omega-3 signaling, mitochondrial remodeling, nitric oxide pathways, and metabolic flexibility all come together in a coordinated “molecular choreography,” and why your insulin sensitivity can completely change how your body responds to the same workout.

We also discuss VO₂ max, the difference between sprinting and steady-state cardio, how to think about recovery, and why exercise affects every organ in your body, from muscles to brain. If you want a deeper understanding of the biology behind fitness — and why personalized exercise matters — this interview is a must-watch. Stay Curious.

Chapters
0:00 – A Workout for Your Brain
0:30 – Re-Introducing Professor Snyder
1:30 – The Exercise Study That Changed Everything
6:29 – The Four Molecular Response Clusters
8:53 – The “Fitness Inflammatory Signature” Explained
12:20 – Omega-3 Surges, Saturated Fats Drop
16:30 – Why I Keep Re-Reading This Study
17:40 – The Discovery of Lac-Phe (A New Appetite Signal)
20:07 – Sprinting vs. Steady State: What Wins?
25:40 – How Insulin Resistance Changes Your Exercise Response
28:53 – The Exercise Graph That Blows People’s Minds
34:40 – Exercise Isn’t About Calories — Here’s Why
37:30 – Morning vs. Afternoon Exercise: What’s Best?
40:53 – Post-Meal Walks and “Exercise Snacks”

#ExerciseScience #MetabolicHealth #InsulinResistance #VO2max #MolecularFitness #StanfordResearch #MichaelSnyder #NickNorwitz #LongevityScience #FitnessMotivation #HealthOptimization #Omega3 #Inflammation #Metabolism #StrengthTraining #Sprinting #EnduranceTraining #Wearables #PersonalizedHealth #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 2991 no 5 Benefits of Omega-7 Fat. Where to get it. 15% off any House of Macadamia products with code "NICK15"Affilitate Link: https://glnk.io/9ymmp/nicknorwitzphd Cao, Cell 2008: https://pubmed.ncbi.nlm.nih.gov/18805087/Chan, Jour Biol Chem 2015: https://www.jbc.org/article/S0021-9258(20)40251-0/fulltextGarg, Jour Nutr 2003: https://pubmed.ncbi.nlm.nih.gov/12672919/Chapters0:00 -- Intro1:09 -- Lipokines2:00 -- 1. Insulin Sensitivity2:43 -- 2. LDL, HDL, TG3:15 -- 3. Anti-inflammatory4:50 -- 4. Satiety 5:30 -- 5. Bone and Skin6:40 -- Complexities in studying POA8:20 -- Others reasons to love Macs!9:41 -- House of Mac*Roasting nuts at home: Roasting nuts is a tricky business. If you like roasted nuts, I suggesting using temperatures at or below 265 - 285 F (130 - 140 C) for 20 minutes. The temperature sensitivity of nuts derives from their fragile omega-6 fats. But because macadamia nuts are low in omega-6, they are more stable. Even at 150 °C/ 300 °F, macadamia are okay. In fact, if you roast equal amounts of macadamia and walnuts at 300 F, the macadamia will end up with 1/30th the oxidized fats (https://pubmed.ncbi.nlm.nih.gov/25766804/). Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 04 Oct 2026 22:46:00 -0000 full Nick Norwitz MD PhD 15% off any House of Macadamia products with code "NICK15"Affilitate Link: https://glnk.io/9ymmp/nicknorwitzphd Cao, Cell 2008: https://pubmed.ncbi.nlm.nih.gov/18805087/Chan, Jour Biol Chem 2015: https://www.jbc.org/article/S0021-9258(20)40251-0/fulltextGarg, Jour Nutr 2003: https://pubmed.ncbi.nlm.nih.gov/12672919/Chapters0:00 -- Intro1:09 -- Lipokines2:00 -- 1. Insulin Sensitivity2:43 -- 2. LDL, HDL, TG3:15 -- 3. Anti-inflammatory4:50 -- 4. Satiety 5:30 -- 5. Bone and Skin6:40 -- Complexities in studying POA8:20 -- Others reasons to love Macs!9:41 -- House of Mac*Roasting nuts at home: Roasting nuts is a tricky business. If you like roasted nuts, I suggesting using temperatures at or below 265 - 285 F (130 - 140 C) for 20 minutes. The temperature sensitivity of nuts derives from their fragile omega-6 fats. But because macadamia nuts are low in omega-6, they are more stable. Even at 150 °C/ 300 °F, macadamia are okay. In fact, if you roast equal amounts of macadamia and walnuts at 300 F, the macadamia will end up with 1/30th the oxidized fats (https://pubmed.ncbi.nlm.nih.gov/25766804/). Learn more about your ad choices. Visit megaphone.fm/adchoices 15% off any House of Macadamia products with code "NICK15"
Affilitate Link: https://glnk.io/9ymmp/nicknorwitzphd

Cao, Cell 2008: https://pubmed.ncbi.nlm.nih.gov/18805087/
Chan, Jour Biol Chem 2015: https://www.jbc.org/article/S0021-9258(20)40251-0/fulltext
Garg, Jour Nutr 2003: https://pubmed.ncbi.nlm.nih.gov/12672919/

Chapters
0:00 -- Intro
1:09 -- Lipokines
2:00 -- 1. Insulin Sensitivity
2:43 -- 2. LDL, HDL, TG
3:15 -- 3. Anti-inflammatory
4:50 -- 4. Satiety
5:30 -- 5. Bone and Skin
6:40 -- Complexities in studying POA
8:20 -- Others reasons to love Macs!
9:41 -- House of Mac

*Roasting nuts at home: Roasting nuts is a tricky business. If you like roasted nuts, I suggesting using temperatures at or below 265 - 285 F (130 - 140 C) for 20 minutes. The temperature sensitivity of nuts derives from their fragile omega-6 fats. But because macadamia nuts are low in omega-6, they are more stable. Even at 150 °C/ 300 °F, macadamia are okay. In fact, if you roast equal amounts of macadamia and walnuts at 300 F, the macadamia will end up with 1/30th the oxidized fats (https://pubmed.ncbi.nlm.nih.gov/25766804/).

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 800 no Decoding Creatine: Muscle, Brain and Myths For all the references and extra details, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2Momentous CreatineUse code StayCurious for up to 35% off your first order at livemomentous.com or follow this link: https://www.livemomentous.com/discount/STAYCURIOUS?redirect=/collections/creatine&utm_source=youtube&utm_medium=sponcon&utm_campaign=nick-norwitz&utm_content=creatine When it comes to reputation, quality, and rigorous third-party testing, you really can’t go wrong with Momentous Creatine Monohydrate. It’s extensively tested for heavy metals and banned substances. My personal preference is their pure, unflavored, no dyes or sweeteners, micronized creatine monohydrateDESCRIPTION: Creatine is one of the most researched supplements in history—yet most people still misunderstand how it works and what it actually does.In this video, I break down creatine from first principles to real-world use. We start with the biochemistry: what creatine is and how it promotes muscle growth—cell hydration, satellite cells, gene expression—and review human randomized controlled trials showing increases in lean mass and even reductions in fat mass.From there, we go beyond muscle. Creatine plays a critical role in brain energy metabolism, and emerging data show benefits for memory, aging, depression, sleep deprivation, and possibly neurodegenerative disease. I walk through the human trial data, explain why higher doses are often needed for brain effects, and outline practical dosing strategies that maximize benefits while minimizing GI issues.We also clear up common myths about creatine—hair loss, kidney damage, cycling—and end with simple, evidence-based protocols you can actually use.Creatine Ice Cream Recipe Warm 1 pint (473 ml) of Heavy Cream in a pan.While the cream is warm, but not hot, add in 5 egg yolks and mix immediately. You don’t want the yolks to cook. If they do cook, start over (but keep your creamy egg accidents for a snack). Add vanilla, organic liquid stevia, and a pinch of salt to taste. Add four 5 g Scoops of creatine. The recipe makes about 3-4 servings. Obviously, you can double, triple or quadruple as you see fit.Here’s where you can get creative. In the batch shown I added Turkish coffee, but you can also add anything you want. Mint, melted chocolate or cocoa powder, berries. Make it your own.Then pile it into an ice cream maker and turn it on until it reaches the desired consistency. Chapters:0:00 – Creatine Panic at the Airport (Why It’s Misunderstood)1:15 – Roadmap: What Creatine Is, How It Works, Muscle and Brain2:00 – What Creatine Actually Is (Biochemistry Basics)4:00 – How Creatine Drives Muscle Growth and Performance6:13 – Creatine Mechanisms Recap (Energy, Cells, Genes)7:00 – Human Meta-Analysis: Creatine Increases Lean Mass8:21 – Evidence-Based Creatine Protocols and Practical Tips11:16 – Creatine for Memory, Aging and Brain Energy13:41 – Can Creatine Offset Sleep Deprivation Effects?14:46 – Optimal Dosing for Brain Health15:03 – Creatine Myths: Hair Loss, Kidneys, Steroids, Cycling17:10 – Behind the Scenes: How This Video Was Made#Creatine #MuscleScience #BrainHealth #Cognition #ExerciseScience #Metabolism #ATP #Hypertrophy #StrengthTraining #Longevity #Neuroscience #MentalHealth #SleepScience #SupplementScience #NutritionScience #HealthEducation #EvidenceBased #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 04 Oct 2026 04:46:00 -0000 full Nick Norwitz MD PhD For all the references and extra details, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2Momentous CreatineUse code StayCurious for up to 35% off your first order at livemomentous.com or follow this link: https://www.livemomentous.com/discount/STAYCURIOUS?redirect=/collections/creatine&utm_source=youtube&utm_medium=sponcon&utm_campaign=nick-norwitz&utm_content=creatine When it comes to reputation, quality, and rigorous third-party testing, you really can’t go wrong with Momentous Creatine Monohydrate. It’s extensively tested for heavy metals and banned substances. My personal preference is their pure, unflavored, no dyes or sweeteners, micronized creatine monohydrateDESCRIPTION: Creatine is one of the most researched supplements in history—yet most people still misunderstand how it works and what it actually does.In this video, I break down creatine from first principles to real-world use. We start with the biochemistry: what creatine is and how it promotes muscle growth—cell hydration, satellite cells, gene expression—and review human randomized controlled trials showing increases in lean mass and even reductions in fat mass.From there, we go beyond muscle. Creatine plays a critical role in brain energy metabolism, and emerging data show benefits for memory, aging, depression, sleep deprivation, and possibly neurodegenerative disease. I walk through the human trial data, explain why higher doses are often needed for brain effects, and outline practical dosing strategies that maximize benefits while minimizing GI issues.We also clear up common myths about creatine—hair loss, kidney damage, cycling—and end with simple, evidence-based protocols you can actually use.Creatine Ice Cream Recipe Warm 1 pint (473 ml) of Heavy Cream in a pan.While the cream is warm, but not hot, add in 5 egg yolks and mix immediately. You don’t want the yolks to cook. If they do cook, start over (but keep your creamy egg accidents for a snack). Add vanilla, organic liquid stevia, and a pinch of salt to taste. Add four 5 g Scoops of creatine. The recipe makes about 3-4 servings. Obviously, you can double, triple or quadruple as you see fit.Here’s where you can get creative. In the batch shown I added Turkish coffee, but you can also add anything you want. Mint, melted chocolate or cocoa powder, berries. Make it your own.Then pile it into an ice cream maker and turn it on until it reaches the desired consistency. Chapters:0:00 – Creatine Panic at the Airport (Why It’s Misunderstood)1:15 – Roadmap: What Creatine Is, How It Works, Muscle and Brain2:00 – What Creatine Actually Is (Biochemistry Basics)4:00 – How Creatine Drives Muscle Growth and Performance6:13 – Creatine Mechanisms Recap (Energy, Cells, Genes)7:00 – Human Meta-Analysis: Creatine Increases Lean Mass8:21 – Evidence-Based Creatine Protocols and Practical Tips11:16 – Creatine for Memory, Aging and Brain Energy13:41 – Can Creatine Offset Sleep Deprivation Effects?14:46 – Optimal Dosing for Brain Health15:03 – Creatine Myths: Hair Loss, Kidneys, Steroids, Cycling17:10 – Behind the Scenes: How This Video Was Made#Creatine #MuscleScience #BrainHealth #Cognition #ExerciseScience #Metabolism #ATP #Hypertrophy #StrengthTraining #Longevity #Neuroscience #MentalHealth #SleepScience #SupplementScience #NutritionScience #HealthEducation #EvidenceBased #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For all the references and extra details, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2

Momentous Creatine
Use code StayCurious for up to 35% off your first order at livemomentous.com or follow this link: https://www.livemomentous.com/discount/STAYCURIOUS?redirect=/collections/creatine&utm_source=youtube&utm_medium=sponcon&utm_campaign=nick-norwitz&utm_content=creatine

When it comes to reputation, quality, and rigorous third-party testing, you really can’t go wrong with Momentous Creatine Monohydrate. It’s extensively tested for heavy metals and banned substances. My personal preference is their pure, unflavored, no dyes or sweeteners, micronized creatine monohydrate

DESCRIPTION:
Creatine is one of the most researched supplements in history—yet most people still misunderstand how it works and what it actually does.
In this video, I break down creatine from first principles to real-world use.

We start with the biochemistry: what creatine is and how it promotes muscle growth—cell hydration, satellite cells, gene expression—and review human randomized controlled trials showing increases in lean mass and even reductions in fat mass.

From there, we go beyond muscle. Creatine plays a critical role in brain energy metabolism, and emerging data show benefits for memory, aging, depression, sleep deprivation, and possibly neurodegenerative disease. I walk through the human trial data, explain why higher doses are often needed for brain effects, and outline practical dosing strategies that maximize benefits while minimizing GI issues.

We also clear up common myths about creatine—hair loss, kidney damage, cycling—and end with simple, evidence-based protocols you can actually use.

Creatine Ice Cream Recipe

Warm 1 pint (473 ml) of Heavy Cream in a pan.

While the cream is warm, but not hot, add in 5 egg yolks and mix immediately. You don’t want the yolks to cook. If they do cook, start over (but keep your creamy egg accidents for a snack).

Add vanilla, organic liquid stevia, and a pinch of salt to taste.

Add four 5 g Scoops of creatine.

The recipe makes about 3-4 servings. Obviously, you can double, triple or quadruple as you see fit.

Here’s where you can get creative. In the batch shown I added Turkish coffee, but you can also add anything you want. Mint, melted chocolate or cocoa powder, berries. Make it your own.

Then pile it into an ice cream maker and turn it on until it reaches the desired consistency.

Chapters:
0:00 – Creatine Panic at the Airport (Why It’s Misunderstood)
1:15 – Roadmap: What Creatine Is, How It Works, Muscle and Brain
2:00 – What Creatine Actually Is (Biochemistry Basics)
4:00 – How Creatine Drives Muscle Growth and Performance
6:13 – Creatine Mechanisms Recap (Energy, Cells, Genes)
7:00 – Human Meta-Analysis: Creatine Increases Lean Mass
8:21 – Evidence-Based Creatine Protocols and Practical Tips
11:16 – Creatine for Memory, Aging and Brain Energy
13:41 – Can Creatine Offset Sleep Deprivation Effects?
14:46 – Optimal Dosing for Brain Health
15:03 – Creatine Myths: Hair Loss, Kidneys, Steroids, Cycling
17:10 – Behind the Scenes: How This Video Was Made

#Creatine #MuscleScience #BrainHealth #Cognition #ExerciseScience #Metabolism #ATP #Hypertrophy #StrengthTraining #Longevity #Neuroscience #MentalHealth #SleepScience #SupplementScience #NutritionScience #HealthEducation #EvidenceBased #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1365 no 12 Diet Myths and Misperceptions. WARNING: This video is Provocatively Reasonable. Meta 41 RCTs (AJCN, 2024): https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltextFiber and IBD (Cell Host and Microbe, 2023): https://pubmed.ncbi.nlm.nih.gov/37967555/Diet Coke Study, PNAS 2022: https://www.pnas.org/doi/full/10.1073/pnas.2213120119 Microbiome and Sweeteners, Nature 2014: https://pubmed.ncbi.nlm.nih.gov/25231862/ OreoVsStatin, Metabolites 2024: https://www.mdpi.com/2218-1989/14/1/730:00 - Introduction0:55 - 1. Keto2:38 - 2. Saturated Fat4:31 - 3. Statin 6:22 - 4. Meat8:45 - 5. Fructose10:54 - 6. Fiber12:29 - 7. Seed oils 13:57 - 8. Diet Coke 16:11 - 9. LMHR and CVD risk 18:17 - 10. Diet and IBD 20:30 - 11. Carbohydrate Insulin Model 23:50 - 12. Oreo Vs StatinHouse Of Macadamia Landing Page: partner.houseofmacadamias.com/nick-norwitz**15% OFF All Bundles! 10% off any item (non-bundle) with code "NICK10" Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 03 Oct 2026 10:46:00 -0000 full Nick Norwitz MD PhD Meta 41 RCTs (AJCN, 2024): https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltextFiber and IBD (Cell Host and Microbe, 2023): https://pubmed.ncbi.nlm.nih.gov/37967555/Diet Coke Study, PNAS 2022: https://www.pnas.org/doi/full/10.1073/pnas.2213120119 Microbiome and Sweeteners, Nature 2014: https://pubmed.ncbi.nlm.nih.gov/25231862/ OreoVsStatin, Metabolites 2024: https://www.mdpi.com/2218-1989/14/1/730:00 - Introduction0:55 - 1. Keto2:38 - 2. Saturated Fat4:31 - 3. Statin 6:22 - 4. Meat8:45 - 5. Fructose10:54 - 6. Fiber12:29 - 7. Seed oils 13:57 - 8. Diet Coke 16:11 - 9. LMHR and CVD risk 18:17 - 10. Diet and IBD 20:30 - 11. Carbohydrate Insulin Model 23:50 - 12. Oreo Vs StatinHouse Of Macadamia Landing Page: partner.houseofmacadamias.com/nick-norwitz**15% OFF All Bundles! 10% off any item (non-bundle) with code "NICK10" Learn more about your ad choices. Visit megaphone.fm/adchoices Meta 41 RCTs (AJCN, 2024): https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltext

Fiber and IBD (Cell Host and Microbe, 2023): https://pubmed.ncbi.nlm.nih.gov/37967555/

Diet Coke Study, PNAS 2022: https://www.pnas.org/doi/full/10.1073/pnas.2213120119

Microbiome and Sweeteners, Nature 2014: https://pubmed.ncbi.nlm.nih.gov/25231862/

OreoVsStatin, Metabolites 2024: https://www.mdpi.com/2218-1989/14/1/73

0:00 - Introduction
0:55 - 1. Keto
2:38 - 2. Saturated Fat
4:31 - 3. Statin
6:22 - 4. Meat
8:45 - 5. Fructose
10:54 - 6. Fiber
12:29 - 7. Seed oils
13:57 - 8. Diet Coke
16:11 - 9. LMHR and CVD risk
18:17 - 10. Diet and IBD
20:30 - 11. Carbohydrate Insulin Model
23:50 - 12. Oreo Vs Statin

House Of Macadamia Landing Page: partner.houseofmacadamias.com/nick-norwitz
**15% OFF All Bundles!
10% off any item (non-bundle) with code "NICK10"

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 2020 no The Surprising Science Behind Sugar Addiction For references, extra details and early access to data like these, see the StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/the-metabolic-origins-of-a-sweet?r=40ekz2 Sugar Diet, Video: https://youtu.be/IAc_7r_hVI8The Gene That Controls Sugar Cravings, Video: https://youtu.be/_gKEV7Wv8z4 Description:Why can some people effortlessly say no to dessert, while others feel pulled toward sugar like metabolic gravity?New research is revealing that sugar cravings aren’t a failure of willpower — they’re encoded in metabolism. In this video, we break down surprising new science showing how a gut-based nutrient sensor, specific microbes, and key hormones work together to dial sugar cravings up or down.You’ll learn how a fatty-acid receptor in the gut (FFAR4) influences sweet preference, how the microbiome and vitamin B5 fit into the picture, and how hormones like GLP-1 and FGF21 signal all the way from the gut to the brain to regulate sugar intake.We’ll also cover practical, evidence-based ways to work with your biology — not against it — if you struggle with intense sugar cravings.Chapters0:00 – The Sugar Black Hole: Why Cravings Feel Unstoppable2:30 – FFAR4: The Gut Receptor That’s Lower in Diabetes3:45 – How FFAR4 Genetics Shape Sugar Preference4:35 – Proving Causality: What Animal Experiments Reveal5:47 – What We Know So Far6:20 – The Gut Microbe and Vitamin That Control Cravings8:08 – The Full Gut–Liver–Brain Sugar Circuit10:20 – 3 Science-Backed Ways to Tame Sugar Cravings#sugaraddiction #sugarfree #neuroscience #metabolism #metabolichealth #FFAR4 #sucrose #glucose #GLP1 #Bvitamins #liverhealth #DHA #omega3 #SugarCravings #AppetiteControl #GutBrainAxis #Hormones #FGF21 #MicrobiomeScience #NutrientSensing #MetabolicFlexibility #InsulinSensitivity #BloodSugarControl #CravingControl #FoodSignals #NeuroscienceOfEating #PrecisionHealth #LongevityScience #HealthEducation #ScienceExplained #NutritionResearch #Biochemistry #MetabolicScience Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 02 Oct 2026 16:46:00 -0000 full Nick Norwitz MD PhD For references, extra details and early access to data like these, see the StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/the-metabolic-origins-of-a-sweet?r=40ekz2 Sugar Diet, Video: https://youtu.be/IAc_7r_hVI8The Gene That Controls Sugar Cravings, Video: https://youtu.be/_gKEV7Wv8z4 Description:Why can some people effortlessly say no to dessert, while others feel pulled toward sugar like metabolic gravity?New research is revealing that sugar cravings aren’t a failure of willpower — they’re encoded in metabolism. In this video, we break down surprising new science showing how a gut-based nutrient sensor, specific microbes, and key hormones work together to dial sugar cravings up or down.You’ll learn how a fatty-acid receptor in the gut (FFAR4) influences sweet preference, how the microbiome and vitamin B5 fit into the picture, and how hormones like GLP-1 and FGF21 signal all the way from the gut to the brain to regulate sugar intake.We’ll also cover practical, evidence-based ways to work with your biology — not against it — if you struggle with intense sugar cravings.Chapters0:00 – The Sugar Black Hole: Why Cravings Feel Unstoppable2:30 – FFAR4: The Gut Receptor That’s Lower in Diabetes3:45 – How FFAR4 Genetics Shape Sugar Preference4:35 – Proving Causality: What Animal Experiments Reveal5:47 – What We Know So Far6:20 – The Gut Microbe and Vitamin That Control Cravings8:08 – The Full Gut–Liver–Brain Sugar Circuit10:20 – 3 Science-Backed Ways to Tame Sugar Cravings#sugaraddiction #sugarfree #neuroscience #metabolism #metabolichealth #FFAR4 #sucrose #glucose #GLP1 #Bvitamins #liverhealth #DHA #omega3 #SugarCravings #AppetiteControl #GutBrainAxis #Hormones #FGF21 #MicrobiomeScience #NutrientSensing #MetabolicFlexibility #InsulinSensitivity #BloodSugarControl #CravingControl #FoodSignals #NeuroscienceOfEating #PrecisionHealth #LongevityScience #HealthEducation #ScienceExplained #NutritionResearch #Biochemistry #MetabolicScience Learn more about your ad choices. Visit megaphone.fm/adchoices For references, extra details and early access to data like these, see the StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/the-metabolic-origins-of-a-sweet?r=40ekz2

Sugar Diet, Video: https://youtu.be/IAc_7r_hVI8

The Gene That Controls Sugar Cravings, Video: https://youtu.be/_gKEV7Wv8z4

Description:
Why can some people effortlessly say no to dessert, while others feel pulled toward sugar like metabolic gravity?

New research is revealing that sugar cravings aren’t a failure of willpower — they’re encoded in metabolism.

In this video, we break down surprising new science showing how a gut-based nutrient sensor, specific microbes, and key hormones work together to dial sugar cravings up or down.

You’ll learn how a fatty-acid receptor in the gut (FFAR4) influences sweet preference, how the microbiome and vitamin B5 fit into the picture, and how hormones like GLP-1 and FGF21 signal all the way from the gut to the brain to regulate sugar intake.

We’ll also cover practical, evidence-based ways to work with your biology — not against it — if you struggle with intense sugar cravings.

Chapters
0:00 – The Sugar Black Hole: Why Cravings Feel Unstoppable
2:30 – FFAR4: The Gut Receptor That’s Lower in Diabetes
3:45 – How FFAR4 Genetics Shape Sugar Preference
4:35 – Proving Causality: What Animal Experiments Reveal
5:47 – What We Know So Far
6:20 – The Gut Microbe and Vitamin That Control Cravings
8:08 – The Full Gut–Liver–Brain Sugar Circuit
10:20 – 3 Science-Backed Ways to Tame Sugar Cravings

#sugaraddiction #sugarfree #neuroscience #metabolism #metabolichealth #FFAR4 #sucrose #glucose #GLP1 #Bvitamins #liverhealth #DHA #omega3 #SugarCravings #AppetiteControl #GutBrainAxis #Hormones #FGF21 #MicrobiomeScience #NutrientSensing #MetabolicFlexibility #InsulinSensitivity #BloodSugarControl #CravingControl #FoodSignals #NeuroscienceOfEating #PrecisionHealth #LongevityScience #HealthEducation #ScienceExplained #NutritionResearch #Biochemistry #MetabolicScience

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 983 no Who does Milk Protect from Diabetes? You will never think of milk the same again. Paper: https://www.nature.com/articles/s42255-023-00961-10:00 - Intro, Study on Milk and Diabetes0:47 - The Nature Metabolism Paper1:10 - LP vs LNP1:40 - LN vs LNP (GG) genetic coding2:50 - LNP + Milk Intake = Reduced Diabetes Risk4:18 - Why? Mechanism?7:00 - Zooming out... Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 01 Oct 2026 22:46:00 -0000 full Nick Norwitz MD PhD Paper: https://www.nature.com/articles/s42255-023-00961-10:00 - Intro, Study on Milk and Diabetes0:47 - The Nature Metabolism Paper1:10 - LP vs LNP1:40 - LN vs LNP (GG) genetic coding2:50 - LNP + Milk Intake = Reduced Diabetes Risk4:18 - Why? Mechanism?7:00 - Zooming out... Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://www.nature.com/articles/s42255-023-00961-1

0:00 - Intro, Study on Milk and Diabetes
0:47 - The Nature Metabolism Paper
1:10 - LP vs LNP
1:40 - LN vs LNP (GG) genetic coding
2:50 - LNP + Milk Intake = Reduced Diabetes Risk
4:18 - Why? Mechanism?
7:00 - Zooming out...

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 741 no The Simple Molecule That Could Save You From a Heart Attack For extra details, references, and early access to content, see the StayCurious Newsletter: https://staycuriousmetabolism.substack.com/p/new-science-identifies-the-specific?r=40ekz2 Referenced VideosTool Cool for Stool, Bile Acids: https://youtu.be/d0WuCIZxPxU Statins, GLP-1, (T)UDCA: https://youtu.be/6NomrgjK1yQ What if a simple molecule made by your gut could literally protect you from a heart attack? New research in Nature Cardiovascular Research reveals that a specific bile acid—DCA—produced by your own microbiome can reduce blood clotting, improve vascular health, and even protect heart tissue during a heart attack.People with coronary artery disease have lower levels of this molecule and fewer microbes that produce it. Lower DCA means “clottier” blood—and a higher chance of heart attacks and strokes. This video breaks down how DCA works, why your gut microbes matter more than you think, and how lifestyle factors may activate the same anti-clotting pathways.The full story is more intricate, more fascinating, and more hopeful than you might expect. StayCurious.Chapters0:00 – A Simple Molecule that Protects Your Heart1:27 – A Transparency Moment: Stay Curious Journey2:21 – Patients with Heart Disease Have Different Microbiomes and Bile Acids4:37 – Summary, So Far…5:05 – Higher DCA Associates Better Cardiovascular Outcomes6:00 – Is This Causal? Yes. Here’s the Mechanism7:00 – The Promise of Microbiome (Poop) Transplants!8:37 – Turning Insights into Action12:32 – Metabolism is Unified#HeartHealth #CardiovascularHealth #Microbiome #GutHealth #BloodClotting #Metabolism #BileAcids #TGR5 #Longevity #HealthScience #NickNorwitz #StayCurious #NatureResearch #StrokePrevention #heartattackprevention Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 01 Oct 2026 04:46:00 -0000 full Nick Norwitz MD PhD For extra details, references, and early access to content, see the StayCurious Newsletter: https://staycuriousmetabolism.substack.com/p/new-science-identifies-the-specific?r=40ekz2 Referenced VideosTool Cool for Stool, Bile Acids: https://youtu.be/d0WuCIZxPxU Statins, GLP-1, (T)UDCA: https://youtu.be/6NomrgjK1yQ What if a simple molecule made by your gut could literally protect you from a heart attack? New research in Nature Cardiovascular Research reveals that a specific bile acid—DCA—produced by your own microbiome can reduce blood clotting, improve vascular health, and even protect heart tissue during a heart attack.People with coronary artery disease have lower levels of this molecule and fewer microbes that produce it. Lower DCA means “clottier” blood—and a higher chance of heart attacks and strokes. This video breaks down how DCA works, why your gut microbes matter more than you think, and how lifestyle factors may activate the same anti-clotting pathways.The full story is more intricate, more fascinating, and more hopeful than you might expect. StayCurious.Chapters0:00 – A Simple Molecule that Protects Your Heart1:27 – A Transparency Moment: Stay Curious Journey2:21 – Patients with Heart Disease Have Different Microbiomes and Bile Acids4:37 – Summary, So Far…5:05 – Higher DCA Associates Better Cardiovascular Outcomes6:00 – Is This Causal? Yes. Here’s the Mechanism7:00 – The Promise of Microbiome (Poop) Transplants!8:37 – Turning Insights into Action12:32 – Metabolism is Unified#HeartHealth #CardiovascularHealth #Microbiome #GutHealth #BloodClotting #Metabolism #BileAcids #TGR5 #Longevity #HealthScience #NickNorwitz #StayCurious #NatureResearch #StrokePrevention #heartattackprevention Learn more about your ad choices. Visit megaphone.fm/adchoices For extra details, references, and early access to content, see the StayCurious Newsletter: https://staycuriousmetabolism.substack.com/p/new-science-identifies-the-specific?r=40ekz2

Referenced Videos
Tool Cool for Stool, Bile Acids: https://youtu.be/d0WuCIZxPxU
Statins, GLP-1, (T)UDCA: https://youtu.be/6NomrgjK1yQ

What if a simple molecule made by your gut could literally protect you from a heart attack? New research in Nature Cardiovascular Research reveals that a specific bile acid—DCA—produced by your own microbiome can reduce blood clotting, improve vascular health, and even protect heart tissue during a heart attack.

People with coronary artery disease have lower levels of this molecule and fewer microbes that produce it.

Lower DCA means “clottier” blood—and a higher chance of heart attacks and strokes.
This video breaks down how DCA works, why your gut microbes matter more than you think, and how lifestyle factors may activate the same anti-clotting pathways.

The full story is more intricate, more fascinating, and more hopeful than you might expect. StayCurious.

Chapters
0:00 – A Simple Molecule that Protects Your Heart
1:27 – A Transparency Moment: Stay Curious Journey
2:21 – Patients with Heart Disease Have Different Microbiomes and Bile Acids
4:37 – Summary, So Far…
5:05 – Higher DCA Associates Better Cardiovascular Outcomes
6:00 – Is This Causal? Yes. Here’s the Mechanism
7:00 – The Promise of Microbiome (Poop) Transplants!
8:37 – Turning Insights into Action
12:32 – Metabolism is Unified

#HeartHealth #CardiovascularHealth #Microbiome #GutHealth #BloodClotting #Metabolism #BileAcids #TGR5 #Longevity #HealthScience #NickNorwitz #StayCurious #NatureResearch #StrokePrevention #heartattackprevention

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1000 no I Ate 4.5 lbs of Butter in 1 Week! 2 Unexpected Twists! First... PLEASE, watch to the end... there's a twist and I want you to see it, hear me out, and contemplate the "WHY" of this video. Not the "click bait" you may be expecting...Diet DetailsButter: 4.55 lbs butter = 2.064 kg. Using 102 kCal/Tbsp (14.2g/Tbsp) that's 145.35 Tbsp servings and ~ 14,825 Calories from Butter alone over the week (2,118 Butter Calories/day). Total daily Calories were 4,317 Calories/day. 81% Cal Fat, 18% Cal protein 1% Cal carbs. Based on my BMR, calculated using the Harris-Benedict equation (1,530 Cal/day) and providing 800 extra Calories/day for activity (a liberal estimate, as I resistance train up to 1 hour daily and don't current do much standard cardio), my daily surplus should have been 1,987 Calories/day and 13,909 Calories over the week. Using 3,500 "excess" Calories/lb I should have gained 4 lbs. But, I lost 0.8 lbs.Lp(a) dropped 10%. TSH was ~1 (which is normal for me). Insulin post-butter week was 3.5.0:00 - 4.5 lbs Butter in 1 Week0:42 - Lesson 11:24 - Lesson 22:03 - Lesson 33:08 - Why it's a Fail3:55 - *Bonus* content: Why This Video?Like this shirt? https://metabolismshirts.myspreadshop.com/all Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 30 Sep 2026 10:46:00 -0000 full Nick Norwitz MD PhD First... PLEASE, watch to the end... there's a twist and I want you to see it, hear me out, and contemplate the "WHY" of this video. Not the "click bait" you may be expecting...Diet DetailsButter: 4.55 lbs butter = 2.064 kg. Using 102 kCal/Tbsp (14.2g/Tbsp) that's 145.35 Tbsp servings and ~ 14,825 Calories from Butter alone over the week (2,118 Butter Calories/day). Total daily Calories were 4,317 Calories/day. 81% Cal Fat, 18% Cal protein 1% Cal carbs. Based on my BMR, calculated using the Harris-Benedict equation (1,530 Cal/day) and providing 800 extra Calories/day for activity (a liberal estimate, as I resistance train up to 1 hour daily and don't current do much standard cardio), my daily surplus should have been 1,987 Calories/day and 13,909 Calories over the week. Using 3,500 "excess" Calories/lb I should have gained 4 lbs. But, I lost 0.8 lbs.Lp(a) dropped 10%. TSH was ~1 (which is normal for me). Insulin post-butter week was 3.5.0:00 - 4.5 lbs Butter in 1 Week0:42 - Lesson 11:24 - Lesson 22:03 - Lesson 33:08 - Why it's a Fail3:55 - *Bonus* content: Why This Video?Like this shirt? https://metabolismshirts.myspreadshop.com/all Learn more about your ad choices. Visit megaphone.fm/adchoices First... PLEASE, watch to the end... there's a twist and I want you to see it, hear me out, and contemplate the "WHY" of this video. Not the "click bait" you may be expecting...

Diet Details
Butter: 4.55 lbs butter = 2.064 kg.

Using 102 kCal/Tbsp (14.2g/Tbsp) that's 145.35 Tbsp servings and ~ 14,825 Calories from Butter alone over the week (2,118 Butter Calories/day).

Total daily Calories were 4,317 Calories/day. 81% Cal Fat, 18% Cal protein 1% Cal carbs.

Based on my BMR, calculated using the Harris-Benedict equation (1,530 Cal/day) and providing 800 extra Calories/day for activity (a liberal estimate, as I resistance train up to 1 hour daily and don't current do much standard cardio), my daily surplus should have been 1,987 Calories/day and 13,909 Calories over the week.

Using 3,500 "excess" Calories/lb I should have gained 4 lbs. But, I lost 0.8 lbs.

Lp(a) dropped 10%. TSH was ~1 (which is normal for me). Insulin post-butter week was 3.5.

0:00 - 4.5 lbs Butter in 1 Week
0:42 - Lesson 1
1:24 - Lesson 2
2:03 - Lesson 3
3:08 - Why it's a Fail
3:55 - *Bonus* content: Why This Video?

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https://metabolismshirts.myspreadshop.com/all

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]]> 690 no Lower Blood Sugar, Without Cutting Carbs For more details and all the references, see the associated letter: https://staycuriousmetabolism.substack.com/p/7-ways-to-lower-blood-sugar-without?r=40ekz2Referenced LettersStatin GLP-1 Letter: https://staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2 Stress Literally Makes Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2Referenced VideosMichael Snyder Interview 1: https://youtu.be/mCrc4gfbK2o Kale and Chocolate Video: https://youtu.be/Shfh8IaRTV4 Statin GLP-1 Video: https://youtu.be/6NomrgjK1yQ Red Light Video: https://youtu.be/X808Rg09JQM EMR TEK Affiliate Link: https://emr-tek.com/?snowball=NICK20Discount Code: NICK20 Description: What if a banana could spike your blood sugar more than a cookie? What if stress could literally force your liver to make sugar? And what if something as simple as light exposure after meals could lower blood glucose?In this video, I break down seven evidence-based ways to control blood sugar that go far beyond “just eat fewer carbs.” We’ll cover how post-meal walking activates insulin-independent glucose uptake, why meal order can reduce glucose spikes by over 70%, how stress directly signals the liver to produce sugar, and why foods like kale can spike glucose more than chocolate in some people.We’ll also dig into continuous glucose monitors, medication effects on blood sugar (including statins and GLP-1 drugs), the surprising benefits of allulose, and how breathing and meditation can directly reduce glucose production through a brain-to-liver neural pathway.All studies and references discussed in this video are linked in the written companion piece linked above.Chapters0:00 – How to control your blood sugar 1:03 – How a Postprandial Stroll Actually Works 3:05 – How Red and Infrared Light Actually Works3:42 – Macronutrient Order Matters. Here’s Why4:38 – Banana, Cookies, and Continuous Glucose Monitor5:30 – Know Your Medications and What They Do to Your Blood Sugar6:03 – Celebrating YOU! Thank You!7:22 – Allulose: Fructose’s Bizarre Twin 8:16 – The Liver-Brain Axis: How Stress Literally Makes Sugar#bloodsugar #diabetes #metabolichealth #obesity #metabolism #redlight #infraredlight #sugar #keto #lowcarb #fruit #microbiome #bloodsugar #glucose #insulinresistance #metabolichealth #diabetes #prediabetes #bloodsugarcontrol #glycemiccontrol #metabolism #healthscience #nutritionscience #precisionnutrition #microbiome #exercisephysiology #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 29 Sep 2026 16:46:00 -0000 full Nick Norwitz MD PhD For more details and all the references, see the associated letter: https://staycuriousmetabolism.substack.com/p/7-ways-to-lower-blood-sugar-without?r=40ekz2Referenced LettersStatin GLP-1 Letter: https://staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2 Stress Literally Makes Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2Referenced VideosMichael Snyder Interview 1: https://youtu.be/mCrc4gfbK2o Kale and Chocolate Video: https://youtu.be/Shfh8IaRTV4 Statin GLP-1 Video: https://youtu.be/6NomrgjK1yQ Red Light Video: https://youtu.be/X808Rg09JQM EMR TEK Affiliate Link: https://emr-tek.com/?snowball=NICK20Discount Code: NICK20 Description: What if a banana could spike your blood sugar more than a cookie? What if stress could literally force your liver to make sugar? And what if something as simple as light exposure after meals could lower blood glucose?In this video, I break down seven evidence-based ways to control blood sugar that go far beyond “just eat fewer carbs.” We’ll cover how post-meal walking activates insulin-independent glucose uptake, why meal order can reduce glucose spikes by over 70%, how stress directly signals the liver to produce sugar, and why foods like kale can spike glucose more than chocolate in some people.We’ll also dig into continuous glucose monitors, medication effects on blood sugar (including statins and GLP-1 drugs), the surprising benefits of allulose, and how breathing and meditation can directly reduce glucose production through a brain-to-liver neural pathway.All studies and references discussed in this video are linked in the written companion piece linked above.Chapters0:00 – How to control your blood sugar 1:03 – How a Postprandial Stroll Actually Works 3:05 – How Red and Infrared Light Actually Works3:42 – Macronutrient Order Matters. Here’s Why4:38 – Banana, Cookies, and Continuous Glucose Monitor5:30 – Know Your Medications and What They Do to Your Blood Sugar6:03 – Celebrating YOU! Thank You!7:22 – Allulose: Fructose’s Bizarre Twin 8:16 – The Liver-Brain Axis: How Stress Literally Makes Sugar#bloodsugar #diabetes #metabolichealth #obesity #metabolism #redlight #infraredlight #sugar #keto #lowcarb #fruit #microbiome #bloodsugar #glucose #insulinresistance #metabolichealth #diabetes #prediabetes #bloodsugarcontrol #glycemiccontrol #metabolism #healthscience #nutritionscience #precisionnutrition #microbiome #exercisephysiology #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices For more details and all the references, see the associated letter: https://staycuriousmetabolism.substack.com/p/7-ways-to-lower-blood-sugar-without?r=40ekz2

Referenced Letters
Statin GLP-1 Letter: https://staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2

Stress Literally Makes Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2

Referenced Videos
Michael Snyder Interview 1: https://youtu.be/mCrc4gfbK2o

Kale and Chocolate Video: https://youtu.be/Shfh8IaRTV4

Statin GLP-1 Video: https://youtu.be/6NomrgjK1yQ

Red Light Video: https://youtu.be/X808Rg09JQM
EMR TEK Affiliate Link: https://emr-tek.com/?snowball=NICK20
Discount Code: NICK20

Description:
What if a banana could spike your blood sugar more than a cookie? What if stress could literally force your liver to make sugar? And what if something as simple as light exposure after meals could lower blood glucose?

In this video, I break down seven evidence-based ways to control blood sugar that go far beyond “just eat fewer carbs.” We’ll cover how post-meal walking activates insulin-independent glucose uptake, why meal order can reduce glucose spikes by over 70%, how stress directly signals the liver to produce sugar, and why foods like kale can spike glucose more than chocolate in some people.

We’ll also dig into continuous glucose monitors, medication effects on blood sugar (including statins and GLP-1 drugs), the surprising benefits of allulose, and how breathing and meditation can directly reduce glucose production through a brain-to-liver neural pathway.

All studies and references discussed in this video are linked in the written companion piece linked above.

Chapters
0:00 – How to control your blood sugar
1:03 – How a Postprandial Stroll Actually Works
3:05 – How Red and Infrared Light Actually Works
3:42 – Macronutrient Order Matters. Here’s Why
4:38 – Banana, Cookies, and Continuous Glucose Monitor
5:30 – Know Your Medications and What They Do to Your Blood Sugar
6:03 – Celebrating YOU! Thank You!
7:22 – Allulose: Fructose’s Bizarre Twin
8:16 – The Liver-Brain Axis: How Stress Literally Makes Sugar

#bloodsugar #diabetes #metabolichealth #obesity #metabolism #redlight #infraredlight #sugar #keto #lowcarb #fruit #microbiome #bloodsugar #glucose #insulinresistance #metabolichealth #diabetes #prediabetes #bloodsugarcontrol #glycemiccontrol #metabolism #healthscience #nutritionscience #precisionnutrition #microbiome #exercisephysiology #staycurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 750 no What is a FAST metabolism, Really?! Paper: https://www.nature.com/articles/s42255-024-00978-0BMJ human RCT: https://pubmed.ncbi.nlm.nih.gov/30429127/Video editing generously provided by Vincent at House of Macadamia http://partner.houseofmacadamias.com/nick-norwitz-15% Off All Bundles-10% off any item (non-bundle) with code "NICK10"0:00 - Fast vs Slow Metabolism, Intro0:37 - Defining the Question1:15 - New research in Nature Metabolism2:26 - Fusion and Fission2:44 - In obesity, Fission and Fusion are out of balance3:03 - Results5:35 - I'm Nerding out, Hard!6:45 - Relevance 7:58 - LCD metabolic advantageWHAT ABOUT specific dietary components and mitochondrial fusion? …Thanks to @AnouarElHaji on X (Twitter) for reminding me about this fantastic 2018 Nat Comm paper and asking me to comment. I LOVE community input!https://www.nature.com/articles/s41467-018-05614-6 (nb: I say remind because he points out “You used to have a YT video discussing this paper,” which I did, lol… TBT!)Overview of this other mito fusion paper: A set of experiments, including a double-blinded human RCT, showing that the saturated fat stearic acid (C18:0; this annotation means 18 carbon fatty acid with 0 double bonds) “[R]apidly and robustly causes mitochondrial fusion in people within 3 h after ingestion.” The authors conclude: Stearic acid “C18:0 [i]s a dietary metabolite that is sensed by our bodies to control our mitochondria… [consistent with data that C18:0 may] decreas[e] cardiovascular and cancer risk.”Rich sources of stearic acid include Tallow (~20g/100g) and Cocoa butter (34g/100g).For more details, see THIS X post: https://x.com/nicknorwitz/status/1774760972973908132?s=20 Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 28 Sep 2026 22:46:00 -0000 full Nick Norwitz MD PhD Paper: https://www.nature.com/articles/s42255-024-00978-0BMJ human RCT: https://pubmed.ncbi.nlm.nih.gov/30429127/Video editing generously provided by Vincent at House of Macadamia http://partner.houseofmacadamias.com/nick-norwitz-15% Off All Bundles-10% off any item (non-bundle) with code "NICK10"0:00 - Fast vs Slow Metabolism, Intro0:37 - Defining the Question1:15 - New research in Nature Metabolism2:26 - Fusion and Fission2:44 - In obesity, Fission and Fusion are out of balance3:03 - Results5:35 - I'm Nerding out, Hard!6:45 - Relevance 7:58 - LCD metabolic advantageWHAT ABOUT specific dietary components and mitochondrial fusion? …Thanks to @AnouarElHaji on X (Twitter) for reminding me about this fantastic 2018 Nat Comm paper and asking me to comment. I LOVE community input!https://www.nature.com/articles/s41467-018-05614-6 (nb: I say remind because he points out “You used to have a YT video discussing this paper,” which I did, lol… TBT!)Overview of this other mito fusion paper: A set of experiments, including a double-blinded human RCT, showing that the saturated fat stearic acid (C18:0; this annotation means 18 carbon fatty acid with 0 double bonds) “[R]apidly and robustly causes mitochondrial fusion in people within 3 h after ingestion.” The authors conclude: Stearic acid “C18:0 [i]s a dietary metabolite that is sensed by our bodies to control our mitochondria… [consistent with data that C18:0 may] decreas[e] cardiovascular and cancer risk.”Rich sources of stearic acid include Tallow (~20g/100g) and Cocoa butter (34g/100g).For more details, see THIS X post: https://x.com/nicknorwitz/status/1774760972973908132?s=20 Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://www.nature.com/articles/s42255-024-00978-0

BMJ human RCT: https://pubmed.ncbi.nlm.nih.gov/30429127/

Video editing generously provided by Vincent at House of Macadamia
http://partner.houseofmacadamias.com/nick-norwitz
-15% Off All Bundles
-10% off any item (non-bundle) with code "NICK10"

0:00 - Fast vs Slow Metabolism, Intro
0:37 - Defining the Question
1:15 - New research in Nature Metabolism
2:26 - Fusion and Fission
2:44 - In obesity, Fission and Fusion are out of balance
3:03 - Results
5:35 - I'm Nerding out, Hard!
6:45 - Relevance
7:58 - LCD metabolic advantage

WHAT ABOUT specific dietary components and mitochondrial fusion? …

Thanks to @AnouarElHaji on X (Twitter) for reminding me about this fantastic 2018 Nat Comm paper and asking me to comment. I LOVE community input!
https://www.nature.com/articles/s41467-018-05614-6
(nb: I say remind because he points out “You used to have a YT video discussing this paper,” which I did, lol… TBT!)

Overview of this other mito fusion paper:

A set of experiments, including a double-blinded human RCT, showing that the saturated fat stearic acid (C18:0; this annotation means 18 carbon fatty acid with 0 double bonds) “[R]apidly and robustly causes mitochondrial fusion in people within 3 h after ingestion.”

The authors conclude: Stearic acid “C18:0 [i]s a dietary metabolite that is sensed by our bodies to control our mitochondria… [consistent with data that C18:0 may] decreas[e] cardiovascular and cancer risk.”

Rich sources of stearic acid include Tallow (~20g/100g) and Cocoa butter (34g/100g).

For more details, see THIS X post: https://x.com/nicknorwitz/status/1774760972973908132?s=20

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 722 no This Study Changed How I See Junk Food For extra details, references, and early access to content, see the StayCurious Newsletter: https://staycuriousmetabolism.substack.com/p/this-study-changed-how-i-see-junk?r=40ekz2 LysovetaLink: https://www.fenixhealthscience.com/staycuriousIf you'd like to try it, you can use the discount code StayCurious for 20% off.Lysoveta is a one-of-a-kind omega-3 supplement featuring specialized lyso-DHA, a form of DHA with preferential transport into the brain. Research shows that this unique form significantly increases brain DHA levels—much more effectively than conventional fish oils, which are more likely to accumulate in fat tissue.For a deeper dive into the science, see the letter below.Lysoveta Letter: https://staycuriousmetabolism.substack.com/p/why-omega-3-supplements-dont-work?r=40ekz2Nick Note: I understand this is a premium product and may not be accessible to everyone. Still, it’s the one I personally use and trust. I’d feel remiss not recommending it—especially for those concerned with long-term brain health, including ApoE4 carriers.Visceral Fat Depression Video: https://youtu.be/m_UcGss_9jc New human research suggests the real damage of junk food goes far beyond calories or short-term weight gain.In a controlled trial published in Nature Metabolism, healthy young men overate junk food for just five days — with no meaningful weight gain. Yet beneath the surface, something far more concerning happened: liver fat increased sharply, blood flow to key brain regions dropped, and the brain developed insulin resistance that persisted even after normal eating resumed.These changes affect areas involved in memory, impulse control, and appetite regulation, creating what researchers describe as prolonged effects on the brain that outlast the binge itself. In other words, short-term junk food intake may leave a metabolic “scar” that makes future overeating more likely.This video breaks down the study, explains why calories alone don’t tell the full story, and shows how food quality shapes communication between organs like the liver and the brain. Nutrition isn’t simple arithmetic — it’s a complex biological conversation.Chapters 0:00 – After Watching This, You’ll Never See Junk Food the Same1:21 – New Human Controlled Trial: A “High Calorie” Diet2:48 – High Calorie Gained 64% Liver Fat 3:30 – Striking Changes in Brain Blood Flow and Insulin Sensitivity5:40 – What Was the Source of the Extra Calories7:10 – The Best Omega-3 for the Brain8:57 – 5,800 Calories Crossover Trial10:59 – The Liver Brain Connection 12:28 – Lean into the Complexity of Metabolism#CaloriesMyth #UltraProcessedFoods #BrainInsulinResistance #LiverBrainAxis #CognitiveHealth #MetabolicFlexibility #HumanTrials #ScientificNutrition #FoodAsInformation #HormonalHealth #DietQuality #CardiometabolicHealth #Inflammation #GlucoseControl #ObesityScience #MetabolicResearch #EvidenceBasedNutrition #SystemsBiology #HealthEducation #NutritionScience #BrainHealth #MetabolicHealth #InsulinResistance #JunkFood #LiverFat #Neuroscience #HealthScience #NatureMetabolism #Metabolism #FoodQuality #NickNorwitz #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 28 Sep 2026 04:46:00 -0000 full Nick Norwitz MD PhD For extra details, references, and early access to content, see the StayCurious Newsletter: https://staycuriousmetabolism.substack.com/p/this-study-changed-how-i-see-junk?r=40ekz2 LysovetaLink: https://www.fenixhealthscience.com/staycuriousIf you'd like to try it, you can use the discount code StayCurious for 20% off.Lysoveta is a one-of-a-kind omega-3 supplement featuring specialized lyso-DHA, a form of DHA with preferential transport into the brain. Research shows that this unique form significantly increases brain DHA levels—much more effectively than conventional fish oils, which are more likely to accumulate in fat tissue.For a deeper dive into the science, see the letter below.Lysoveta Letter: https://staycuriousmetabolism.substack.com/p/why-omega-3-supplements-dont-work?r=40ekz2Nick Note: I understand this is a premium product and may not be accessible to everyone. Still, it’s the one I personally use and trust. I’d feel remiss not recommending it—especially for those concerned with long-term brain health, including ApoE4 carriers.Visceral Fat Depression Video: https://youtu.be/m_UcGss_9jc New human research suggests the real damage of junk food goes far beyond calories or short-term weight gain.In a controlled trial published in Nature Metabolism, healthy young men overate junk food for just five days — with no meaningful weight gain. Yet beneath the surface, something far more concerning happened: liver fat increased sharply, blood flow to key brain regions dropped, and the brain developed insulin resistance that persisted even after normal eating resumed.These changes affect areas involved in memory, impulse control, and appetite regulation, creating what researchers describe as prolonged effects on the brain that outlast the binge itself. In other words, short-term junk food intake may leave a metabolic “scar” that makes future overeating more likely.This video breaks down the study, explains why calories alone don’t tell the full story, and shows how food quality shapes communication between organs like the liver and the brain. Nutrition isn’t simple arithmetic — it’s a complex biological conversation.Chapters 0:00 – After Watching This, You’ll Never See Junk Food the Same1:21 – New Human Controlled Trial: A “High Calorie” Diet2:48 – High Calorie Gained 64% Liver Fat 3:30 – Striking Changes in Brain Blood Flow and Insulin Sensitivity5:40 – What Was the Source of the Extra Calories7:10 – The Best Omega-3 for the Brain8:57 – 5,800 Calories Crossover Trial10:59 – The Liver Brain Connection 12:28 – Lean into the Complexity of Metabolism#CaloriesMyth #UltraProcessedFoods #BrainInsulinResistance #LiverBrainAxis #CognitiveHealth #MetabolicFlexibility #HumanTrials #ScientificNutrition #FoodAsInformation #HormonalHealth #DietQuality #CardiometabolicHealth #Inflammation #GlucoseControl #ObesityScience #MetabolicResearch #EvidenceBasedNutrition #SystemsBiology #HealthEducation #NutritionScience #BrainHealth #MetabolicHealth #InsulinResistance #JunkFood #LiverFat #Neuroscience #HealthScience #NatureMetabolism #Metabolism #FoodQuality #NickNorwitz #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For extra details, references, and early access to content, see the StayCurious Newsletter: https://staycuriousmetabolism.substack.com/p/this-study-changed-how-i-see-junk?r=40ekz2

Lysoveta

Link: https://www.fenixhealthscience.com/staycurious
If you'd like to try it, you can use the discount code StayCurious for 20% off.

Lysoveta is a one-of-a-kind omega-3 supplement featuring specialized lyso-DHA, a form of DHA with preferential transport into the brain. Research shows that this unique form significantly increases brain DHA levels—much more effectively than conventional fish oils, which are more likely to accumulate in fat tissue.

For a deeper dive into the science, see the letter below.

Lysoveta Letter: https://staycuriousmetabolism.substack.com/p/why-omega-3-supplements-dont-work?r=40ekz2

Nick Note: I understand this is a premium product and may not be accessible to everyone. Still, it’s the one I personally use and trust. I’d feel remiss not recommending it—especially for those concerned with long-term brain health, including ApoE4 carriers.

Visceral Fat Depression Video: https://youtu.be/m_UcGss_9jc

New human research suggests the real damage of junk food goes far beyond calories or short-term weight gain.

In a controlled trial published in Nature Metabolism, healthy young men overate junk food for just five days — with no meaningful weight gain. Yet beneath the surface, something far more concerning happened: liver fat increased sharply, blood flow to key brain regions dropped, and the brain developed insulin resistance that persisted even after normal eating resumed.

These changes affect areas involved in memory, impulse control, and appetite regulation, creating what researchers describe as prolonged effects on the brain that outlast the binge itself. In other words, short-term junk food intake may leave a metabolic “scar” that makes future overeating more likely.

This video breaks down the study, explains why calories alone don’t tell the full story, and shows how food quality shapes communication between organs like the liver and the brain. Nutrition isn’t simple arithmetic — it’s a complex biological conversation.

Chapters
0:00 – After Watching This, You’ll Never See Junk Food the Same
1:21 – New Human Controlled Trial: A “High Calorie” Diet
2:48 – High Calorie Gained 64% Liver Fat
3:30 – Striking Changes in Brain Blood Flow and Insulin Sensitivity
5:40 – What Was the Source of the Extra Calories
7:10 – The Best Omega-3 for the Brain
8:57 – 5,800 Calories Crossover Trial
10:59 – The Liver Brain Connection
12:28 – Lean into the Complexity of Metabolism

#CaloriesMyth #UltraProcessedFoods #BrainInsulinResistance #LiverBrainAxis #CognitiveHealth #MetabolicFlexibility #HumanTrials #ScientificNutrition #FoodAsInformation #HormonalHealth #DietQuality #CardiometabolicHealth #Inflammation #GlucoseControl #ObesityScience #MetabolicResearch #EvidenceBasedNutrition #SystemsBiology #HealthEducation #NutritionScience #BrainHealth #MetabolicHealth #InsulinResistance #JunkFood #LiverFat #Neuroscience #HealthScience #NatureMetabolism #Metabolism #FoodQuality #NickNorwitz #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1031 no Vegan Keto vs Carby Carnivore: Cholesterol Conundrum OreoVsStatin: https://pubmed.ncbi.nlm.nih.gov/38276308/Meta of 41 RCT: https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltextCooper et al.: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1326768/fullCase series (Table 4): https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltextLow-Sat Fat Keto Case Report: https://pubmed.ncbi.nlm.nih.gov/35498420/Like this shirt? https://metabolismshirts.myspreadshop.com/allhttp://partner.houseofmacadamias.com/nick-norwitz-15% Off All Bundles-10% off any item (non-bundle) with code "NICK10"0:00 - Something weird (Intro)0:46 - HOW is this possible? (LEM)3:46 - LDL 545 mg/dl!4:37 - "Remove the driving factor" 5:12 - Why not "healthy" carbs?5:58 - Returning to thought puzzle6:35 - Why YOU should care7:48 - Productive Provocation Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 27 Sep 2026 10:46:00 -0000 full Nick Norwitz MD PhD OreoVsStatin: https://pubmed.ncbi.nlm.nih.gov/38276308/Meta of 41 RCT: https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltextCooper et al.: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1326768/fullCase series (Table 4): https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltextLow-Sat Fat Keto Case Report: https://pubmed.ncbi.nlm.nih.gov/35498420/Like this shirt? https://metabolismshirts.myspreadshop.com/allhttp://partner.houseofmacadamias.com/nick-norwitz-15% Off All Bundles-10% off any item (non-bundle) with code "NICK10"0:00 - Something weird (Intro)0:46 - HOW is this possible? (LEM)3:46 - LDL 545 mg/dl!4:37 - "Remove the driving factor" 5:12 - Why not "healthy" carbs?5:58 - Returning to thought puzzle6:35 - Why YOU should care7:48 - Productive Provocation Learn more about your ad choices. Visit megaphone.fm/adchoices OreoVsStatin: https://pubmed.ncbi.nlm.nih.gov/38276308/

Meta of 41 RCT: https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltext

Cooper et al.: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1326768/full

Case series (Table 4): https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext

Low-Sat Fat Keto Case Report: https://pubmed.ncbi.nlm.nih.gov/35498420/

Like this shirt?
https://metabolismshirts.myspreadshop.com/all

http://partner.houseofmacadamias.com/nick-norwitz
-15% Off All Bundles
-10% off any item (non-bundle) with code "NICK10"

0:00 - Something weird (Intro)
0:46 - HOW is this possible? (LEM)
3:46 - LDL 545 mg/dl!
4:37 - "Remove the driving factor"
5:12 - Why not "healthy" carbs?
5:58 - Returning to thought puzzle
6:35 - Why YOU should care
7:48 - Productive Provocation

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 692 no The 20-Year-Old Cholesterol Study Everyone Missed For extra nuances, all the references and early access to data like these, see the best-selling science letter: https://staycuriousmetabolism.substack.com/p/how-berberine-lowers-cholesterol?r=40ekz2 In this video, we unpack the stunning mechanism behind berberine, the yellow plant alkaloid that increases LDL receptors not by starving the liver of cholesterol, but by stabilizing the blueprint that cells use to builds them. It’s a twist in human biochemistry that reshaped how I think about cholesterol manipulation — and it might reshape how you do too. Then I’ll take you inside my own high-stakes N=1 experimentHundred Health Link: https://www.hundred.com/STAYCURIOUSDiscount Code: STAYCURIOUS50 knocks $50 off membershipAs a scientific advisor at Hundred Health, I candidly hold a small equity stake in the company. I’ve chosen to partner with Hundred Health because I genuinely believe it has the potential to be a disruptive force for good in personalized healthcare. It’s a tool unlike anything else currently on the market.Here’s how it works: Hundred Health’s AI integrates your biodata, questionnaire responses, health priorities, and medical records (aggregated from over 400 EMRs). It then uses this foundation to interrogate the scientific literature and generate a personalized health protocol. That protocol is stress-tested through multiple AI “judges” to ensure robustness and validity and continued evolution. The entire rationale and referencing process is transparent—and we’re continually working to evolve this platform from a powerful tool into something that could transform the future of healthcare.That’s the audacious goal. And with this team, I believe it’s within reach. Whether you’re an early adopter or plan to join later, this is something I’d feel confident recommending to a loved one. I think it can truly help. Referenced Content: Statins and GLP-1Letter: https://staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2 Statins and Mitochondrial HealthLetter: https://staycuriousmetabolism.substack.com/p/the-mitochondrial-cost-of-statins?r=40ekz2 Breaking Into StatinsVideo: https://youtu.be/cX7qzj4qazg Lipid Energy ModelPaper: https://pubmed.ncbi.nlm.nih.gov/35629964/ Chapters0:00 – Intro: Berberine vs Statins1:24 – Roadmap to this Video2:09 – Chapter 1, How Statins Work4:32 – The Very Real Downsides of Statins5:20 – Chapter 2, The Berberine Paradox9:21 – Chapter 3, Berberine Randomized Controlled Trial11:13 – Chapter 4, Statin vs Berberine Mechanisms13:35 – Chapter 5, My Next Big Experiment 17:37 – Chapter 6, Why I Wasn’t ToldCommon Question: How Does Hundred Health Compare to Function Health?Since I know I’ll be asked — I figured I’d write out the answer to this question prophylactically: How does HundredHealth compare to Function Health?Let me start by saying I have nothing personal against Function. In fact, I’m generally a big supporter of companies trying to empower individuals with access to their own health data.That’s a mission I believe in. That said, here’s where I think Function falls short: Actionability. They run a battery of tests and return results. But when it comes to translating those results into meaningful, individualized protocols? In my view, that’s their real weak spot. I’ve reviewed a number of Function protocols and suggestions from colleagues and friends, and to be blunt, they’ve been disappointing.For example: Recommending cashews to lower lipoprotein(a). Cashews are unlikely to impact Lp(a). But were there an impact, it would be more likely to be to increase Lp(a).It appears to me the action steps are boilerplate recommendations post-hoc rationalized by appending biomarkers outside the normal range. In fairness, they now have a notification in their terms and conditions that Function AI “may make mistakes.” So, I look Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 26 Sep 2026 16:46:00 -0000 full Nick Norwitz MD PhD For extra nuances, all the references and early access to data like these, see the best-selling science letter: https://staycuriousmetabolism.substack.com/p/how-berberine-lowers-cholesterol?r=40ekz2 In this video, we unpack the stunning mechanism behind berberine, the yellow plant alkaloid that increases LDL receptors not by starving the liver of cholesterol, but by stabilizing the blueprint that cells use to builds them. It’s a twist in human biochemistry that reshaped how I think about cholesterol manipulation — and it might reshape how you do too. Then I’ll take you inside my own high-stakes N=1 experimentHundred Health Link: https://www.hundred.com/STAYCURIOUSDiscount Code: STAYCURIOUS50 knocks $50 off membershipAs a scientific advisor at Hundred Health, I candidly hold a small equity stake in the company. I’ve chosen to partner with Hundred Health because I genuinely believe it has the potential to be a disruptive force for good in personalized healthcare. It’s a tool unlike anything else currently on the market.Here’s how it works: Hundred Health’s AI integrates your biodata, questionnaire responses, health priorities, and medical records (aggregated from over 400 EMRs). It then uses this foundation to interrogate the scientific literature and generate a personalized health protocol. That protocol is stress-tested through multiple AI “judges” to ensure robustness and validity and continued evolution. The entire rationale and referencing process is transparent—and we’re continually working to evolve this platform from a powerful tool into something that could transform the future of healthcare.That’s the audacious goal. And with this team, I believe it’s within reach. Whether you’re an early adopter or plan to join later, this is something I’d feel confident recommending to a loved one. I think it can truly help. Referenced Content: Statins and GLP-1Letter: https://staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2 Statins and Mitochondrial HealthLetter: https://staycuriousmetabolism.substack.com/p/the-mitochondrial-cost-of-statins?r=40ekz2 Breaking Into StatinsVideo: https://youtu.be/cX7qzj4qazg Lipid Energy ModelPaper: https://pubmed.ncbi.nlm.nih.gov/35629964/ Chapters0:00 – Intro: Berberine vs Statins1:24 – Roadmap to this Video2:09 – Chapter 1, How Statins Work4:32 – The Very Real Downsides of Statins5:20 – Chapter 2, The Berberine Paradox9:21 – Chapter 3, Berberine Randomized Controlled Trial11:13 – Chapter 4, Statin vs Berberine Mechanisms13:35 – Chapter 5, My Next Big Experiment 17:37 – Chapter 6, Why I Wasn’t ToldCommon Question: How Does Hundred Health Compare to Function Health?Since I know I’ll be asked — I figured I’d write out the answer to this question prophylactically: How does HundredHealth compare to Function Health?Let me start by saying I have nothing personal against Function. In fact, I’m generally a big supporter of companies trying to empower individuals with access to their own health data.That’s a mission I believe in. That said, here’s where I think Function falls short: Actionability. They run a battery of tests and return results. But when it comes to translating those results into meaningful, individualized protocols? In my view, that’s their real weak spot. I’ve reviewed a number of Function protocols and suggestions from colleagues and friends, and to be blunt, they’ve been disappointing.For example: Recommending cashews to lower lipoprotein(a). Cashews are unlikely to impact Lp(a). But were there an impact, it would be more likely to be to increase Lp(a).It appears to me the action steps are boilerplate recommendations post-hoc rationalized by appending biomarkers outside the normal range. In fairness, they now have a notification in their terms and conditions that Function AI “may make mistakes.” So, I look Learn more about your ad choices. Visit megaphone.fm/adchoices For extra nuances, all the references and early access to data like these, see the best-selling science letter: https://staycuriousmetabolism.substack.com/p/how-berberine-lowers-cholesterol?r=40ekz2
In this video, we unpack the stunning mechanism behind berberine, the yellow plant alkaloid that increases LDL receptors not by starving the liver of cholesterol, but by stabilizing the blueprint that cells use to builds them. It’s a twist in human biochemistry that reshaped how I think about cholesterol manipulation — and it might reshape how you do too. Then I’ll take you inside my own high-stakes N=1 experiment

Hundred Health Link: https://www.hundred.com/STAYCURIOUS
Discount Code: STAYCURIOUS50 knocks $50 off membership

As a scientific advisor at Hundred Health, I candidly hold a small equity stake in the company. I’ve chosen to partner with Hundred Health because I genuinely believe it has the potential to be a disruptive force for good in personalized healthcare. It’s a tool unlike anything else currently on the market.

Here’s how it works: Hundred Health’s AI integrates your biodata, questionnaire responses, health priorities, and medical records (aggregated from over 400 EMRs). It then uses this foundation to interrogate the scientific literature and generate a personalized health protocol. That protocol is stress-tested through multiple AI “judges” to ensure robustness and validity and continued evolution. The entire rationale and referencing process is transparent—and we’re continually working to evolve this platform from a powerful tool into something that could transform the future of healthcare.

That’s the audacious goal. And with this team, I believe it’s within reach. Whether you’re an early adopter or plan to join later, this is something I’d feel confident recommending to a loved one. I think it can truly help.

Referenced Content:

Statins and GLP-1
Letter: https://staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2

Statins and Mitochondrial Health
Letter: https://staycuriousmetabolism.substack.com/p/the-mitochondrial-cost-of-statins?r=40ekz2

Breaking Into Statins
Video: https://youtu.be/cX7qzj4qazg

Lipid Energy Model
Paper: https://pubmed.ncbi.nlm.nih.gov/35629964/

Chapters
0:00 – Intro: Berberine vs Statins
1:24 – Roadmap to this Video
2:09 – Chapter 1, How Statins Work
4:32 – The Very Real Downsides of Statins
5:20 – Chapter 2, The Berberine Paradox
9:21 – Chapter 3, Berberine Randomized Controlled Trial
11:13 – Chapter 4, Statin vs Berberine Mechanisms
13:35 – Chapter 5, My Next Big Experiment
17:37 – Chapter 6, Why I Wasn’t Told

Common Question: How Does Hundred Health Compare to Function Health?

Since I know I’ll be asked — I figured I’d write out the answer to this question prophylactically: How does HundredHealth compare to Function Health?

Let me start by saying I have nothing personal against Function. In fact, I’m generally a big supporter of companies trying to empower individuals with access to their own health data.

That’s a mission I believe in. That said, here’s where I think Function falls short: Actionability. They run a battery of tests and return results. But when it comes to translating those results into meaningful, individualized protocols? In my view, that’s their real weak spot. I’ve reviewed a number of Function protocols and suggestions from colleagues and friends, and to be blunt, they’ve been disappointing.

For example: Recommending cashews to lower lipoprotein(a). Cashews are unlikely to impact Lp(a). But were there an impact, it would be more likely to be to increase Lp(a).

It appears to me the action steps are boilerplate recommendations post-hoc rationalized by appending biomarkers outside the normal range. In fairness, they now have a notification in their terms and conditions that Function AI “may make mistakes.” So, I look

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1436 no Stanford Keto Study is Revolutionizing Mental Health Paper: https://pubmed.ncbi.nlm.nih.gov/38547601/Metabolic Psychiatry website: https://www.metabolicpsychiatry.comAuthors: Shebani Sethi, Diane Wakeham, Terence Ketter, Farnaz Hooshmand, Julia Bjornstad, Blair Richards, Eric Westman, Ronald M Krauss, Laura Saslow * Minor corrections- In the MetS pentad there is a typo where "low" TG should be "high" TG. Kudos to those who were paying attention and caught this. I could say, "it was a test and you passed," but in truth it was just a typo introduced by the editor that I (we) missed. - Nutritional ketosis threshold is 0.5 mM.- "Blue whale" B roll doesn't show blue whales. We couldn't find Blue whale B-roll. But as a fun fact, they can grow up to 200 tons and their only natural predator is Orcas. Also, their latin name is Balaenoptera musculus, which means - roughly - winged whale and mouse, respectively... which may be a pun by Carl Linnaeus when he named the species.0:00 - Intro, New Study!0:47 - Metabolic Psychiatry 2:22 - Study, Metabolic and Mental Health5:01 - Closing, Thank You. Inspired!6:22 - Patients' Quotes Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 25 Sep 2026 22:46:00 -0000 full Nick Norwitz MD PhD Paper: https://pubmed.ncbi.nlm.nih.gov/38547601/Metabolic Psychiatry website: https://www.metabolicpsychiatry.comAuthors: Shebani Sethi, Diane Wakeham, Terence Ketter, Farnaz Hooshmand, Julia Bjornstad, Blair Richards, Eric Westman, Ronald M Krauss, Laura Saslow * Minor corrections- In the MetS pentad there is a typo where "low" TG should be "high" TG. Kudos to those who were paying attention and caught this. I could say, "it was a test and you passed," but in truth it was just a typo introduced by the editor that I (we) missed. - Nutritional ketosis threshold is 0.5 mM.- "Blue whale" B roll doesn't show blue whales. We couldn't find Blue whale B-roll. But as a fun fact, they can grow up to 200 tons and their only natural predator is Orcas. Also, their latin name is Balaenoptera musculus, which means - roughly - winged whale and mouse, respectively... which may be a pun by Carl Linnaeus when he named the species.0:00 - Intro, New Study!0:47 - Metabolic Psychiatry 2:22 - Study, Metabolic and Mental Health5:01 - Closing, Thank You. Inspired!6:22 - Patients' Quotes Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://pubmed.ncbi.nlm.nih.gov/38547601/

Metabolic Psychiatry website: https://www.metabolicpsychiatry.com

Authors: Shebani Sethi, Diane Wakeham, Terence Ketter, Farnaz Hooshmand, Julia Bjornstad, Blair Richards, Eric Westman, Ronald M Krauss, Laura Saslow

* Minor corrections
- In the MetS pentad there is a typo where "low" TG should be "high" TG. Kudos to those who were paying attention and caught this. I could say, "it was a test and you passed," but in truth it was just a typo introduced by the editor that I (we) missed.
- Nutritional ketosis threshold is 0.5 mM.
- "Blue whale" B roll doesn't show blue whales. We couldn't find Blue whale B-roll. But as a fun fact, they can grow up to 200 tons and their only natural predator is Orcas. Also, their latin name is Balaenoptera musculus, which means - roughly - winged whale and mouse, respectively... which may be a pun by Carl Linnaeus when he named the species.

0:00 - Intro, New Study!
0:47 - Metabolic Psychiatry
2:22 - Study, Metabolic and Mental Health
5:01 - Closing, Thank You. Inspired!
6:22 - Patients' Quotes

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 603 no Why Cutting Calories Triggers Weight Regain | Dr. Jason Fung The Hunger Code Book: https://www.amazon.com/Hunger-Code-Resetting-Thermostat-Ultra-Processed/dp/1778401562 Weighted Vest Letter: https://staycuriousmetabolism.substack.com/p/how-weighted-vests-trick-your-body?r=40ekz2 Brain Insulin Resistance Letter: https://staycuriousmetabolism.substack.com/p/this-study-changed-how-i-see-junk?r=40ekz2 “Calories don’t cause obesity” is a provocative phrase—but it’s biologically accurate. It challenges a deeply entrenched misconception: that overeating causes obesity, rather than obesity driving overeating. If that sounds confusing, you’re not alone. Most people have been taught to think about it the other way around.In this discussion, Dr. Jason Fung and I work to untangle that misunderstanding. We explore how energy imbalance—so-called “overeating” and "excess calories"—is more often a consequence of obesity, not its root cause.What truly drives obesity is a complex interplay of social and hormonal factors that increase hunger and/or reduce energy expenditure. Until we address those underlying forces, we can’t meaningfully solve the problem. This isn’t an issue you can fix through sheer willpower—so it’s time we stop pretending that you can.Chapters0:00 – Calories Don’t Cause Obesity: A Provocative Experiment2:08 – A Misunderstanding of The Energy Balance Equation 5:38 – What Happens When You Force Feed People to Gain Weight? 14:39 – The Problem of Over-Hunger and History of Bariatric Surgery 19:52 – Homeostatic Hunger: Physical Signals and Hormones20:40 – Hedonic Hunger: Pleasure, Reward, and Food Addiction30:50 – Conditioned Hunger: Pavlov, Environment, and Social Triggers35:50 – Social Influence: Obesity Spreads Like a Virus38:40 – Building Tools to Fight Conditioned Hunger41:18 – The Powers of Mental Reprogramming and Mantras #HungerCode #Obesity #Hunger #ProcessedFood #Carbohydrate #Fasting #IntermittentFasting #LowCarb #KetogenicDiet #Keto #KetoDiet #WeightLossScience #Ghrelin #FatLoss #Metabolism #HomeostaticHunger #HedonicHunger #ConditionedHunger #Dopamine #HungerHormones #JasonFung #Diabetes #NutritionScience #HealthEducation #FoodAddiction #Hormones #GLP1 #Insulin #DietMyths #MetabolicHealth #BodyFat #PrecisionNutrition #SelfExperiment #Carbs #SugarFree #BehavioralScience #EatingHabits #Fiber #Protein #NeuroScience #HungerScience #EvidenceBased #HealthResearch #FoodAddiction #MMindset #StayCurious #NickNorwitz Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 25 Sep 2026 04:46:00 -0000 full Nick Norwitz MD PhD The Hunger Code Book: https://www.amazon.com/Hunger-Code-Resetting-Thermostat-Ultra-Processed/dp/1778401562 Weighted Vest Letter: https://staycuriousmetabolism.substack.com/p/how-weighted-vests-trick-your-body?r=40ekz2 Brain Insulin Resistance Letter: https://staycuriousmetabolism.substack.com/p/this-study-changed-how-i-see-junk?r=40ekz2 “Calories don’t cause obesity” is a provocative phrase—but it’s biologically accurate. It challenges a deeply entrenched misconception: that overeating causes obesity, rather than obesity driving overeating. If that sounds confusing, you’re not alone. Most people have been taught to think about it the other way around.In this discussion, Dr. Jason Fung and I work to untangle that misunderstanding. We explore how energy imbalance—so-called “overeating” and "excess calories"—is more often a consequence of obesity, not its root cause.What truly drives obesity is a complex interplay of social and hormonal factors that increase hunger and/or reduce energy expenditure. Until we address those underlying forces, we can’t meaningfully solve the problem. This isn’t an issue you can fix through sheer willpower—so it’s time we stop pretending that you can.Chapters0:00 – Calories Don’t Cause Obesity: A Provocative Experiment2:08 – A Misunderstanding of The Energy Balance Equation 5:38 – What Happens When You Force Feed People to Gain Weight? 14:39 – The Problem of Over-Hunger and History of Bariatric Surgery 19:52 – Homeostatic Hunger: Physical Signals and Hormones20:40 – Hedonic Hunger: Pleasure, Reward, and Food Addiction30:50 – Conditioned Hunger: Pavlov, Environment, and Social Triggers35:50 – Social Influence: Obesity Spreads Like a Virus38:40 – Building Tools to Fight Conditioned Hunger41:18 – The Powers of Mental Reprogramming and Mantras #HungerCode #Obesity #Hunger #ProcessedFood #Carbohydrate #Fasting #IntermittentFasting #LowCarb #KetogenicDiet #Keto #KetoDiet #WeightLossScience #Ghrelin #FatLoss #Metabolism #HomeostaticHunger #HedonicHunger #ConditionedHunger #Dopamine #HungerHormones #JasonFung #Diabetes #NutritionScience #HealthEducation #FoodAddiction #Hormones #GLP1 #Insulin #DietMyths #MetabolicHealth #BodyFat #PrecisionNutrition #SelfExperiment #Carbs #SugarFree #BehavioralScience #EatingHabits #Fiber #Protein #NeuroScience #HungerScience #EvidenceBased #HealthResearch #FoodAddiction #MMindset #StayCurious #NickNorwitz Learn more about your ad choices. Visit megaphone.fm/adchoices The Hunger Code Book: https://www.amazon.com/Hunger-Code-Resetting-Thermostat-Ultra-Processed/dp/1778401562

Weighted Vest Letter: https://staycuriousmetabolism.substack.com/p/how-weighted-vests-trick-your-body?r=40ekz2

Brain Insulin Resistance Letter: https://staycuriousmetabolism.substack.com/p/this-study-changed-how-i-see-junk?r=40ekz2

“Calories don’t cause obesity” is a provocative phrase—but it’s biologically accurate. It challenges a deeply entrenched misconception: that overeating causes obesity, rather than obesity driving overeating. If that sounds confusing, you’re not alone. Most people have been taught to think about it the other way around.

In this discussion, Dr. Jason Fung and I work to untangle that misunderstanding. We explore how energy imbalance—so-called “overeating” and "excess calories"—is more often a consequence of obesity, not its root cause.

What truly drives obesity is a complex interplay of social and hormonal factors that increase hunger and/or reduce energy expenditure. Until we address those underlying forces, we can’t meaningfully solve the problem. This isn’t an issue you can fix through sheer willpower—so it’s time we stop pretending that you can.

Chapters
0:00 – Calories Don’t Cause Obesity: A Provocative Experiment
2:08 – A Misunderstanding of The Energy Balance Equation
5:38 – What Happens When You Force Feed People to Gain Weight?
14:39 – The Problem of Over-Hunger and History of Bariatric Surgery
19:52 – Homeostatic Hunger: Physical Signals and Hormones
20:40 – Hedonic Hunger: Pleasure, Reward, and Food Addiction
30:50 – Conditioned Hunger: Pavlov, Environment, and Social Triggers
35:50 – Social Influence: Obesity Spreads Like a Virus
38:40 – Building Tools to Fight Conditioned Hunger
41:18 – The Powers of Mental Reprogramming and Mantras

#HungerCode #Obesity #Hunger #ProcessedFood #Carbohydrate #Fasting #IntermittentFasting #LowCarb #KetogenicDiet #Keto #KetoDiet #WeightLossScience #Ghrelin #FatLoss #Metabolism #HomeostaticHunger #HedonicHunger #ConditionedHunger #Dopamine #HungerHormones #JasonFung #Diabetes #NutritionScience #HealthEducation #FoodAddiction #Hormones #GLP1 #Insulin #DietMyths #MetabolicHealth #BodyFat #PrecisionNutrition #SelfExperiment #Carbs #SugarFree #BehavioralScience #EatingHabits #Fiber #Protein #NeuroScience #HungerScience #EvidenceBased #HealthResearch #FoodAddiction #MMindset #StayCurious #NickNorwitz

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]]> 3474 no Walter Willett on Controversial Low-Carb vs Low-Fat Study Reanalysis: https://www.sciencedirect.com/science/article/pii/S002231662372806X?via%3Dihub0:00 - Intro0:52 - Study description4:05 - Does this invalidate the results? 4:43 - Between group vs Within participant6:22 - Missing the point (with animation)10:15 - Retraction11:56 - Conclusions ("worse than useless") Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 24 Sep 2026 10:46:00 -0000 full Nick Norwitz MD PhD Reanalysis: https://www.sciencedirect.com/science/article/pii/S002231662372806X?via%3Dihub0:00 - Intro0:52 - Study description4:05 - Does this invalidate the results? 4:43 - Between group vs Within participant6:22 - Missing the point (with animation)10:15 - Retraction11:56 - Conclusions ("worse than useless") Learn more about your ad choices. Visit megaphone.fm/adchoices Reanalysis: https://www.sciencedirect.com/science/article/pii/S002231662372806X?via%3Dihub

0:00 - Intro
0:52 - Study description
4:05 - Does this invalidate the results?
4:43 - Between group vs Within participant
6:22 - Missing the point (with animation)
10:15 - Retraction
11:56 - Conclusions ("worse than useless")

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1055 no I Ate 1000 Sardines for Science — Nobody Saw This Coming For more details and references see the StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/the-weird-anti-insulin-hormone-that?r=40ekz2 To try the specific Lyso-DHA supplement I use, click this link: https://www.fenixhealthscience.com/staycuriousDiscount Code: StayCurious (20% off)And for more about the biochemistry of omega-3 and why Lyso-DHA is superior for brain health to other supplements, see this letter https://staycuriousmetabolism.substack.com/p/why-omega-3-supplements-dont-work?r=40ekz2 Description:After a month-long sardine diet, something unexpected happened: I became cold-resistant. Walking shirtless in a Boston winter felt comfortable. That experience sent me deep into the scientific literature, where I uncovered a fascinating metabolic pathway linking omega-3 fats, brown fat, hormone signaling, and thermogenesis.In this video, I break down one possible mechanism behind that effect, starting with a Cell Metabolism paper showing how brown fat converts omega-3 fatty acids into a hormone called 12-HEPE. This hormone increases heat production, boosts glucose uptake into brown fat and muscle, and shifts energy away from storage and toward thermogenesis.We’ll cover the animal data, the human controlled study, and how this pathway reframes obesity as a signaling. As always, this is about nuance, mechanisms, and asking better questions about how nutrition actually works.Chapters:0:00 – The Sardine Diet’s Most Unexpected Effect1:33 – The Sardine Diet: What I Actually Did2:16 – My Omega-3 Levels Went Off the Charts2:45 – Why I Suddenly Became Cold-Resistant3:15 – The Key Paper: Brown Fat, Omega-3s, and 12-HEPE4:30 – Mechanism Explained: What the Animal Data Show6:10 – The Full Pathway (Simple Summary)7:12 – Human Trial Evidence: Does This Work in People?10:20 – What This Means for You (Practical Takeaways)10:48 – Critical Nuance: Not All Omega-3s Act the Same#brownfat #omega3 #sardines #sardinediet #sardinefasting #Omega3 #BrownFat #Thermogenesis #MetabolicHealth #NutritionScience #Mitochondria #ColdExposure #InsulinSensitivity #ObesityScience #FatMetabolism #HormoneHealth #HealthEducation #ScienceExplained #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 23 Sep 2026 16:46:00 -0000 full Nick Norwitz MD PhD For more details and references see the StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/the-weird-anti-insulin-hormone-that?r=40ekz2 To try the specific Lyso-DHA supplement I use, click this link: https://www.fenixhealthscience.com/staycuriousDiscount Code: StayCurious (20% off)And for more about the biochemistry of omega-3 and why Lyso-DHA is superior for brain health to other supplements, see this letter https://staycuriousmetabolism.substack.com/p/why-omega-3-supplements-dont-work?r=40ekz2 Description:After a month-long sardine diet, something unexpected happened: I became cold-resistant. Walking shirtless in a Boston winter felt comfortable. That experience sent me deep into the scientific literature, where I uncovered a fascinating metabolic pathway linking omega-3 fats, brown fat, hormone signaling, and thermogenesis.In this video, I break down one possible mechanism behind that effect, starting with a Cell Metabolism paper showing how brown fat converts omega-3 fatty acids into a hormone called 12-HEPE. This hormone increases heat production, boosts glucose uptake into brown fat and muscle, and shifts energy away from storage and toward thermogenesis.We’ll cover the animal data, the human controlled study, and how this pathway reframes obesity as a signaling. As always, this is about nuance, mechanisms, and asking better questions about how nutrition actually works.Chapters:0:00 – The Sardine Diet’s Most Unexpected Effect1:33 – The Sardine Diet: What I Actually Did2:16 – My Omega-3 Levels Went Off the Charts2:45 – Why I Suddenly Became Cold-Resistant3:15 – The Key Paper: Brown Fat, Omega-3s, and 12-HEPE4:30 – Mechanism Explained: What the Animal Data Show6:10 – The Full Pathway (Simple Summary)7:12 – Human Trial Evidence: Does This Work in People?10:20 – What This Means for You (Practical Takeaways)10:48 – Critical Nuance: Not All Omega-3s Act the Same#brownfat #omega3 #sardines #sardinediet #sardinefasting #Omega3 #BrownFat #Thermogenesis #MetabolicHealth #NutritionScience #Mitochondria #ColdExposure #InsulinSensitivity #ObesityScience #FatMetabolism #HormoneHealth #HealthEducation #ScienceExplained #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For more details and references see the StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/the-weird-anti-insulin-hormone-that?r=40ekz2

To try the specific Lyso-DHA supplement I use, click this link: https://www.fenixhealthscience.com/staycurious
Discount Code: StayCurious (20% off)

And for more about the biochemistry of omega-3 and why Lyso-DHA is superior for brain health to other supplements, see this letter https://staycuriousmetabolism.substack.com/p/why-omega-3-supplements-dont-work?r=40ekz2

Description:
After a month-long sardine diet, something unexpected happened: I became cold-resistant. Walking shirtless in a Boston winter felt comfortable. That experience sent me deep into the scientific literature, where I uncovered a fascinating metabolic pathway linking omega-3 fats, brown fat, hormone signaling, and thermogenesis.

In this video, I break down one possible mechanism behind that effect, starting with a Cell Metabolism paper showing how brown fat converts omega-3 fatty acids into a hormone called 12-HEPE. This hormone increases heat production, boosts glucose uptake into brown fat and muscle, and shifts energy away from storage and toward thermogenesis.

We’ll cover the animal data, the human controlled study, and how this pathway reframes obesity as a signaling. As always, this is about nuance, mechanisms, and asking better questions about how nutrition actually works.

Chapters:
0:00 – The Sardine Diet’s Most Unexpected Effect
1:33 – The Sardine Diet: What I Actually Did
2:16 – My Omega-3 Levels Went Off the Charts
2:45 – Why I Suddenly Became Cold-Resistant
3:15 – The Key Paper: Brown Fat, Omega-3s, and 12-HEPE
4:30 – Mechanism Explained: What the Animal Data Show
6:10 – The Full Pathway (Simple Summary)
7:12 – Human Trial Evidence: Does This Work in People?
10:20 – What This Means for You (Practical Takeaways)
10:48 – Critical Nuance: Not All Omega-3s Act the Same

#brownfat #omega3 #sardines #sardinediet #sardinefasting #Omega3 #BrownFat #Thermogenesis #MetabolicHealth #NutritionScience #Mitochondria #ColdExposure #InsulinSensitivity #ObesityScience #FatMetabolism #HormoneHealth #HealthEducation #ScienceExplained #StayCurious

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]]> 1028 no Allulose: Healthiest Sugar in the World Fructose and Metabolic SyndromeCell Metabolism: https://pubmed.ncbi.nlm.nih.gov/32502381/ Fructose, intracellular pathwayJ. Biol Chem: https://pubmed.ncbi.nlm.nih.gov/23035112/ Allulose RCT, glucose and insulinJour. Func Foods: https://www.sciencedirect.com/science/article/pii/S175646462300169XOn GLP-1Nature Comm: https://www.nature.com/articles/s41467-017-02488-y Nature Letters: https://www.nature.com/articles/s41586-018-0849-9 Cell Metabolism: https://pubmed.ncbi.nlm.nih.gov/30943389/ 0:00 – Intro. Could a Sugar be a Healthy?0:46 – Roadmap of this video. 3 chapters.1:20 – Chapter 1. Fructose5:19 – Chapter 2. Allulose9:05 – Chapter 3. Allulose and the obesity epidemic12:33 – Conclusion and Call to Action#RxMetabolism University!I hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enhance the lessons, Steve and RxSugar are supporting video editing fees.Perhaps this will build brand trust and in that way work into the business model? Or maybe not. But I share this with you in the spirit of openness and transparency. And if you can believe me, I feel the strength of our movement comes from the fact that all of us, from me to Steve to you, are bonded by a deep desire and passion to Make Metabolic Health Mainstream! Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 22 Sep 2026 22:46:00 -0000 full Nick Norwitz MD PhD Fructose and Metabolic SyndromeCell Metabolism: https://pubmed.ncbi.nlm.nih.gov/32502381/ Fructose, intracellular pathwayJ. Biol Chem: https://pubmed.ncbi.nlm.nih.gov/23035112/ Allulose RCT, glucose and insulinJour. Func Foods: https://www.sciencedirect.com/science/article/pii/S175646462300169XOn GLP-1Nature Comm: https://www.nature.com/articles/s41467-017-02488-y Nature Letters: https://www.nature.com/articles/s41586-018-0849-9 Cell Metabolism: https://pubmed.ncbi.nlm.nih.gov/30943389/ 0:00 – Intro. Could a Sugar be a Healthy?0:46 – Roadmap of this video. 3 chapters.1:20 – Chapter 1. Fructose5:19 – Chapter 2. Allulose9:05 – Chapter 3. Allulose and the obesity epidemic12:33 – Conclusion and Call to Action#RxMetabolism University!I hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enhance the lessons, Steve and RxSugar are supporting video editing fees.Perhaps this will build brand trust and in that way work into the business model? Or maybe not. But I share this with you in the spirit of openness and transparency. And if you can believe me, I feel the strength of our movement comes from the fact that all of us, from me to Steve to you, are bonded by a deep desire and passion to Make Metabolic Health Mainstream! Learn more about your ad choices. Visit megaphone.fm/adchoices Fructose and Metabolic Syndrome
Cell Metabolism: https://pubmed.ncbi.nlm.nih.gov/32502381/

Fructose, intracellular pathway
J. Biol Chem: https://pubmed.ncbi.nlm.nih.gov/23035112/

Allulose RCT, glucose and insulin
Jour. Func Foods: https://www.sciencedirect.com/science/article/pii/S175646462300169X

On GLP-1
Nature Comm: https://www.nature.com/articles/s41467-017-02488-y
Nature Letters: https://www.nature.com/articles/s41586-018-0849-9
Cell Metabolism: https://pubmed.ncbi.nlm.nih.gov/30943389/

0:00 – Intro. Could a Sugar be a Healthy?
0:46 – Roadmap of this video. 3 chapters.
1:20 – Chapter 1. Fructose
5:19 – Chapter 2. Allulose
9:05 – Chapter 3. Allulose and the obesity epidemic
12:33 – Conclusion and Call to Action

#RxMetabolism University!

I hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.

These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!

My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enhance the lessons, Steve and RxSugar are supporting video editing fees.

Perhaps this will build brand trust and in that way work into the business model? Or maybe not. But I share this with you in the spirit of openness and transparency. And if you can believe me, I feel the strength of our movement comes from the fact that all of us, from me to Steve to you, are bonded by a deep desire and passion to Make Metabolic Health Mainstream!

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1049 no Is Your Gut Broken? Here's the Reset Button For all the references and early access to content like this, see the letter: https://staycuriousmetabolism.substack.com/p/how-im-rebuilding-my-microbiomeafter?r=40ekz2Try Winnow Labs Probiotic: https://www.winnowlabs.com/STAYCURIOUSCode “StayCurious” for 15% offLearn more about microplastics and human health belowInterview with CEO, Matthew Dunn PhD: https://youtu.be/9jSZh6kqfuE Microplastics and Brain Health: https://open.substack.com/pub/staycuriousmetabolism/p/this-graph-changed-how-i-think-about?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Microplastics and Heart Health: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Constipation Masterclass: https://open.substack.com/pub/staycuriousmetabolism/p/the-constipation-masterclass?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Lithium video: https://youtu.be/Hcz0Eyp1LE4 Description:Modern life is hostile to the human microbiome. Processed food, antibiotics, artificial sweeteners, stress, and disrupted circadian rhythms have pushed our gut ecosystems far from what our biology evolved to handle. In this video, I walk through a self-experimental framework for resetting the microbiome. We’ll cover a 4-phase microbiome reset: elimination, early repopulation, advanced repopulation, and long-term maintenance. This is not medical advice. It’s a structured way to explore your N=1 safely.Chapters0:00 – Can You Truly Reset Your Microbiome?1:36 – The 4-Phase Microbiome Reset Framework1:58 – Phase 1: Elimination (Starving Problematic Gut Bacteria)5:40 – Phase 2: Careful Repopulation (Rebuilding the Microbiome)11:13 – Phase 3: Expansion and Food Challenges12:18 – Phase 4: Long-Term Maintenance and Resilience#gutmicrobiome #microbiomereset #gutbrainaxis #digestivewellness #leakygut #dysbiosis #IBDawareness #inflammationhealth #metabolicflexibility #insulinsensitivity #bloodsugarcontrol #hormonehealth #circadianrhythm #stressandhealth #vagusnerve #fermentedfoods #probioticscience #prebiotics #eliminationdiet #carnivorediet #microbiome #guthealth #digestivehealth #metabolichealth #inflammation #IBD #insulinresistance #nutritionscience #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 22 Sep 2026 04:46:00 -0000 full Nick Norwitz MD PhD For all the references and early access to content like this, see the letter: https://staycuriousmetabolism.substack.com/p/how-im-rebuilding-my-microbiomeafter?r=40ekz2Try Winnow Labs Probiotic: https://www.winnowlabs.com/STAYCURIOUSCode “StayCurious” for 15% offLearn more about microplastics and human health belowInterview with CEO, Matthew Dunn PhD: https://youtu.be/9jSZh6kqfuE Microplastics and Brain Health: https://open.substack.com/pub/staycuriousmetabolism/p/this-graph-changed-how-i-think-about?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Microplastics and Heart Health: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Constipation Masterclass: https://open.substack.com/pub/staycuriousmetabolism/p/the-constipation-masterclass?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Lithium video: https://youtu.be/Hcz0Eyp1LE4 Description:Modern life is hostile to the human microbiome. Processed food, antibiotics, artificial sweeteners, stress, and disrupted circadian rhythms have pushed our gut ecosystems far from what our biology evolved to handle. In this video, I walk through a self-experimental framework for resetting the microbiome. We’ll cover a 4-phase microbiome reset: elimination, early repopulation, advanced repopulation, and long-term maintenance. This is not medical advice. It’s a structured way to explore your N=1 safely.Chapters0:00 – Can You Truly Reset Your Microbiome?1:36 – The 4-Phase Microbiome Reset Framework1:58 – Phase 1: Elimination (Starving Problematic Gut Bacteria)5:40 – Phase 2: Careful Repopulation (Rebuilding the Microbiome)11:13 – Phase 3: Expansion and Food Challenges12:18 – Phase 4: Long-Term Maintenance and Resilience#gutmicrobiome #microbiomereset #gutbrainaxis #digestivewellness #leakygut #dysbiosis #IBDawareness #inflammationhealth #metabolicflexibility #insulinsensitivity #bloodsugarcontrol #hormonehealth #circadianrhythm #stressandhealth #vagusnerve #fermentedfoods #probioticscience #prebiotics #eliminationdiet #carnivorediet #microbiome #guthealth #digestivehealth #metabolichealth #inflammation #IBD #insulinresistance #nutritionscience #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices For all the references and early access to content like this, see the letter: https://staycuriousmetabolism.substack.com/p/how-im-rebuilding-my-microbiomeafter?r=40ekz2

Try Winnow Labs Probiotic: https://www.winnowlabs.com/STAYCURIOUS
Code “StayCurious” for 15% off
Learn more about microplastics and human health below

Interview with CEO, Matthew Dunn PhD: https://youtu.be/9jSZh6kqfuE

Microplastics and Brain Health: https://open.substack.com/pub/staycuriousmetabolism/p/this-graph-changed-how-i-think-about?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Microplastics and Heart Health: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2

Constipation Masterclass: https://open.substack.com/pub/staycuriousmetabolism/p/the-constipation-masterclass?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Lithium video: https://youtu.be/Hcz0Eyp1LE4

Description:
Modern life is hostile to the human microbiome. Processed food, antibiotics, artificial sweeteners, stress, and disrupted circadian rhythms have pushed our gut ecosystems far from what our biology evolved to handle. In this video, I walk through a self-experimental framework for resetting the microbiome. We’ll cover a 4-phase microbiome reset: elimination, early repopulation, advanced repopulation, and long-term maintenance. This is not medical advice. It’s a structured way to explore your N=1 safely.

Chapters
0:00 – Can You Truly Reset Your Microbiome?
1:36 – The 4-Phase Microbiome Reset Framework
1:58 – Phase 1: Elimination (Starving Problematic Gut Bacteria)
5:40 – Phase 2: Careful Repopulation (Rebuilding the Microbiome)
11:13 – Phase 3: Expansion and Food Challenges
12:18 – Phase 4: Long-Term Maintenance and Resilience

#gutmicrobiome #microbiomereset #gutbrainaxis #digestivewellness #leakygut #dysbiosis #IBDawareness #inflammationhealth #metabolicflexibility #insulinsensitivity #bloodsugarcontrol #hormonehealth #circadianrhythm #stressandhealth #vagusnerve #fermentedfoods #probioticscience #prebiotics #eliminationdiet #carnivorediet #microbiome #guthealth #digestivehealth #metabolichealth #inflammation #IBD #insulinresistance #nutritionscience #staycurious

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]]> 1181 no Athletes DON'T need Carbs! FASTER trial: https://pubmed.ncbi.nlm.nih.gov/26892521/Yes... I'm feeling Cheeky...0:00 - Intro0:22 - FASTER1:14 - Peak fat oxidation2:10 - Muscle glycogen3:34 - Summary and "spicy sauce"4:13 - Let's go back in time! Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 21 Sep 2026 10:46:00 -0000 full Nick Norwitz MD PhD FASTER trial: https://pubmed.ncbi.nlm.nih.gov/26892521/Yes... I'm feeling Cheeky...0:00 - Intro0:22 - FASTER1:14 - Peak fat oxidation2:10 - Muscle glycogen3:34 - Summary and "spicy sauce"4:13 - Let's go back in time! Learn more about your ad choices. Visit megaphone.fm/adchoices FASTER trial: https://pubmed.ncbi.nlm.nih.gov/26892521/

Yes... I'm feeling Cheeky...

0:00 - Intro
0:22 - FASTER
1:14 - Peak fat oxidation
2:10 - Muscle glycogen
3:34 - Summary and "spicy sauce"
4:13 - Let's go back in time!

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 472 no The 75-Year-Old Obesity Riddle Science Just Solved For the references, deeper nuances, and additional content the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/can-visceral-fat-cause-depression?r=40ekz2 Hidden in this letter is a secret — a scientific breakthrough more than 75 years in the making. By the end of this video, I’ll show you exactly what’s inside it. But before we get there, understand this: I mean it literally.Scientists have just discovered that fat cells send secret letters to the brain — and the messages encoded inside them control your hunger, your energy, your metabolism, and potentially the root cause of obesity itself. These letters determine whether your brain feels satisfied and energized… or hungry, sluggish, and metabolically broken.Here’s the shocking part: if your biology writes the right message, you stay lean and healthy almost effortlessly. If it writes the wrong one, your brain goes blind to satiety, your metabolism slows, and your body enters a hormonal state that drives weight gain no matter what diet you follow.For nearly a century, we’ve known these “letters” existed but had no idea what was actually written inside them. What was the message? What caused it to change? Why did it trigger leptin resistance — one of the core drivers of obesity?The new study we’re about to break down finally opens the letter. And what’s inside is more profound — and more hopeful — than anyone expected.Chapters0:00 – A Secret Letter to Obesity 1:37 – Let’s Rewind to 1949 to the Discovery of Leptin2:31 – Leptin Resistance: Biology Thwarted Us!4:20 – What Happens What Your Fat Cells Can’t Send Letters5:30 – The Results of Extracellular Vesicle Letter Transplants7:00 – Human to Mouse Transplants: The Biology is Conserved7:49 – Scientists Mail Letters to the Brain8:25 – A Summary So Far…8:47 – microRNA: the message in the letters9:25 – In Obesity, the microRNA Messages Change10:55 – Reversing Obesity a with Re-Written Letters12:55 – The Riddle and Award#Obesity #Metabolism #LeptinResistance #WeightLossScience #MicroRNA #CellMetabolism #HealthScience #FatLoss #MetabolicHealth #NickNorwitz #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 20 Sep 2026 16:46:00 -0000 full Nick Norwitz MD PhD For the references, deeper nuances, and additional content the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/can-visceral-fat-cause-depression?r=40ekz2 Hidden in this letter is a secret — a scientific breakthrough more than 75 years in the making. By the end of this video, I’ll show you exactly what’s inside it. But before we get there, understand this: I mean it literally.Scientists have just discovered that fat cells send secret letters to the brain — and the messages encoded inside them control your hunger, your energy, your metabolism, and potentially the root cause of obesity itself. These letters determine whether your brain feels satisfied and energized… or hungry, sluggish, and metabolically broken.Here’s the shocking part: if your biology writes the right message, you stay lean and healthy almost effortlessly. If it writes the wrong one, your brain goes blind to satiety, your metabolism slows, and your body enters a hormonal state that drives weight gain no matter what diet you follow.For nearly a century, we’ve known these “letters” existed but had no idea what was actually written inside them. What was the message? What caused it to change? Why did it trigger leptin resistance — one of the core drivers of obesity?The new study we’re about to break down finally opens the letter. And what’s inside is more profound — and more hopeful — than anyone expected.Chapters0:00 – A Secret Letter to Obesity 1:37 – Let’s Rewind to 1949 to the Discovery of Leptin2:31 – Leptin Resistance: Biology Thwarted Us!4:20 – What Happens What Your Fat Cells Can’t Send Letters5:30 – The Results of Extracellular Vesicle Letter Transplants7:00 – Human to Mouse Transplants: The Biology is Conserved7:49 – Scientists Mail Letters to the Brain8:25 – A Summary So Far…8:47 – microRNA: the message in the letters9:25 – In Obesity, the microRNA Messages Change10:55 – Reversing Obesity a with Re-Written Letters12:55 – The Riddle and Award#Obesity #Metabolism #LeptinResistance #WeightLossScience #MicroRNA #CellMetabolism #HealthScience #FatLoss #MetabolicHealth #NickNorwitz #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For the references, deeper nuances, and additional content the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/can-visceral-fat-cause-depression?r=40ekz2

Hidden in this letter is a secret — a scientific breakthrough more than 75 years in the making. By the end of this video, I’ll show you exactly what’s inside it. But before we get there, understand this: I mean it literally.

Scientists have just discovered that fat cells send secret letters to the brain — and the messages encoded inside them control your hunger, your energy, your metabolism, and potentially the root cause of obesity itself. These letters determine whether your brain feels satisfied and energized… or hungry, sluggish, and metabolically broken.

Here’s the shocking part: if your biology writes the right message, you stay lean and healthy almost effortlessly. If it writes the wrong one, your brain goes blind to satiety, your metabolism slows, and your body enters a hormonal state that drives weight gain no matter what diet you follow.

For nearly a century, we’ve known these “letters” existed but had no idea what was actually written inside them. What was the message? What caused it to change? Why did it trigger leptin resistance — one of the core drivers of obesity?

The new study we’re about to break down finally opens the letter. And what’s inside is more profound — and more hopeful — than anyone expected.

Chapters
0:00 – A Secret Letter to Obesity
1:37 – Let’s Rewind to 1949 to the Discovery of Leptin
2:31 – Leptin Resistance: Biology Thwarted Us!
4:20 – What Happens What Your Fat Cells Can’t Send Letters
5:30 – The Results of Extracellular Vesicle Letter Transplants
7:00 – Human to Mouse Transplants: The Biology is Conserved
7:49 – Scientists Mail Letters to the Brain
8:25 – A Summary So Far…
8:47 – microRNA: the message in the letters
9:25 – In Obesity, the microRNA Messages Change
10:55 – Reversing Obesity a with Re-Written Letters
12:55 – The Riddle and Award

#Obesity #Metabolism #LeptinResistance #WeightLossScience #MicroRNA #CellMetabolism #HealthScience #FatLoss #MetabolicHealth #NickNorwitz #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1084 no Celery has more Calories than Butter! A provocative thought puzzle. I want to get you thinking about how you define a caloric deficit and how "Calories" as a concept is, or isn't, relevant to the choices you make and a productive variable to focus on when deciding what to eat to manage your weight, if that's something that's of concern to you. *Disclaimer: Human beings cannot live on butter. Duh. This is a thought puzzle.Videos listed at the end:Slow/Fast Metabolism: https://youtu.be/X1EXMEE2g_MObesity, GLP-1 deficit: https://youtu.be/9GMPNwazuEIOmega-7: https://youtu.be/Vngn6i-rmZIMilk and Diabetes: https://youtu.be/427ryaFko_ESome readings, meant to get you thinking:NEAT, overfeeding study: https://pubmed.ncbi.nlm.nih.gov/9880251/Carb-Insulin Model, 2023 review: https://royalsocietypublishing.org/doi/10.1098/rstb.2022.0211Yo-Yo diet and microbiome, mouse study: https://www.nature.com/articles/nature20796DIETFITS: Calories of Glycemia? https://pubmed.ncbi.nlm.nih.gov/36811468/0:00 – Intro. 0:53 – 3,500 kCal/lb of weight loss. Fail!2:19 – CICO is circular logic, a tautology. 3:29 – Celery has more calories than butter.Macadamia http://partner.houseofmacadamias.com/nick-norwitz -15% Off All Bundles -10% off any item (non-bundle) with code "NICK10" Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 19 Sep 2026 22:46:00 -0000 full Nick Norwitz MD PhD A provocative thought puzzle. I want to get you thinking about how you define a caloric deficit and how "Calories" as a concept is, or isn't, relevant to the choices you make and a productive variable to focus on when deciding what to eat to manage your weight, if that's something that's of concern to you. *Disclaimer: Human beings cannot live on butter. Duh. This is a thought puzzle.Videos listed at the end:Slow/Fast Metabolism: https://youtu.be/X1EXMEE2g_MObesity, GLP-1 deficit: https://youtu.be/9GMPNwazuEIOmega-7: https://youtu.be/Vngn6i-rmZIMilk and Diabetes: https://youtu.be/427ryaFko_ESome readings, meant to get you thinking:NEAT, overfeeding study: https://pubmed.ncbi.nlm.nih.gov/9880251/Carb-Insulin Model, 2023 review: https://royalsocietypublishing.org/doi/10.1098/rstb.2022.0211Yo-Yo diet and microbiome, mouse study: https://www.nature.com/articles/nature20796DIETFITS: Calories of Glycemia? https://pubmed.ncbi.nlm.nih.gov/36811468/0:00 – Intro. 0:53 – 3,500 kCal/lb of weight loss. Fail!2:19 – CICO is circular logic, a tautology. 3:29 – Celery has more calories than butter.Macadamia http://partner.houseofmacadamias.com/nick-norwitz -15% Off All Bundles -10% off any item (non-bundle) with code "NICK10" Learn more about your ad choices. Visit megaphone.fm/adchoices A provocative thought puzzle. I want to get you thinking about how you define a caloric deficit and how "Calories" as a concept is, or isn't, relevant to the choices you make and a productive variable to focus on when deciding what to eat to manage your weight, if that's something that's of concern to you.

*Disclaimer: Human beings cannot live on butter. Duh. This is a thought puzzle.

Videos listed at the end:
Slow/Fast Metabolism: https://youtu.be/X1EXMEE2g_M
Obesity, GLP-1 deficit: https://youtu.be/9GMPNwazuEI
Omega-7: https://youtu.be/Vngn6i-rmZI
Milk and Diabetes: https://youtu.be/427ryaFko_E

Some readings, meant to get you thinking:
NEAT, overfeeding study: https://pubmed.ncbi.nlm.nih.gov/9880251/
Carb-Insulin Model, 2023 review: https://royalsocietypublishing.org/doi/10.1098/rstb.2022.0211
Yo-Yo diet and microbiome, mouse study: https://www.nature.com/articles/nature20796
DIETFITS: Calories of Glycemia? https://pubmed.ncbi.nlm.nih.gov/36811468/

0:00 – Intro.
0:53 – 3,500 kCal/lb of weight loss. Fail!
2:19 – CICO is circular logic, a tautology.
3:29 – Celery has more calories than butter.

Macadamia
http://partner.houseofmacadamias.com/nick-norwitz
-15% Off All Bundles
-10% off any item (non-bundle) with code "NICK10"

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 406 no Does the World’s Most Profitable Drug Damage Muscle? For the references, extra details, and early access to content, see the letter: https://staycuriousmetabolism.substack.com/p/a-doctor-texted-me-im-stopping-my?r=40ekz2Additional Resources and Deep Dives. Stay Curious!Berberine Cholesterol, Letter: https://staycuriousmetabolism.substack.com/p/how-berberine-lowers-cholesterol?r=40ekz2 Statins Mitochondria, Letter: https://staycuriousmetabolism.substack.com/p/the-mitochondrial-cost-of-statins?r=40ekz2 Statins GLP-1, Letter: https://staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2 TUDCA, Letter: https://open.substack.com/pub/staycuriousmetabolism/p/can-tudca-protect-from-atherosclerosis?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Creatine, Letter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2 Sarcosine, Letter: https://staycuriousmetabolism.substack.com/p/age-related-muscle-loss-may-soon?r=40ekz2 Cholesterol Lowering Drug Masterclass, Letter: https://open.substack.com/pub/staycuriousmetabolism/p/a-concise-masterclass-on-cholesterol?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Description:Statins are the most prescribed drugs on Earth—but what if their long-term effects on muscle health are being overlooked?In this video, I break down a massive new analysis of nearly 300,000 participants, some followed for over a decade, showing that continuous statin use is associated with accelerated declines in muscle strength and lean mass. This matters because muscle loss is one of the strongest predictors of disability, frailty, and mortality with aging.We go beyond headlines and a single study to examine the biological mechanisms that could explain this observation—from mitochondrial dysfunction and CoQ10 depletion to insulin resistance and more. This is not an anti-statin video. It’s a pro-nuance video. If you care about longevity, strength, and making informed medical decisions, this is an important conversation.Chapters :0:00 – Do Statins Accelerate Muscle Loss? (The Surprising Signal)1:28 – What This Video Will Cover (Study → Mechanisms → Solutions)2:34 – Chapter 1: Study Design and Core Findings (300,000+ People)4:15 – Chapter 2: The Most Unexpected Result (Active People Declined Faster)7:24 – A Self-Experiment I’m Running (Why This Matters Personally)7:52 – Chapter 3: How Statins Can Impair Muscle Biology9:03 – Chapter 4: Statins—Real Benefits vs. Real Trade-Offs10:10 – Chapter 5: How to Protect Muscle While Aging (With or Without Statins)#statins #muscleloss #sarcopenia #musclehealth #aging #longevity #cholesterol #cardiovascularhealth #metabolichealth #strengthtraining #exercisephysiology #mitochondria #coq10 #diabetesrisk #healthscience #evidencebased #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 19 Sep 2026 04:46:00 -0000 full Nick Norwitz MD PhD For the references, extra details, and early access to content, see the letter: https://staycuriousmetabolism.substack.com/p/a-doctor-texted-me-im-stopping-my?r=40ekz2Additional Resources and Deep Dives. Stay Curious!Berberine Cholesterol, Letter: https://staycuriousmetabolism.substack.com/p/how-berberine-lowers-cholesterol?r=40ekz2 Statins Mitochondria, Letter: https://staycuriousmetabolism.substack.com/p/the-mitochondrial-cost-of-statins?r=40ekz2 Statins GLP-1, Letter: https://staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2 TUDCA, Letter: https://open.substack.com/pub/staycuriousmetabolism/p/can-tudca-protect-from-atherosclerosis?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Creatine, Letter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2 Sarcosine, Letter: https://staycuriousmetabolism.substack.com/p/age-related-muscle-loss-may-soon?r=40ekz2 Cholesterol Lowering Drug Masterclass, Letter: https://open.substack.com/pub/staycuriousmetabolism/p/a-concise-masterclass-on-cholesterol?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Description:Statins are the most prescribed drugs on Earth—but what if their long-term effects on muscle health are being overlooked?In this video, I break down a massive new analysis of nearly 300,000 participants, some followed for over a decade, showing that continuous statin use is associated with accelerated declines in muscle strength and lean mass. This matters because muscle loss is one of the strongest predictors of disability, frailty, and mortality with aging.We go beyond headlines and a single study to examine the biological mechanisms that could explain this observation—from mitochondrial dysfunction and CoQ10 depletion to insulin resistance and more. This is not an anti-statin video. It’s a pro-nuance video. If you care about longevity, strength, and making informed medical decisions, this is an important conversation.Chapters :0:00 – Do Statins Accelerate Muscle Loss? (The Surprising Signal)1:28 – What This Video Will Cover (Study → Mechanisms → Solutions)2:34 – Chapter 1: Study Design and Core Findings (300,000+ People)4:15 – Chapter 2: The Most Unexpected Result (Active People Declined Faster)7:24 – A Self-Experiment I’m Running (Why This Matters Personally)7:52 – Chapter 3: How Statins Can Impair Muscle Biology9:03 – Chapter 4: Statins—Real Benefits vs. Real Trade-Offs10:10 – Chapter 5: How to Protect Muscle While Aging (With or Without Statins)#statins #muscleloss #sarcopenia #musclehealth #aging #longevity #cholesterol #cardiovascularhealth #metabolichealth #strengthtraining #exercisephysiology #mitochondria #coq10 #diabetesrisk #healthscience #evidencebased #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices For the references, extra details, and early access to content, see the letter: https://staycuriousmetabolism.substack.com/p/a-doctor-texted-me-im-stopping-my?r=40ekz2

Additional Resources and Deep Dives. Stay Curious!
Berberine Cholesterol, Letter: https://staycuriousmetabolism.substack.com/p/how-berberine-lowers-cholesterol?r=40ekz2

Statins Mitochondria, Letter: https://staycuriousmetabolism.substack.com/p/the-mitochondrial-cost-of-statins?r=40ekz2

Statins GLP-1, Letter: https://staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2

TUDCA, Letter: https://open.substack.com/pub/staycuriousmetabolism/p/can-tudca-protect-from-atherosclerosis?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Creatine, Letter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2

Sarcosine, Letter: https://staycuriousmetabolism.substack.com/p/age-related-muscle-loss-may-soon?r=40ekz2

Cholesterol Lowering Drug Masterclass, Letter: https://open.substack.com/pub/staycuriousmetabolism/p/a-concise-masterclass-on-cholesterol?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Description:
Statins are the most prescribed drugs on Earth—but what if their long-term effects on muscle health are being overlooked?

In this video, I break down a massive new analysis of nearly 300,000 participants, some followed for over a decade, showing that continuous statin use is associated with accelerated declines in muscle strength and lean mass. This matters because muscle loss is one of the strongest predictors of disability, frailty, and mortality with aging.

We go beyond headlines and a single study to examine the biological mechanisms that could explain this observation—from mitochondrial dysfunction and CoQ10 depletion to insulin resistance and more. This is not an anti-statin video. It’s a pro-nuance video.

If you care about longevity, strength, and making informed medical decisions, this is an important conversation.

Chapters :
0:00 – Do Statins Accelerate Muscle Loss? (The Surprising Signal)
1:28 – What This Video Will Cover (Study → Mechanisms → Solutions)
2:34 – Chapter 1: Study Design and Core Findings (300,000+ People)
4:15 – Chapter 2: The Most Unexpected Result (Active People Declined Faster)
7:24 – A Self-Experiment I’m Running (Why This Matters Personally)
7:52 – Chapter 3: How Statins Can Impair Muscle Biology
9:03 – Chapter 4: Statins—Real Benefits vs. Real Trade-Offs
10:10 – Chapter 5: How to Protect Muscle While Aging (With or Without Statins)

#statins #muscleloss #sarcopenia #musclehealth #aging #longevity #cholesterol #cardiovascularhealth #metabolichealth #strengthtraining #exercisephysiology #mitochondria #coq10 #diabetesrisk #healthscience #evidencebased #staycurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1029 no Fructose Blocks Fat Burning. 4 Far-Fetched Facts Cell Metabolism Paper (should be open access): https://pubmed.ncbi.nlm.nih.gov/32502381/Prior video on mitochondrial fusion/fission: https://youtu.be/X1EXMEE2g_MPrior video on Fructose and Allulose: https://youtu.be/pr93EsEV2bM(and see #RxMetabolism project, below)Chapters0:00 – Introduction0:41 – Necessary background: Transcriptional, Post-Translational, Mitochondrial, Metabolical, CPT1, Ketohexokinase2:42 – 1) Transcriptional4:57 – 2) Post-translational5:52 – 3) Mitochondrial 6:50 – 4) Metabolical8:41 – Review and main figure 8:49 – Caveats and Common Sense#RxMetabolism University!I hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enhance the lessons, Steve and RxSugar are supporting video editing fees.Perhaps this will build brand trust and in that way work into the business model? Or maybe not. But I share this with you in the spirit of openness and transparency. And if you can believe me, I feel the strength of our movement comes from the fact that all of us, from me to Steve to you, are bonded by a deep desire and passion to Make Metabolic Health Mainstream! Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 18 Sep 2026 10:46:00 -0000 full Nick Norwitz MD PhD Cell Metabolism Paper (should be open access): https://pubmed.ncbi.nlm.nih.gov/32502381/Prior video on mitochondrial fusion/fission: https://youtu.be/X1EXMEE2g_MPrior video on Fructose and Allulose: https://youtu.be/pr93EsEV2bM(and see #RxMetabolism project, below)Chapters0:00 – Introduction0:41 – Necessary background: Transcriptional, Post-Translational, Mitochondrial, Metabolical, CPT1, Ketohexokinase2:42 – 1) Transcriptional4:57 – 2) Post-translational5:52 – 3) Mitochondrial 6:50 – 4) Metabolical8:41 – Review and main figure 8:49 – Caveats and Common Sense#RxMetabolism University!I hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enhance the lessons, Steve and RxSugar are supporting video editing fees.Perhaps this will build brand trust and in that way work into the business model? Or maybe not. But I share this with you in the spirit of openness and transparency. And if you can believe me, I feel the strength of our movement comes from the fact that all of us, from me to Steve to you, are bonded by a deep desire and passion to Make Metabolic Health Mainstream! Learn more about your ad choices. Visit megaphone.fm/adchoices Cell Metabolism Paper (should be open access): https://pubmed.ncbi.nlm.nih.gov/32502381/

Prior video on mitochondrial fusion/fission: https://youtu.be/X1EXMEE2g_M

Prior video on Fructose and Allulose: https://youtu.be/pr93EsEV2bM
(and see #RxMetabolism project, below)

Chapters
0:00 – Introduction
0:41 – Necessary background: Transcriptional, Post-Translational, Mitochondrial, Metabolical, CPT1, Ketohexokinase
2:42 – 1) Transcriptional
4:57 – 2) Post-translational
5:52 – 3) Mitochondrial
6:50 – 4) Metabolical
8:41 – Review and main figure
8:49 – Caveats and Common Sense

#RxMetabolism University!

I hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.

These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!

My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enhance the lessons, Steve and RxSugar are supporting video editing fees.

Perhaps this will build brand trust and in that way work into the business model? Or maybe not. But I share this with you in the spirit of openness and transparency. And if you can believe me, I feel the strength of our movement comes from the fact that all of us, from me to Steve to you, are bonded by a deep desire and passion to Make Metabolic Health Mainstream!

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 776 no The Statin Data Peter Attia Deleted For extra nuances and references, see the associated written content: https://staycuriousmetabolism.substack.com/p/peter-attia-is-hiding-something-not?r=40ekz2 To enjoy many more deep dives on heart health, see the Heart Health Library at the Best-Selling in Science StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/hearthealth The original video cover these data on this channel: https://youtu.be/6NomrgjK1yQ Prior response to Peter Attia, Pitting Facts Against Sensationalism Regarding the Role of LDL Cholesterol in ASCVD: https://staycuriousmetabolism.substack.com/p/pitting-facts-against-sensationalism?r=40ekz2 DescriptionStatins are among the most prescribed and profitable drugs in history—but how often do we fully examine the data behind them? In this video, I respond to a rebuttal by Peter Attia concerning a controlled human trial published in Cell Metabolism showing a striking reduction in GLP-1 levels in people taking atorvastatin, alongside worsening glycemic markers. I highlight why the omission of a central graph undermines his rebuttal and scientific argument.This is not an argument against statins per se, nor a personal critique. It’s a case study in how scientific conversations unfold, how data can be selectively emphasized, and why shared decision-making depends on full disclosure. We’ll dig into physiology, logic, and incentive structures that shape what information reaches clinicians and patients.If you want a deeper dive, the full written analysis is linked above. This video is about curiosity, accountability, and building a healthier intellectual ecosystem around medicine—one honest conversation at a time.Chapters0:00 – Peter Attia is Hiding Something… 1:13 – What This Video is About. And What It’s Not About 2:15 – Establishing Context: Who is Responding to Who?4:01 – What the Statin-GLP-1 Controlled Trial Shows A Category Error Explained5:13 – My Real Concern is Not GLP-1. It Is…6:29 – Truth 1: Absence of Evidence vs Evidence of Absence7:56 – Truth 2: Incentive Structures Shape Medical Research9:24 – Truth 3: Trust, Transparency, and Informed Consent10:27 – A Personal Reflection on Scientific Discourse13:12 – A Big Thank You to YOU#statins #cholesterol #GLP1 #metabolichealth #medicine #medicalresearch #sciencecommunication #precisionmedicine #endocrinology #cardiology #diabetes #insulinresistance #clinicaltrials #evidencebasedmedicine #healthpolicy #pharma #biochemistry #physiology #scientificdebate #informedconsent #doctorpatient #healthcare #publichealth #medicalethics #nutrition #longevity #healthscience #academicmedicine #researchmethods #criticalthinking #dataanalysis #cellmetabolism #statinsideeffects #healthdiscussion #scienceyoutube #medtwitter #staycurious #healthliteracy #medicaleducation #trustinscience #transparency Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 17 Sep 2026 16:46:00 -0000 full Nick Norwitz MD PhD For extra nuances and references, see the associated written content: https://staycuriousmetabolism.substack.com/p/peter-attia-is-hiding-something-not?r=40ekz2 To enjoy many more deep dives on heart health, see the Heart Health Library at the Best-Selling in Science StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/hearthealth The original video cover these data on this channel: https://youtu.be/6NomrgjK1yQ Prior response to Peter Attia, Pitting Facts Against Sensationalism Regarding the Role of LDL Cholesterol in ASCVD: https://staycuriousmetabolism.substack.com/p/pitting-facts-against-sensationalism?r=40ekz2 DescriptionStatins are among the most prescribed and profitable drugs in history—but how often do we fully examine the data behind them? In this video, I respond to a rebuttal by Peter Attia concerning a controlled human trial published in Cell Metabolism showing a striking reduction in GLP-1 levels in people taking atorvastatin, alongside worsening glycemic markers. I highlight why the omission of a central graph undermines his rebuttal and scientific argument.This is not an argument against statins per se, nor a personal critique. It’s a case study in how scientific conversations unfold, how data can be selectively emphasized, and why shared decision-making depends on full disclosure. We’ll dig into physiology, logic, and incentive structures that shape what information reaches clinicians and patients.If you want a deeper dive, the full written analysis is linked above. This video is about curiosity, accountability, and building a healthier intellectual ecosystem around medicine—one honest conversation at a time.Chapters0:00 – Peter Attia is Hiding Something… 1:13 – What This Video is About. And What It’s Not About 2:15 – Establishing Context: Who is Responding to Who?4:01 – What the Statin-GLP-1 Controlled Trial Shows A Category Error Explained5:13 – My Real Concern is Not GLP-1. It Is…6:29 – Truth 1: Absence of Evidence vs Evidence of Absence7:56 – Truth 2: Incentive Structures Shape Medical Research9:24 – Truth 3: Trust, Transparency, and Informed Consent10:27 – A Personal Reflection on Scientific Discourse13:12 – A Big Thank You to YOU#statins #cholesterol #GLP1 #metabolichealth #medicine #medicalresearch #sciencecommunication #precisionmedicine #endocrinology #cardiology #diabetes #insulinresistance #clinicaltrials #evidencebasedmedicine #healthpolicy #pharma #biochemistry #physiology #scientificdebate #informedconsent #doctorpatient #healthcare #publichealth #medicalethics #nutrition #longevity #healthscience #academicmedicine #researchmethods #criticalthinking #dataanalysis #cellmetabolism #statinsideeffects #healthdiscussion #scienceyoutube #medtwitter #staycurious #healthliteracy #medicaleducation #trustinscience #transparency Learn more about your ad choices. Visit megaphone.fm/adchoices For extra nuances and references, see the associated written content: https://staycuriousmetabolism.substack.com/p/peter-attia-is-hiding-something-not?r=40ekz2

To enjoy many more deep dives on heart health, see the Heart Health Library at the Best-Selling in Science StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/hearthealth

The original video cover these data on this channel: https://youtu.be/6NomrgjK1yQ

Prior response to Peter Attia, Pitting Facts Against Sensationalism Regarding the Role of LDL Cholesterol in ASCVD: https://staycuriousmetabolism.substack.com/p/pitting-facts-against-sensationalism?r=40ekz2

Description
Statins are among the most prescribed and profitable drugs in history—but how often do we fully examine the data behind them? In this video, I respond to a rebuttal by Peter Attia concerning a controlled human trial published in Cell Metabolism showing a striking reduction in GLP-1 levels in people taking atorvastatin, alongside worsening glycemic markers. I highlight why the omission of a central graph undermines his rebuttal and scientific argument.

This is not an argument against statins per se, nor a personal critique. It’s a case study in how scientific conversations unfold, how data can be selectively emphasized, and why shared decision-making depends on full disclosure. We’ll dig into physiology, logic, and incentive structures that shape what information reaches clinicians and patients.

If you want a deeper dive, the full written analysis is linked above. This video is about curiosity, accountability, and building a healthier intellectual ecosystem around medicine—one honest conversation at a time.

Chapters
0:00 – Peter Attia is Hiding Something…
1:13 – What This Video is About. And What It’s Not About
2:15 – Establishing Context: Who is Responding to Who?
4:01 – What the Statin-GLP-1 Controlled Trial Shows A Category Error Explained
5:13 – My Real Concern is Not GLP-1. It Is…
6:29 – Truth 1: Absence of Evidence vs Evidence of Absence
7:56 – Truth 2: Incentive Structures Shape Medical Research
9:24 – Truth 3: Trust, Transparency, and Informed Consent
10:27 – A Personal Reflection on Scientific Discourse
13:12 – A Big Thank You to YOU

#statins #cholesterol #GLP1 #metabolichealth #medicine #medicalresearch #sciencecommunication #precisionmedicine #endocrinology #cardiology #diabetes #insulinresistance #clinicaltrials #evidencebasedmedicine #healthpolicy #pharma #biochemistry #physiology #scientificdebate #informedconsent #doctorpatient #healthcare #publichealth #medicalethics #nutrition #longevity #healthscience #academicmedicine #researchmethods #criticalthinking #dataanalysis #cellmetabolism #statinsideeffects #healthdiscussion #scienceyoutube #medtwitter #staycurious #healthliteracy #medicaleducation #trustinscience #transparency

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1132 no Reactions to Oreo Versus Statin Study Oreo vs Statin Paper: https://www.mdpi.com/2218-1989/14/1/73 Oreo vs Statin Video Abstract: https://youtu.be/L1mMnnyJrgkResponse to Layne on Lipid Energy: https://youtu.be/yiq67wpUhIsLDL manipulation on ketogenic diet: https://youtu.be/-HZEjnw4WTs Editing by the brilliant and passionate Mr. Max Simmons6 select Prior publications 1/ META of RCTs (new, 1/16/24) Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis. Amer J of Clin Nutr. 2024; doi: 10.1016/j.ajcnut.2024.01.009 LINK: https://www.sciencedirect.com/science/article/pii/S0002916524000091** VIDEO: https://youtu.be/FcUUqGJBXFM 2/ n = 10 lean healthy women Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, Sota-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Frontiers in Endocrinology. 2023; doi: 10.3389/fendo.2023.1326768 LINK: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full VIDEO: https://youtu.be/OpOkeXVUotU?si=vHmfywr3CH27B2w5 3/ JCL editorial Norwitz NG, Mindrum M, Giral P, Kontush A, Soto-Mota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyper-responders on low-carbohydrate diets deserve urgent clinical attention and further research. Journal of Clinical Lipidology. 2022; doi:10.1016/j.jacl.2022.10.010 Link: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltext 4/ Lipid Energy Model Norwitz NG, Soto-Mota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets. Metabolites. 2022; doi: 10.3390/metabo12050460 LINK: https://pubmed.ncbi.nlm.nih.gov/35629964/ VIDEO: https://youtu.be/AkzxESsTJyM?si=A8lfhLXp_U1wPRdx 5/ LMHR, first paper Norwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype. Current Developments in Nutrition. 2022; doi: 10.1093/cdn/nzab144 LINK: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext 6/ Low Sat Fat LMHR case report Norwitz NG, Soto-Mota A, Feldman D, Parpos S, Budoff M. Case report: hypercholesterolemia “lean mass hyper-responder” phenotype presents in the context of a low saturated fat carbohydrate restricted diet. Frontiers in Endocrinology. 2022; doi: 10.3389/fendo.2022.830325 LINK: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/ VIDEO: https://youtu.be/JSEqIsYBZxU?si=lJ0_dnDYlDzvNyjt #RxMetabolism University ProjectI hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enh Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 16 Sep 2026 22:46:00 -0000 full Nick Norwitz MD PhD Oreo vs Statin Paper: https://www.mdpi.com/2218-1989/14/1/73 Oreo vs Statin Video Abstract: https://youtu.be/L1mMnnyJrgkResponse to Layne on Lipid Energy: https://youtu.be/yiq67wpUhIsLDL manipulation on ketogenic diet: https://youtu.be/-HZEjnw4WTs Editing by the brilliant and passionate Mr. Max Simmons6 select Prior publications 1/ META of RCTs (new, 1/16/24) Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis. Amer J of Clin Nutr. 2024; doi: 10.1016/j.ajcnut.2024.01.009 LINK: https://www.sciencedirect.com/science/article/pii/S0002916524000091** VIDEO: https://youtu.be/FcUUqGJBXFM 2/ n = 10 lean healthy women Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, Sota-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Frontiers in Endocrinology. 2023; doi: 10.3389/fendo.2023.1326768 LINK: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full VIDEO: https://youtu.be/OpOkeXVUotU?si=vHmfywr3CH27B2w5 3/ JCL editorial Norwitz NG, Mindrum M, Giral P, Kontush A, Soto-Mota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyper-responders on low-carbohydrate diets deserve urgent clinical attention and further research. Journal of Clinical Lipidology. 2022; doi:10.1016/j.jacl.2022.10.010 Link: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltext 4/ Lipid Energy Model Norwitz NG, Soto-Mota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets. Metabolites. 2022; doi: 10.3390/metabo12050460 LINK: https://pubmed.ncbi.nlm.nih.gov/35629964/ VIDEO: https://youtu.be/AkzxESsTJyM?si=A8lfhLXp_U1wPRdx 5/ LMHR, first paper Norwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype. Current Developments in Nutrition. 2022; doi: 10.1093/cdn/nzab144 LINK: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext 6/ Low Sat Fat LMHR case report Norwitz NG, Soto-Mota A, Feldman D, Parpos S, Budoff M. Case report: hypercholesterolemia “lean mass hyper-responder” phenotype presents in the context of a low saturated fat carbohydrate restricted diet. Frontiers in Endocrinology. 2022; doi: 10.3389/fendo.2022.830325 LINK: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/ VIDEO: https://youtu.be/JSEqIsYBZxU?si=lJ0_dnDYlDzvNyjt #RxMetabolism University ProjectI hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enh Learn more about your ad choices. Visit megaphone.fm/adchoices Oreo vs Statin Paper: https://www.mdpi.com/2218-1989/14/1/73
Oreo vs Statin Video Abstract: https://youtu.be/L1mMnnyJrgk

Response to Layne on Lipid Energy: https://youtu.be/yiq67wpUhIs

LDL manipulation on ketogenic diet: https://youtu.be/-HZEjnw4WTs

Editing by the brilliant and passionate Mr. Max Simmons

6 select Prior publications

1/ META of RCTs (new, 1/16/24) Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis. Amer J of Clin Nutr. 2024; doi: 10.1016/j.ajcnut.2024.01.009
LINK: https://www.sciencedirect.com/science/article/pii/S0002916524000091**
VIDEO: https://youtu.be/FcUUqGJBXFM

2/ n = 10 lean healthy women Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, Sota-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Frontiers in Endocrinology. 2023; doi: 10.3389/fendo.2023.1326768
LINK: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full
VIDEO: https://youtu.be/OpOkeXVUotU?si=vHmfywr3CH27B2w5

3/ JCL editorial Norwitz NG, Mindrum M, Giral P, Kontush A, Soto-Mota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyper-responders on low-carbohydrate diets deserve urgent clinical attention and further research. Journal of Clinical Lipidology. 2022; doi:10.1016/j.jacl.2022.10.010

Link: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltext 4/ Lipid Energy Model Norwitz NG, Soto-Mota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets. Metabolites. 2022; doi: 10.3390/metabo12050460
LINK: https://pubmed.ncbi.nlm.nih.gov/35629964/
VIDEO: https://youtu.be/AkzxESsTJyM?si=A8lfhLXp_U1wPRdx

5/ LMHR, first paper Norwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype. Current Developments in Nutrition. 2022; doi: 10.1093/cdn/nzab144 LINK: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext

6/ Low Sat Fat LMHR case report Norwitz NG, Soto-Mota A, Feldman D, Parpos S, Budoff M. Case report: hypercholesterolemia “lean mass hyper-responder” phenotype presents in the context of a low saturated fat carbohydrate restricted diet. Frontiers in Endocrinology. 2022; doi: 10.3389/fendo.2022.830325
LINK: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/
VIDEO: https://youtu.be/JSEqIsYBZxU?si=lJ0_dnDYlDzvNyjt


#RxMetabolism University Project

I hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.

These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!

My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enh

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1356 no This New Invention Blocks Microplastics Microplastics in my Heart Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSOr use discount code STAYCURIOUS at checkout.Stanford Fiber RCT, Letter https://staycuriousmetabolism.substack.com/p/fiber-is-good-for-you-is-lazy-science?r=40ekz2 Microbiome Reset, Letter https://staycuriousmetabolism.substack.com/p/how-im-rebuilding-my-microbiomeafter?r=40ekz2Description:Microplastics are everywhere—in our food, water, and inside our bodies—and avoiding them completely is nearly impossible. In this conversation, I sit down with Dr. Matthew Dunn PhD, a molecular biologist working at the intersection of biotechnology and human health, to unpack what the science actually says about microplastics and how they may be linked to cardiovascular disease, reproductive health issues, and gut inflammationWe break down the landmark human data, the animal and cellular studies that help explain possible mechanisms, and dissect the state of the data. We also explore a potential inside-out solution: using specific probiotic strains to bind microplastics in the gut and help eliminate them before they cause harm, along with practical steps anyone can take today to reduce exposure without spiraling into fear.Chapters:0:00 – The Microplastics Problem: Why This Matters2:00 – Microplastics and Heart Disease (NEJM Evidence)6:38 – Reproductive Health Red Flags: Fertility, Pregnancy, Offspring11:00 – Microplastics in the Gut and Microbiome Disruption15:00 – How Microplastics Damage the Intestinal Lining17:46 – Experimental Evidence for “Leaky Gut”20:00 – Can Probiotics Bind and Remove Microplastics?31:33 – What We Don’t Know Yet: Limits of Human Evidence34:38 – Microplastic Testing: What Can (and Can’t) Be Measured36:24 – Practical Ways to Reduce Microplastic Exposure Today#microplastics #microbiome #nanoplastics #plastic #cardiovascularhealth #hearthealth #guthealth #reproductivehealth#brainhealth #metabolichealth #precisionhealth #personalizedmedicine#nutritionscience #healthscience #medicaleducation #scienceexplained#microbiomescience #gutbrainaxis #inflammation #longevityscience#exposomescience #environmentaltoxins #publichealth #winnowlabs Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 16 Sep 2026 04:46:00 -0000 full Nick Norwitz MD PhD Microplastics in my Heart Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSOr use discount code STAYCURIOUS at checkout.Stanford Fiber RCT, Letter https://staycuriousmetabolism.substack.com/p/fiber-is-good-for-you-is-lazy-science?r=40ekz2 Microbiome Reset, Letter https://staycuriousmetabolism.substack.com/p/how-im-rebuilding-my-microbiomeafter?r=40ekz2Description:Microplastics are everywhere—in our food, water, and inside our bodies—and avoiding them completely is nearly impossible. In this conversation, I sit down with Dr. Matthew Dunn PhD, a molecular biologist working at the intersection of biotechnology and human health, to unpack what the science actually says about microplastics and how they may be linked to cardiovascular disease, reproductive health issues, and gut inflammationWe break down the landmark human data, the animal and cellular studies that help explain possible mechanisms, and dissect the state of the data. We also explore a potential inside-out solution: using specific probiotic strains to bind microplastics in the gut and help eliminate them before they cause harm, along with practical steps anyone can take today to reduce exposure without spiraling into fear.Chapters:0:00 – The Microplastics Problem: Why This Matters2:00 – Microplastics and Heart Disease (NEJM Evidence)6:38 – Reproductive Health Red Flags: Fertility, Pregnancy, Offspring11:00 – Microplastics in the Gut and Microbiome Disruption15:00 – How Microplastics Damage the Intestinal Lining17:46 – Experimental Evidence for “Leaky Gut”20:00 – Can Probiotics Bind and Remove Microplastics?31:33 – What We Don’t Know Yet: Limits of Human Evidence34:38 – Microplastic Testing: What Can (and Can’t) Be Measured36:24 – Practical Ways to Reduce Microplastic Exposure Today#microplastics #microbiome #nanoplastics #plastic #cardiovascularhealth #hearthealth #guthealth #reproductivehealth#brainhealth #metabolichealth #precisionhealth #personalizedmedicine#nutritionscience #healthscience #medicaleducation #scienceexplained#microbiomescience #gutbrainaxis #inflammation #longevityscience#exposomescience #environmentaltoxins #publichealth #winnowlabs Learn more about your ad choices. Visit megaphone.fm/adchoices Microplastics in my Heart Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2

Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUS
Or use discount code STAYCURIOUS at checkout.

Stanford Fiber RCT, Letter https://staycuriousmetabolism.substack.com/p/fiber-is-good-for-you-is-lazy-science?r=40ekz2

Microbiome Reset, Letter https://staycuriousmetabolism.substack.com/p/how-im-rebuilding-my-microbiomeafter?r=40ekz2

Description:
Microplastics are everywhere—in our food, water, and inside our bodies—and avoiding them completely is nearly impossible. In this conversation, I sit down with Dr. Matthew Dunn PhD, a molecular biologist working at the intersection of biotechnology and human health, to unpack what the science actually says about microplastics and how they may be linked to cardiovascular disease, reproductive health issues, and gut inflammation
We break down the landmark human data, the animal and cellular studies that help explain possible mechanisms, and dissect the state of the data.
We also explore a potential inside-out solution: using specific probiotic strains to bind microplastics in the gut and help eliminate them before they cause harm, along with practical steps anyone can take today to reduce exposure without spiraling into fear.

Chapters:
0:00 – The Microplastics Problem: Why This Matters
2:00 – Microplastics and Heart Disease (NEJM Evidence)
6:38 – Reproductive Health Red Flags: Fertility, Pregnancy, Offspring
11:00 – Microplastics in the Gut and Microbiome Disruption
15:00 – How Microplastics Damage the Intestinal Lining
17:46 – Experimental Evidence for “Leaky Gut”
20:00 – Can Probiotics Bind and Remove Microplastics?
31:33 – What We Don’t Know Yet: Limits of Human Evidence
34:38 – Microplastic Testing: What Can (and Can’t) Be Measured
36:24 – Practical Ways to Reduce Microplastic Exposure Today

#microplastics #microbiome #nanoplastics #plastic #cardiovascularhealth #hearthealth #guthealth #reproductivehealth
#brainhealth #metabolichealth #precisionhealth #personalizedmedicine
#nutritionscience #healthscience #medicaleducation #scienceexplained
#microbiomescience #gutbrainaxis #inflammation #longevityscience
#exposomescience #environmentaltoxins #publichealth #winnowlabs

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 3036 no Eggs DO NOT Increase Cholesterol: NEW Mechanism! Paper: https://www.cell.com/cell/pdf/S0092-8674(24)00226-5.pdfSome people were wondering about human RCTs on egg intake and cholesterol. This is from the most recent (n = 140) RCT, showing no impact of egg intake on LDL cholesterol: “Changes in HDL- and LDL levels were similar for Fortified Egg (FE) compared with Non-Egg (NE). Subgroup analyses revealed increased HDL and decreased LDL in patients ≥65 years for FE compared with NE, though not statistically significant.” https://www.jacc.org/doi/10.1016/S0735-1097%2824%2903789-6Prior video on manipulating LDL levels on a ketogenic diet: https://youtu.be/-HZEjnw4WTsThumbnail created using meal photo from @ZackStrength on Twitter, with permission.Chapters 0:00 – Intro, Cholesin 1:00 – Cholesterol Inhibitor Mechanism 3:36 – Relevance in humans4:36 – Medications and Mechanism8:01 – Disclaimer#RxMetabolism University ProjectI hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enhance the lessons, Steve and RxSugar are supporting video editing fees.Perhaps this will build brand trust and in that way work into the business model? Or maybe not. But I share this with you in the spirit of openness and transparency. And if you can believe me, I feel the strength of our movement comes from the fact that all of us, from me to Steve to you, are bonded by a deep desire and passion to Make Metabolic Health Mainstream! For more on the science of allulose, see this video: https://youtu.be/pr93EsEV2bM Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 15 Sep 2026 10:46:00 -0000 full Nick Norwitz MD PhD Paper: https://www.cell.com/cell/pdf/S0092-8674(24)00226-5.pdfSome people were wondering about human RCTs on egg intake and cholesterol. This is from the most recent (n = 140) RCT, showing no impact of egg intake on LDL cholesterol: “Changes in HDL- and LDL levels were similar for Fortified Egg (FE) compared with Non-Egg (NE). Subgroup analyses revealed increased HDL and decreased LDL in patients ≥65 years for FE compared with NE, though not statistically significant.” https://www.jacc.org/doi/10.1016/S0735-1097%2824%2903789-6Prior video on manipulating LDL levels on a ketogenic diet: https://youtu.be/-HZEjnw4WTsThumbnail created using meal photo from @ZackStrength on Twitter, with permission.Chapters 0:00 – Intro, Cholesin 1:00 – Cholesterol Inhibitor Mechanism 3:36 – Relevance in humans4:36 – Medications and Mechanism8:01 – Disclaimer#RxMetabolism University ProjectI hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enhance the lessons, Steve and RxSugar are supporting video editing fees.Perhaps this will build brand trust and in that way work into the business model? Or maybe not. But I share this with you in the spirit of openness and transparency. And if you can believe me, I feel the strength of our movement comes from the fact that all of us, from me to Steve to you, are bonded by a deep desire and passion to Make Metabolic Health Mainstream! For more on the science of allulose, see this video: https://youtu.be/pr93EsEV2bM Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://www.cell.com/cell/pdf/S0092-8674(24)00226-5.pdf

Some people were wondering about human RCTs on egg intake and cholesterol. This is from the most recent (n = 140) RCT, showing no impact of egg intake on LDL cholesterol: “Changes in HDL- and LDL levels were similar for Fortified Egg (FE) compared with Non-Egg (NE). Subgroup analyses revealed increased HDL and decreased LDL in patients ≥65 years for FE compared with NE, though not statistically significant.” https://www.jacc.org/doi/10.1016/S0735-1097%2824%2903789-6

Prior video on manipulating LDL levels on a ketogenic diet: https://youtu.be/-HZEjnw4WTs

Thumbnail created using meal photo from @ZackStrength on Twitter, with permission.

Chapters
0:00 – Intro, Cholesin
1:00 – Cholesterol Inhibitor Mechanism
3:36 – Relevance in humans
4:36 – Medications and Mechanism
8:01 – Disclaimer

#RxMetabolism University Project

I hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.

These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!

My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enhance the lessons, Steve and RxSugar are supporting video editing fees.

Perhaps this will build brand trust and in that way work into the business model? Or maybe not. But I share this with you in the spirit of openness and transparency. And if you can believe me, I feel the strength of our movement comes from the fact that all of us, from me to Steve to you, are bonded by a deep desire and passion to Make Metabolic Health Mainstream!

For more on the science of allulose, see this video: https://youtu.be/pr93EsEV2bM

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 715 no Low Cholesterol Won’t Save You. Measure This Instead. For all the references, extra nuance and early access to content like this, join the Best-Selling in Science StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/beyond-ldl-rethinking-cardiovascular?r=40ekz2 Referenced ContentMasterclass on Cholesterol-Lowering Medications, Letter: https://staycuriousmetabolism.substack.com/p/a-concise-masterclass-on-cholesterol?r=40ekz2 Statins Slash GLP-1, Video: https://youtu.be/6NomrgjK1yQ Statins Harms Mitochondria, Video: https://youtu.be/qHXMI3DudEc What Statin Trials Really Show, Video: https://youtu.be/Y3JKgfKqiBQ Statins Associated with Muscle Loss, Letter: https://staycuriousmetabolism.substack.com/p/a-doctor-texted-me-im-stopping-my?r=40ekz2 Lp(a) and Waist-to-Hip Ratio, Video: https://youtu.be/UOtYZ0ZSp24 DescriptionDecades of cardiovascular research have focused on LDL cholesterol as the primary driver of atherosclerosis, yet even individuals with “optimal” LDL often develop arterial plaque. In this video, we examine the limitations of LDL-centric models and highlight why single-biomarker approaches can misrepresent true cardiovascular risk.We break down recent cohort studies, explore critiques of the data, and discuss why broader metabolic factors—insulin resistance, inflammation, triglyceride levels, and visceral adiposity—provide a more complete picture of heart health. Finally, we provide framework for tracking biomarkers that better reflect systemic cardiovascular risk.Chapters0:00 – Low Cholesterol Isn’t Enough2:00 – Roadmap to this Video2:23 – Chapter 1: What Happens When LDL Cholesterol is “Optimal?”5:00 – Chapter 2: What the Critics Say About the Data7:17 – Chapters 3: What I Am—and Am Not—Saying9:23 – Chapter 4: Why Is This Personal? 11:00 – Chapter 5: The “Not Low Enough” Trap in Conventional Cardiology13:44 – Chapter 6: Science-Based Biomarkers to Track for Heart Health#HeartHealth #LDLCholesterol #Atherosclerosis #MetabolicHealth #InsulinResistance #Statins #CholesterolMyths #CardiovascularRisk #HealthEducation #NickNorwitz #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 14 Sep 2026 16:46:00 -0000 full Nick Norwitz MD PhD For all the references, extra nuance and early access to content like this, join the Best-Selling in Science StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/beyond-ldl-rethinking-cardiovascular?r=40ekz2 Referenced ContentMasterclass on Cholesterol-Lowering Medications, Letter: https://staycuriousmetabolism.substack.com/p/a-concise-masterclass-on-cholesterol?r=40ekz2 Statins Slash GLP-1, Video: https://youtu.be/6NomrgjK1yQ Statins Harms Mitochondria, Video: https://youtu.be/qHXMI3DudEc What Statin Trials Really Show, Video: https://youtu.be/Y3JKgfKqiBQ Statins Associated with Muscle Loss, Letter: https://staycuriousmetabolism.substack.com/p/a-doctor-texted-me-im-stopping-my?r=40ekz2 Lp(a) and Waist-to-Hip Ratio, Video: https://youtu.be/UOtYZ0ZSp24 DescriptionDecades of cardiovascular research have focused on LDL cholesterol as the primary driver of atherosclerosis, yet even individuals with “optimal” LDL often develop arterial plaque. In this video, we examine the limitations of LDL-centric models and highlight why single-biomarker approaches can misrepresent true cardiovascular risk.We break down recent cohort studies, explore critiques of the data, and discuss why broader metabolic factors—insulin resistance, inflammation, triglyceride levels, and visceral adiposity—provide a more complete picture of heart health. Finally, we provide framework for tracking biomarkers that better reflect systemic cardiovascular risk.Chapters0:00 – Low Cholesterol Isn’t Enough2:00 – Roadmap to this Video2:23 – Chapter 1: What Happens When LDL Cholesterol is “Optimal?”5:00 – Chapter 2: What the Critics Say About the Data7:17 – Chapters 3: What I Am—and Am Not—Saying9:23 – Chapter 4: Why Is This Personal? 11:00 – Chapter 5: The “Not Low Enough” Trap in Conventional Cardiology13:44 – Chapter 6: Science-Based Biomarkers to Track for Heart Health#HeartHealth #LDLCholesterol #Atherosclerosis #MetabolicHealth #InsulinResistance #Statins #CholesterolMyths #CardiovascularRisk #HealthEducation #NickNorwitz #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For all the references, extra nuance and early access to content like this, join the Best-Selling in Science StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/beyond-ldl-rethinking-cardiovascular?r=40ekz2

Referenced Content
Masterclass on Cholesterol-Lowering Medications, Letter: https://staycuriousmetabolism.substack.com/p/a-concise-masterclass-on-cholesterol?r=40ekz2

Statins Slash GLP-1, Video: https://youtu.be/6NomrgjK1yQ

Statins Harms Mitochondria, Video: https://youtu.be/qHXMI3DudEc

What Statin Trials Really Show, Video: https://youtu.be/Y3JKgfKqiBQ

Statins Associated with Muscle Loss, Letter: https://staycuriousmetabolism.substack.com/p/a-doctor-texted-me-im-stopping-my?r=40ekz2

Lp(a) and Waist-to-Hip Ratio, Video: https://youtu.be/UOtYZ0ZSp24

Description
Decades of cardiovascular research have focused on LDL cholesterol as the primary driver of atherosclerosis, yet even individuals with “optimal” LDL often develop arterial plaque. In this video, we examine the limitations of LDL-centric models and highlight why single-biomarker approaches can misrepresent true cardiovascular risk.

We break down recent cohort studies, explore critiques of the data, and discuss why broader metabolic factors—insulin resistance, inflammation, triglyceride levels, and visceral adiposity—provide a more complete picture of heart health. Finally, we provide framework for tracking biomarkers that better reflect systemic cardiovascular risk.

Chapters
0:00 – Low Cholesterol Isn’t Enough
2:00 – Roadmap to this Video
2:23 – Chapter 1: What Happens When LDL Cholesterol is “Optimal?”
5:00 – Chapter 2: What the Critics Say About the Data
7:17 – Chapters 3: What I Am—and Am Not—Saying
9:23 – Chapter 4: Why Is This Personal?
11:00 – Chapter 5: The “Not Low Enough” Trap in Conventional Cardiology
13:44 – Chapter 6: Science-Based Biomarkers to Track for Heart Health

#HeartHealth #LDLCholesterol #Atherosclerosis #MetabolicHealth #InsulinResistance #Statins #CholesterolMyths #CardiovascularRisk #HealthEducation #NickNorwitz #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1391 no THIS is Why There is Confusion about Lean Mass Hyper-Responders with high LDL on Ketogenic Diets Chapters 0:00 -- Introduction, 3 goals 1:02 -- Part 1, Defining LMHR 4:10 -- Part 2, LDL-C and ASCVD risk 9:00 - Point 3, Why the Confusion?25:22 -- Conclusion Part 3 features: Spencer Nadolsky, Layne Norton, Mohammed Alo, Thomas DayspringVideos: LDL lowering: https://youtu.be/-HZEjnw4WTs Response to Layne Norton: https://youtu.be/yiq67wpUhIs Meta of RCTs: https://youtu.be/FcUUqGJBXFM OreoVsStatin: https://youtu.be/L1mMnnyJrgk Discussion on PlantChompers: https://youtu.be/4KYsa7zG9TE?si=9lmyOCGfbsciDgBx Discussion on Physionic: https://youtu.be/08IFnuWiltA?si=9nesI7XZ921UhdBa TheProof with Dave and William Cromwell: https://youtu.be/gfzxnz1sdi0?si=3HAEh60fGu2gwcaJ Paper References Meta of RCTs https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltext OreoVsStatin https://pubmed.ncbi.nlm.nih.gov/38276308/ Lipid Energy Modelhttps://pubmed.ncbi.nlm.nih.gov/35629964/ LMHR paper in CDN https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext JCL Editorial https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltext Cooper et al. BMI, Thyroid, LMHR https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768172/ LDLR in mice in ketosis https://pubmed.ncbi.nlm.nih.gov/26498829/ LDLR in humans on LCHF https://pubmed.ncbi.nlm.nih.gov/30408717/ Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 13 Sep 2026 22:46:00 -0000 full Nick Norwitz MD PhD Chapters 0:00 -- Introduction, 3 goals 1:02 -- Part 1, Defining LMHR 4:10 -- Part 2, LDL-C and ASCVD risk 9:00 - Point 3, Why the Confusion?25:22 -- Conclusion Part 3 features: Spencer Nadolsky, Layne Norton, Mohammed Alo, Thomas DayspringVideos: LDL lowering: https://youtu.be/-HZEjnw4WTs Response to Layne Norton: https://youtu.be/yiq67wpUhIs Meta of RCTs: https://youtu.be/FcUUqGJBXFM OreoVsStatin: https://youtu.be/L1mMnnyJrgk Discussion on PlantChompers: https://youtu.be/4KYsa7zG9TE?si=9lmyOCGfbsciDgBx Discussion on Physionic: https://youtu.be/08IFnuWiltA?si=9nesI7XZ921UhdBa TheProof with Dave and William Cromwell: https://youtu.be/gfzxnz1sdi0?si=3HAEh60fGu2gwcaJ Paper References Meta of RCTs https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltext OreoVsStatin https://pubmed.ncbi.nlm.nih.gov/38276308/ Lipid Energy Modelhttps://pubmed.ncbi.nlm.nih.gov/35629964/ LMHR paper in CDN https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext JCL Editorial https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltext Cooper et al. BMI, Thyroid, LMHR https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768172/ LDLR in mice in ketosis https://pubmed.ncbi.nlm.nih.gov/26498829/ LDLR in humans on LCHF https://pubmed.ncbi.nlm.nih.gov/30408717/ Learn more about your ad choices. Visit megaphone.fm/adchoices Chapters
0:00 -- Introduction, 3 goals
1:02 -- Part 1, Defining LMHR
4:10 -- Part 2, LDL-C and ASCVD risk
9:00 - Point 3, Why the Confusion?
25:22 -- Conclusion

Part 3 features: Spencer Nadolsky, Layne Norton, Mohammed Alo, Thomas Dayspring

Videos:
LDL lowering: https://youtu.be/-HZEjnw4WTs
Response to Layne Norton: https://youtu.be/yiq67wpUhIs
Meta of RCTs: https://youtu.be/FcUUqGJBXFM
OreoVsStatin: https://youtu.be/L1mMnnyJrgk
Discussion on PlantChompers: https://youtu.be/4KYsa7zG9TE?si=9lmyOCGfbsciDgBx
Discussion on Physionic: https://youtu.be/08IFnuWiltA?si=9nesI7XZ921UhdBa
TheProof with Dave and William Cromwell: https://youtu.be/gfzxnz1sdi0?si=3HAEh60fGu2gwcaJ

Paper References
Meta of RCTs
https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltext
OreoVsStatin
https://pubmed.ncbi.nlm.nih.gov/38276308/
Lipid Energy Model
https://pubmed.ncbi.nlm.nih.gov/35629964/
LMHR paper in CDN
https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext
JCL Editorial
https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltext
Cooper et al. BMI, Thyroid, LMHR https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768172/
LDLR in mice in ketosis
https://pubmed.ncbi.nlm.nih.gov/26498829/
LDLR in humans on LCHF
https://pubmed.ncbi.nlm.nih.gov/30408717/

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]]> 2013 no Muscle is Not What We Thought (ft’ Dr Gabrielle Lyon) If you’re interested in getting Dr Gabrielle Lyon’s Forever Stronger Playbook, check it out here: https://drgabriellelyon.com/playbook/You can also win one of 5 signed copies if you’re a premium StayCurious Metabolism subscriber and you read and leave a thoughtful comment at this Protein Paradox Letter:mTOR Muscle Paradox Letter: https://staycuriousmetabolism.substack.com/p/the-aging-muscle-paradox-how-to-keep?r=40ekz2 Molecular Choreography of Acute Exercise, Interview with Michael Snyder: https://youtu.be/_9ywulQF2Ho Description:Skeletal muscle isn’t just about strength or aesthetics. In this video, we break down why muscle quality may be one of the most underappreciated determinants of long-term health, and why it’s never too late to start building it.We unpack a core idea that reframes modern metabolic disease: healthy skeletal muscle can be more important than a “healthy weight,” not the other way around. From muscle’s role in glucose disposal and fat oxidation to its signaling effects on the brain, immune system, and mitochondria, muscle emerges as a central regulator of whole-body health.We also explore emerging concerns and controversies—GLP-1 drugs and sarcopenia risk, the mTOR “muscle paradox,” protein intake in light of new dietary guidelines, and how exercise-induced myokines drive inter-organ communication with implications for Alzheimer’s disease and aging.Chapters0:00 – Introducing Muscle as a Health Insurance Policy2:45 – The #1 Misconception About Muscle: It’s Too Late to Start3:11 – Understanding the Nuances of Body Fat vs Muscle Quality6:40 – Markers of Unhealthy Skeletal Muscle Mass8:33 – “Obesity is Secondary to Unhealthy Skeletal Muscle” 9:53 – Exercise, Muscle, NAD and Alzheimer’s Disease13:56 – Myokines, Interorgan Crosstalk and Precision Exercise 19:20 – Are GLP-1s Going to Create a Sarcopenic Crisis?26:16 – mTOR Muscle Paradox and Surprise Giveaway29:32 – Data Over Feelings and a Moment of Creator Transparency 31:20 – The Discussion of Protein Intake Based on New Dietary Guidelines39:00 – Rapid Fire Question: MVP Protein, Junk Protein, Best Exercises, and More#Exercise #Muscle #GabrielleLyon #BodyFat #iMAD #Lonngevity #Health #Insulin #InsulinResistance #Diabetes #GLP1 #NickNorwitz #Myokines #SkeletalMuscle #MuscleMass #BrainHealth #NAD #MetabolicSyndrome #Interview #PushUps #Obesity #WeightLoss #BDNF #Endocrinology #Alzheimer #PrecisionExercise #Neuroscience #DietaryGuidelines #Protein #ProteinIntake #Macrophages #Inflammation #Immunity #ScienceBased #EvidenceBased #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 13 Sep 2026 04:46:00 -0000 full Nick Norwitz MD PhD If you’re interested in getting Dr Gabrielle Lyon’s Forever Stronger Playbook, check it out here: https://drgabriellelyon.com/playbook/You can also win one of 5 signed copies if you’re a premium StayCurious Metabolism subscriber and you read and leave a thoughtful comment at this Protein Paradox Letter:mTOR Muscle Paradox Letter: https://staycuriousmetabolism.substack.com/p/the-aging-muscle-paradox-how-to-keep?r=40ekz2 Molecular Choreography of Acute Exercise, Interview with Michael Snyder: https://youtu.be/_9ywulQF2Ho Description:Skeletal muscle isn’t just about strength or aesthetics. In this video, we break down why muscle quality may be one of the most underappreciated determinants of long-term health, and why it’s never too late to start building it.We unpack a core idea that reframes modern metabolic disease: healthy skeletal muscle can be more important than a “healthy weight,” not the other way around. From muscle’s role in glucose disposal and fat oxidation to its signaling effects on the brain, immune system, and mitochondria, muscle emerges as a central regulator of whole-body health.We also explore emerging concerns and controversies—GLP-1 drugs and sarcopenia risk, the mTOR “muscle paradox,” protein intake in light of new dietary guidelines, and how exercise-induced myokines drive inter-organ communication with implications for Alzheimer’s disease and aging.Chapters0:00 – Introducing Muscle as a Health Insurance Policy2:45 – The #1 Misconception About Muscle: It’s Too Late to Start3:11 – Understanding the Nuances of Body Fat vs Muscle Quality6:40 – Markers of Unhealthy Skeletal Muscle Mass8:33 – “Obesity is Secondary to Unhealthy Skeletal Muscle” 9:53 – Exercise, Muscle, NAD and Alzheimer’s Disease13:56 – Myokines, Interorgan Crosstalk and Precision Exercise 19:20 – Are GLP-1s Going to Create a Sarcopenic Crisis?26:16 – mTOR Muscle Paradox and Surprise Giveaway29:32 – Data Over Feelings and a Moment of Creator Transparency 31:20 – The Discussion of Protein Intake Based on New Dietary Guidelines39:00 – Rapid Fire Question: MVP Protein, Junk Protein, Best Exercises, and More#Exercise #Muscle #GabrielleLyon #BodyFat #iMAD #Lonngevity #Health #Insulin #InsulinResistance #Diabetes #GLP1 #NickNorwitz #Myokines #SkeletalMuscle #MuscleMass #BrainHealth #NAD #MetabolicSyndrome #Interview #PushUps #Obesity #WeightLoss #BDNF #Endocrinology #Alzheimer #PrecisionExercise #Neuroscience #DietaryGuidelines #Protein #ProteinIntake #Macrophages #Inflammation #Immunity #ScienceBased #EvidenceBased #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices If you’re interested in getting Dr Gabrielle Lyon’s Forever Stronger Playbook, check it out here: https://drgabriellelyon.com/playbook/

You can also win one of 5 signed copies if you’re a premium StayCurious Metabolism subscriber and you read and leave a thoughtful comment at this Protein Paradox Letter:

mTOR Muscle Paradox Letter: https://staycuriousmetabolism.substack.com/p/the-aging-muscle-paradox-how-to-keep?r=40ekz2

Molecular Choreography of Acute Exercise, Interview with Michael Snyder: https://youtu.be/_9ywulQF2Ho

Description:
Skeletal muscle isn’t just about strength or aesthetics. In this video, we break down why muscle quality may be one of the most underappreciated determinants of long-term health, and why it’s never too late to start building it.

We unpack a core idea that reframes modern metabolic disease: healthy skeletal muscle can be more important than a “healthy weight,” not the other way around. From muscle’s role in glucose disposal and fat oxidation to its signaling effects on the brain, immune system, and mitochondria, muscle emerges as a central regulator of whole-body health.

We also explore emerging concerns and controversies—GLP-1 drugs and sarcopenia risk, the mTOR “muscle paradox,” protein intake in light of new dietary guidelines, and how exercise-induced myokines drive inter-organ communication with implications for Alzheimer’s disease and aging.

Chapters
0:00 – Introducing Muscle as a Health Insurance Policy
2:45 – The #1 Misconception About Muscle: It’s Too Late to Start
3:11 – Understanding the Nuances of Body Fat vs Muscle Quality
6:40 – Markers of Unhealthy Skeletal Muscle Mass
8:33 – “Obesity is Secondary to Unhealthy Skeletal Muscle”
9:53 – Exercise, Muscle, NAD and Alzheimer’s Disease
13:56 – Myokines, Interorgan Crosstalk and Precision Exercise
19:20 – Are GLP-1s Going to Create a Sarcopenic Crisis?
26:16 – mTOR Muscle Paradox and Surprise Giveaway
29:32 – Data Over Feelings and a Moment of Creator Transparency
31:20 – The Discussion of Protein Intake Based on New Dietary Guidelines
39:00 – Rapid Fire Question: MVP Protein, Junk Protein, Best Exercises, and More

#Exercise #Muscle #GabrielleLyon #BodyFat #iMAD #Lonngevity #Health #Insulin #InsulinResistance #Diabetes #GLP1 #NickNorwitz #Myokines #SkeletalMuscle #MuscleMass #BrainHealth #NAD #MetabolicSyndrome #Interview #PushUps #Obesity #WeightLoss #BDNF #Endocrinology #Alzheimer #PrecisionExercise #Neuroscience #DietaryGuidelines #Protein #ProteinIntake #Macrophages #Inflammation #Immunity #ScienceBased #EvidenceBased #StayCurious

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]]> 3279 no NEW Anti-Aging Science: Crazy Immortal Multi-Millionaire Bryan Johnson Was Right!? Nature Aging Paper (April 2024): https://www.nature.com/articles/s43587-024-00612-4Trevor Noah Podcast with Bryan Johnson: https://open.spotify.com/episode/1CT74C37OYKFC7GZpHMhjh SocialsTwitter: @nicknorwitzInstagram (I’m new!): @nicknorwitzPhD0:00 – Intro, Bryan Johnson the Anti-Aging Millionaire1:20 – small Extracellular Vesicles (sEV) Chronic Benefits 4:10 – sEV Acute Anti-Aging Benefits 6:14 – sEVs and mitochondrial health7:18 – Young human sEV to aged mice8:02 – sEV contents include microRNA that boost PGC1alpha10:05 – Pause and reflect on this…10:38 – Bryan Johnson Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 12 Sep 2026 10:46:00 -0000 full Nick Norwitz MD PhD Nature Aging Paper (April 2024): https://www.nature.com/articles/s43587-024-00612-4Trevor Noah Podcast with Bryan Johnson: https://open.spotify.com/episode/1CT74C37OYKFC7GZpHMhjh SocialsTwitter: @nicknorwitzInstagram (I’m new!): @nicknorwitzPhD0:00 – Intro, Bryan Johnson the Anti-Aging Millionaire1:20 – small Extracellular Vesicles (sEV) Chronic Benefits 4:10 – sEV Acute Anti-Aging Benefits 6:14 – sEVs and mitochondrial health7:18 – Young human sEV to aged mice8:02 – sEV contents include microRNA that boost PGC1alpha10:05 – Pause and reflect on this…10:38 – Bryan Johnson Learn more about your ad choices. Visit megaphone.fm/adchoices Nature Aging Paper (April 2024): https://www.nature.com/articles/s43587-024-00612-4

Trevor Noah Podcast with Bryan Johnson: https://open.spotify.com/episode/1CT74C37OYKFC7GZpHMhjh

Socials
Twitter: @nicknorwitz
Instagram (I’m new!): @nicknorwitzPhD

0:00 – Intro, Bryan Johnson the Anti-Aging Millionaire
1:20 – small Extracellular Vesicles (sEV) Chronic Benefits
4:10 – sEV Acute Anti-Aging Benefits
6:14 – sEVs and mitochondrial health
7:18 – Young human sEV to aged mice
8:02 – sEV contents include microRNA that boost PGC1alpha
10:05 – Pause and reflect on this…
10:38 – Bryan Johnson

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]]> 1130 no Protein Maxing and the Illusion of Nutrition Progress For extra details and references, see the StayCurious Newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/protein-maxing-david-bar-and-the?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true We have entered the era of Protein Maxing. From protein ice cream to protein chips, culture has swung the pendulum from low-fat to high-protein. But one product has climbed to the top of the food chain: The David Bar.This product is a case study in marketing genius and chemical engineering. But how do you create a shelf-stable bar that tastes like a candy bar (maybe…) but has the macros of a chicken breast?In this video, I break down the science behind the ingredients that make this possible and explore why the internet is so split on David Bar. Chapters0:00 – Intro: PROTEIN 1:16 – Roadmap to this Video2:25 – Chapter 1. Era of Protein Maxin4:49 – Chapter 2. Case Study in Marketing Genius7:58 – Chapter 3. Formulation and Ingredients 12:59 – Chapter 4. The Big EPG Controversy16:43 – Chapter 5. Taste Test and Other Options#DavidBar #Protein #NutritionScience #MetabolicHealth #EPG #Maltitol #GutHealth #ProteinMaxing #NickNorwitz #StayCurious #Biohacking #FoodIndustry #Supplements #CleanEating #Keto #LowCarb #PeterRahal #FoodScience #InsulinResistance #Microbiome Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 11 Sep 2026 16:46:00 -0000 full Nick Norwitz MD PhD For extra details and references, see the StayCurious Newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/protein-maxing-david-bar-and-the?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true We have entered the era of Protein Maxing. From protein ice cream to protein chips, culture has swung the pendulum from low-fat to high-protein. But one product has climbed to the top of the food chain: The David Bar.This product is a case study in marketing genius and chemical engineering. But how do you create a shelf-stable bar that tastes like a candy bar (maybe…) but has the macros of a chicken breast?In this video, I break down the science behind the ingredients that make this possible and explore why the internet is so split on David Bar. Chapters0:00 – Intro: PROTEIN 1:16 – Roadmap to this Video2:25 – Chapter 1. Era of Protein Maxin4:49 – Chapter 2. Case Study in Marketing Genius7:58 – Chapter 3. Formulation and Ingredients 12:59 – Chapter 4. The Big EPG Controversy16:43 – Chapter 5. Taste Test and Other Options#DavidBar #Protein #NutritionScience #MetabolicHealth #EPG #Maltitol #GutHealth #ProteinMaxing #NickNorwitz #StayCurious #Biohacking #FoodIndustry #Supplements #CleanEating #Keto #LowCarb #PeterRahal #FoodScience #InsulinResistance #Microbiome Learn more about your ad choices. Visit megaphone.fm/adchoices For extra details and references, see the StayCurious Newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/protein-maxing-david-bar-and-the?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

We have entered the era of Protein Maxing. From protein ice cream to protein chips, culture has swung the pendulum from low-fat to high-protein. But one product has climbed to the top of the food chain: The David Bar.

This product is a case study in marketing genius and chemical engineering. But how do you create a shelf-stable bar that tastes like a candy bar (maybe…) but has the macros of a chicken breast?

In this video, I break down the science behind the ingredients that make this possible and explore why the internet is so split on David Bar.

Chapters
0:00 – Intro: PROTEIN
1:16 – Roadmap to this Video
2:25 – Chapter 1. Era of Protein Maxin
4:49 – Chapter 2. Case Study in Marketing Genius
7:58 – Chapter 3. Formulation and Ingredients
12:59 – Chapter 4. The Big EPG Controversy
16:43 – Chapter 5. Taste Test and Other Options

#DavidBar #Protein #NutritionScience #MetabolicHealth #EPG #Maltitol #GutHealth #ProteinMaxing #NickNorwitz #StayCurious #Biohacking #FoodIndustry #Supplements #CleanEating #Keto #LowCarb #PeterRahal #FoodScience #InsulinResistance #Microbiome

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1494 no Modern healthcare is broken, why do we still use it? 0:00 – Introduction 1:28 – Research Business Model(s): Drugs vs Metabolic Health4:01 – Absence of evidence isn’t evidence of absence 4:54 – Social Food Norms6:02 – Research, Food and Social ecosystem 6:36 – Solutions Goofy Math600 Billion / 10 million = 60,000- Cairo Spiney Mouse, ~1.5 oz - Adult Hippo, ~1.5 tons ea (X2)~6000 lbs / (1.5 oz/16oz/lb) = 64,000 Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 10 Sep 2026 22:46:00 -0000 full Nick Norwitz MD PhD 0:00 – Introduction 1:28 – Research Business Model(s): Drugs vs Metabolic Health4:01 – Absence of evidence isn’t evidence of absence 4:54 – Social Food Norms6:02 – Research, Food and Social ecosystem 6:36 – Solutions Goofy Math600 Billion / 10 million = 60,000- Cairo Spiney Mouse, ~1.5 oz - Adult Hippo, ~1.5 tons ea (X2)~6000 lbs / (1.5 oz/16oz/lb) = 64,000 Learn more about your ad choices. Visit megaphone.fm/adchoices 0:00 – Introduction
1:28 – Research Business Model(s): Drugs vs Metabolic Health
4:01 – Absence of evidence isn’t evidence of absence
4:54 – Social Food Norms
6:02 – Research, Food and Social ecosystem
6:36 – Solutions

Goofy Math
600 Billion / 10 million = 60,000
- Cairo Spiney Mouse, ~1.5 oz
- Adult Hippo, ~1.5 tons ea (X2)
~6000 lbs / (1.5 oz/16oz/lb) = 64,000

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]]> 620 no The Great Carb Con: Scientists Break Down a Shocking New Study For a written breakdown and key references, see the associated letter: https://open.substack.com/pub/staycuriousmetabolism/p/the-carb-loading-myth-is-finally?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Paper: https://academic.oup.com/edrv/advance-article/doi/10.1210/endrev/bnaf038/8432248?login=falseDescription:Do you really need to carb-load for peak performance, or is that just sports nutrition inertia?In this conversation, Nick sits down with Dr. Andrew Koutnik to break down a new meta-analysis of randomized controlled trials challenging the classic “you need carbs for performance” narrative. The key twist is that the strongest predictor of fatigue across studies isn’t muscle glycogen, but a subtle drop in blood glucose and overall brain fuel. You’ll learn where the carb-loading doctrine came from, what the original studies missed, why glycogen/performance links were largely associative rather than causal, and how the “brain energy” model (glucose, ketones, and lactate) explains fatigue more cleanly. We also get into real-world implications, including why tiny intakes like ~10 g carbs/hour may capture the performance benefit seen with far higher recommendations, and why some endurance athletes drift toward prediabetes despite elite fitness—plus how precision fueling may help protect health without sacrificing performance.For references and deeper notes, check the Stay Curious newsletter linked above.Chapter:0:00 – Carbs for Performance: Essential or Overhyped?1:46 – New Meta-Analysis Challenges Carb-Loading Dogma3:56 – Where the Carb-Loading Idea Actually Came From5:52 – Glycogen and Carb-Burning: Correlation, Not Causation9:16 – The Missing Variable: Blood Sugar, Brain Fuel, and Fatigue12:28 – Pasta vs Grapes: How Little Fuel May Matter16:34 – The Causal Case: Brain Energy Deficit → Performance Drop21:33 – The “10g/Hour” Rule: How Much Carbs You Really Need26:22 – When Carbs Help (and When They Don’t)27:26 – Keto vs High-Carb Athletes: Same Performance, Different Fuel29:46 – Mind Over Muscle: The Brain-Energy Model of Endurance34:30 – The Metabolic Cost: High-Carb Athlete Diets and Prediabetes Risk38:20 – What to Study Next: Dose-Response + Tracer Studies#SportsNutrition #EnduranceTraining #CarbLoading #MetabolicHealth #BloodSugar #KetoAthlete #PerformanceScience #ExercisePhysiology #Triathlon #VO2max #GlucoseControl #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 10 Sep 2026 04:46:00 -0000 full Nick Norwitz MD PhD For a written breakdown and key references, see the associated letter: https://open.substack.com/pub/staycuriousmetabolism/p/the-carb-loading-myth-is-finally?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Paper: https://academic.oup.com/edrv/advance-article/doi/10.1210/endrev/bnaf038/8432248?login=falseDescription:Do you really need to carb-load for peak performance, or is that just sports nutrition inertia?In this conversation, Nick sits down with Dr. Andrew Koutnik to break down a new meta-analysis of randomized controlled trials challenging the classic “you need carbs for performance” narrative. The key twist is that the strongest predictor of fatigue across studies isn’t muscle glycogen, but a subtle drop in blood glucose and overall brain fuel. You’ll learn where the carb-loading doctrine came from, what the original studies missed, why glycogen/performance links were largely associative rather than causal, and how the “brain energy” model (glucose, ketones, and lactate) explains fatigue more cleanly. We also get into real-world implications, including why tiny intakes like ~10 g carbs/hour may capture the performance benefit seen with far higher recommendations, and why some endurance athletes drift toward prediabetes despite elite fitness—plus how precision fueling may help protect health without sacrificing performance.For references and deeper notes, check the Stay Curious newsletter linked above.Chapter:0:00 – Carbs for Performance: Essential or Overhyped?1:46 – New Meta-Analysis Challenges Carb-Loading Dogma3:56 – Where the Carb-Loading Idea Actually Came From5:52 – Glycogen and Carb-Burning: Correlation, Not Causation9:16 – The Missing Variable: Blood Sugar, Brain Fuel, and Fatigue12:28 – Pasta vs Grapes: How Little Fuel May Matter16:34 – The Causal Case: Brain Energy Deficit → Performance Drop21:33 – The “10g/Hour” Rule: How Much Carbs You Really Need26:22 – When Carbs Help (and When They Don’t)27:26 – Keto vs High-Carb Athletes: Same Performance, Different Fuel29:46 – Mind Over Muscle: The Brain-Energy Model of Endurance34:30 – The Metabolic Cost: High-Carb Athlete Diets and Prediabetes Risk38:20 – What to Study Next: Dose-Response + Tracer Studies#SportsNutrition #EnduranceTraining #CarbLoading #MetabolicHealth #BloodSugar #KetoAthlete #PerformanceScience #ExercisePhysiology #Triathlon #VO2max #GlucoseControl #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For a written breakdown and key references, see the associated letter: https://open.substack.com/pub/staycuriousmetabolism/p/the-carb-loading-myth-is-finally?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Paper: https://academic.oup.com/edrv/advance-article/doi/10.1210/endrev/bnaf038/8432248?login=false

Description:
Do you really need to carb-load for peak performance, or is that just sports nutrition inertia?
In this conversation, Nick sits down with Dr. Andrew Koutnik to break down a new meta-analysis of randomized controlled trials challenging the classic “you need carbs for performance” narrative. The key twist is that the strongest predictor of fatigue across studies isn’t muscle glycogen, but a subtle drop in blood glucose and overall brain fuel.

You’ll learn where the carb-loading doctrine came from, what the original studies missed, why glycogen/performance links were largely associative rather than causal, and how the “brain energy” model (glucose, ketones, and lactate) explains fatigue more cleanly.

We also get into real-world implications, including why tiny intakes like ~10 g carbs/hour may capture the performance benefit seen with far higher recommendations, and why some endurance athletes drift toward prediabetes despite elite fitness—plus how precision fueling may help protect health without sacrificing performance.

For references and deeper notes, check the Stay Curious newsletter linked above.

Chapter:
0:00 – Carbs for Performance: Essential or Overhyped?
1:46 – New Meta-Analysis Challenges Carb-Loading Dogma
3:56 – Where the Carb-Loading Idea Actually Came From
5:52 – Glycogen and Carb-Burning: Correlation, Not Causation
9:16 – The Missing Variable: Blood Sugar, Brain Fuel, and Fatigue
12:28 – Pasta vs Grapes: How Little Fuel May Matter
16:34 – The Causal Case: Brain Energy Deficit → Performance Drop
21:33 – The “10g/Hour” Rule: How Much Carbs You Really Need
26:22 – When Carbs Help (and When They Don’t)
27:26 – Keto vs High-Carb Athletes: Same Performance, Different Fuel
29:46 – Mind Over Muscle: The Brain-Energy Model of Endurance
34:30 – The Metabolic Cost: High-Carb Athlete Diets and Prediabetes Risk
38:20 – What to Study Next: Dose-Response + Tracer Studies

#SportsNutrition #EnduranceTraining #CarbLoading #MetabolicHealth #BloodSugar #KetoAthlete #PerformanceScience #ExercisePhysiology #Triathlon #VO2max #GlucoseControl #StayCurious

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]]> 2899 no Brain-Body Immune Axis Controls Inflammatory Response Paper: https://www.nature.com/articles/s41586-024-07469-yChapters0:00 – Introduction0:48 – Inflammatory insult activates cNST2:20 – Vagus nerve signals to CNS2:44 – Look! I’m green!3:42 – cNST controls immune response5:34 – Two Vagus Tracks6:26 – Closing Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 09 Sep 2026 10:46:00 -0000 full Nick Norwitz MD PhD Paper: https://www.nature.com/articles/s41586-024-07469-yChapters0:00 – Introduction0:48 – Inflammatory insult activates cNST2:20 – Vagus nerve signals to CNS2:44 – Look! I’m green!3:42 – cNST controls immune response5:34 – Two Vagus Tracks6:26 – Closing Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://www.nature.com/articles/s41586-024-07469-y

Chapters
0:00 – Introduction
0:48 – Inflammatory insult activates cNST
2:20 – Vagus nerve signals to CNS
2:44 – Look! I’m green!
3:42 – cNST controls immune response
5:34 – Two Vagus Tracks
6:26 – Closing

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]]> 613 no Sardines and Seed Oils: The Controversy is Heating Up Professor Bill Harris, Part 1 Interview: https://youtu.be/rZT4Y6T_0Vc Related LettersBreakdown of the Famous Minnesota Coronary Experiment: https://open.substack.com/pub/staycuriousmetabolism/p/lowering-cholesterol-killed-a-study?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Molecular Choreograph of Acute Exercise Breakdown: https://staycuriousmetabolism.substack.com/p/the-art-of-a-heartbeat-one-of-the?r=40ekz2 Cold Resistance Breakdown: https://staycuriousmetabolism.substack.com/p/the-weird-anti-insulin-hormone-that?r=40ekz2 If you want to get your Omega-3 via Omega Quant, click on this link: https://omegaquant.com/ref/864Discount Code: NickNorwitz for 10% offFatty Acid Research Institute: https://www.faresinst.org Related VideosSardine Diet Video: https://youtu.be/_Th54GWd8WY Cold Resistance Video: https://youtu.be/x5ndOr1ZQ2s Description:Enter Part 2 of my deep-dive with Professor William “Bill” Harris—world expert on omega-3 and omega-6 fats and creator of the Omega-3 Index. We get into the “seed oils” controversy and then… we go full sardine-mode! We discuss the dolphin-like omega-3 index and what it might mean, why I became cold-resistance, and the side effect that almost ended my relationship. Chapters0:00 – Meet World Expert in Omega Fats, Professor Harris1:28 – Seed Oil Controversy: Processed Oils vs Omega-6 and Linoleic Acid4:40 – The Norway Study: Oxidation of Fish Oils7:27 – Minnesota Coronary Experiment (See Link)8:55 – Seed Oils are Everywhere, Especially Processed Foods10:54 – Omega-6 Vulnerability Hypothesis 13:59 – Prostaglandins, Thromboxane, Prostacyclin, Oxylipins, SPMs16:26 – Molecular Choreograph of Acute Exercise 18:30 – Professor Harris Reacts to 1000 Sardines in a Month! 25:10 – The Omega-3 Underwear Experiment 26:36 – FDA Warnings on Maternal Fish Intake. Valid or Harmful?30:10 – The Future of Omega-3 Research#omega3 #omega6 #seedoils #linoleicacid #fishoil #EPA #DHA #omega3index #sardines #mercury #pregnancyhealth #cardiovascularhealth #nutritionscience #metabolichealth #inflammation #oxylipins #SPMs #prostaglandins #processedfoods #evidencebasednutrition #staycurious #nicknorwitz #billharris #omegaquant Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 08 Sep 2026 16:46:00 -0000 full Nick Norwitz MD PhD Professor Bill Harris, Part 1 Interview: https://youtu.be/rZT4Y6T_0Vc Related LettersBreakdown of the Famous Minnesota Coronary Experiment: https://open.substack.com/pub/staycuriousmetabolism/p/lowering-cholesterol-killed-a-study?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Molecular Choreograph of Acute Exercise Breakdown: https://staycuriousmetabolism.substack.com/p/the-art-of-a-heartbeat-one-of-the?r=40ekz2 Cold Resistance Breakdown: https://staycuriousmetabolism.substack.com/p/the-weird-anti-insulin-hormone-that?r=40ekz2 If you want to get your Omega-3 via Omega Quant, click on this link: https://omegaquant.com/ref/864Discount Code: NickNorwitz for 10% offFatty Acid Research Institute: https://www.faresinst.org Related VideosSardine Diet Video: https://youtu.be/_Th54GWd8WY Cold Resistance Video: https://youtu.be/x5ndOr1ZQ2s Description:Enter Part 2 of my deep-dive with Professor William “Bill” Harris—world expert on omega-3 and omega-6 fats and creator of the Omega-3 Index. We get into the “seed oils” controversy and then… we go full sardine-mode! We discuss the dolphin-like omega-3 index and what it might mean, why I became cold-resistance, and the side effect that almost ended my relationship. Chapters0:00 – Meet World Expert in Omega Fats, Professor Harris1:28 – Seed Oil Controversy: Processed Oils vs Omega-6 and Linoleic Acid4:40 – The Norway Study: Oxidation of Fish Oils7:27 – Minnesota Coronary Experiment (See Link)8:55 – Seed Oils are Everywhere, Especially Processed Foods10:54 – Omega-6 Vulnerability Hypothesis 13:59 – Prostaglandins, Thromboxane, Prostacyclin, Oxylipins, SPMs16:26 – Molecular Choreograph of Acute Exercise 18:30 – Professor Harris Reacts to 1000 Sardines in a Month! 25:10 – The Omega-3 Underwear Experiment 26:36 – FDA Warnings on Maternal Fish Intake. Valid or Harmful?30:10 – The Future of Omega-3 Research#omega3 #omega6 #seedoils #linoleicacid #fishoil #EPA #DHA #omega3index #sardines #mercury #pregnancyhealth #cardiovascularhealth #nutritionscience #metabolichealth #inflammation #oxylipins #SPMs #prostaglandins #processedfoods #evidencebasednutrition #staycurious #nicknorwitz #billharris #omegaquant Learn more about your ad choices. Visit megaphone.fm/adchoices Professor Bill Harris, Part 1 Interview: https://youtu.be/rZT4Y6T_0Vc

Related Letters
Breakdown of the Famous Minnesota Coronary Experiment: https://open.substack.com/pub/staycuriousmetabolism/p/lowering-cholesterol-killed-a-study?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Molecular Choreograph of Acute Exercise Breakdown: https://staycuriousmetabolism.substack.com/p/the-art-of-a-heartbeat-one-of-the?r=40ekz2

Cold Resistance Breakdown: https://staycuriousmetabolism.substack.com/p/the-weird-anti-insulin-hormone-that?r=40ekz2

If you want to get your Omega-3 via Omega Quant, click on this link: https://omegaquant.com/ref/864
Discount Code: NickNorwitz for 10% off

Fatty Acid Research Institute: https://www.faresinst.org

Related Videos
Sardine Diet Video: https://youtu.be/_Th54GWd8WY

Cold Resistance Video: https://youtu.be/x5ndOr1ZQ2s

Description:

Enter Part 2 of my deep-dive with Professor William “Bill” Harris—world expert on omega-3 and omega-6 fats and creator of the Omega-3 Index. We get into the “seed oils” controversy and then… we go full sardine-mode! We discuss the dolphin-like omega-3 index and what it might mean, why I became cold-resistance, and the side effect that almost ended my relationship.

Chapters
0:00 – Meet World Expert in Omega Fats, Professor Harris
1:28 – Seed Oil Controversy: Processed Oils vs Omega-6 and Linoleic Acid
4:40 – The Norway Study: Oxidation of Fish Oils
7:27 – Minnesota Coronary Experiment (See Link)
8:55 – Seed Oils are Everywhere, Especially Processed Foods
10:54 – Omega-6 Vulnerability Hypothesis
13:59 – Prostaglandins, Thromboxane, Prostacyclin, Oxylipins, SPMs
16:26 – Molecular Choreograph of Acute Exercise
18:30 – Professor Harris Reacts to 1000 Sardines in a Month!
25:10 – The Omega-3 Underwear Experiment
26:36 – FDA Warnings on Maternal Fish Intake. Valid or Harmful?
30:10 – The Future of Omega-3 Research

#omega3 #omega6 #seedoils #linoleicacid #fishoil #EPA #DHA #omega3index #sardines #mercury #pregnancyhealth #cardiovascularhealth #nutritionscience #metabolichealth #inflammation #oxylipins #SPMs #prostaglandins #processedfoods #evidencebasednutrition #staycurious #nicknorwitz #billharris #omegaquant

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 2444 no Insulin Makes your Mitochondria Young and PINK Nature Metabolism Paper: https://www.nature.com/articles/s42255-024-01007-wChapters 0:00 – Introduction, Mitophagy 1: 31 – New paper about PINK2:14 – Core mechanism 5:37 – Looking at the data, Pretty Pink Pictures 6:41 – ApoE4, the Alzheimer’s risk factor 8:42 – Relevance. Fasting and Feeding cycles10:13 – My intellectual ecosystem Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 07 Sep 2026 22:46:00 -0000 full Nick Norwitz MD PhD Nature Metabolism Paper: https://www.nature.com/articles/s42255-024-01007-wChapters 0:00 – Introduction, Mitophagy 1: 31 – New paper about PINK2:14 – Core mechanism 5:37 – Looking at the data, Pretty Pink Pictures 6:41 – ApoE4, the Alzheimer’s risk factor 8:42 – Relevance. Fasting and Feeding cycles10:13 – My intellectual ecosystem Learn more about your ad choices. Visit megaphone.fm/adchoices Nature Metabolism Paper: https://www.nature.com/articles/s42255-024-01007-w

Chapters
0:00 – Introduction, Mitophagy
1: 31 – New paper about PINK
2:14 – Core mechanism
5:37 – Looking at the data, Pretty Pink Pictures
6:41 – ApoE4, the Alzheimer’s risk factor
8:42 – Relevance. Fasting and Feeding cycles
10:13 – My intellectual ecosystem

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]]> 849 no The Cholesterol Data That Didn’t Fit the Narrative For the references, extra nuance and access to more deep-dives, join the StayCurious Metabolism community: https://staycuriousmetabolism.substack.com/p/this-drug-raises-ldl-cholesteroland?r=40ekz2 For so much more on heart health, just out our heart health library, HERE: https://staycuriousmetabolism.substack.com/p/hearthealth What if a medication can raise LDL cholesterol yet still reduce cardiovascular deaths? In this video, I walk through the science behind SGLT2 inhibitors. We will discuss a landmark trial published in The New England Journal of Medicine, dive deeper into the mechanism using new animal and human data published in Nature Aging. This isn’t a video about a simple drug, but a case study in how cholesterol narratives are built.Chapters0:00 – A Paradox: A Drug That Raises LDL but Saves Lives1:32 – Roadmap: Cholesterol Narratives, Clinical Trials, and Mechanisms2:12 – Chapter 1: The Pattern. LDL is “Bad” Cholesterol 5:45 – Chapter 2: SGLT2 Inhibitor and a Major Clinical Trial10:18 – Chapter 3: Mechanisms and Mysteries! How They Work14:12 – Proof People Want Nuance… #CardiovascularHealth #LDL #Cholesterol #ApoB #HDL #SGLT2 #Diabetes #HeartDiseaseResearch #Longevity #AMPK #RCT #KetogenicDiet #FastingScience #MetabolicHealth #Atherosclerosis #CardiovascularDisease #InsulinResistance #Obesity #Healthspan #EvidenceBasedMedicine #ClinicalTrials #MedicalEducation #PreventiveCardiology #SystemsBiology #StayCurious #Metabolism Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 07 Sep 2026 04:46:00 -0000 full Nick Norwitz MD PhD For the references, extra nuance and access to more deep-dives, join the StayCurious Metabolism community: https://staycuriousmetabolism.substack.com/p/this-drug-raises-ldl-cholesteroland?r=40ekz2 For so much more on heart health, just out our heart health library, HERE: https://staycuriousmetabolism.substack.com/p/hearthealth What if a medication can raise LDL cholesterol yet still reduce cardiovascular deaths? In this video, I walk through the science behind SGLT2 inhibitors. We will discuss a landmark trial published in The New England Journal of Medicine, dive deeper into the mechanism using new animal and human data published in Nature Aging. This isn’t a video about a simple drug, but a case study in how cholesterol narratives are built.Chapters0:00 – A Paradox: A Drug That Raises LDL but Saves Lives1:32 – Roadmap: Cholesterol Narratives, Clinical Trials, and Mechanisms2:12 – Chapter 1: The Pattern. LDL is “Bad” Cholesterol 5:45 – Chapter 2: SGLT2 Inhibitor and a Major Clinical Trial10:18 – Chapter 3: Mechanisms and Mysteries! How They Work14:12 – Proof People Want Nuance… #CardiovascularHealth #LDL #Cholesterol #ApoB #HDL #SGLT2 #Diabetes #HeartDiseaseResearch #Longevity #AMPK #RCT #KetogenicDiet #FastingScience #MetabolicHealth #Atherosclerosis #CardiovascularDisease #InsulinResistance #Obesity #Healthspan #EvidenceBasedMedicine #ClinicalTrials #MedicalEducation #PreventiveCardiology #SystemsBiology #StayCurious #Metabolism Learn more about your ad choices. Visit megaphone.fm/adchoices For the references, extra nuance and access to more deep-dives, join the StayCurious Metabolism community: https://staycuriousmetabolism.substack.com/p/this-drug-raises-ldl-cholesteroland?r=40ekz2

For so much more on heart health, just out our heart health library, HERE: https://staycuriousmetabolism.substack.com/p/hearthealth

What if a medication can raise LDL cholesterol yet still reduce cardiovascular deaths? In this video, I walk through the science behind SGLT2 inhibitors. We will discuss a landmark trial published in The New England Journal of Medicine, dive deeper into the mechanism using new animal and human data published in Nature Aging. This isn’t a video about a simple drug, but a case study in how cholesterol narratives are built.

Chapters
0:00 – A Paradox: A Drug That Raises LDL but Saves Lives
1:32 – Roadmap: Cholesterol Narratives, Clinical Trials, and Mechanisms
2:12 – Chapter 1: The Pattern. LDL is “Bad” Cholesterol
5:45 – Chapter 2: SGLT2 Inhibitor and a Major Clinical Trial
10:18 – Chapter 3: Mechanisms and Mysteries! How They Work
14:12 – Proof People Want Nuance…

#CardiovascularHealth #LDL #Cholesterol #ApoB #HDL #SGLT2 #Diabetes #HeartDiseaseResearch #Longevity #AMPK #RCT #KetogenicDiet #FastingScience #MetabolicHealth #Atherosclerosis #CardiovascularDisease #InsulinResistance #Obesity #Healthspan #EvidenceBasedMedicine #ClinicalTrials #MedicalEducation #PreventiveCardiology #SystemsBiology #StayCurious #Metabolism

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1172 no Debating Death: What does the Research Really Say about Cholesterol, ApoB and Mortality? 0:00 – Introduction0:43 – Background: ApoB and LDL cholesterol 2:38 – Metabolic Vulnerability and All Cause Mortality 4:38 – Two things can be true at the same time…6:06 – Predictors of Fatal and Non-fatal events are different6:47 – Metabolic Signatures tell us about Metabolism: MVX and LMHR7:55 – Interventions come with side effects9:02 – Thanks to Simon and BillOtvos 2023: https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00001-6/fulltextLI 2022: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821163/Simon Hill @theProof podcast: COMING SOON! Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 06 Sep 2026 10:46:00 -0000 full Nick Norwitz MD PhD 0:00 – Introduction0:43 – Background: ApoB and LDL cholesterol 2:38 – Metabolic Vulnerability and All Cause Mortality 4:38 – Two things can be true at the same time…6:06 – Predictors of Fatal and Non-fatal events are different6:47 – Metabolic Signatures tell us about Metabolism: MVX and LMHR7:55 – Interventions come with side effects9:02 – Thanks to Simon and BillOtvos 2023: https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00001-6/fulltextLI 2022: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821163/Simon Hill @theProof podcast: COMING SOON! Learn more about your ad choices. Visit megaphone.fm/adchoices 0:00 – Introduction
0:43 – Background: ApoB and LDL cholesterol
2:38 – Metabolic Vulnerability and All Cause Mortality
4:38 – Two things can be true at the same time…
6:06 – Predictors of Fatal and Non-fatal events are different
6:47 – Metabolic Signatures tell us about Metabolism: MVX and LMHR
7:55 – Interventions come with side effects
9:02 – Thanks to Simon and Bill

Otvos 2023: https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00001-6/fulltext

LI 2022: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821163/

Simon Hill @theProof podcast: COMING SOON!

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 769 no Why Aging Muscles Shrink — And How to Stop It For the written breakdown, references and more nuances, see the StayCurious Letter: https://staycuriousmetabolism.substack.com/p/the-aging-muscle-paradox-how-to-keep?r=40ekz2 Additional referenced letters, including those on creatine and sarcosine can be found at our Muscle Health Archives, here: https://staycuriousmetabolism.substack.com/p/musclehealth Sarcosine Video: https://youtu.be/0thK-Flb1KQ Oleuropein Video: https://youtu.be/ljuimrT2a1s Adapt (Inter-organ Communication) Video: https://youtu.be/R9x5Y57HuoA Creatine Video: https://youtu.be/qdt6xwzeAx0 *Use code StayCurious for up to 35% off at livemomentous.com or follow this link: https://www.livemomentous.com/discount/STAYCURIOUS?redirect=/collections/creatine&utm_source=youtube&utm_medium=sponcon&utm_campaign=nick-norwitz&utm_content=creatine *When it comes to reputation, quality, and rigorous third-party testing, you really can’t go wrong with Momentous Creatine Monohydrate. It’s extensively tested for heavy metals and banned substances. My personal preference is their pure, unflavored, no dyes or sweeteners, micronized creatine monohydrate* Creatine Ice Cream Recipe Warm 1 pint (473 ml) of Heavy Cream in a pan.While the cream is warm, but not hot, add in 5 egg yolks and mix immediately. You don’t want the yolks to cook. If they do cook, start over (but keep your creamy egg accidents for a snack). Add vanilla, organic liquid stevia, and a pinch of salt to taste. Add four 5 g Scoops of creatine. The recipe makes about 3-4 servings. Obviously, you can double, triple or quadruple as you see fitHere’s where you can get creative. In the batch shown I added Turkish coffee, but you can also add anything you want. Mint, melted chocolate or cocoa powder, berries. Make it your own.Then pile it into an ice cream maker and turn it on until it reaches the desired consistency. Video Description:We’re told muscle loss with age is simple: you get older, you lose muscle — so just lift weights and eat protein. But new research reveals a surprising paradox inside aging muscle. The very pathway that tells your muscles to grow — mTOR — is often more active in older muscle, not less. So why does muscle still shrink?In this video, we break down new findings published in PNAS and explore how chronically elevated mTOR can impair cellular recycling (autophagy), accelerate senescence, and ultimately degrade muscle quality. You’ll see how this paradox actually makes sense — and how exercise uniquely solves it by stimulating growth while restoring cellular renewal.Finally, we cover evidence-based strategies to support healthy muscle aging — including resistance training, creatine, omega-3s, sarcosine, and oleuropein — grounded in current research.Chapters0:00 – A Mind-Bending Assumption About Muscle and Aging1:34 – Roadmap: The Muscle Paradox, Rejuvenation, and Practical Strategies2:27 – Chapter 1: The Aging Muscle Paradox7:22 – Quick Summary So Far7:45 – Chapter 2: How Exercise Makes Muscle Younger While Building It8:52 – Chapter 3: Muscles Are More Than What You Think 10:15 – Chapter 4: How to Protect Your Muscles as You Age14:08 – The Big Picture – Muscle, Aging, and Whole-Body Health#MuscleAging #Sarcopenia #Creatine #MuscleScience #mTOR #Autophagy #LongevityScience #HealthyAging #ResistanceTraining #MuscleLoss #Metabolism #StrengthTraining #PNAS #ExerciseScience #CellularHealth #Senescence #NAD #Mitochondria #MuscleHealth #AgingResearch #FitnessScience #Creatine #Omega3 #Sarcosine #Oleuropein #EndocrineSystem #MetabolicHealth #Longevity #Biohacking #HealthOptimization #ExerciseBenefits #MolecularBiology #ProteinSynthesis #StrengthForLife #MuscleBiology #DEAF1 #AutophagyResearch #AgingWell #PreventSarcopenia #BrainHealth #HeartHealth #Healthspan #Lifespan #ScientificWellness #CellBiology #HealthEducation #ScienceExplained #FunctionalAging #HealthyMus Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 05 Sep 2026 16:46:00 -0000 full Nick Norwitz MD PhD For the written breakdown, references and more nuances, see the StayCurious Letter: https://staycuriousmetabolism.substack.com/p/the-aging-muscle-paradox-how-to-keep?r=40ekz2 Additional referenced letters, including those on creatine and sarcosine can be found at our Muscle Health Archives, here: https://staycuriousmetabolism.substack.com/p/musclehealth Sarcosine Video: https://youtu.be/0thK-Flb1KQ Oleuropein Video: https://youtu.be/ljuimrT2a1s Adapt (Inter-organ Communication) Video: https://youtu.be/R9x5Y57HuoA Creatine Video: https://youtu.be/qdt6xwzeAx0 *Use code StayCurious for up to 35% off at livemomentous.com or follow this link: https://www.livemomentous.com/discount/STAYCURIOUS?redirect=/collections/creatine&utm_source=youtube&utm_medium=sponcon&utm_campaign=nick-norwitz&utm_content=creatine *When it comes to reputation, quality, and rigorous third-party testing, you really can’t go wrong with Momentous Creatine Monohydrate. It’s extensively tested for heavy metals and banned substances. My personal preference is their pure, unflavored, no dyes or sweeteners, micronized creatine monohydrate* Creatine Ice Cream Recipe Warm 1 pint (473 ml) of Heavy Cream in a pan.While the cream is warm, but not hot, add in 5 egg yolks and mix immediately. You don’t want the yolks to cook. If they do cook, start over (but keep your creamy egg accidents for a snack). Add vanilla, organic liquid stevia, and a pinch of salt to taste. Add four 5 g Scoops of creatine. The recipe makes about 3-4 servings. Obviously, you can double, triple or quadruple as you see fitHere’s where you can get creative. In the batch shown I added Turkish coffee, but you can also add anything you want. Mint, melted chocolate or cocoa powder, berries. Make it your own.Then pile it into an ice cream maker and turn it on until it reaches the desired consistency. Video Description:We’re told muscle loss with age is simple: you get older, you lose muscle — so just lift weights and eat protein. But new research reveals a surprising paradox inside aging muscle. The very pathway that tells your muscles to grow — mTOR — is often more active in older muscle, not less. So why does muscle still shrink?In this video, we break down new findings published in PNAS and explore how chronically elevated mTOR can impair cellular recycling (autophagy), accelerate senescence, and ultimately degrade muscle quality. You’ll see how this paradox actually makes sense — and how exercise uniquely solves it by stimulating growth while restoring cellular renewal.Finally, we cover evidence-based strategies to support healthy muscle aging — including resistance training, creatine, omega-3s, sarcosine, and oleuropein — grounded in current research.Chapters0:00 – A Mind-Bending Assumption About Muscle and Aging1:34 – Roadmap: The Muscle Paradox, Rejuvenation, and Practical Strategies2:27 – Chapter 1: The Aging Muscle Paradox7:22 – Quick Summary So Far7:45 – Chapter 2: How Exercise Makes Muscle Younger While Building It8:52 – Chapter 3: Muscles Are More Than What You Think 10:15 – Chapter 4: How to Protect Your Muscles as You Age14:08 – The Big Picture – Muscle, Aging, and Whole-Body Health#MuscleAging #Sarcopenia #Creatine #MuscleScience #mTOR #Autophagy #LongevityScience #HealthyAging #ResistanceTraining #MuscleLoss #Metabolism #StrengthTraining #PNAS #ExerciseScience #CellularHealth #Senescence #NAD #Mitochondria #MuscleHealth #AgingResearch #FitnessScience #Creatine #Omega3 #Sarcosine #Oleuropein #EndocrineSystem #MetabolicHealth #Longevity #Biohacking #HealthOptimization #ExerciseBenefits #MolecularBiology #ProteinSynthesis #StrengthForLife #MuscleBiology #DEAF1 #AutophagyResearch #AgingWell #PreventSarcopenia #BrainHealth #HeartHealth #Healthspan #Lifespan #ScientificWellness #CellBiology #HealthEducation #ScienceExplained #FunctionalAging #HealthyMus Learn more about your ad choices. Visit megaphone.fm/adchoices For the written breakdown, references and more nuances, see the StayCurious Letter: https://staycuriousmetabolism.substack.com/p/the-aging-muscle-paradox-how-to-keep?r=40ekz2

Additional referenced letters, including those on creatine and sarcosine can be found at our Muscle Health Archives, here: https://staycuriousmetabolism.substack.com/p/musclehealth

Sarcosine Video: https://youtu.be/0thK-Flb1KQ
Oleuropein Video: https://youtu.be/ljuimrT2a1s
Adapt (Inter-organ Communication) Video: https://youtu.be/R9x5Y57HuoA

Creatine Video: https://youtu.be/qdt6xwzeAx0
*Use code StayCurious for up to 35% off at livemomentous.com or follow this link: https://www.livemomentous.com/discount/STAYCURIOUS?redirect=/collections/creatine&utm_source=youtube&utm_medium=sponcon&utm_campaign=nick-norwitz&utm_content=creatine

*When it comes to reputation, quality, and rigorous third-party testing, you really can’t go wrong with Momentous Creatine Monohydrate. It’s extensively tested for heavy metals and banned substances. My personal preference is their pure, unflavored, no dyes or sweeteners, micronized creatine monohydrate

* Creatine Ice Cream Recipe
Warm 1 pint (473 ml) of Heavy Cream in a pan.

While the cream is warm, but not hot, add in 5 egg yolks and mix immediately. You don’t want the yolks to cook. If they do cook, start over (but keep your creamy egg accidents for a snack).

Add vanilla, organic liquid stevia, and a pinch of salt to taste.

Add four 5 g Scoops of creatine. The recipe makes about 3-4 servings. Obviously, you can double, triple or quadruple as you see fit

Here’s where you can get creative. In the batch shown I added Turkish coffee, but you can also add anything you want. Mint, melted chocolate or cocoa powder, berries. Make it your own.

Then pile it into an ice cream maker and turn it on until it reaches the desired consistency.

Video Description:
We’re told muscle loss with age is simple: you get older, you lose muscle — so just lift weights and eat protein. But new research reveals a surprising paradox inside aging muscle. The very pathway that tells your muscles to grow — mTOR — is often more active in older muscle, not less. So why does muscle still shrink?

In this video, we break down new findings published in PNAS and explore how chronically elevated mTOR can impair cellular recycling (autophagy), accelerate senescence, and ultimately degrade muscle quality. You’ll see how this paradox actually makes sense — and how exercise uniquely solves it by stimulating growth while restoring cellular renewal.

Finally, we cover evidence-based strategies to support healthy muscle aging — including resistance training, creatine, omega-3s, sarcosine, and oleuropein — grounded in current research.

Chapters
0:00 – A Mind-Bending Assumption About Muscle and Aging
1:34 – Roadmap: The Muscle Paradox, Rejuvenation, and Practical Strategies
2:27 – Chapter 1: The Aging Muscle Paradox
7:22 – Quick Summary So Far
7:45 – Chapter 2: How Exercise Makes Muscle Younger While Building It
8:52 – Chapter 3: Muscles Are More Than What You Think
10:15 – Chapter 4: How to Protect Your Muscles as You Age
14:08 – The Big Picture – Muscle, Aging, and Whole-Body Health

#MuscleAging #Sarcopenia #Creatine #MuscleScience #mTOR #Autophagy #LongevityScience #HealthyAging #ResistanceTraining #MuscleLoss #Metabolism #StrengthTraining #PNAS #ExerciseScience #CellularHealth #Senescence #NAD #Mitochondria #MuscleHealth #AgingResearch #FitnessScience #Creatine #Omega3 #Sarcosine #Oleuropein #EndocrineSystem #MetabolicHealth #Longevity #Biohacking #HealthOptimization #ExerciseBenefits #MolecularBiology #ProteinSynthesis #StrengthForLife #MuscleBiology #DEAF1 #AutophagyResearch #AgingWell #PreventSarcopenia #BrainHealth #HeartHealth #Healthspan #Lifespan #ScientificWellness #CellBiology #HealthEducation #ScienceExplained #FunctionalAging #HealthyMus

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]]> 1130 no Low Carb Diet DATA Distortion For more on LDL and ApoB, see these prior videos: - Cardiovascular Controversy: ApoB and All Cause Mortality https://youtu.be/sAjDjLJUlQQ - THIS is Why There is Confusion about Lean Mass Hyper-Responders with high LDL on Ketogenic Diets: https://youtu.be/4_9UFPopl2g - How to LOWER LDL on Keto. No meds! https://youtu.be/-HZEjnw4WTs Supplemental Table 5 Lists Lipid Levels for the whole LCHF cohort of 2,034 participants. LDL-C levels were 3.71 mmol/l vs 3.62 mmol/l in the SD group. That’s a difference of 0.09, which can be converted to mg/dl by multiplying by 38.67. 0.09 * 38.67 = 3.48 mg/dl. Absolute mean levels of ApoB were 1.06 g/L and 1.03 g/L in the LCHF and SD groups, respectively.For interest - and because I know the question will arise - TG mean levels in the LCHF cohort were 133 mg/dl in the LCHF group and 137 mg/dl in the SD group.A point I do not make in the video regarding the JACC Advances paper, but that's worth considering, is that when they restrict analysis to subjects who completed at least 2 dietary questionnaires (Supplemental Table 7C), covering at least 2 days of eating (rather than 1), between group significance disappears, p = 0.34 (aHR CI: 0.49 - 8.14). This is likely due to decrease in power, but is nevertheless notable. With respect to my comment on the macronutrient profile of a Burger King Whopper and Fries, Nutritionix lists the following macronutrient profile(s):Whopper: 680 kCal, 40g fat, 55g total carbohydrate, 4g fiber, 35g proteinMedium Fries: 328 kCal, 15g fat, 45g total carbohydrate, 3.4g fiber, 3.8g proteinMath:55g fat * 9 Cal/g + 92.6g net carbohydrate*4 Cal/g + 38.8g protein*4 Cal/g = 495 Cal fr Fat + 370.4 Cal fr Carbs + Cal + 155.2 Cal fr Pro%Cal Carbs using Cal reported = 370.4 Cal / (1008 Cal) = 36.7%* using the Cal sum from macros, which can and usually do vary slightly, the denominator is adjusted to 1020.6 Cal, and the %Cal Carbs is 36.3%ReferencesIatan I et al. Association of a Low-carbohydrate High-fat Diet with Plasma Lipid Levels and Cardiovascular Risk. JACC Advances. Siedelmann SB et al. Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis. The Lancet Public Health. Kukuc L et al. Abstract 17808: Rapid Progression of CAD after stopping a statin and starting a ketogenic diet in a phenotypic lean mass hyper-responder. Circulation.Chapters0:00 – Introduction1:12 – JACC Advances Paper8:48 – Keto Diet Shorten Lifespan10:00 – LMHR with rapid Plaque Progression13:33 – Conclusion Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 04 Sep 2026 22:46:00 -0000 full Nick Norwitz MD PhD For more on LDL and ApoB, see these prior videos: - Cardiovascular Controversy: ApoB and All Cause Mortality https://youtu.be/sAjDjLJUlQQ - THIS is Why There is Confusion about Lean Mass Hyper-Responders with high LDL on Ketogenic Diets: https://youtu.be/4_9UFPopl2g - How to LOWER LDL on Keto. No meds! https://youtu.be/-HZEjnw4WTs Supplemental Table 5 Lists Lipid Levels for the whole LCHF cohort of 2,034 participants. LDL-C levels were 3.71 mmol/l vs 3.62 mmol/l in the SD group. That’s a difference of 0.09, which can be converted to mg/dl by multiplying by 38.67. 0.09 * 38.67 = 3.48 mg/dl. Absolute mean levels of ApoB were 1.06 g/L and 1.03 g/L in the LCHF and SD groups, respectively.For interest - and because I know the question will arise - TG mean levels in the LCHF cohort were 133 mg/dl in the LCHF group and 137 mg/dl in the SD group.A point I do not make in the video regarding the JACC Advances paper, but that's worth considering, is that when they restrict analysis to subjects who completed at least 2 dietary questionnaires (Supplemental Table 7C), covering at least 2 days of eating (rather than 1), between group significance disappears, p = 0.34 (aHR CI: 0.49 - 8.14). This is likely due to decrease in power, but is nevertheless notable. With respect to my comment on the macronutrient profile of a Burger King Whopper and Fries, Nutritionix lists the following macronutrient profile(s):Whopper: 680 kCal, 40g fat, 55g total carbohydrate, 4g fiber, 35g proteinMedium Fries: 328 kCal, 15g fat, 45g total carbohydrate, 3.4g fiber, 3.8g proteinMath:55g fat * 9 Cal/g + 92.6g net carbohydrate*4 Cal/g + 38.8g protein*4 Cal/g = 495 Cal fr Fat + 370.4 Cal fr Carbs + Cal + 155.2 Cal fr Pro%Cal Carbs using Cal reported = 370.4 Cal / (1008 Cal) = 36.7%* using the Cal sum from macros, which can and usually do vary slightly, the denominator is adjusted to 1020.6 Cal, and the %Cal Carbs is 36.3%ReferencesIatan I et al. Association of a Low-carbohydrate High-fat Diet with Plasma Lipid Levels and Cardiovascular Risk. JACC Advances. Siedelmann SB et al. Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis. The Lancet Public Health. Kukuc L et al. Abstract 17808: Rapid Progression of CAD after stopping a statin and starting a ketogenic diet in a phenotypic lean mass hyper-responder. Circulation.Chapters0:00 – Introduction1:12 – JACC Advances Paper8:48 – Keto Diet Shorten Lifespan10:00 – LMHR with rapid Plaque Progression13:33 – Conclusion Learn more about your ad choices. Visit megaphone.fm/adchoices For more on LDL and ApoB, see these prior videos:

- Cardiovascular Controversy: ApoB and All Cause Mortality https://youtu.be/sAjDjLJUlQQ

- THIS is Why There is Confusion about Lean Mass Hyper-Responders with high LDL on Ketogenic Diets: https://youtu.be/4_9UFPopl2g

- How to LOWER LDL on Keto. No meds! https://youtu.be/-HZEjnw4WTs

Supplemental Table 5 Lists Lipid Levels for the whole LCHF cohort of 2,034 participants. LDL-C levels were 3.71 mmol/l vs 3.62 mmol/l in the SD group. That’s a difference of 0.09, which can be converted to mg/dl by multiplying by 38.67. 0.09 * 38.67 = 3.48 mg/dl. Absolute mean levels of ApoB were 1.06 g/L and 1.03 g/L in the LCHF and SD groups, respectively.

For interest - and because I know the question will arise - TG mean levels in the LCHF cohort were 133 mg/dl in the LCHF group and 137 mg/dl in the SD group.

A point I do not make in the video regarding the JACC Advances paper, but that's worth considering, is that when they restrict analysis to subjects who completed at least 2 dietary questionnaires (Supplemental Table 7C), covering at least 2 days of eating (rather than 1), between group significance disappears, p = 0.34 (aHR CI: 0.49 - 8.14). This is likely due to decrease in power, but is nevertheless notable.

With respect to my comment on the macronutrient profile of a Burger King Whopper and Fries, Nutritionix lists the following macronutrient profile(s):

Whopper: 680 kCal, 40g fat, 55g total carbohydrate, 4g fiber, 35g protein
Medium Fries: 328 kCal, 15g fat, 45g total carbohydrate, 3.4g fiber, 3.8g protein

Math:
55g fat * 9 Cal/g + 92.6g net carbohydrate*4 Cal/g + 38.8g protein*4 Cal/g =
495 Cal fr Fat + 370.4 Cal fr Carbs + Cal + 155.2 Cal fr Pro

%Cal Carbs using Cal reported = 370.4 Cal / (1008 Cal) = 36.7%
* using the Cal sum from macros, which can and usually do vary slightly, the denominator is adjusted to 1020.6 Cal, and the %Cal Carbs is 36.3%

References
Iatan I et al. Association of a Low-carbohydrate High-fat Diet with Plasma Lipid Levels and Cardiovascular Risk. JACC Advances.

Siedelmann SB et al. Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis. The Lancet Public Health.

Kukuc L et al. Abstract 17808: Rapid Progression of CAD after stopping a statin and starting a ketogenic diet in a phenotypic lean mass hyper-responder. Circulation.

Chapters
0:00 – Introduction
1:12 – JACC Advances Paper
8:48 – Keto Diet Shorten Lifespan
10:00 – LMHR with rapid Plaque Progression
13:33 – Conclusion

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]]> 1110 no Nutrition Experts are Wrong About Fiber. I’ll Prove It! For extra details and all the references, see this letter: https://staycuriousmetabolism.substack.com/p/fiber-is-good-for-you-is-lazy-science?r=40ekz2 Winnow Microplastic Binding Probiotic: https://www.winnowlabs.com/STAYCURIOUS Use Discount Code “StayCurious” for 15% Off Microplastics and Heart Health, Letter https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Description:Fiber gets treated like one simple “good for gut health” nutrient… but that’s a massive oversimplification.In this video, I break down a high-resolution Stanford human crossover trial comparing two “soluble fibers” that produced radically different outcomes: arabinoxylan vs inulin. Same category label, completely different biology.You’ll see why dose matters, why host response matters, and how “fiber is good” or “fiber is bad” is so oversimplified these statements are effectively full-blown misinformation.For extra nuance, references, and commentary from the senior author, check out the Stay Curious Metabolism newsletter linked aboveChapters0:00 – Fiber Isn’t “Just Healthy” (This Paper Changed My Mind, Again)1:46 – The 5-Chapter Roadmap (And the Nuance Everyone Misses)3:15 – The Stanford RCT: AX vs Inulin (Randomized Crossover Trial)4:52 – What AX and Inulin Actually Are (Same Label, Different Biology)6:33 – High-Dose Inulin: Liver Stress + Inflammation in Some People7:54 – The Real Lesson: Fiber Type + Dose + Your Biology (Host Response)10:19 – AX Drops LDL (Inulin Doesn’t… and Can Even Raise It)13:17 – Wild Finding: Protein Intake May Boost AX’s Cholesterol Effect14:57 – What To Do for Gut Health Today (Practical Takeaways)17:16 – Microplastics, the Gut, and Why I Use This Probiotic18:58 – Final Punchline: Fiber Isn’t One Thing (Context Over Labels)#Fiber #GutHealth #Microbiome #NutritionScience #Cholesterol #LDL #ApoB #Inulin #MetabolicHealth #Stanford #LiverHealth #Inflammation #PrecisionNutrition #HealthPodcast #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 04 Sep 2026 04:46:00 -0000 full Nick Norwitz MD PhD For extra details and all the references, see this letter: https://staycuriousmetabolism.substack.com/p/fiber-is-good-for-you-is-lazy-science?r=40ekz2 Winnow Microplastic Binding Probiotic: https://www.winnowlabs.com/STAYCURIOUS Use Discount Code “StayCurious” for 15% Off Microplastics and Heart Health, Letter https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Description:Fiber gets treated like one simple “good for gut health” nutrient… but that’s a massive oversimplification.In this video, I break down a high-resolution Stanford human crossover trial comparing two “soluble fibers” that produced radically different outcomes: arabinoxylan vs inulin. Same category label, completely different biology.You’ll see why dose matters, why host response matters, and how “fiber is good” or “fiber is bad” is so oversimplified these statements are effectively full-blown misinformation.For extra nuance, references, and commentary from the senior author, check out the Stay Curious Metabolism newsletter linked aboveChapters0:00 – Fiber Isn’t “Just Healthy” (This Paper Changed My Mind, Again)1:46 – The 5-Chapter Roadmap (And the Nuance Everyone Misses)3:15 – The Stanford RCT: AX vs Inulin (Randomized Crossover Trial)4:52 – What AX and Inulin Actually Are (Same Label, Different Biology)6:33 – High-Dose Inulin: Liver Stress + Inflammation in Some People7:54 – The Real Lesson: Fiber Type + Dose + Your Biology (Host Response)10:19 – AX Drops LDL (Inulin Doesn’t… and Can Even Raise It)13:17 – Wild Finding: Protein Intake May Boost AX’s Cholesterol Effect14:57 – What To Do for Gut Health Today (Practical Takeaways)17:16 – Microplastics, the Gut, and Why I Use This Probiotic18:58 – Final Punchline: Fiber Isn’t One Thing (Context Over Labels)#Fiber #GutHealth #Microbiome #NutritionScience #Cholesterol #LDL #ApoB #Inulin #MetabolicHealth #Stanford #LiverHealth #Inflammation #PrecisionNutrition #HealthPodcast #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For extra details and all the references, see this letter: https://staycuriousmetabolism.substack.com/p/fiber-is-good-for-you-is-lazy-science?r=40ekz2

Winnow Microplastic Binding Probiotic: https://www.winnowlabs.com/STAYCURIOUS
Use Discount Code “StayCurious” for 15% Off

Microplastics and Heart Health, Letter https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2

Description:
Fiber gets treated like one simple “good for gut health” nutrient… but that’s a massive oversimplification.

In this video, I break down a high-resolution Stanford human crossover trial comparing two “soluble fibers” that produced radically different outcomes: arabinoxylan vs inulin. Same category label, completely different biology.

You’ll see why dose matters, why host response matters, and how “fiber is good” or “fiber is bad” is so oversimplified these statements are effectively full-blown misinformation.
For extra nuance, references, and commentary from the senior author, check out the Stay Curious Metabolism newsletter linked above

Chapters
0:00 – Fiber Isn’t “Just Healthy” (This Paper Changed My Mind, Again)
1:46 – The 5-Chapter Roadmap (And the Nuance Everyone Misses)
3:15 – The Stanford RCT: AX vs Inulin (Randomized Crossover Trial)
4:52 – What AX and Inulin Actually Are (Same Label, Different Biology)
6:33 – High-Dose Inulin: Liver Stress + Inflammation in Some People
7:54 – The Real Lesson: Fiber Type + Dose + Your Biology (Host Response)
10:19 – AX Drops LDL (Inulin Doesn’t… and Can Even Raise It)
13:17 – Wild Finding: Protein Intake May Boost AX’s Cholesterol Effect
14:57 – What To Do for Gut Health Today (Practical Takeaways)
17:16 – Microplastics, the Gut, and Why I Use This Probiotic
18:58 – Final Punchline: Fiber Isn’t One Thing (Context Over Labels)

#Fiber #GutHealth #Microbiome #NutritionScience #Cholesterol #LDL #ApoB #Inulin #MetabolicHealth #Stanford #LiverHealth #Inflammation #PrecisionNutrition #HealthPodcast #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1536 no Keto Diet Zombifies Your Organs! Quit Now. Paper: Ketogenic diet induces p53-dependent cellular senescence in multiple organs, https://www.science.org/doi/10.1126/sciadv.ado1463Chapters0:00 – Media Mayhem about New Study 1:02 – Background: Conflicting Data2:00 – The Diets (Crisco and Cocoa Butter)3:07 – Biomarker of Aging Increased in Organs of Keto Mice3:42 – Ketogenic Diets extend Lifespan and Health-span in Mice4:36 – Oddities in the Data 5:16 – Are my Cytokines Elevated?7:39 – Summary Clinical Trials ID: NCT05071287Paper: A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice,https://pubmed.ncbi.nlm.nih.gov/28877457/ Like My “Stay Curious” Shirt?https://metabolismshirts.myspreadshop.com Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 03 Sep 2026 10:46:00 -0000 full Nick Norwitz MD PhD Paper: Ketogenic diet induces p53-dependent cellular senescence in multiple organs, https://www.science.org/doi/10.1126/sciadv.ado1463Chapters0:00 – Media Mayhem about New Study 1:02 – Background: Conflicting Data2:00 – The Diets (Crisco and Cocoa Butter)3:07 – Biomarker of Aging Increased in Organs of Keto Mice3:42 – Ketogenic Diets extend Lifespan and Health-span in Mice4:36 – Oddities in the Data 5:16 – Are my Cytokines Elevated?7:39 – Summary Clinical Trials ID: NCT05071287Paper: A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice,https://pubmed.ncbi.nlm.nih.gov/28877457/ Like My “Stay Curious” Shirt?https://metabolismshirts.myspreadshop.com Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: Ketogenic diet induces p53-dependent cellular senescence in multiple organs, https://www.science.org/doi/10.1126/sciadv.ado1463

Chapters
0:00 – Media Mayhem about New Study
1:02 – Background: Conflicting Data
2:00 – The Diets (Crisco and Cocoa Butter)
3:07 – Biomarker of Aging Increased in Organs of Keto Mice
3:42 – Ketogenic Diets extend Lifespan and Health-span in Mice
4:36 – Oddities in the Data
5:16 – Are my Cytokines Elevated?
7:39 – Summary

Clinical Trials ID: NCT05071287

Paper: A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice,
https://pubmed.ncbi.nlm.nih.gov/28877457/

Like My “Stay Curious” Shirt?
https://metabolismshirts.myspreadshop.com

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 669 no Can Nattokinase Reverse Atherosclerosis? If you want early access to these sorts of breakdowns, all the references and extra nuances, join the Best-Selling StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/nattokinase-the-heart-health-supplement?r=40ekz2Can a fermented soybean enzyme actually reverse arterial plaque? In this video, we dive deep into the science behind nattokinase—one of the most misunderstood yet promising supplements in cardiovascular health. From its ancient samurai-era origins to modern clinical studies, we unpack whether this enzyme can truly lower your risk of heart disease.You'll learn how nattokinase works on a biochemical level—breaking down blood clots, lowering blood pressure, and reducing oxidative stress. We'll examine the latest research, including a 1,000-person study showing potential regression of atherosclerosis and improvements in cholesterol markers. And yes, we’ll talk dosing, safety, and how this fits into a broader heart health strategy.If you care about your heart, aging well, or simply staying ahead of the curve on evidence-based supplements, this one’s for you. For all the references, visuals, and extra resources (including my recommended 5-ingredient heart stack), check out the StayCurious metabolism letter at https://staycuriousmetabolism.com Chapters 0:00 – Nattokinase: One of the Most Misunderstood Supplements in Heart Health 1:42 – The Video Roadmap2:42 – Chapter 1: Natto, Samurai Lore and Cardiovascular Longevity4:48 – Chapter 2. Does Nattokinase Improve Atherosclerosis?6:46 – Chapter 3. Cardioprotective Mechanisms of Nattokinase13:00 – Chapter 4. Dosing Nattokinase 13:58 – The Final Verdict#Nattokinase #Health #HeartHealth #Atherosclerosis #CardiovascularHealth #HeartDisease #RandomisedControlledTrial #Antioxidants #Cholesterol #BloodPressure #Supplements #SupplementsScience #Japan #Microbiome #Longevity #NickNorwitz #MetabolicHealth #EvidenceBased #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 02 Sep 2026 16:46:00 -0000 full Nick Norwitz MD PhD If you want early access to these sorts of breakdowns, all the references and extra nuances, join the Best-Selling StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/nattokinase-the-heart-health-supplement?r=40ekz2Can a fermented soybean enzyme actually reverse arterial plaque? In this video, we dive deep into the science behind nattokinase—one of the most misunderstood yet promising supplements in cardiovascular health. From its ancient samurai-era origins to modern clinical studies, we unpack whether this enzyme can truly lower your risk of heart disease.You'll learn how nattokinase works on a biochemical level—breaking down blood clots, lowering blood pressure, and reducing oxidative stress. We'll examine the latest research, including a 1,000-person study showing potential regression of atherosclerosis and improvements in cholesterol markers. And yes, we’ll talk dosing, safety, and how this fits into a broader heart health strategy.If you care about your heart, aging well, or simply staying ahead of the curve on evidence-based supplements, this one’s for you. For all the references, visuals, and extra resources (including my recommended 5-ingredient heart stack), check out the StayCurious metabolism letter at https://staycuriousmetabolism.com Chapters 0:00 – Nattokinase: One of the Most Misunderstood Supplements in Heart Health 1:42 – The Video Roadmap2:42 – Chapter 1: Natto, Samurai Lore and Cardiovascular Longevity4:48 – Chapter 2. Does Nattokinase Improve Atherosclerosis?6:46 – Chapter 3. Cardioprotective Mechanisms of Nattokinase13:00 – Chapter 4. Dosing Nattokinase 13:58 – The Final Verdict#Nattokinase #Health #HeartHealth #Atherosclerosis #CardiovascularHealth #HeartDisease #RandomisedControlledTrial #Antioxidants #Cholesterol #BloodPressure #Supplements #SupplementsScience #Japan #Microbiome #Longevity #NickNorwitz #MetabolicHealth #EvidenceBased #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices If you want early access to these sorts of breakdowns, all the references and extra nuances, join the Best-Selling StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/nattokinase-the-heart-health-supplement?r=40ekz2

Can a fermented soybean enzyme actually reverse arterial plaque? In this video, we dive deep into the science behind nattokinase—one of the most misunderstood yet promising supplements in cardiovascular health. From its ancient samurai-era origins to modern clinical studies, we unpack whether this enzyme can truly lower your risk of heart disease.

You'll learn how nattokinase works on a biochemical level—breaking down blood clots, lowering blood pressure, and reducing oxidative stress. We'll examine the latest research, including a 1,000-person study showing potential regression of atherosclerosis and improvements in cholesterol markers. And yes, we’ll talk dosing, safety, and how this fits into a broader heart health strategy.

If you care about your heart, aging well, or simply staying ahead of the curve on evidence-based supplements, this one’s for you. For all the references, visuals, and extra resources (including my recommended 5-ingredient heart stack), check out the StayCurious metabolism letter at https://staycuriousmetabolism.com

Chapters
0:00 – Nattokinase: One of the Most Misunderstood Supplements in Heart Health
1:42 – The Video Roadmap
2:42 – Chapter 1: Natto, Samurai Lore and Cardiovascular Longevity
4:48 – Chapter 2. Does Nattokinase Improve Atherosclerosis?
6:46 – Chapter 3. Cardioprotective Mechanisms of Nattokinase
13:00 – Chapter 4. Dosing Nattokinase
13:58 – The Final Verdict

#Nattokinase #Health #HeartHealth #Atherosclerosis #CardiovascularHealth #HeartDisease #RandomisedControlledTrial #Antioxidants #Cholesterol #BloodPressure #Supplements #SupplementsScience #Japan #Microbiome #Longevity #NickNorwitz #MetabolicHealth #EvidenceBased #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1103 no Sugar Metabolite Bypasses Genetics in Cancer Cell paper: https://www.cell.com/cell/fulltext/S0092-8674(24)00255-1 0:00 – Introduction:1:13 – Two Hit Hypothesis in Cancer2:41 – MGO is the Evil Dobby! Metabolic Bypass4:35 – Lovely Comment. Stay Curious!Martina's Cheesecake with Allulose: https://ketodietapp.com/Blog/lchf/no-bake-keto-dulce-de-leche-cheesecake#RxMetabolism University ProjectI hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enhance the lessons, Steve and RxSugar are supporting video editing fees.Perhaps this will build brand trust and in that way work into the business model? Or maybe not. But I share this with you in the spirit of openness and transparency. And if you can believe me, I feel the strength of our movement comes from the fact that all of us, from me to Steve to you, are bonded by a deep desire and passion to Make Metabolic Health Mainstream! For more on the science of allulose, see this video: https://youtu.be/pr93EsEV2bM And RxSugar: https://rxsugar.comDiscount code: NICK20 Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 01 Sep 2026 22:46:00 -0000 full Nick Norwitz MD PhD Cell paper: https://www.cell.com/cell/fulltext/S0092-8674(24)00255-1 0:00 – Introduction:1:13 – Two Hit Hypothesis in Cancer2:41 – MGO is the Evil Dobby! Metabolic Bypass4:35 – Lovely Comment. Stay Curious!Martina's Cheesecake with Allulose: https://ketodietapp.com/Blog/lchf/no-bake-keto-dulce-de-leche-cheesecake#RxMetabolism University ProjectI hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enhance the lessons, Steve and RxSugar are supporting video editing fees.Perhaps this will build brand trust and in that way work into the business model? Or maybe not. But I share this with you in the spirit of openness and transparency. And if you can believe me, I feel the strength of our movement comes from the fact that all of us, from me to Steve to you, are bonded by a deep desire and passion to Make Metabolic Health Mainstream! For more on the science of allulose, see this video: https://youtu.be/pr93EsEV2bM And RxSugar: https://rxsugar.comDiscount code: NICK20 Learn more about your ad choices. Visit megaphone.fm/adchoices Cell paper: https://www.cell.com/cell/fulltext/S0092-8674(24)00255-1

0:00 – Introduction:
1:13 – Two Hit Hypothesis in Cancer
2:41 – MGO is the Evil Dobby! Metabolic Bypass
4:35 – Lovely Comment. Stay Curious!

Martina's Cheesecake with Allulose: https://ketodietapp.com/Blog/lchf/no-bake-keto-dulce-de-leche-cheesecake

#RxMetabolism University Project

I hope you’re all appreciating the improvement in my channels’ production quality. My earlier videos were all recorded on an iPhone, with minimal editing, and I have since transitioned to 4K filming on a Sony alpha 6700 camera, coupled with crisp audio on Rode microphones and topped off with outsourced professional video editing.

These improvements in your educational experience would not be possible without the extremely generous support of RxSugar (https://rxsugar.com, discount code NICK20), and company CEO Steve Hanley. I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!

My friend Steve, and by extension his company, are devoted to promoting population metabolic health, as a mission I share! To that end, WE feel compelled to provide free education on metabolic health you all of you via YouTube. I do my part by generating video content, but I require support, especially as a busy PhD and MD trainee. (I’m not a career influencer). To amplify the message and enhance the lessons, Steve and RxSugar are supporting video editing fees.

Perhaps this will build brand trust and in that way work into the business model? Or maybe not. But I share this with you in the spirit of openness and transparency. And if you can believe me, I feel the strength of our movement comes from the fact that all of us, from me to Steve to you, are bonded by a deep desire and passion to Make Metabolic Health Mainstream!

For more on the science of allulose, see this video: https://youtu.be/pr93EsEV2bM

And RxSugar: https://rxsugar.com
Discount code: NICK20

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 588 no Never get Alzheimer’s Disease: The NAD Breakthrough For all the references, added nuanced, and early access to breakdowns like these, see the StayCurious Metabolism Letter: https://staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2 Other Referenced ContentOmega-3 Video: https://youtu.be/B-kEn0FukXM If you want to try the Lyso-DHA omega supplement I use, Accentrate Omega Max, here’s the https://www.fenixhealthscience.com/staycurious Use Discount Code StayCurious for 20% OffLithium Video: https://youtu.be/Hcz0Eyp1LE4 Alzheimer’s Unfolded Video (throw back!): https://youtu.be/oRaNzfHF_do Aging Spikes, Interview with Stanford’s Professor Michael Snyder: https://youtu.be/kMpGkg4zMOU Alzheimer’s disease is usually framed as a problem of amyloid plaques and tau tangles. But a growing body of research suggests a deeper, upstream issue: loss of brain energy metabolism—and declining NAD+ (nicotinamide adenine dinucleotide). In this video, we walk through new experimental and human data showing how reduced NAD+ impairs mitochondrial health and brain function—and why restoring NAD in animal models improves learning and memory while reducing key features of Alzheimer’s pathology. We will also translate this biology into practical context and give you evidence-based ways to boost your NAD long-term brain health.Chapters0:00 – Can We Finally Reverse Alzheimer’s Disease?1:40 – Roadmap to the Video2:25 – Chapter 1: NAD Depletion and Brain Energy Failure in Alzheimer’s Disease3:55 – Chapter 2: The Amyloid Paradox and Cognitive Resilience5:41 – Chapter 3: Restoring NAD in Animal Models of Alzheimer’s Disease11:03 – Chapter 4: Do These Mechanisms Translate to Humans?12:49 – Chapter 5: Evidence-Based Ways to Support NAD Levels Naturally18:48 – Practical Checklist: Science-Based Strategies to Boost and Preserve NAD19:38 – Lyso-DHA For Brain Health and (Hopefully) Alzheimer’s Prevention20:33 – Low-Dose Lithium Orotate and Emerging Alzheimer’s Prevention Data#Alzheimer’s #NAD #BrainHealth #BrainEnergy #KetogenicDiet #Dementia #Neuroscience #Neurons #Glia #Mitochondria #MitochondrialHealth #Metabolism #CognitiveDecline #AgingBrain #Amyloid #Neuroinflammation #TauProtein #AmyloidPlaques #ApoE4 #KetogenicDiet #Exercise #NMN #NR #Longevity #NickNorwitz #MetabolicHealth #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 01 Sep 2026 04:46:00 -0000 full Nick Norwitz MD PhD For all the references, added nuanced, and early access to breakdowns like these, see the StayCurious Metabolism Letter: https://staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2 Other Referenced ContentOmega-3 Video: https://youtu.be/B-kEn0FukXM If you want to try the Lyso-DHA omega supplement I use, Accentrate Omega Max, here’s the https://www.fenixhealthscience.com/staycurious Use Discount Code StayCurious for 20% OffLithium Video: https://youtu.be/Hcz0Eyp1LE4 Alzheimer’s Unfolded Video (throw back!): https://youtu.be/oRaNzfHF_do Aging Spikes, Interview with Stanford’s Professor Michael Snyder: https://youtu.be/kMpGkg4zMOU Alzheimer’s disease is usually framed as a problem of amyloid plaques and tau tangles. But a growing body of research suggests a deeper, upstream issue: loss of brain energy metabolism—and declining NAD+ (nicotinamide adenine dinucleotide). In this video, we walk through new experimental and human data showing how reduced NAD+ impairs mitochondrial health and brain function—and why restoring NAD in animal models improves learning and memory while reducing key features of Alzheimer’s pathology. We will also translate this biology into practical context and give you evidence-based ways to boost your NAD long-term brain health.Chapters0:00 – Can We Finally Reverse Alzheimer’s Disease?1:40 – Roadmap to the Video2:25 – Chapter 1: NAD Depletion and Brain Energy Failure in Alzheimer’s Disease3:55 – Chapter 2: The Amyloid Paradox and Cognitive Resilience5:41 – Chapter 3: Restoring NAD in Animal Models of Alzheimer’s Disease11:03 – Chapter 4: Do These Mechanisms Translate to Humans?12:49 – Chapter 5: Evidence-Based Ways to Support NAD Levels Naturally18:48 – Practical Checklist: Science-Based Strategies to Boost and Preserve NAD19:38 – Lyso-DHA For Brain Health and (Hopefully) Alzheimer’s Prevention20:33 – Low-Dose Lithium Orotate and Emerging Alzheimer’s Prevention Data#Alzheimer’s #NAD #BrainHealth #BrainEnergy #KetogenicDiet #Dementia #Neuroscience #Neurons #Glia #Mitochondria #MitochondrialHealth #Metabolism #CognitiveDecline #AgingBrain #Amyloid #Neuroinflammation #TauProtein #AmyloidPlaques #ApoE4 #KetogenicDiet #Exercise #NMN #NR #Longevity #NickNorwitz #MetabolicHealth #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For all the references, added nuanced, and early access to breakdowns like these, see the StayCurious Metabolism Letter: https://staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2

Other Referenced Content
Omega-3 Video: https://youtu.be/B-kEn0FukXM

If you want to try the Lyso-DHA omega supplement I use, Accentrate Omega Max, here’s the https://www.fenixhealthscience.com/staycurious

Use Discount Code StayCurious for 20% Off

Lithium Video: https://youtu.be/Hcz0Eyp1LE4

Alzheimer’s Unfolded Video (throw back!): https://youtu.be/oRaNzfHF_do

Aging Spikes, Interview with Stanford’s Professor Michael Snyder: https://youtu.be/kMpGkg4zMOU

Alzheimer’s disease is usually framed as a problem of amyloid plaques and tau tangles. But a growing body of research suggests a deeper, upstream issue: loss of brain energy metabolism—and declining NAD+ (nicotinamide adenine dinucleotide). In this video, we walk through new experimental and human data showing how reduced NAD+ impairs mitochondrial health and brain function—and why restoring NAD in animal models improves learning and memory while reducing key features of Alzheimer’s pathology. We will also translate this biology into practical context and give you evidence-based ways to boost your NAD long-term brain health.

Chapters
0:00 – Can We Finally Reverse Alzheimer’s Disease?
1:40 – Roadmap to the Video
2:25 – Chapter 1: NAD Depletion and Brain Energy Failure in Alzheimer’s Disease
3:55 – Chapter 2: The Amyloid Paradox and Cognitive Resilience
5:41 – Chapter 3: Restoring NAD in Animal Models of Alzheimer’s Disease
11:03 – Chapter 4: Do These Mechanisms Translate to Humans?
12:49 – Chapter 5: Evidence-Based Ways to Support NAD Levels Naturally
18:48 – Practical Checklist: Science-Based Strategies to Boost and Preserve NAD
19:38 – Lyso-DHA For Brain Health and (Hopefully) Alzheimer’s Prevention
20:33 – Low-Dose Lithium Orotate and Emerging Alzheimer’s Prevention Data

#Alzheimer’s #NAD #BrainHealth #BrainEnergy #KetogenicDiet #Dementia #Neuroscience #Neurons #Glia #Mitochondria #MitochondrialHealth #Metabolism #CognitiveDecline #AgingBrain #Amyloid #Neuroinflammation #TauProtein #AmyloidPlaques #ApoE4 #KetogenicDiet #Exercise #NMN #NR #Longevity #NickNorwitz #MetabolicHealth #StayCurious

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]]> 1651 no 6 Keto Myths that Need to Die Chapters0:00 – Intro0:41 – (1) Athletes Need Carbs2:24 – (2) Keto is Unsustainable 4:22 – (3) Longevity 6:17 – (4) LMHR 9:55 – (5) Thyroid12:28 – (6) THE keto dietAthletes don’t need carbs video: https://youtu.be/r6oPwDbrFjQRoberts et al. (Keto Mice and Longevity): https://www.cell.com/cell-metabolism/pdf/S1550-4131(17)30490-4.pdfAlso related to (3), see coverage of recent "Keto Zombie" paper: https://youtu.be/qxGg3VlOtdsCooper et al. (Keto Thyroid): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768172/Technically, “myth” 4 should be LMHR “aren’t” a unique phenotype since it’s myth busting, but thought that wording was confusing.Like the shirt?https://metabolismshirts.myspreadshop.com Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 31 Aug 2026 10:46:00 -0000 full Nick Norwitz MD PhD Chapters0:00 – Intro0:41 – (1) Athletes Need Carbs2:24 – (2) Keto is Unsustainable 4:22 – (3) Longevity 6:17 – (4) LMHR 9:55 – (5) Thyroid12:28 – (6) THE keto dietAthletes don’t need carbs video: https://youtu.be/r6oPwDbrFjQRoberts et al. (Keto Mice and Longevity): https://www.cell.com/cell-metabolism/pdf/S1550-4131(17)30490-4.pdfAlso related to (3), see coverage of recent "Keto Zombie" paper: https://youtu.be/qxGg3VlOtdsCooper et al. (Keto Thyroid): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768172/Technically, “myth” 4 should be LMHR “aren’t” a unique phenotype since it’s myth busting, but thought that wording was confusing.Like the shirt?https://metabolismshirts.myspreadshop.com Learn more about your ad choices. Visit megaphone.fm/adchoices Chapters
0:00 – Intro
0:41 – (1) Athletes Need Carbs
2:24 – (2) Keto is Unsustainable
4:22 – (3) Longevity
6:17 – (4) LMHR
9:55 – (5) Thyroid
12:28 – (6) THE keto diet

Athletes don’t need carbs video: https://youtu.be/r6oPwDbrFjQ
Roberts et al. (Keto Mice and Longevity): https://www.cell.com/cell-metabolism/pdf/S1550-4131(17)30490-4.pdf

Also related to (3), see coverage of recent "Keto Zombie" paper: https://youtu.be/qxGg3VlOtds

Cooper et al. (Keto Thyroid): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768172/

Technically, “myth” 4 should be LMHR “aren’t” a unique phenotype since it’s myth busting, but thought that wording was confusing.

Like the shirt?
https://metabolismshirts.myspreadshop.com

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1112 no TUDCA: The Ultimate Driver of Clean Arteries For added nuance and all the references, see the letter: https://staycuriousmetabolism.substack.com/p/can-tudca-protect-from-atherosclerosis?r=40ekz2 Description:A gut-made hormone (and trending supplement) called TUDCA may reduce plaque formation in atherosclerosis—not by lowering cholesterol, but by changing the inflammatory biology that drives plaque growth in the first place.In this video, we walk through the data step-by-step: the key molecular players (ER stress → ATF4 → inflammasome), how a Western-style diet can trigger this cascade, and why TUDCA appears to interrupt it—quieting inflammatory signaling and improving macrophage “cholesterol efflux” (the ability to clear cholesterol out of artery walls).Important caveat: the main plaque findings are preclinical (animal), and we do not yet have large human RCTs showing TUDCA slows or reverses atherosclerosis. Still, the mechanism is compelling, and it connects to a fascinating thread: statins, gut bile acids (UDCA/TUDCA), and GLP-1 biology.For extra nuance, references, and sourcing notes, see the Stay Curious Metabolism newsletter linked above.Chapters:0:00 – TUDCA: The Gut-Made “Hormone” That Could Slow Atherosclerosis1:19 – The Plaque Result: What TUDCA Does to Arteries (and Why It’s Wild)1:53 – What You’ll Learn (5 Chapters + The Big Takeaway)2:22 – Key Players: TUDCA, ER Stress, Inflammasomes, ATF4, Foam Cells5:37 – How a Western Diet Triggers Arterial Inflammation + Plaque Growth7:14 – Enter TUDCA: Turning Down Inflammation Without Lowering Cholesterol8:00 – The Mechanism in Plain English: How TUDCA Breaks the Plaque Cycle8:50 – The Catch: Limitations, Caveats, and Missing Human RCTs9:51 – Statin Irony: GLP-1, the Microbiome, and Why UDCA Matters11:24 – TUDCA Dosing: Evidence-Based Protocols, Safety, and How to Start13:21 – Final Verdict: Promising Signal for Heart Health (Not a Miracle Pill)#TUDCA #UDCA #BileAcids #GutHealth #GutMicrobiome #Microbiome #HeartHealth #CardiovascularHealth #Atherosclerosis #Plaque #ArteryHealth #Inflammation #AntiInflammatory #Inflammasome #ERStress #ATF4 #FoamCells #Macrophages #CholesterolEfflux #Cholesterol #LDL #OxidizedLDL #MetabolicHealth #InsulinSensitivity #GLP1 #Statins #Atorvastatin #BloodSugar #DiabetesRisk #Mitochondria #LiverHealth #Longevity #NutritionScience #Supplements #Biohacking #HealthOptimization #ScienceBased #EvidenceBased #PreventiveHealth #Wellness #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 30 Aug 2026 16:46:00 -0000 full Nick Norwitz MD PhD For added nuance and all the references, see the letter: https://staycuriousmetabolism.substack.com/p/can-tudca-protect-from-atherosclerosis?r=40ekz2 Description:A gut-made hormone (and trending supplement) called TUDCA may reduce plaque formation in atherosclerosis—not by lowering cholesterol, but by changing the inflammatory biology that drives plaque growth in the first place.In this video, we walk through the data step-by-step: the key molecular players (ER stress → ATF4 → inflammasome), how a Western-style diet can trigger this cascade, and why TUDCA appears to interrupt it—quieting inflammatory signaling and improving macrophage “cholesterol efflux” (the ability to clear cholesterol out of artery walls).Important caveat: the main plaque findings are preclinical (animal), and we do not yet have large human RCTs showing TUDCA slows or reverses atherosclerosis. Still, the mechanism is compelling, and it connects to a fascinating thread: statins, gut bile acids (UDCA/TUDCA), and GLP-1 biology.For extra nuance, references, and sourcing notes, see the Stay Curious Metabolism newsletter linked above.Chapters:0:00 – TUDCA: The Gut-Made “Hormone” That Could Slow Atherosclerosis1:19 – The Plaque Result: What TUDCA Does to Arteries (and Why It’s Wild)1:53 – What You’ll Learn (5 Chapters + The Big Takeaway)2:22 – Key Players: TUDCA, ER Stress, Inflammasomes, ATF4, Foam Cells5:37 – How a Western Diet Triggers Arterial Inflammation + Plaque Growth7:14 – Enter TUDCA: Turning Down Inflammation Without Lowering Cholesterol8:00 – The Mechanism in Plain English: How TUDCA Breaks the Plaque Cycle8:50 – The Catch: Limitations, Caveats, and Missing Human RCTs9:51 – Statin Irony: GLP-1, the Microbiome, and Why UDCA Matters11:24 – TUDCA Dosing: Evidence-Based Protocols, Safety, and How to Start13:21 – Final Verdict: Promising Signal for Heart Health (Not a Miracle Pill)#TUDCA #UDCA #BileAcids #GutHealth #GutMicrobiome #Microbiome #HeartHealth #CardiovascularHealth #Atherosclerosis #Plaque #ArteryHealth #Inflammation #AntiInflammatory #Inflammasome #ERStress #ATF4 #FoamCells #Macrophages #CholesterolEfflux #Cholesterol #LDL #OxidizedLDL #MetabolicHealth #InsulinSensitivity #GLP1 #Statins #Atorvastatin #BloodSugar #DiabetesRisk #Mitochondria #LiverHealth #Longevity #NutritionScience #Supplements #Biohacking #HealthOptimization #ScienceBased #EvidenceBased #PreventiveHealth #Wellness #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For added nuance and all the references, see the letter: https://staycuriousmetabolism.substack.com/p/can-tudca-protect-from-atherosclerosis?r=40ekz2

Description:
A gut-made hormone (and trending supplement) called TUDCA may reduce plaque formation in atherosclerosis—not by lowering cholesterol, but by changing the inflammatory biology that drives plaque growth in the first place.

In this video, we walk through the data step-by-step: the key molecular players (ER stress → ATF4 → inflammasome), how a Western-style diet can trigger this cascade, and why TUDCA appears to interrupt it—quieting inflammatory signaling and improving macrophage “cholesterol efflux” (the ability to clear cholesterol out of artery walls).

Important caveat: the main plaque findings are preclinical (animal), and we do not yet have large human RCTs showing TUDCA slows or reverses atherosclerosis. Still, the mechanism is compelling, and it connects to a fascinating thread: statins, gut bile acids (UDCA/TUDCA), and GLP-1 biology.

For extra nuance, references, and sourcing notes, see the Stay Curious Metabolism newsletter linked above.

Chapters:
0:00 – TUDCA: The Gut-Made “Hormone” That Could Slow Atherosclerosis
1:19 – The Plaque Result: What TUDCA Does to Arteries (and Why It’s Wild)
1:53 – What You’ll Learn (5 Chapters + The Big Takeaway)
2:22 – Key Players: TUDCA, ER Stress, Inflammasomes, ATF4, Foam Cells
5:37 – How a Western Diet Triggers Arterial Inflammation + Plaque Growth
7:14 – Enter TUDCA: Turning Down Inflammation Without Lowering Cholesterol
8:00 – The Mechanism in Plain English: How TUDCA Breaks the Plaque Cycle
8:50 – The Catch: Limitations, Caveats, and Missing Human RCTs
9:51 – Statin Irony: GLP-1, the Microbiome, and Why UDCA Matters
11:24 – TUDCA Dosing: Evidence-Based Protocols, Safety, and How to Start
13:21 – Final Verdict: Promising Signal for Heart Health (Not a Miracle Pill)

#TUDCA #UDCA #BileAcids #GutHealth #GutMicrobiome #Microbiome #HeartHealth #CardiovascularHealth #Atherosclerosis #Plaque #ArteryHealth #Inflammation #AntiInflammatory #Inflammasome #ERStress #ATF4 #FoamCells #Macrophages #CholesterolEfflux #Cholesterol #LDL #OxidizedLDL #MetabolicHealth #InsulinSensitivity #GLP1 #Statins #Atorvastatin #BloodSugar #DiabetesRisk #Mitochondria #LiverHealth #Longevity #NutritionScience #Supplements #Biohacking #HealthOptimization #ScienceBased #EvidenceBased #PreventiveHealth #Wellness #StayCurious

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]]> 1080 no Heart Health in the Light of Evolution: What Can Chimps Teach Us About Cardiovascular Disease? Paper: https://journals.physiology.org/doi/abs/10.1152/ajpheart.00744.2023Chapters0:00 – Introduction1:07 – Inflammatory Immune Systems, Man vs Chimp2:52 – Siglecs2:32 – Caspase 124:12 – Neurobiological Stress5:30 – Relevance and Conclusion #Cholesterol #LDL #KetoDiet #ApoB #SaturatedFat #HeartHealth #MetabolicHealth #Educational #StayCurious #Wellness #Fitness #CardiovascularRisk #Inflammation #HeartDisease #CardiovascularHealth #MetabolicSyndrome #HealthResearch #HealthAndWellness #CardiovascularDiseasePrevention #CholesterolResearch #KetogenicLifestyle #HeartWellness #ScienceBasedHealth Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 29 Aug 2026 22:46:00 -0000 full Nick Norwitz MD PhD Paper: https://journals.physiology.org/doi/abs/10.1152/ajpheart.00744.2023Chapters0:00 – Introduction1:07 – Inflammatory Immune Systems, Man vs Chimp2:52 – Siglecs2:32 – Caspase 124:12 – Neurobiological Stress5:30 – Relevance and Conclusion #Cholesterol #LDL #KetoDiet #ApoB #SaturatedFat #HeartHealth #MetabolicHealth #Educational #StayCurious #Wellness #Fitness #CardiovascularRisk #Inflammation #HeartDisease #CardiovascularHealth #MetabolicSyndrome #HealthResearch #HealthAndWellness #CardiovascularDiseasePrevention #CholesterolResearch #KetogenicLifestyle #HeartWellness #ScienceBasedHealth Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://journals.physiology.org/doi/abs/10.1152/ajpheart.00744.2023

Chapters
0:00 – Introduction
1:07 – Inflammatory Immune Systems, Man vs Chimp
2:52 – Siglecs
2:32 – Caspase 12
4:12 – Neurobiological Stress
5:30 – Relevance and Conclusion

#Cholesterol #LDL #KetoDiet #ApoB #SaturatedFat #HeartHealth #MetabolicHealth #Educational #StayCurious #Wellness #Fitness #CardiovascularRisk #Inflammation #HeartDisease #CardiovascularHealth #MetabolicSyndrome #HealthResearch #HealthAndWellness #CardiovascularDiseasePrevention #CholesterolResearch #KetogenicLifestyle #HeartWellness #ScienceBasedHealth

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 586 no Statins: What "Experts" Get Wrong For references and even deeper nuances, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/the-big-new-statin-study-has-a-big?r=40ekz2 Statins Cause Weight Gain (RCT Data, Lancet 2015): https://staycuriousmetabolism.substack.com/p/do-statins-cause-weight-gain-its?r=40ekz2For many more nuanced deep dives into in Heart Health, see our StayCurious Metabolism Heart Health archives: https://staycuriousmetabolism.substack.com/p/hearthealth Ezetimibe Letter: https://staycuriousmetabolism.substack.com/p/this-study-completely-changed-how?r=40ekz2 Statin GLP-1 Letter: https://staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2 Peter Attia is Hiding: https://staycuriousmetabolism.substack.com/p/peter-attia-is-hiding-something-not?r=40ekz2 Description:A major meta-analysis published in The Lancet made headlines claiming that “almost all” feared side effects of statins aren’t actually caused by statins—and the internet ran with it. In this video, I take you inside the actual data and show why those confident headlines don’t match the results. We’ll break down how to read the study’s key graphs, what “non-significant” does and doesn’t mean, and why “not proven” is not the same as “proven false.”Then we’ll look at the blind spots and limitations that matter for real-world decisions. I’ll also address common pushback—like fears of “fear-mongering” and the argument that “statins save lives”—and explain why the ethical core here is informed consent: clear communication of uncertainty, signals, and tradeoffs. If you want deeper nuance, extra references, and a written breakdown, check the links above. Chapters0:00 – A Headline-Breaking Statin Study—and Why It Frustrated Me3:09 – A Concise Roadmap to This Video3:37 – A Meta-Analysis of Randomized Controlled Trials4:25 – The Headline Conclusions Were Wrong4:52 – How to Read the Main Graph 6:25 – What Does “Non-Significant” Really Mean?8:05 – A Strong Trend to Statins Causing Weight Gain (Plus Dose-Response)10:20 – Conflicts of Interest with Pharmaceutical Industry 11:00 – Other Major Limitations of this Paper that Headlines Miss12:57 – Can Statins Kill? “People Still Died”13:40 – Biochemical Analysis: GLP-1 and Leptin14:51 – Responding to Pushback18:55 – Accurate Communication Matters. Informed Consent Matters#statins #cholesterol #hearthealth #cardiology #medicine #medicalscience #evidencebasedmedicine #clinicaltrials #metaanalysis #thelancet #randomizedcontrolledtrial #forestplot #statistics #pvalues #confidenceinterval #risks #sideeffects #informedconsent #healthcommunication #sciencecommunication #criticalthinking #healthnews #medicalmisinformation #riskratio #relativeRisk #biostatistics #metabolichealth #diabetesrisk #weightgain #GLP1 #liverhealth #edema #gynecomastia #musclepain #placebo #doseResponse #primaryprevention #secondaryprevention #LDLcholesterol #preventivemedicine #publichealth #pharmacology #drugSafety #patienteducation #healthliteracy #nuance #scientificliteracy #researchreview #MDPhD #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 29 Aug 2026 04:46:00 -0000 full Nick Norwitz MD PhD For references and even deeper nuances, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/the-big-new-statin-study-has-a-big?r=40ekz2 Statins Cause Weight Gain (RCT Data, Lancet 2015): https://staycuriousmetabolism.substack.com/p/do-statins-cause-weight-gain-its?r=40ekz2For many more nuanced deep dives into in Heart Health, see our StayCurious Metabolism Heart Health archives: https://staycuriousmetabolism.substack.com/p/hearthealth Ezetimibe Letter: https://staycuriousmetabolism.substack.com/p/this-study-completely-changed-how?r=40ekz2 Statin GLP-1 Letter: https://staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2 Peter Attia is Hiding: https://staycuriousmetabolism.substack.com/p/peter-attia-is-hiding-something-not?r=40ekz2 Description:A major meta-analysis published in The Lancet made headlines claiming that “almost all” feared side effects of statins aren’t actually caused by statins—and the internet ran with it. In this video, I take you inside the actual data and show why those confident headlines don’t match the results. We’ll break down how to read the study’s key graphs, what “non-significant” does and doesn’t mean, and why “not proven” is not the same as “proven false.”Then we’ll look at the blind spots and limitations that matter for real-world decisions. I’ll also address common pushback—like fears of “fear-mongering” and the argument that “statins save lives”—and explain why the ethical core here is informed consent: clear communication of uncertainty, signals, and tradeoffs. If you want deeper nuance, extra references, and a written breakdown, check the links above. Chapters0:00 – A Headline-Breaking Statin Study—and Why It Frustrated Me3:09 – A Concise Roadmap to This Video3:37 – A Meta-Analysis of Randomized Controlled Trials4:25 – The Headline Conclusions Were Wrong4:52 – How to Read the Main Graph 6:25 – What Does “Non-Significant” Really Mean?8:05 – A Strong Trend to Statins Causing Weight Gain (Plus Dose-Response)10:20 – Conflicts of Interest with Pharmaceutical Industry 11:00 – Other Major Limitations of this Paper that Headlines Miss12:57 – Can Statins Kill? “People Still Died”13:40 – Biochemical Analysis: GLP-1 and Leptin14:51 – Responding to Pushback18:55 – Accurate Communication Matters. Informed Consent Matters#statins #cholesterol #hearthealth #cardiology #medicine #medicalscience #evidencebasedmedicine #clinicaltrials #metaanalysis #thelancet #randomizedcontrolledtrial #forestplot #statistics #pvalues #confidenceinterval #risks #sideeffects #informedconsent #healthcommunication #sciencecommunication #criticalthinking #healthnews #medicalmisinformation #riskratio #relativeRisk #biostatistics #metabolichealth #diabetesrisk #weightgain #GLP1 #liverhealth #edema #gynecomastia #musclepain #placebo #doseResponse #primaryprevention #secondaryprevention #LDLcholesterol #preventivemedicine #publichealth #pharmacology #drugSafety #patienteducation #healthliteracy #nuance #scientificliteracy #researchreview #MDPhD #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For references and even deeper nuances, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/the-big-new-statin-study-has-a-big?r=40ekz2

Statins Cause Weight Gain (RCT Data, Lancet 2015): https://staycuriousmetabolism.substack.com/p/do-statins-cause-weight-gain-its?r=40ekz2

For many more nuanced deep dives into in Heart Health, see our StayCurious Metabolism Heart Health archives: https://staycuriousmetabolism.substack.com/p/hearthealth

Ezetimibe Letter: https://staycuriousmetabolism.substack.com/p/this-study-completely-changed-how?r=40ekz2

Statin GLP-1 Letter: https://staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2

Peter Attia is Hiding: https://staycuriousmetabolism.substack.com/p/peter-attia-is-hiding-something-not?r=40ekz2

Description:

A major meta-analysis published in The Lancet made headlines claiming that “almost all” feared side effects of statins aren’t actually caused by statins—and the internet ran with it. In this video, I take you inside the actual data and show why those confident headlines don’t match the results. We’ll break down how to read the study’s key graphs, what “non-significant” does and doesn’t mean, and why “not proven” is not the same as “proven false.”

Then we’ll look at the blind spots and limitations that matter for real-world decisions. I’ll also address common pushback—like fears of “fear-mongering” and the argument that “statins save lives”—and explain why the ethical core here is informed consent: clear communication of uncertainty, signals, and tradeoffs. If you want deeper nuance, extra references, and a written breakdown, check the links above.

Chapters
0:00 – A Headline-Breaking Statin Study—and Why It Frustrated Me
3:09 – A Concise Roadmap to This Video
3:37 – A Meta-Analysis of Randomized Controlled Trials
4:25 – The Headline Conclusions Were Wrong
4:52 – How to Read the Main Graph
6:25 – What Does “Non-Significant” Really Mean?
8:05 – A Strong Trend to Statins Causing Weight Gain (Plus Dose-Response)
10:20 – Conflicts of Interest with Pharmaceutical Industry
11:00 – Other Major Limitations of this Paper that Headlines Miss
12:57 – Can Statins Kill? “People Still Died”
13:40 – Biochemical Analysis: GLP-1 and Leptin
14:51 – Responding to Pushback
18:55 – Accurate Communication Matters. Informed Consent Matters

#statins #cholesterol #hearthealth #cardiology #medicine #medicalscience #evidencebasedmedicine #clinicaltrials #metaanalysis #thelancet #randomizedcontrolledtrial #forestplot #statistics #pvalues #confidenceinterval #risks #sideeffects #informedconsent #healthcommunication #sciencecommunication #criticalthinking #healthnews #medicalmisinformation #riskratio #relativeRisk #biostatistics #metabolichealth #diabetesrisk #weightgain #GLP1 #liverhealth #edema #gynecomastia #musclepain #placebo #doseResponse #primaryprevention #secondaryprevention #LDLcholesterol #preventivemedicine #publichealth #pharmacology #drugSafety #patienteducation #healthliteracy #nuance #scientificliteracy #researchreview #MDPhD #StayCurious

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]]> 1456 no Want Stronger Bones? This Amino Acid Could Help Paper: https://pubmed.ncbi.nlm.nih.gov/38718794/ Chapters0:00 – Introduction, and a personal frame1:12 – Paper Title and Background2:07 – Experiments 7:21 – Dietary sources of L-citrulline9:00 – Expanding the camp of metabolic health enthusiasts! WOOT!10:14 – My personal story Allulose Deep Dive: https://youtu.be/pr93EsEV2bM Fructose Deep Dive: https://youtu.be/eN5tJ53WQ8E Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 28 Aug 2026 10:46:00 -0000 full Nick Norwitz MD PhD Paper: https://pubmed.ncbi.nlm.nih.gov/38718794/ Chapters0:00 – Introduction, and a personal frame1:12 – Paper Title and Background2:07 – Experiments 7:21 – Dietary sources of L-citrulline9:00 – Expanding the camp of metabolic health enthusiasts! WOOT!10:14 – My personal story Allulose Deep Dive: https://youtu.be/pr93EsEV2bM Fructose Deep Dive: https://youtu.be/eN5tJ53WQ8E Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://pubmed.ncbi.nlm.nih.gov/38718794/

Chapters
0:00 – Introduction, and a personal frame
1:12 – Paper Title and Background
2:07 – Experiments
7:21 – Dietary sources of L-citrulline
9:00 – Expanding the camp of metabolic health enthusiasts! WOOT!
10:14 – My personal story

Allulose Deep Dive: https://youtu.be/pr93EsEV2bM
Fructose Deep Dive: https://youtu.be/eN5tJ53WQ8E

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 942 no The Statin Experiment That Changed My Mind For the references, extra nuance and early access to deep dives like this, see the best-selling StayCurious Metabolism Newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/statins-annihilated-my-workouts-a?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Referenced Content and More Learning ResourcesMy Cholesterol is 700 (Confessions of an MD PhD): https://staycuriousmetabolism.substack.com/p/im-a-harvard-trained-md-phd-and-my?r=40ekz2 Prior statin and muscle loss video: https://youtu.be/s05mUXTcKCg For a library of the sort of nuanced heart health deep-dives you won’t find anywhere else, check out the Heart Health Library at StayCurious Metabolism, here: https://staycuriousmetabolism.substack.com/p/hearthealth Description:Statins are among the most prescribed drugs in the world, yet concerns remain about their effects on muscle function and long-term physical performance. In this video, I run a blinded, randomized crossover self-experiment using high-dose atorvastatin versus placebo to directly test whether statins impair real-world exercise performance. We walk through the study design, the objective performance results, and the symptoms I experienced during each phase. I then discuss biologically plausible mechanisms—including mitochondrial inhibition, coenzyme Q10 depletion, and altered energy metabolism. Finally, I reveal the real purpose of this project…Chapters0:00 – The Controversy: Statins and Muscle Loss1:38 – Roadmap for this Video: Four Chapters2:16 – Chapter 1: Randomized Controlled Trial Design5:47 – Chapter 2: Statins vs Exercise Performance — Results and Symptoms9:17 – Chapter 3: How Statins Could Impair Muscle and Energy Metabolism11:45 – Chapter 4: Burden of Proof, Risk Disclosure, and the Plot Twist#Statins #MuscleHealth #ExercisePerformance #ClinicalTrials #SelfExperiment #Nof1Trial #CardiovascularHealth #LipidEnergyModel #Cholesterol #LDL #Lipids #Mitochondria #CoQ10 #RCT #ApoB #MuscleFatigue #Myalgia #SportsScience #MetabolicHealth #PrecisionMedicine #EvidenceBased #Pharmacology #AthleticPerformance #EnduranceTraining #RecoveryScience #HumanPerformance #HealthResearch #Atherosclerosis #PreventiveMedicine #HeartHealth #MedicineExplained #PatientExperience #HealthEducation #ResearchMethods #Longevity #RiskCommunication #Educational #MusclePain #HealthcarePolicy #MedicalEthics #StatinSideEffects #Placebo #NickNorwitz #Metabolism #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 27 Aug 2026 16:46:00 -0000 full Nick Norwitz MD PhD For the references, extra nuance and early access to deep dives like this, see the best-selling StayCurious Metabolism Newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/statins-annihilated-my-workouts-a?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Referenced Content and More Learning ResourcesMy Cholesterol is 700 (Confessions of an MD PhD): https://staycuriousmetabolism.substack.com/p/im-a-harvard-trained-md-phd-and-my?r=40ekz2 Prior statin and muscle loss video: https://youtu.be/s05mUXTcKCg For a library of the sort of nuanced heart health deep-dives you won’t find anywhere else, check out the Heart Health Library at StayCurious Metabolism, here: https://staycuriousmetabolism.substack.com/p/hearthealth Description:Statins are among the most prescribed drugs in the world, yet concerns remain about their effects on muscle function and long-term physical performance. In this video, I run a blinded, randomized crossover self-experiment using high-dose atorvastatin versus placebo to directly test whether statins impair real-world exercise performance. We walk through the study design, the objective performance results, and the symptoms I experienced during each phase. I then discuss biologically plausible mechanisms—including mitochondrial inhibition, coenzyme Q10 depletion, and altered energy metabolism. Finally, I reveal the real purpose of this project…Chapters0:00 – The Controversy: Statins and Muscle Loss1:38 – Roadmap for this Video: Four Chapters2:16 – Chapter 1: Randomized Controlled Trial Design5:47 – Chapter 2: Statins vs Exercise Performance — Results and Symptoms9:17 – Chapter 3: How Statins Could Impair Muscle and Energy Metabolism11:45 – Chapter 4: Burden of Proof, Risk Disclosure, and the Plot Twist#Statins #MuscleHealth #ExercisePerformance #ClinicalTrials #SelfExperiment #Nof1Trial #CardiovascularHealth #LipidEnergyModel #Cholesterol #LDL #Lipids #Mitochondria #CoQ10 #RCT #ApoB #MuscleFatigue #Myalgia #SportsScience #MetabolicHealth #PrecisionMedicine #EvidenceBased #Pharmacology #AthleticPerformance #EnduranceTraining #RecoveryScience #HumanPerformance #HealthResearch #Atherosclerosis #PreventiveMedicine #HeartHealth #MedicineExplained #PatientExperience #HealthEducation #ResearchMethods #Longevity #RiskCommunication #Educational #MusclePain #HealthcarePolicy #MedicalEthics #StatinSideEffects #Placebo #NickNorwitz #Metabolism #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For the references, extra nuance and early access to deep dives like this, see the best-selling StayCurious Metabolism Newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/statins-annihilated-my-workouts-a?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Referenced Content and More Learning Resources

My Cholesterol is 700 (Confessions of an MD PhD): https://staycuriousmetabolism.substack.com/p/im-a-harvard-trained-md-phd-and-my?r=40ekz2

Prior statin and muscle loss video: https://youtu.be/s05mUXTcKCg

For a library of the sort of nuanced heart health deep-dives you won’t find anywhere else, check out the Heart Health Library at StayCurious Metabolism, here: https://staycuriousmetabolism.substack.com/p/hearthealth

Description:
Statins are among the most prescribed drugs in the world, yet concerns remain about their effects on muscle function and long-term physical performance. In this video, I run a blinded, randomized crossover self-experiment using high-dose atorvastatin versus placebo to directly test whether statins impair real-world exercise performance. We walk through the study design, the objective performance results, and the symptoms I experienced during each phase. I then discuss biologically plausible mechanisms—including mitochondrial inhibition, coenzyme Q10 depletion, and altered energy metabolism. Finally, I reveal the real purpose of this project…

Chapters
0:00 – The Controversy: Statins and Muscle Loss
1:38 – Roadmap for this Video: Four Chapters
2:16 – Chapter 1: Randomized Controlled Trial Design
5:47 – Chapter 2: Statins vs Exercise Performance — Results and Symptoms
9:17 – Chapter 3: How Statins Could Impair Muscle and Energy Metabolism
11:45 – Chapter 4: Burden of Proof, Risk Disclosure, and the Plot Twist

#Statins #MuscleHealth #ExercisePerformance #ClinicalTrials #SelfExperiment #Nof1Trial #CardiovascularHealth #LipidEnergyModel #Cholesterol #LDL #Lipids #Mitochondria #CoQ10 #RCT #ApoB #MuscleFatigue #Myalgia #SportsScience #MetabolicHealth #PrecisionMedicine #EvidenceBased #Pharmacology #AthleticPerformance #EnduranceTraining #RecoveryScience #HumanPerformance #HealthResearch #Atherosclerosis #PreventiveMedicine #HeartHealth #MedicineExplained #PatientExperience #HealthEducation #ResearchMethods #Longevity #RiskCommunication #Educational #MusclePain #HealthcarePolicy #MedicalEthics #StatinSideEffects #Placebo #NickNorwitz #Metabolism #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1213 no I Ate 6000 Calories Per Day. Here's What Happened to My Cholesterol Prior Butter Drop Video: https://youtu.be/QjPeUDR24Ec OreoVsStatin, paper: https://pubmed.ncbi.nlm.nih.gov/38276308/ Feldman Protocol Variation (Siobham Huggins LDL-C Heavy Cream “Drop”: https://cholesterolcode.com/tandem-experiment-p1/ Macadamia!http://partner.houseofmacadamias.com/nick-norwitz -15% Off All Bundles –10% off any item (non-bundle) with code "NICK10"Omega-7, video: https://youtu.be/Vngn6i-rmZI KetoBricks: https://www.ketobrick.com Lipid Energy Model, paper: https://pubmed.ncbi.nlm.nih.gov/35629964/Lipid Energy Model, video: https://youtu.be/AkzxESsTJyM?si=NEsuY-E7arxWy23f Like My Shirt? https://metabolismshirts.myspreadshop.com Chapters0:00 – Intro1:53 – Background 4:32 – My 6000 Calorie Diet5:39 – Results 9:00 – Discussion16:40 – Disclaimer Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 26 Aug 2026 22:46:00 -0000 full Nick Norwitz MD PhD Prior Butter Drop Video: https://youtu.be/QjPeUDR24Ec OreoVsStatin, paper: https://pubmed.ncbi.nlm.nih.gov/38276308/ Feldman Protocol Variation (Siobham Huggins LDL-C Heavy Cream “Drop”: https://cholesterolcode.com/tandem-experiment-p1/ Macadamia!http://partner.houseofmacadamias.com/nick-norwitz -15% Off All Bundles –10% off any item (non-bundle) with code "NICK10"Omega-7, video: https://youtu.be/Vngn6i-rmZI KetoBricks: https://www.ketobrick.com Lipid Energy Model, paper: https://pubmed.ncbi.nlm.nih.gov/35629964/Lipid Energy Model, video: https://youtu.be/AkzxESsTJyM?si=NEsuY-E7arxWy23f Like My Shirt? https://metabolismshirts.myspreadshop.com Chapters0:00 – Intro1:53 – Background 4:32 – My 6000 Calorie Diet5:39 – Results 9:00 – Discussion16:40 – Disclaimer Learn more about your ad choices. Visit megaphone.fm/adchoices Prior Butter Drop Video: https://youtu.be/QjPeUDR24Ec

OreoVsStatin, paper: https://pubmed.ncbi.nlm.nih.gov/38276308/

Feldman Protocol Variation (Siobham Huggins LDL-C Heavy Cream “Drop”: https://cholesterolcode.com/tandem-experiment-p1/

Macadamia!
http://partner.houseofmacadamias.com/nick-norwitz
-15% Off All Bundles –
10% off any item (non-bundle) with code "NICK10"

Omega-7, video: https://youtu.be/Vngn6i-rmZI

KetoBricks: https://www.ketobrick.com

Lipid Energy Model, paper: https://pubmed.ncbi.nlm.nih.gov/35629964/
Lipid Energy Model, video: https://youtu.be/AkzxESsTJyM?si=NEsuY-E7arxWy23f

Like My Shirt? https://metabolismshirts.myspreadshop.com

Chapters
0:00 – Intro
1:53 – Background
4:32 – My 6000 Calorie Diet
5:39 – Results
9:00 – Discussion
16:40 – Disclaimer

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1408 no Can This Nut Make New Neurons? For extra nuances and references see, the associated newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/what-happens-to-your-brain-after?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Omega-3 Brain Video: https://youtu.be/B-kEn0FukXMIf you want to try the Lyso-DHA omega supplement I use, Accentrate Omega Max, here’s the https://www.fenixhealthscience.com/staycurious Use Discount Code StayCurious for 20% OffLithium Video: https://youtu.be/Hcz0Eyp1LE4 NAD Video: https://youtu.be/-R7sPPQTtco For more, please see the StayCurious Metabolism Brain Health Archive: https://staycuriousmetabolism.substack.com/p/brainhealthWhat if a single Brazil nut could boost brain health? In this video, we explore the science behind selenium—a element essential for antioxidant defense and neuronal function—and its potential role in supporting neurogenesis and cognitive performance.We break down mechanistic research showing how exercise may increase selenium transport into the brain, alongside animal studies linking selenium to increased neurogenesis and improved learning. We also examine human randomized controlled trial data on Brazil nut supplementation and cognitive outcomes.Finally, we zoom out to a broader framework for brain health, covering key nutrients like DHA, lithium, and NAD, and how lifestyle factors such as diet and exercise interact with these pathways.Chapters0:00 – Can a Single Nut Affect the Brain?1:19 – Roadmap: What We’ll Cover1:57 – Exercise, Selenium, and Neurogenesis3:04 – Study Breakdown: Selenium and Brain Plasticity5:06 – Mechanisms: Oxidative Stress and Stem Cells6:50 – Aging, Selenium, and Cognitive Decline7:30 – Selenium Supplementation and Learning8:34 – Key Takeaways So Far9:22 – Brazil Nuts as a Selenium Source10:04 – Human RCT: Brazil Nuts and Cognition11:40 – Brain Health Stack Overview14:01 – Lithium, NAD, and Final Takeaways#Selenium #BrainHealth #Neurogenesis #CognitiveHealth #NutritionScience #Longevity #AlzheimersPrevention #BrainFunction #DietAndHealth #Micronutrients #HealthyAging #Memory #Neuroscience #Biohacking #Supplements #Omega3 #NAD #Lithium #BrazilNuts #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 26 Aug 2026 04:46:00 -0000 full Nick Norwitz MD PhD For extra nuances and references see, the associated newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/what-happens-to-your-brain-after?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Omega-3 Brain Video: https://youtu.be/B-kEn0FukXMIf you want to try the Lyso-DHA omega supplement I use, Accentrate Omega Max, here’s the https://www.fenixhealthscience.com/staycurious Use Discount Code StayCurious for 20% OffLithium Video: https://youtu.be/Hcz0Eyp1LE4 NAD Video: https://youtu.be/-R7sPPQTtco For more, please see the StayCurious Metabolism Brain Health Archive: https://staycuriousmetabolism.substack.com/p/brainhealthWhat if a single Brazil nut could boost brain health? In this video, we explore the science behind selenium—a element essential for antioxidant defense and neuronal function—and its potential role in supporting neurogenesis and cognitive performance.We break down mechanistic research showing how exercise may increase selenium transport into the brain, alongside animal studies linking selenium to increased neurogenesis and improved learning. We also examine human randomized controlled trial data on Brazil nut supplementation and cognitive outcomes.Finally, we zoom out to a broader framework for brain health, covering key nutrients like DHA, lithium, and NAD, and how lifestyle factors such as diet and exercise interact with these pathways.Chapters0:00 – Can a Single Nut Affect the Brain?1:19 – Roadmap: What We’ll Cover1:57 – Exercise, Selenium, and Neurogenesis3:04 – Study Breakdown: Selenium and Brain Plasticity5:06 – Mechanisms: Oxidative Stress and Stem Cells6:50 – Aging, Selenium, and Cognitive Decline7:30 – Selenium Supplementation and Learning8:34 – Key Takeaways So Far9:22 – Brazil Nuts as a Selenium Source10:04 – Human RCT: Brazil Nuts and Cognition11:40 – Brain Health Stack Overview14:01 – Lithium, NAD, and Final Takeaways#Selenium #BrainHealth #Neurogenesis #CognitiveHealth #NutritionScience #Longevity #AlzheimersPrevention #BrainFunction #DietAndHealth #Micronutrients #HealthyAging #Memory #Neuroscience #Biohacking #Supplements #Omega3 #NAD #Lithium #BrazilNuts #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For extra nuances and references see, the associated newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/what-happens-to-your-brain-after?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Omega-3 Brain Video: https://youtu.be/B-kEn0FukXM

If you want to try the Lyso-DHA omega supplement I use, Accentrate Omega Max, here’s the https://www.fenixhealthscience.com/staycurious

Use Discount Code StayCurious for 20% Off

Lithium Video: https://youtu.be/Hcz0Eyp1LE4

NAD Video: https://youtu.be/-R7sPPQTtco
For more, please see the StayCurious Metabolism Brain Health Archive: https://staycuriousmetabolism.substack.com/p/brainhealth

What if a single Brazil nut could boost brain health? In this video, we explore the science behind selenium—a element essential for antioxidant defense and neuronal function—and its potential role in supporting neurogenesis and cognitive performance.
We break down mechanistic research showing how exercise may increase selenium transport into the brain, alongside animal studies linking selenium to increased neurogenesis and improved learning. We also examine human randomized controlled trial data on Brazil nut supplementation and cognitive outcomes.

Finally, we zoom out to a broader framework for brain health, covering key nutrients like DHA, lithium, and NAD, and how lifestyle factors such as diet and exercise interact with these pathways.

Chapters
0:00 – Can a Single Nut Affect the Brain?
1:19 – Roadmap: What We’ll Cover
1:57 – Exercise, Selenium, and Neurogenesis
3:04 – Study Breakdown: Selenium and Brain Plasticity
5:06 – Mechanisms: Oxidative Stress and Stem Cells
6:50 – Aging, Selenium, and Cognitive Decline
7:30 – Selenium Supplementation and Learning
8:34 – Key Takeaways So Far
9:22 – Brazil Nuts as a Selenium Source
10:04 – Human RCT: Brazil Nuts and Cognition
11:40 – Brain Health Stack Overview
14:01 – Lithium, NAD, and Final Takeaways

#Selenium #BrainHealth #Neurogenesis #CognitiveHealth #NutritionScience #Longevity #AlzheimersPrevention #BrainFunction #DietAndHealth #Micronutrients #HealthyAging #Memory #Neuroscience #Biohacking #Supplements #Omega3 #NAD #Lithium #BrazilNuts #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1364 no How Your Brain is Weighing You Down Paper: https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00053-6Chapters0:00 – Intro, Leptin Basics1:56 – Mechanism of Leptin Resistance3:46 – HDAC6 inhibitor treatment 4:30 – Whoops! Molecular Mystery!?#neuroscience #obesitymedicine #brainhealth Like my shirt? Many more designs here, thanks to my friend Andrew D.https://metabolismshirts.myspreadshop.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 25 Aug 2026 10:46:00 -0000 full Nick Norwitz MD PhD Paper: https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00053-6Chapters0:00 – Intro, Leptin Basics1:56 – Mechanism of Leptin Resistance3:46 – HDAC6 inhibitor treatment 4:30 – Whoops! Molecular Mystery!?#neuroscience #obesitymedicine #brainhealth Like my shirt? Many more designs here, thanks to my friend Andrew D.https://metabolismshirts.myspreadshop.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00053-6

Chapters
0:00 – Intro, Leptin Basics
1:56 – Mechanism of Leptin Resistance
3:46 – HDAC6 inhibitor treatment
4:30 – Whoops! Molecular Mystery!?

#neuroscience #obesitymedicine #brainhealth

Like my shirt? Many more designs here, thanks to my friend Andrew D.
https://metabolismshirts.myspreadshop.com/

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 644 no The Most Important Lipid Marker for Longevity For extra nuances and all the references, please see the newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/the-untold-story-of-apoc3-and-human?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true DescriptionFor decades, cardiology has focused on a simple principle: “lower is better” when it comes to LDL and ApoB. But data tells a more complicated story. In this video, we examine evidence showing that dramatically lowering LDL doesn’t necessarily increase lifespan—and explore a lesser-known player in lipid metabolism called ApoC3, a regulator of triglyceride metabolism that may be more tightly linked to metabolic health, cardiovascular risk, and even longevity.We’ll break down the human genetic data, including centenarian studies and large meta-analyses, and then translate the science into practical, evidence-based lifestyle tools you can use today—from carbohydrate and fructose restriction to improving insulin sensitivity and optimizing omega-3 status. If you care about heart health, metabolic health, and healthspan, this is a conversation worth having.Chapters0:00 – I’m a Walking Talking Paradox2:19 – Roadmap to This Video3:10 – Chapter 1: The “Lower Is Better” Fallacy for LDL and ApoB4:56 – Chapter 2: Introducing ApoC3: A Key Regulator of Fat Metabolism6:48 – Chapter 3: Lower ApoC3 and Longevity10:55 – Chapter 4: Actionable Tips to Lower ApoC3 and Improve Health15:18 – Let’s Rethink Cardiovascular Health and Longevity #cholesterol #LDL #ApoC3 #ApoB #triglycerides #heartdisease #cardiology #metabolichealth #longevity #healthspan #lifespan #lipids #HDL #insulinsensitivity #ketogenicdiet #lowcarb #nutrition #preventivemedicine #cardiovascularhealth #biochemistry #medicalresearch #genetics #centenarians #aging #metabolism #healthscience #cholesterolmyths #PCSK9 #omega3 #EPA #DHA #fructose #glucose #hypertriglyceridemia #insulinresistance #type2diabetes #weightloss #fasting #exercise #sleephealth #evidencebased #medicaleducation #publichealth #wellness #healthoptimization #longevityscience #biomarkers #clinicalresearch #hearthealth #nutritionscience #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 24 Aug 2026 16:46:00 -0000 full Nick Norwitz MD PhD For extra nuances and all the references, please see the newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/the-untold-story-of-apoc3-and-human?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true DescriptionFor decades, cardiology has focused on a simple principle: “lower is better” when it comes to LDL and ApoB. But data tells a more complicated story. In this video, we examine evidence showing that dramatically lowering LDL doesn’t necessarily increase lifespan—and explore a lesser-known player in lipid metabolism called ApoC3, a regulator of triglyceride metabolism that may be more tightly linked to metabolic health, cardiovascular risk, and even longevity.We’ll break down the human genetic data, including centenarian studies and large meta-analyses, and then translate the science into practical, evidence-based lifestyle tools you can use today—from carbohydrate and fructose restriction to improving insulin sensitivity and optimizing omega-3 status. If you care about heart health, metabolic health, and healthspan, this is a conversation worth having.Chapters0:00 – I’m a Walking Talking Paradox2:19 – Roadmap to This Video3:10 – Chapter 1: The “Lower Is Better” Fallacy for LDL and ApoB4:56 – Chapter 2: Introducing ApoC3: A Key Regulator of Fat Metabolism6:48 – Chapter 3: Lower ApoC3 and Longevity10:55 – Chapter 4: Actionable Tips to Lower ApoC3 and Improve Health15:18 – Let’s Rethink Cardiovascular Health and Longevity #cholesterol #LDL #ApoC3 #ApoB #triglycerides #heartdisease #cardiology #metabolichealth #longevity #healthspan #lifespan #lipids #HDL #insulinsensitivity #ketogenicdiet #lowcarb #nutrition #preventivemedicine #cardiovascularhealth #biochemistry #medicalresearch #genetics #centenarians #aging #metabolism #healthscience #cholesterolmyths #PCSK9 #omega3 #EPA #DHA #fructose #glucose #hypertriglyceridemia #insulinresistance #type2diabetes #weightloss #fasting #exercise #sleephealth #evidencebased #medicaleducation #publichealth #wellness #healthoptimization #longevityscience #biomarkers #clinicalresearch #hearthealth #nutritionscience #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices For extra nuances and all the references, please see the newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/the-untold-story-of-apoc3-and-human?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Description
For decades, cardiology has focused on a simple principle: “lower is better” when it comes to LDL and ApoB. But data tells a more complicated story. In this video, we examine evidence showing that dramatically lowering LDL doesn’t necessarily increase lifespan—and explore a lesser-known player in lipid metabolism called ApoC3, a regulator of triglyceride metabolism that may be more tightly linked to metabolic health, cardiovascular risk, and even longevity.

We’ll break down the human genetic data, including centenarian studies and large meta-analyses, and then translate the science into practical, evidence-based lifestyle tools you can use today—from carbohydrate and fructose restriction to improving insulin sensitivity and optimizing omega-3 status. If you care about heart health, metabolic health, and healthspan, this is a conversation worth having.

Chapters
0:00 – I’m a Walking Talking Paradox
2:19 – Roadmap to This Video
3:10 – Chapter 1: The “Lower Is Better” Fallacy for LDL and ApoB
4:56 – Chapter 2: Introducing ApoC3: A Key Regulator of Fat Metabolism
6:48 – Chapter 3: Lower ApoC3 and Longevity
10:55 – Chapter 4: Actionable Tips to Lower ApoC3 and Improve Health
15:18 – Let’s Rethink Cardiovascular Health and Longevity

#cholesterol #LDL #ApoC3 #ApoB #triglycerides #heartdisease #cardiology #metabolichealth #longevity #healthspan #lifespan #lipids #HDL #insulinsensitivity #ketogenicdiet #lowcarb #nutrition #preventivemedicine #cardiovascularhealth #biochemistry #medicalresearch #genetics #centenarians #aging #metabolism #healthscience #cholesterolmyths #PCSK9 #omega3 #EPA #DHA #fructose #glucose #hypertriglyceridemia #insulinresistance #type2diabetes #weightloss #fasting #exercise #sleephealth #evidencebased #medicaleducation #publichealth #wellness #healthoptimization #longevityscience #biomarkers #clinicalresearch #hearthealth #nutritionscience #staycurious

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]]> 1181 no High Cholesterol Conundrum: A Thought Puzzle Releasing this on the tails of release of LMHR CCTA study data, here: https://www.metabolismjournal.com/article/S0026-0495(24)00080-5/abstract Follow on X: https://x.com/nicknorwitz/status/1803088031689367761Quote: "After a mean duration of 4.7 years of carbohydrate restriction-induced elevations in #LDL-cholesterol [mean 272 mg/dl, max 591 mg/dl], a metabolically healthy cohort of subjects on a ketogenic diet [#LMHR] did not have greater atherosclerotic burden than participants from a population based cohort with similar risk profiles but markedly lower [123 mg/dl] LDL-C." JAMA Cardiology Paper: https://pubmed.ncbi.nlm.nih.gov/32049305/ Chapters0:00 – Introduction0:41 – Thought Puzzle: Patient A (FH) vs Patient B (LMHR)2:34 – JAMA Cardiology Study4:35 – LDL/ApoB vs Plaque Progression Graph5:20 – Lizards 5:55 – Return to Thought PuzzleTerms- LDL cholesterol: The cholesterol component found in circulating LDL lipoprotein particles.- ApoB: An apolipoprotein on LDL and related particles. There is one ApoB per LDL particle.- Lean Mass Hyper-Responder (LMHR): Defined by the union of LDL-C ≥ 200 mg/dl, HDL-C, ≥ 80 mg/dl and TG ≤ 70 mg/dl. This phenotype occurs primarily in lean people on very low-carbohydrate diets and is explained by the lipid energy model.Nano-Chameleon: Smallest reptile on earth, about the size of a sunflower seed. Found in Madagascar. Cannot save you money on car insurance. Like my shirt?https://metabolismshirts.myspreadshop.com Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 23 Aug 2026 22:46:00 -0000 full Nick Norwitz MD PhD Releasing this on the tails of release of LMHR CCTA study data, here: https://www.metabolismjournal.com/article/S0026-0495(24)00080-5/abstract Follow on X: https://x.com/nicknorwitz/status/1803088031689367761Quote: "After a mean duration of 4.7 years of carbohydrate restriction-induced elevations in #LDL-cholesterol [mean 272 mg/dl, max 591 mg/dl], a metabolically healthy cohort of subjects on a ketogenic diet [#LMHR] did not have greater atherosclerotic burden than participants from a population based cohort with similar risk profiles but markedly lower [123 mg/dl] LDL-C." JAMA Cardiology Paper: https://pubmed.ncbi.nlm.nih.gov/32049305/ Chapters0:00 – Introduction0:41 – Thought Puzzle: Patient A (FH) vs Patient B (LMHR)2:34 – JAMA Cardiology Study4:35 – LDL/ApoB vs Plaque Progression Graph5:20 – Lizards 5:55 – Return to Thought PuzzleTerms- LDL cholesterol: The cholesterol component found in circulating LDL lipoprotein particles.- ApoB: An apolipoprotein on LDL and related particles. There is one ApoB per LDL particle.- Lean Mass Hyper-Responder (LMHR): Defined by the union of LDL-C ≥ 200 mg/dl, HDL-C, ≥ 80 mg/dl and TG ≤ 70 mg/dl. This phenotype occurs primarily in lean people on very low-carbohydrate diets and is explained by the lipid energy model.Nano-Chameleon: Smallest reptile on earth, about the size of a sunflower seed. Found in Madagascar. Cannot save you money on car insurance. Like my shirt?https://metabolismshirts.myspreadshop.com Learn more about your ad choices. Visit megaphone.fm/adchoices Releasing this on the tails of release of LMHR CCTA study data, here: https://www.metabolismjournal.com/article/S0026-0495(24)00080-5/abstract

Follow on X: https://x.com/nicknorwitz/status/1803088031689367761

Quote: "After a mean duration of 4.7 years of carbohydrate restriction-induced elevations in #LDL-cholesterol [mean 272 mg/dl, max 591 mg/dl], a metabolically healthy cohort of subjects on a ketogenic diet [#LMHR] did not have greater atherosclerotic burden than participants from a population based cohort with similar risk profiles but markedly lower [123 mg/dl] LDL-C."

JAMA Cardiology Paper: https://pubmed.ncbi.nlm.nih.gov/32049305/

Chapters
0:00 – Introduction
0:41 – Thought Puzzle: Patient A (FH) vs Patient B (LMHR)
2:34 – JAMA Cardiology Study
4:35 – LDL/ApoB vs Plaque Progression Graph
5:20 – Lizards
5:55 – Return to Thought Puzzle

Terms
- LDL cholesterol: The cholesterol component found in circulating LDL lipoprotein particles.
- ApoB: An apolipoprotein on LDL and related particles. There is one ApoB per LDL particle.
- Lean Mass Hyper-Responder (LMHR): Defined by the union of LDL-C ≥ 200 mg/dl, HDL-C, ≥ 80 mg/dl and TG ≤ 70 mg/dl. This phenotype occurs primarily in lean people on very low-carbohydrate diets and is explained by the lipid energy model.

Nano-Chameleon: Smallest reptile on earth, about the size of a sunflower seed. Found in Madagascar. Cannot save you money on car insurance.

Like my shirt?
https://metabolismshirts.myspreadshop.com

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 668 no Surprising Weight Loss Tips | Dr. Jason Fung Part 1 Interview with Dr. Jason Fung: https://youtu.be/CdpuY7Kz7BI Resistant Starch and Visceral Fat Loss (Randomized Trial): https://open.substack.com/pub/staycuriousmetabolism/p/shrink-visceral-fat-by-feeding-your?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Dr. Jason Fung Website: https://drjasonfung.com Statin GLP-1, Video: https://youtu.be/6NomrgjK1yQ Description:In this discussion with Dr. Jason Fung, we break down high-yield health hacks for weight loss. We discuss the best ways to eat rice and potatoes, the importance of food order, and what might be the best drink for weight loss. We delve deep into the physiology, explain why hormones matter, and kick dietary dogma in the teeth. If you’re someone who loves practical science and a few jokes along the way, this discussion is for you.Chapters0:00 – The Hunger Code with Dr. Jason Fung1:13 – What’s the Best Way to Eat Rice? The Importance of Resistant Starch4:53 – Baked Potato or Potato Salad — What’s Healthier?6:54 – The Effect of Organic Acids on Insulin Spikes9:19 – Food Order Matters — What to Eat Last?12:33 – Is This the Best Drink for Weight Loss — and Why?16:43 – Stress Makes Your Body Produce Sugar19:38 – How the Microbiome Promotes Stress Eating22:13 – Medications, Incentives, and What Gets Missed23:50 – Calories Don’t Cause Obesity#WeightLossScience #InsulinResistance #fatloss #ResistantStarch #BloodSugarControl #MealTiming #FoodOrderMatters #MetabolicHealth #JasonFung #TheHungerCode #GlycemicIndex #LowInsulinLiving #GreenTeaBenefits #GutBrainAxis #MicrobiomeHealth #GLP1 #HormoneHealth #EvidenceBasedNutrition #ObesityScience #HealthEducation #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 23 Aug 2026 04:46:00 -0000 full Nick Norwitz MD PhD Part 1 Interview with Dr. Jason Fung: https://youtu.be/CdpuY7Kz7BI Resistant Starch and Visceral Fat Loss (Randomized Trial): https://open.substack.com/pub/staycuriousmetabolism/p/shrink-visceral-fat-by-feeding-your?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Dr. Jason Fung Website: https://drjasonfung.com Statin GLP-1, Video: https://youtu.be/6NomrgjK1yQ Description:In this discussion with Dr. Jason Fung, we break down high-yield health hacks for weight loss. We discuss the best ways to eat rice and potatoes, the importance of food order, and what might be the best drink for weight loss. We delve deep into the physiology, explain why hormones matter, and kick dietary dogma in the teeth. If you’re someone who loves practical science and a few jokes along the way, this discussion is for you.Chapters0:00 – The Hunger Code with Dr. Jason Fung1:13 – What’s the Best Way to Eat Rice? The Importance of Resistant Starch4:53 – Baked Potato or Potato Salad — What’s Healthier?6:54 – The Effect of Organic Acids on Insulin Spikes9:19 – Food Order Matters — What to Eat Last?12:33 – Is This the Best Drink for Weight Loss — and Why?16:43 – Stress Makes Your Body Produce Sugar19:38 – How the Microbiome Promotes Stress Eating22:13 – Medications, Incentives, and What Gets Missed23:50 – Calories Don’t Cause Obesity#WeightLossScience #InsulinResistance #fatloss #ResistantStarch #BloodSugarControl #MealTiming #FoodOrderMatters #MetabolicHealth #JasonFung #TheHungerCode #GlycemicIndex #LowInsulinLiving #GreenTeaBenefits #GutBrainAxis #MicrobiomeHealth #GLP1 #HormoneHealth #EvidenceBasedNutrition #ObesityScience #HealthEducation #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Part 1 Interview with Dr. Jason Fung: https://youtu.be/CdpuY7Kz7BI

Resistant Starch and Visceral Fat Loss (Randomized Trial): https://open.substack.com/pub/staycuriousmetabolism/p/shrink-visceral-fat-by-feeding-your?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Dr. Jason Fung Website: https://drjasonfung.com

Statin GLP-1, Video: https://youtu.be/6NomrgjK1yQ

Description:
In this discussion with Dr. Jason Fung, we break down high-yield health hacks for weight loss. We discuss the best ways to eat rice and potatoes, the importance of food order, and what might be the best drink for weight loss.

We delve deep into the physiology, explain why hormones matter, and kick dietary dogma in the teeth. If you’re someone who loves practical science and a few jokes along the way, this discussion is for you.

Chapters
0:00 – The Hunger Code with Dr. Jason Fung
1:13 – What’s the Best Way to Eat Rice? The Importance of Resistant Starch
4:53 – Baked Potato or Potato Salad — What’s Healthier?
6:54 – The Effect of Organic Acids on Insulin Spikes
9:19 – Food Order Matters — What to Eat Last?
12:33 – Is This the Best Drink for Weight Loss — and Why?
16:43 – Stress Makes Your Body Produce Sugar
19:38 – How the Microbiome Promotes Stress Eating
22:13 – Medications, Incentives, and What Gets Missed
23:50 – Calories Don’t Cause Obesity

#WeightLossScience #InsulinResistance #fatloss #ResistantStarch #BloodSugarControl #MealTiming #FoodOrderMatters #MetabolicHealth #JasonFung #TheHungerCode #GlycemicIndex #LowInsulinLiving #GreenTeaBenefits #GutBrainAxis #MicrobiomeHealth #GLP1 #HormoneHealth #EvidenceBasedNutrition #ObesityScience #HealthEducation #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 2173 no Surprisingly Sensible Truths About Metabolism Chapters0:00 – Introduction 0:58 – 1. Physiology does not care about cut points 2:00 – 2. Ketogenic diet is not defined by a specific carb intake 4:03 – 3. Biology isn’t about balance, it’s about cycles5:02 – 4. There is no one best human diet6:46 – 5. Metabolic adaptation takes time8:40 – 6. You can’t target a biomarker in isolation 10:02 – 7. Metabolic context mattersScience is a Process, Not an Institution, link: https://metabolismshirts.myspreadshop.comFiber study: https://pubmed.ncbi.nlm.nih.gov/34256014/ Exercise study: https://pubmed.ncbi.nlm.nih.gov/32470399/ Re-analysis: https://pubmed.ncbi.nlm.nih.gov/38128881/ Related video, abstract: https://youtu.be/gKX2Bnii9C0 Related video, interview with Professor Willett: https://youtu.be/tIPX_TnUAWQ Letter: https://pubmed.ncbi.nlm.nih.gov/38316213/ Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 22 Aug 2026 10:46:00 -0000 full Nick Norwitz MD PhD Chapters0:00 – Introduction 0:58 – 1. Physiology does not care about cut points 2:00 – 2. Ketogenic diet is not defined by a specific carb intake 4:03 – 3. Biology isn’t about balance, it’s about cycles5:02 – 4. There is no one best human diet6:46 – 5. Metabolic adaptation takes time8:40 – 6. You can’t target a biomarker in isolation 10:02 – 7. Metabolic context mattersScience is a Process, Not an Institution, link: https://metabolismshirts.myspreadshop.comFiber study: https://pubmed.ncbi.nlm.nih.gov/34256014/ Exercise study: https://pubmed.ncbi.nlm.nih.gov/32470399/ Re-analysis: https://pubmed.ncbi.nlm.nih.gov/38128881/ Related video, abstract: https://youtu.be/gKX2Bnii9C0 Related video, interview with Professor Willett: https://youtu.be/tIPX_TnUAWQ Letter: https://pubmed.ncbi.nlm.nih.gov/38316213/ Learn more about your ad choices. Visit megaphone.fm/adchoices Chapters
0:00 – Introduction
0:58 – 1. Physiology does not care about cut points
2:00 – 2. Ketogenic diet is not defined by a specific carb intake
4:03 – 3. Biology isn’t about balance, it’s about cycles
5:02 – 4. There is no one best human diet
6:46 – 5. Metabolic adaptation takes time
8:40 – 6. You can’t target a biomarker in isolation
10:02 – 7. Metabolic context matters

Science is a Process, Not an Institution, link: https://metabolismshirts.myspreadshop.com

Fiber study: https://pubmed.ncbi.nlm.nih.gov/34256014/
Exercise study: https://pubmed.ncbi.nlm.nih.gov/32470399/
Re-analysis: https://pubmed.ncbi.nlm.nih.gov/38128881/
Related video, abstract: https://youtu.be/gKX2Bnii9C0
Related video, interview with Professor Willett: https://youtu.be/tIPX_TnUAWQ
Letter: https://pubmed.ncbi.nlm.nih.gov/38316213/

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 836 no Why I’m Starting this Cholesterol Drug (For My Brain) For more nuances and all the references, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/this-study-completely-changed-how?r=40ekz2 Cholesterol Mini-Masterclass Letter: https://staycuriousmetabolism.substack.com/p/a-concise-masterclass-on-cholesterol?r=40ekz2 Lithium Video: https://youtu.be/Hcz0Eyp1LE4 LPC-DHA (Omega-3) Video: https://youtu.be/B-kEn0FukXM And to try the Accentrate Omega Max supplement containing LPC-DHA, click HERE: https://www.fenixhealthscience.com/staycuriousUse code StayCurious for 20% off.NAD Letter: https://staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2 DescriptionEzetimibe is usually thought of as a cholesterol-lowering drug. But a new study suggests it may be doing something completely unexpected — in the brain. In this video, I break down fascinating new mechanistic, cellular, animal, and human data suggesting ezetimibe may interrupt a key protein interaction implicated in Alzheimer’s disease and reduce amyloid and tau accumulation, boost autophagy, and associate with dramatically lower rates of dementia.I also walk through the limitations, safety considerations, my own personal risk–benefit thinking (as someone with ApoE4/4), and what I’m currently doing for brain health. As always, this is not medical advice — it’s an exploration of emerging data so you can make more informed, individualized decisions. Chapters 0:00 – A Cholesterol Drug… for the Brain?1:45 – Roadmap to This Video: Background, New Study, Personal Plan, and Brain Health Tips2:28 – Chapter 1: Background on Ezetimibe and Alzheimer’s Disease5:30 – Chapter 2: New Study on Ezetimibe and Alzheimer’s Disease9:40 – Caveats, Limitations, and Clarifications12:56 – Chapter 3: What I’m Personally Doing Next14:47 – Chapter 4: High-Yield Rapid Fire Tips for Brain Health14:51 – Lithium For Brain Health15:01 – LPC-DHA For Brain Health15:33 – NAD For Brain Health: NR and NMN15:53 – Closing Message of Hope for Cognitive Longevity #Ezetimibe #Alzheimers #Dementia #BrainHealth #Neurodegeneration #Cholesterol #ApoE4 #ApoE4 #CognitiveHealth #Longevity #Neuroscience #MedicalResearch #DrugRepurposing #Autophagy #Amyloid #Tau #ProteinAggregation #Hexokinase #1433Protein #MetabolicHealth #PreventAlzheimers #CognitiveLongevity #Biohacking #HealthScience #StayCurious #NPC1L1 #LDL #Cardiology #Neurology #AgingResearch #AlzheimersPrevention #BrainOptimization #Pharmacology #EvidenceBased #ClinicalScience #TranslationalMedicine #WormModel #CellBiology #MechanisticMedicine #PrecisionHealth #RCT #MedicalEducation #BrainAging #Supplements #LithiumOrotate #Omega3 #LPCDHA #NAD #NMN #NicotinamideRiboside #CETP Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 21 Aug 2026 16:46:00 -0000 full Nick Norwitz MD PhD For more nuances and all the references, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/this-study-completely-changed-how?r=40ekz2 Cholesterol Mini-Masterclass Letter: https://staycuriousmetabolism.substack.com/p/a-concise-masterclass-on-cholesterol?r=40ekz2 Lithium Video: https://youtu.be/Hcz0Eyp1LE4 LPC-DHA (Omega-3) Video: https://youtu.be/B-kEn0FukXM And to try the Accentrate Omega Max supplement containing LPC-DHA, click HERE: https://www.fenixhealthscience.com/staycuriousUse code StayCurious for 20% off.NAD Letter: https://staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2 DescriptionEzetimibe is usually thought of as a cholesterol-lowering drug. But a new study suggests it may be doing something completely unexpected — in the brain. In this video, I break down fascinating new mechanistic, cellular, animal, and human data suggesting ezetimibe may interrupt a key protein interaction implicated in Alzheimer’s disease and reduce amyloid and tau accumulation, boost autophagy, and associate with dramatically lower rates of dementia.I also walk through the limitations, safety considerations, my own personal risk–benefit thinking (as someone with ApoE4/4), and what I’m currently doing for brain health. As always, this is not medical advice — it’s an exploration of emerging data so you can make more informed, individualized decisions. Chapters 0:00 – A Cholesterol Drug… for the Brain?1:45 – Roadmap to This Video: Background, New Study, Personal Plan, and Brain Health Tips2:28 – Chapter 1: Background on Ezetimibe and Alzheimer’s Disease5:30 – Chapter 2: New Study on Ezetimibe and Alzheimer’s Disease9:40 – Caveats, Limitations, and Clarifications12:56 – Chapter 3: What I’m Personally Doing Next14:47 – Chapter 4: High-Yield Rapid Fire Tips for Brain Health14:51 – Lithium For Brain Health15:01 – LPC-DHA For Brain Health15:33 – NAD For Brain Health: NR and NMN15:53 – Closing Message of Hope for Cognitive Longevity #Ezetimibe #Alzheimers #Dementia #BrainHealth #Neurodegeneration #Cholesterol #ApoE4 #ApoE4 #CognitiveHealth #Longevity #Neuroscience #MedicalResearch #DrugRepurposing #Autophagy #Amyloid #Tau #ProteinAggregation #Hexokinase #1433Protein #MetabolicHealth #PreventAlzheimers #CognitiveLongevity #Biohacking #HealthScience #StayCurious #NPC1L1 #LDL #Cardiology #Neurology #AgingResearch #AlzheimersPrevention #BrainOptimization #Pharmacology #EvidenceBased #ClinicalScience #TranslationalMedicine #WormModel #CellBiology #MechanisticMedicine #PrecisionHealth #RCT #MedicalEducation #BrainAging #Supplements #LithiumOrotate #Omega3 #LPCDHA #NAD #NMN #NicotinamideRiboside #CETP Learn more about your ad choices. Visit megaphone.fm/adchoices For more nuances and all the references, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/this-study-completely-changed-how?r=40ekz2

Cholesterol Mini-Masterclass Letter: https://staycuriousmetabolism.substack.com/p/a-concise-masterclass-on-cholesterol?r=40ekz2

Lithium Video: https://youtu.be/Hcz0Eyp1LE4

LPC-DHA (Omega-3) Video: https://youtu.be/B-kEn0FukXM
And to try the Accentrate Omega Max supplement containing LPC-DHA, click HERE: https://www.fenixhealthscience.com/staycurious

Use code StayCurious for 20% off.

NAD Letter: https://staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2

Description

Ezetimibe is usually thought of as a cholesterol-lowering drug. But a new study suggests it may be doing something completely unexpected — in the brain. In this video, I break down fascinating new mechanistic, cellular, animal, and human data suggesting ezetimibe may interrupt a key protein interaction implicated in Alzheimer’s disease and reduce amyloid and tau accumulation, boost autophagy, and associate with dramatically lower rates of dementia.

I also walk through the limitations, safety considerations, my own personal risk–benefit thinking (as someone with ApoE4/4), and what I’m currently doing for brain health. As always, this is not medical advice — it’s an exploration of emerging data so you can make more informed, individualized decisions.

Chapters
0:00 – A Cholesterol Drug… for the Brain?
1:45 – Roadmap to This Video: Background, New Study, Personal Plan, and Brain Health Tips
2:28 – Chapter 1: Background on Ezetimibe and Alzheimer’s Disease
5:30 – Chapter 2: New Study on Ezetimibe and Alzheimer’s Disease
9:40 – Caveats, Limitations, and Clarifications
12:56 – Chapter 3: What I’m Personally Doing Next
14:47 – Chapter 4: High-Yield Rapid Fire Tips for Brain Health
14:51 – Lithium For Brain Health
15:01 – LPC-DHA For Brain Health
15:33 – NAD For Brain Health: NR and NMN
15:53 – Closing Message of Hope for Cognitive Longevity

#Ezetimibe #Alzheimers #Dementia #BrainHealth #Neurodegeneration #Cholesterol #ApoE4 #ApoE4 #CognitiveHealth #Longevity #Neuroscience #MedicalResearch #DrugRepurposing #Autophagy #Amyloid #Tau #ProteinAggregation #Hexokinase #1433Protein #MetabolicHealth #PreventAlzheimers #CognitiveLongevity #Biohacking #HealthScience #StayCurious #NPC1L1 #LDL #Cardiology #Neurology #AgingResearch #AlzheimersPrevention #BrainOptimization #Pharmacology #EvidenceBased #ClinicalScience #TranslationalMedicine #WormModel #CellBiology #MechanisticMedicine #PrecisionHealth #RCT #MedicalEducation #BrainAging #Supplements #LithiumOrotate #Omega3 #LPCDHA #NAD #NMN #NicotinamideRiboside #CETP

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1307 no Lifting and Lipids: Exercise Reverses a Signature of Aging in Fat Nature Aging Paper: https://www.nature.com/articles/s43587-024-00595-2 L-Citrulline, Exercise, and Bone Video: https://youtu.be/8FH_8pFXFBE For the BEST Thread on Protein and Exercise You've Ever Read: https://x.com/nicknorwitz/status/1805576266994565120Chapters0:00 – Introduction0:41 – BMP lipids accumulate with age1:25 – Young and Old Humans1:57 – Rejuvenate Aging Lipid Signature with Exercise4:28 – Bonus Q and A on Protein and Exercise4:49 – How much protein?5:14 – Protein Spacing?5:31 – Plant vs Animal Protein?6:40 – Keto-Adaptation?#Longevity #Healthspan #AntiAging #Epigenetics #Exercise #Educational #MetabolicHealth #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 20 Aug 2026 22:46:00 -0000 full Nick Norwitz MD PhD Nature Aging Paper: https://www.nature.com/articles/s43587-024-00595-2 L-Citrulline, Exercise, and Bone Video: https://youtu.be/8FH_8pFXFBE For the BEST Thread on Protein and Exercise You've Ever Read: https://x.com/nicknorwitz/status/1805576266994565120Chapters0:00 – Introduction0:41 – BMP lipids accumulate with age1:25 – Young and Old Humans1:57 – Rejuvenate Aging Lipid Signature with Exercise4:28 – Bonus Q and A on Protein and Exercise4:49 – How much protein?5:14 – Protein Spacing?5:31 – Plant vs Animal Protein?6:40 – Keto-Adaptation?#Longevity #Healthspan #AntiAging #Epigenetics #Exercise #Educational #MetabolicHealth #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Nature Aging Paper: https://www.nature.com/articles/s43587-024-00595-2

L-Citrulline, Exercise, and Bone Video: https://youtu.be/8FH_8pFXFBE

For the BEST Thread on Protein and Exercise You've Ever Read: https://x.com/nicknorwitz/status/1805576266994565120

Chapters
0:00 – Introduction
0:41 – BMP lipids accumulate with age
1:25 – Young and Old Humans
1:57 – Rejuvenate Aging Lipid Signature with Exercise
4:28 – Bonus Q and A on Protein and Exercise
4:49 – How much protein?
5:14 – Protein Spacing?
5:31 – Plant vs Animal Protein?
6:40 – Keto-Adaptation?

#Longevity #Healthspan #AntiAging #Epigenetics #Exercise #Educational #MetabolicHealth #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 665 no This Particle Raises Heart Disease Risk 230% — How to Stop It For all references, extra nuances, and more practical insights, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/the-hidden-mechanism-behind-lpa-riskand?r=40ekz2 And don’t miss out on the StayCurious Metabolism Heart Health Library, here: https://staycuriousmetabolism.substack.com/p/hearthealth Other Lp(a) content:Lp(a) and Vitamin C: https://staycuriousmetabolism.substack.com/p/why-vitamin-c-is-the-most-underrated?r=40ekz2 Lp(a) and Waist-to-Hip Ratio: https://staycuriousmetabolism.substack.com/p/why-lpa-may-not-be-as-dangerous-as?r=40ekz2 Lp(a) 101: https://staycuriousmetabolism.substack.com/p/lpa-explained-genetics-risk-and-what?r=40ekz2 Resistant Starch Letter: https://staycuriousmetabolism.substack.com/p/shrink-visceral-fat-by-feeding-your?r=40ekz2 Description: Lp(a), is one a genetically determined risk factors for cardiovascular disease. People with high Lp(a) can face dramatically elevated risks of heart attack, stroke, and premature death—and unlike LDL cholesterol, there are currently no widely available treatments specifically designed to lower its risk. In this video, we explore a new mechanistic perspective on how Lp(a) damages blood vessels. The pathway we review operates independently of LDL and ApoB and could represent a key biological driver of Lp(a)-associated disease. We then examine whether a well-formulated ketogenic diet help interrupt this mechanism. While definitive clinical trials are still lacking, the biological framework is fascinating and potentially powerful.Chapters00:00 – Can Keto Offset Genetic Heart Risk? (Lp(a) Intro)02:01 – What is Lp(a) and Why It’s Dangerous03:44 – The Mechanism: Superoxide, Nitric Oxide and Damage08:41 – Key Nuances: Superoxide and ApoB Independence10:53 – Can a Ketogenic Diet Help? (Mechanistic Framework)14:58 – Practical Strategies + Final Takeaways#LpA #LipoproteinA #HeartDisease #CardiovascularDisease #KetoDiet #KetogenicDiet #Ketosis #NitricOxide #Superoxide #OxidativeStress #Atherosclerosis #MetabolicHealth #LongevityScience #Cardiology #PreventHeartDisease #GeneticRisk #HeartHealth #Metabolism #Biohacking #HealthScience #NutritionScience #Ketones #BetaHydroxybutyrate #NADPH #BH4 #eNOS #Inflammation #VisceralFat #WaistToHipRatio #VitaminC #5MTHF #Folate #MTHFR #DarkChocolate #CocoaFlavanols #EndothelialHealth #LDL #ApoB #PlaqueFormation #OxidativeDamage #HealthEducation #ScientificExplained #MedicalScience #NutritionResearch #PreventiveMedicine #StayCurious #MetabolicTherapy #HealthOptimization #HumanBiology #FunctionalMedicine #heartdisease #cardiovascularhealth #keto #ketogenicdiet #lp(a) #cholesterol #oxidativestress #nitricoxide Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 20 Aug 2026 04:46:00 -0000 full Nick Norwitz MD PhD For all references, extra nuances, and more practical insights, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/the-hidden-mechanism-behind-lpa-riskand?r=40ekz2 And don’t miss out on the StayCurious Metabolism Heart Health Library, here: https://staycuriousmetabolism.substack.com/p/hearthealth Other Lp(a) content:Lp(a) and Vitamin C: https://staycuriousmetabolism.substack.com/p/why-vitamin-c-is-the-most-underrated?r=40ekz2 Lp(a) and Waist-to-Hip Ratio: https://staycuriousmetabolism.substack.com/p/why-lpa-may-not-be-as-dangerous-as?r=40ekz2 Lp(a) 101: https://staycuriousmetabolism.substack.com/p/lpa-explained-genetics-risk-and-what?r=40ekz2 Resistant Starch Letter: https://staycuriousmetabolism.substack.com/p/shrink-visceral-fat-by-feeding-your?r=40ekz2 Description: Lp(a), is one a genetically determined risk factors for cardiovascular disease. People with high Lp(a) can face dramatically elevated risks of heart attack, stroke, and premature death—and unlike LDL cholesterol, there are currently no widely available treatments specifically designed to lower its risk. In this video, we explore a new mechanistic perspective on how Lp(a) damages blood vessels. The pathway we review operates independently of LDL and ApoB and could represent a key biological driver of Lp(a)-associated disease. We then examine whether a well-formulated ketogenic diet help interrupt this mechanism. While definitive clinical trials are still lacking, the biological framework is fascinating and potentially powerful.Chapters00:00 – Can Keto Offset Genetic Heart Risk? (Lp(a) Intro)02:01 – What is Lp(a) and Why It’s Dangerous03:44 – The Mechanism: Superoxide, Nitric Oxide and Damage08:41 – Key Nuances: Superoxide and ApoB Independence10:53 – Can a Ketogenic Diet Help? (Mechanistic Framework)14:58 – Practical Strategies + Final Takeaways#LpA #LipoproteinA #HeartDisease #CardiovascularDisease #KetoDiet #KetogenicDiet #Ketosis #NitricOxide #Superoxide #OxidativeStress #Atherosclerosis #MetabolicHealth #LongevityScience #Cardiology #PreventHeartDisease #GeneticRisk #HeartHealth #Metabolism #Biohacking #HealthScience #NutritionScience #Ketones #BetaHydroxybutyrate #NADPH #BH4 #eNOS #Inflammation #VisceralFat #WaistToHipRatio #VitaminC #5MTHF #Folate #MTHFR #DarkChocolate #CocoaFlavanols #EndothelialHealth #LDL #ApoB #PlaqueFormation #OxidativeDamage #HealthEducation #ScientificExplained #MedicalScience #NutritionResearch #PreventiveMedicine #StayCurious #MetabolicTherapy #HealthOptimization #HumanBiology #FunctionalMedicine #heartdisease #cardiovascularhealth #keto #ketogenicdiet #lp(a) #cholesterol #oxidativestress #nitricoxide Learn more about your ad choices. Visit megaphone.fm/adchoices For all references, extra nuances, and more practical insights, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/the-hidden-mechanism-behind-lpa-riskand?r=40ekz2

And don’t miss out on the StayCurious Metabolism Heart Health Library, here: https://staycuriousmetabolism.substack.com/p/hearthealth

Other Lp(a) content:

Lp(a) and Vitamin C: https://staycuriousmetabolism.substack.com/p/why-vitamin-c-is-the-most-underrated?r=40ekz2

Lp(a) and Waist-to-Hip Ratio: https://staycuriousmetabolism.substack.com/p/why-lpa-may-not-be-as-dangerous-as?r=40ekz2

Lp(a) 101: https://staycuriousmetabolism.substack.com/p/lpa-explained-genetics-risk-and-what?r=40ekz2

Resistant Starch Letter: https://staycuriousmetabolism.substack.com/p/shrink-visceral-fat-by-feeding-your?r=40ekz2

Description:
Lp(a), is one a genetically determined risk factors for cardiovascular disease. People with high Lp(a) can face dramatically elevated risks of heart attack, stroke, and premature death—and unlike LDL cholesterol, there are currently no widely available treatments specifically designed to lower its risk. In this video, we explore a new mechanistic perspective on how Lp(a) damages blood vessels.

The pathway we review operates independently of LDL and ApoB and could represent a key biological driver of Lp(a)-associated disease. We then examine whether a well-formulated ketogenic diet help interrupt this mechanism. While definitive clinical trials are still lacking, the biological framework is fascinating and potentially powerful.

Chapters
00:00 – Can Keto Offset Genetic Heart Risk? (Lp(a) Intro)
02:01 – What is Lp(a) and Why It’s Dangerous
03:44 – The Mechanism: Superoxide, Nitric Oxide and Damage
08:41 – Key Nuances: Superoxide and ApoB Independence
10:53 – Can a Ketogenic Diet Help? (Mechanistic Framework)
14:58 – Practical Strategies + Final Takeaways

#LpA #LipoproteinA #HeartDisease #CardiovascularDisease #KetoDiet #KetogenicDiet #Ketosis #NitricOxide #Superoxide #OxidativeStress #Atherosclerosis #MetabolicHealth #LongevityScience #Cardiology #PreventHeartDisease #GeneticRisk #HeartHealth #Metabolism #Biohacking #HealthScience #NutritionScience #Ketones #BetaHydroxybutyrate #NADPH #BH4 #eNOS #Inflammation #VisceralFat #WaistToHipRatio #VitaminC #5MTHF #Folate #MTHFR #DarkChocolate #CocoaFlavanols #EndothelialHealth #LDL #ApoB #PlaqueFormation #OxidativeDamage #HealthEducation #ScientificExplained #MedicalScience #NutritionResearch #PreventiveMedicine #StayCurious #MetabolicTherapy #HealthOptimization #HumanBiology #FunctionalMedicine #heartdisease #cardiovascularhealth #keto #ketogenicdiet #lp(a) #cholesterol #oxidativestress #nitricoxide

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1532 no Wait, What? How Your Gut Can Sense Sweetness "Gut Sense" @hubermanlab with Dr Diego Bohorquez (May 27, 2024)YouTube: https://youtu.be/SZSRgyl7pyQ?si=ZuEzZVtXdTQbxC_5Spotify: https://open.spotify.com/episode/4g7DtKQzRU29qQVPgUmaMS?si=00044f469a8945bc&nd=1&dlsi=8e7290ca9ba14eb4Paper: https://pubmed.ncbi.nlm.nih.gov/35027761/Chapters0:00 – Intro0:56 – Flavor-Nutrient Conditioning 2:06 – Bohorquez Nature Neuroscience Paper2:56 – Neuropod cells3:19 – Optogenetics! 4:38 – How the System Outsmarts the Sweet7:35 – 50,000-foot view8:04 – Manipulating the system with optogenetics 9:44 – Takeaways Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 19 Aug 2026 10:46:00 -0000 full Nick Norwitz MD PhD "Gut Sense" @hubermanlab with Dr Diego Bohorquez (May 27, 2024)YouTube: https://youtu.be/SZSRgyl7pyQ?si=ZuEzZVtXdTQbxC_5Spotify: https://open.spotify.com/episode/4g7DtKQzRU29qQVPgUmaMS?si=00044f469a8945bc&nd=1&dlsi=8e7290ca9ba14eb4Paper: https://pubmed.ncbi.nlm.nih.gov/35027761/Chapters0:00 – Intro0:56 – Flavor-Nutrient Conditioning 2:06 – Bohorquez Nature Neuroscience Paper2:56 – Neuropod cells3:19 – Optogenetics! 4:38 – How the System Outsmarts the Sweet7:35 – 50,000-foot view8:04 – Manipulating the system with optogenetics 9:44 – Takeaways Learn more about your ad choices. Visit megaphone.fm/adchoices "Gut Sense" @hubermanlab with Dr Diego Bohorquez (May 27, 2024)

YouTube: https://youtu.be/SZSRgyl7pyQ?si=ZuEzZVtXdTQbxC_5

Spotify: https://open.spotify.com/episode/4g7DtKQzRU29qQVPgUmaMS?si=00044f469a8945bc&nd=1&dlsi=8e7290ca9ba14eb4

Paper: https://pubmed.ncbi.nlm.nih.gov/35027761/

Chapters
0:00 – Intro
0:56 – Flavor-Nutrient Conditioning
2:06 – Bohorquez Nature Neuroscience Paper
2:56 – Neuropod cells
3:19 – Optogenetics!
4:38 – How the System Outsmarts the Sweet
7:35 – 50,000-foot view
8:04 – Manipulating the system with optogenetics
9:44 – Takeaways

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 841 no An Astounding Breakthrough in the Fight Against Alzheimer's For additional nuances, references, and early access to content, see the StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/hijacking-cancer-to-kill-alzheimers?r=40ekz2 Check out this link to access our StayCurious Brain Health Archives: https://staycuriousmetabolism.substack.com/p/brainhealth Omega-3 and Brain Health Video: https://youtu.be/B-kEn0FukXM To try the Accentrate Omega Max supplement containing LPC-DHA, click here: https://www.fenixhealthscience.com/staycuriousUse code StayCurious for 20% off.Lithium Brain Health Video: https://youtu.be/Hcz0Eyp1LE4 NAD+ Brain Health Letter: https://staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2 A new paper published in Cell reveals an unexpected biological connection between cancer and Alzheimer’s disease—one that challenges long-held assumptions about both. In this video, MD-PhD neuroscientist Nick Norwitz walks through the actual data behind the study, showing how proteins secreted by cancer cells reduced amyloid pathology and improved cognition in Alzheimer’s mouse models. The effect was traced to a single protein, cystatin C, which appears to help the brain’s immune system clear amyloid plaques.Rather than relying on headlines or hype, this video carefully breaks down what the researchers did, what they found, and what the results do—and do not—mean for Alzheimer’s treatment. You’ll see how multiple cancer types produced similar effects, why the tumor itself wasn’t responsible, and how purified human cystatin C reversed memory deficits in preclinical models.In the second half, the video zooms out to share a concise, evidence-backed review of practical strategies for long-term brain health, including DHA delivery to the brain, lithium, and NAD⁺ metabolism. Chapters0:00 – Biological Plot Twist!? Cancer and Alzheimer’s Unexpectedly Collide1:27 – A Roadmap to This Video2:07 – Background: Cancer Linked to Lower Alzheimer’s Risk3:55 – Is It the Cancer or ‘Something Else’ Protecting from Alzheimer’s Disease?4:36 – Cancer-Secreted Proteins Improve Cognition and Memory 5:56 – The Key Ingredient in Cancer-Secreted Proteins Responsible for the Effect8:05 – Open Questions for Future Research 9:15 – Part 2: High-Yield Review of Supplements for Brain Health9:30 – LPC-DHA: Omega-3 for the Brain11:15 – Microdosed Lithium for Alzheimer’s Prevention 13:17 – NAD to ‘Never get Alzheimer’s Disease’#Alzheimers #CognitiveHealth #Neuroscience #BrainHealth #CognitiveLongevity #Amyloid #CystatinC #CancerResearch #Neurodegeneration #MedicalScience #CellJournal #ScienceExplained #MDPhD #LongevityScience #BrainAging #Microglia #MemoryResearch #DementiaResearch #BiologyExplained #TranslationalScience #BrainMetabolism #Omega3 #DHA #Lithium #NAD #NMN #NR #MetabolicHealth #EvidenceBased #ScienceYouTube #StayCurious #Neuroimmunology #AgingBrain #BiomedicalResearch #HealthScience #MouseModels #Cognition #BrainProtection #AlzheimersResearch #Longevity Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 18 Aug 2026 16:46:00 -0000 full Nick Norwitz MD PhD For additional nuances, references, and early access to content, see the StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/hijacking-cancer-to-kill-alzheimers?r=40ekz2 Check out this link to access our StayCurious Brain Health Archives: https://staycuriousmetabolism.substack.com/p/brainhealth Omega-3 and Brain Health Video: https://youtu.be/B-kEn0FukXM To try the Accentrate Omega Max supplement containing LPC-DHA, click here: https://www.fenixhealthscience.com/staycuriousUse code StayCurious for 20% off.Lithium Brain Health Video: https://youtu.be/Hcz0Eyp1LE4 NAD+ Brain Health Letter: https://staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2 A new paper published in Cell reveals an unexpected biological connection between cancer and Alzheimer’s disease—one that challenges long-held assumptions about both. In this video, MD-PhD neuroscientist Nick Norwitz walks through the actual data behind the study, showing how proteins secreted by cancer cells reduced amyloid pathology and improved cognition in Alzheimer’s mouse models. The effect was traced to a single protein, cystatin C, which appears to help the brain’s immune system clear amyloid plaques.Rather than relying on headlines or hype, this video carefully breaks down what the researchers did, what they found, and what the results do—and do not—mean for Alzheimer’s treatment. You’ll see how multiple cancer types produced similar effects, why the tumor itself wasn’t responsible, and how purified human cystatin C reversed memory deficits in preclinical models.In the second half, the video zooms out to share a concise, evidence-backed review of practical strategies for long-term brain health, including DHA delivery to the brain, lithium, and NAD⁺ metabolism. Chapters0:00 – Biological Plot Twist!? Cancer and Alzheimer’s Unexpectedly Collide1:27 – A Roadmap to This Video2:07 – Background: Cancer Linked to Lower Alzheimer’s Risk3:55 – Is It the Cancer or ‘Something Else’ Protecting from Alzheimer’s Disease?4:36 – Cancer-Secreted Proteins Improve Cognition and Memory 5:56 – The Key Ingredient in Cancer-Secreted Proteins Responsible for the Effect8:05 – Open Questions for Future Research 9:15 – Part 2: High-Yield Review of Supplements for Brain Health9:30 – LPC-DHA: Omega-3 for the Brain11:15 – Microdosed Lithium for Alzheimer’s Prevention 13:17 – NAD to ‘Never get Alzheimer’s Disease’#Alzheimers #CognitiveHealth #Neuroscience #BrainHealth #CognitiveLongevity #Amyloid #CystatinC #CancerResearch #Neurodegeneration #MedicalScience #CellJournal #ScienceExplained #MDPhD #LongevityScience #BrainAging #Microglia #MemoryResearch #DementiaResearch #BiologyExplained #TranslationalScience #BrainMetabolism #Omega3 #DHA #Lithium #NAD #NMN #NR #MetabolicHealth #EvidenceBased #ScienceYouTube #StayCurious #Neuroimmunology #AgingBrain #BiomedicalResearch #HealthScience #MouseModels #Cognition #BrainProtection #AlzheimersResearch #Longevity Learn more about your ad choices. Visit megaphone.fm/adchoices For additional nuances, references, and early access to content, see the StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/hijacking-cancer-to-kill-alzheimers?r=40ekz2

Check out this link to access our StayCurious Brain Health Archives: https://staycuriousmetabolism.substack.com/p/brainhealth

Omega-3 and Brain Health Video: https://youtu.be/B-kEn0FukXM

To try the Accentrate Omega Max supplement containing LPC-DHA, click here: https://www.fenixhealthscience.com/staycurious
Use code StayCurious for 20% off.

Lithium Brain Health Video: https://youtu.be/Hcz0Eyp1LE4

NAD+ Brain Health Letter: https://staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2

A new paper published in Cell reveals an unexpected biological connection between cancer and Alzheimer’s disease—one that challenges long-held assumptions about both. In this video, MD-PhD neuroscientist Nick Norwitz walks through the actual data behind the study, showing how proteins secreted by cancer cells reduced amyloid pathology and improved cognition in Alzheimer’s mouse models. The effect was traced to a single protein, cystatin C, which appears to help the brain’s immune system clear amyloid plaques.

Rather than relying on headlines or hype, this video carefully breaks down what the researchers did, what they found, and what the results do—and do not—mean for Alzheimer’s treatment. You’ll see how multiple cancer types produced similar effects, why the tumor itself wasn’t responsible, and how purified human cystatin C reversed memory deficits in preclinical models.
In the second half, the video zooms out to share a concise, evidence-backed review of practical strategies for long-term brain health, including DHA delivery to the brain, lithium, and NAD⁺ metabolism.

Chapters
0:00 – Biological Plot Twist!? Cancer and Alzheimer’s Unexpectedly Collide
1:27 – A Roadmap to This Video
2:07 – Background: Cancer Linked to Lower Alzheimer’s Risk
3:55 – Is It the Cancer or ‘Something Else’ Protecting from Alzheimer’s Disease?
4:36 – Cancer-Secreted Proteins Improve Cognition and Memory
5:56 – The Key Ingredient in Cancer-Secreted Proteins Responsible for the Effect
8:05 – Open Questions for Future Research
9:15 – Part 2: High-Yield Review of Supplements for Brain Health
9:30 – LPC-DHA: Omega-3 for the Brain
11:15 – Microdosed Lithium for Alzheimer’s Prevention
13:17 – NAD to ‘Never get Alzheimer’s Disease’

#Alzheimers #CognitiveHealth #Neuroscience #BrainHealth #CognitiveLongevity #Amyloid #CystatinC #CancerResearch #Neurodegeneration #MedicalScience #CellJournal #ScienceExplained #MDPhD #LongevityScience #BrainAging #Microglia #MemoryResearch #DementiaResearch #BiologyExplained #TranslationalScience #BrainMetabolism #Omega3 #DHA #Lithium #NAD #NMN #NR #MetabolicHealth #EvidenceBased #ScienceYouTube #StayCurious #Neuroimmunology #AgingBrain #BiomedicalResearch #HealthScience #MouseModels #Cognition #BrainProtection #AlzheimersResearch #Longevity

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1145 no Could Ozempic Help Solve PCOS? Paper: https://www.nature.com/articles/s42255-024-01041-8 Chapters0:00 – New Paper1:09 – PCOS, The Puzzle1:36 – The Hormone, GLP-1 2:30 – The Bug, B. Vulgatus3:56 – The Receptor, FXR5:40 – The Metabolite, Agmatine6:37 – Disease modification? Allulose Deep Dive: https://youtu.be/pr93EsEV2bMRxSugar: https://rxsugar.com, discount code NICK20-- NOTE: I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different! Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 17 Aug 2026 22:46:00 -0000 full Nick Norwitz MD PhD Paper: https://www.nature.com/articles/s42255-024-01041-8 Chapters0:00 – New Paper1:09 – PCOS, The Puzzle1:36 – The Hormone, GLP-1 2:30 – The Bug, B. Vulgatus3:56 – The Receptor, FXR5:40 – The Metabolite, Agmatine6:37 – Disease modification? Allulose Deep Dive: https://youtu.be/pr93EsEV2bMRxSugar: https://rxsugar.com, discount code NICK20-- NOTE: I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different! Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://www.nature.com/articles/s42255-024-01041-8

Chapters
0:00 – New Paper
1:09 – PCOS, The Puzzle
1:36 – The Hormone, GLP-1
2:30 – The Bug, B. Vulgatus
3:56 – The Receptor, FXR
5:40 – The Metabolite, Agmatine
6:37 – Disease modification?

Allulose Deep Dive: https://youtu.be/pr93EsEV2bM

RxSugar: https://rxsugar.com, discount code NICK20
-- NOTE: I am NOT paid to explicitly promote their product, NOR given profits on sales, NOR otherwise incentivized to try to exploit you for my own gain. No, this is a different!

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 713 no Why We Wanted to Retract Our Own Paper For the written breakdown, see this letter: https://staycuriousmetabolism.substack.com/p/we-want-to-retract-our-own-paper?r=40ekz2In this conversation, I sit down with my friend and colleague Dave Feldman to explain why we’re seeking to retract our own study. For context: on April 7th, 2025 we published results from a trial of ~100 individuals on low-carb diets whose LDL cholesterol dramatically increased—so-called “lean mass hyper-responders.” We set out to answer a critical question: does this group experience accelerated plaque progression, and what predicts that risk?Our original headline finding—that LDL cholesterol and ApoB did not predict plaque progression—still stands. However, the plaque progression data itself was based on an AI-guided analysis conducted by the company Cleerly. After publication, we discovered that their analysis was performed inappropriately (unblinded) with data suggesting errors or bias in the analysis. Unfortunately, the company declined to reanalyze or validate the work. Meanwhile, multiple independent, properly conducted analyses failed to replicate their findings.At that point, it became clear: we could no longer stand behind the original plaque progression results. Importantly, the updated evidence suggests this population may actually be at lower risk than initially implied by the initial anomalous Cleerly findings. In this discussion, we walk through exactly what happened—the data, the errors, and the decision to retract—with full transparency. For those who’ve followed this story, I hope this provides clarity, closure, and a glimpse of where the science goes next.Chapters:0:31 — Why We Want the Paper Retracted1:18 — How This Research Began3:49 — The Study, the Patients, and the Core Finding5:59 — Where the Results Started to Break Apart12:29 — Why We Didn’t See the Full Data Before Publication20:54 — The Raw Dataset Review28:03 — The Independent Analyses That Changed Everything41:04 — The Participant Reanalysis Plot Twist49:43 — The Next Phase of the Research Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 17 Aug 2026 04:46:00 -0000 full Nick Norwitz MD PhD For the written breakdown, see this letter: https://staycuriousmetabolism.substack.com/p/we-want-to-retract-our-own-paper?r=40ekz2In this conversation, I sit down with my friend and colleague Dave Feldman to explain why we’re seeking to retract our own study. For context: on April 7th, 2025 we published results from a trial of ~100 individuals on low-carb diets whose LDL cholesterol dramatically increased—so-called “lean mass hyper-responders.” We set out to answer a critical question: does this group experience accelerated plaque progression, and what predicts that risk?Our original headline finding—that LDL cholesterol and ApoB did not predict plaque progression—still stands. However, the plaque progression data itself was based on an AI-guided analysis conducted by the company Cleerly. After publication, we discovered that their analysis was performed inappropriately (unblinded) with data suggesting errors or bias in the analysis. Unfortunately, the company declined to reanalyze or validate the work. Meanwhile, multiple independent, properly conducted analyses failed to replicate their findings.At that point, it became clear: we could no longer stand behind the original plaque progression results. Importantly, the updated evidence suggests this population may actually be at lower risk than initially implied by the initial anomalous Cleerly findings. In this discussion, we walk through exactly what happened—the data, the errors, and the decision to retract—with full transparency. For those who’ve followed this story, I hope this provides clarity, closure, and a glimpse of where the science goes next.Chapters:0:31 — Why We Want the Paper Retracted1:18 — How This Research Began3:49 — The Study, the Patients, and the Core Finding5:59 — Where the Results Started to Break Apart12:29 — Why We Didn’t See the Full Data Before Publication20:54 — The Raw Dataset Review28:03 — The Independent Analyses That Changed Everything41:04 — The Participant Reanalysis Plot Twist49:43 — The Next Phase of the Research Learn more about your ad choices. Visit megaphone.fm/adchoices For the written breakdown, see this letter: https://staycuriousmetabolism.substack.com/p/we-want-to-retract-our-own-paper?r=40ekz2

In this conversation, I sit down with my friend and colleague Dave Feldman to explain why we’re seeking to retract our own study. For context: on April 7th, 2025 we published results from a trial of ~100 individuals on low-carb diets whose LDL cholesterol dramatically increased—so-called “lean mass hyper-responders.” We set out to answer a critical question: does this group experience accelerated plaque progression, and what predicts that risk?

Our original headline finding—that LDL cholesterol and ApoB did not predict plaque progression—still stands. However, the plaque progression data itself was based on an AI-guided analysis conducted by the company Cleerly. After publication, we discovered that their analysis was performed inappropriately (unblinded) with data suggesting errors or bias in the analysis. Unfortunately, the company declined to reanalyze or validate the work. Meanwhile, multiple independent, properly conducted analyses failed to replicate their findings.

At that point, it became clear: we could no longer stand behind the original plaque progression results. Importantly, the updated evidence suggests this population may actually be at lower risk than initially implied by the initial anomalous Cleerly findings. In this discussion, we walk through exactly what happened—the data, the errors, and the decision to retract—with full transparency. For those who’ve followed this story, I hope this provides clarity, closure, and a glimpse of where the science goes next.

Chapters:
0:31 — Why We Want the Paper Retracted
1:18 — How This Research Began
3:49 — The Study, the Patients, and the Core Finding
5:59 — Where the Results Started to Break Apart
12:29 — Why We Didn’t See the Full Data Before Publication
20:54 — The Raw Dataset Review
28:03 — The Independent Analyses That Changed Everything
41:04 — The Participant Reanalysis Plot Twist
49:43 — The Next Phase of the Research

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 3593 no How Gut Bacteria Influence Protein Bioavailability Paper: https://www.sciencedirect.com/science/article/pii/S19313128240012150:00 – Introduction0:58 –Microbes Gobble Amino Acids 2:28 – Specific genes Influence Bioavailability4:16 – Trp and BCAA Bioavailability Influence Glucose Tolerance6:06 – Summary and concluding thoughtsLike My Shirt?https://metabolismshirts.myspreadshop.com Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 16 Aug 2026 10:46:00 -0000 full Nick Norwitz MD PhD Paper: https://www.sciencedirect.com/science/article/pii/S19313128240012150:00 – Introduction0:58 –Microbes Gobble Amino Acids 2:28 – Specific genes Influence Bioavailability4:16 – Trp and BCAA Bioavailability Influence Glucose Tolerance6:06 – Summary and concluding thoughtsLike My Shirt?https://metabolismshirts.myspreadshop.com Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://www.sciencedirect.com/science/article/pii/S1931312824001215

0:00 – Introduction
0:58 –Microbes Gobble Amino Acids
2:28 – Specific genes Influence Bioavailability
4:16 – Trp and BCAA Bioavailability Influence Glucose Tolerance
6:06 – Summary and concluding thoughts

Like My Shirt?
https://metabolismshirts.myspreadshop.com

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 617 no Blood Sugar According to a Stanford Scientist StayCurious Newsletter on Snyder’s Fiber Randomized Controlled Trial: https://staycuriousmetabolism.substack.com/p/fiber-is-good-for-you-is-lazy-science?r=40ekz2 StayCurious Newsletter on Inulin and Fructose Resistance: https://staycuriousmetabolism.substack.com/p/the-fiber-that-fights-fat-how-inulin?r=40ekz2 Snyder Interview 1, Four Types of Diabetes: https://youtu.be/mCrc4gfbK2o Snyder Interview 2, Most Viral Aging Study: https://youtu.be/kMpGkg4zMOU Snyder Interview 3, Most Beautiful Exercise Study: https://youtu.be/_9ywulQF2Ho Why does the same food spike one person’s blood sugar while barely affecting another?In this fourth conversation with Stanford’s Professor Michael Snyder, we explore new research on individualized glycemic responses, insulin resistance subtypes, and why one-size-fits-all nutrition advice keeps failing. From rice spiking glucose more than ice cream, to the power of the grape-to-potato ratio, and beyond, this discussion reveals how metabolism, microbiome, immune signaling, and insulin sensitivity interact in deeply personal ways.We unpack Snyder’s latest Nature Medicine work, including the “potato-to-grape ratio,” food mitigators like protein and fiber, why fiber doesn’t work the same in insulin-resistant individuals, and how future AI-driven profiling could finally make personalized nutrition practical. If you’ve ever felt confused by conflicting diet advice, this conversation explains why—and where the science is heading next.Chapters 0:00 – Introduction: Get Excited for Professor Snyder!1:08 – Nature Medicine 2025 Personalized Medicine Paper2:56 – Grapes Sky-Rocket Blood Sugar! 5:05 – “For Many People Rice is Worse than Ice Cream” 6:45 – People With High Blood Pressure Are “Bread-Spikers”7:33 – The Brilliant Grape-to-Potato Ratio!12:10 – Those With Insulin Resistance Have Worse Response to Fiber14:40 – The (Second) Coolest Fiber Paper I Ever Read17:00 – Professor Snyders Fiber Randomized Controlled Trial 20:03 – Nick and Professor Snyder Reveal Their Fiber Responses24:48 – The Future of Personalized Medicine is Bright!#nutritionscience #glucose #glycemicresponse #insulin #insulinresistance #prediabetes #type2diabetes #continuousglucosemonitor #cgm #wearabletech #metabolicflexibility #metabolomics #genomics #systemsbiology #biohacking #longevity #healthoptimization #fiber #inulin #psyllium #resistantstarch #betaglucan #cholesterol #inflammation #gutbrainaxis #precisionmedicine #stanfordmedicine #microbiome #bloodsugar #precisionnutrition #metabolichealth #metabolism #stanford #harvard #grapes #diabetes #obesity #guthealth #personalizedmedicine #educational #medicaleducation #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 15 Aug 2026 16:46:00 -0000 full Nick Norwitz MD PhD StayCurious Newsletter on Snyder’s Fiber Randomized Controlled Trial: https://staycuriousmetabolism.substack.com/p/fiber-is-good-for-you-is-lazy-science?r=40ekz2 StayCurious Newsletter on Inulin and Fructose Resistance: https://staycuriousmetabolism.substack.com/p/the-fiber-that-fights-fat-how-inulin?r=40ekz2 Snyder Interview 1, Four Types of Diabetes: https://youtu.be/mCrc4gfbK2o Snyder Interview 2, Most Viral Aging Study: https://youtu.be/kMpGkg4zMOU Snyder Interview 3, Most Beautiful Exercise Study: https://youtu.be/_9ywulQF2Ho Why does the same food spike one person’s blood sugar while barely affecting another?In this fourth conversation with Stanford’s Professor Michael Snyder, we explore new research on individualized glycemic responses, insulin resistance subtypes, and why one-size-fits-all nutrition advice keeps failing. From rice spiking glucose more than ice cream, to the power of the grape-to-potato ratio, and beyond, this discussion reveals how metabolism, microbiome, immune signaling, and insulin sensitivity interact in deeply personal ways.We unpack Snyder’s latest Nature Medicine work, including the “potato-to-grape ratio,” food mitigators like protein and fiber, why fiber doesn’t work the same in insulin-resistant individuals, and how future AI-driven profiling could finally make personalized nutrition practical. If you’ve ever felt confused by conflicting diet advice, this conversation explains why—and where the science is heading next.Chapters 0:00 – Introduction: Get Excited for Professor Snyder!1:08 – Nature Medicine 2025 Personalized Medicine Paper2:56 – Grapes Sky-Rocket Blood Sugar! 5:05 – “For Many People Rice is Worse than Ice Cream” 6:45 – People With High Blood Pressure Are “Bread-Spikers”7:33 – The Brilliant Grape-to-Potato Ratio!12:10 – Those With Insulin Resistance Have Worse Response to Fiber14:40 – The (Second) Coolest Fiber Paper I Ever Read17:00 – Professor Snyders Fiber Randomized Controlled Trial 20:03 – Nick and Professor Snyder Reveal Their Fiber Responses24:48 – The Future of Personalized Medicine is Bright!#nutritionscience #glucose #glycemicresponse #insulin #insulinresistance #prediabetes #type2diabetes #continuousglucosemonitor #cgm #wearabletech #metabolicflexibility #metabolomics #genomics #systemsbiology #biohacking #longevity #healthoptimization #fiber #inulin #psyllium #resistantstarch #betaglucan #cholesterol #inflammation #gutbrainaxis #precisionmedicine #stanfordmedicine #microbiome #bloodsugar #precisionnutrition #metabolichealth #metabolism #stanford #harvard #grapes #diabetes #obesity #guthealth #personalizedmedicine #educational #medicaleducation #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices StayCurious Newsletter on Snyder’s Fiber Randomized Controlled Trial: https://staycuriousmetabolism.substack.com/p/fiber-is-good-for-you-is-lazy-science?r=40ekz2

StayCurious Newsletter on Inulin and Fructose Resistance: https://staycuriousmetabolism.substack.com/p/the-fiber-that-fights-fat-how-inulin?r=40ekz2

Snyder Interview 1, Four Types of Diabetes: https://youtu.be/mCrc4gfbK2o
Snyder Interview 2, Most Viral Aging Study: https://youtu.be/kMpGkg4zMOU
Snyder Interview 3, Most Beautiful Exercise Study: https://youtu.be/_9ywulQF2Ho

Why does the same food spike one person’s blood sugar while barely affecting another?

In this fourth conversation with Stanford’s Professor Michael Snyder, we explore new research on individualized glycemic responses, insulin resistance subtypes, and why one-size-fits-all nutrition advice keeps failing. From rice spiking glucose more than ice cream, to the power of the grape-to-potato ratio, and beyond, this discussion reveals how metabolism, microbiome, immune signaling, and insulin sensitivity interact in deeply personal ways.

We unpack Snyder’s latest Nature Medicine work, including the “potato-to-grape ratio,” food mitigators like protein and fiber, why fiber doesn’t work the same in insulin-resistant individuals, and how future AI-driven profiling could finally make personalized nutrition practical. If you’ve ever felt confused by conflicting diet advice, this conversation explains why—and where the science is heading next.

Chapters
0:00 – Introduction: Get Excited for Professor Snyder!
1:08 – Nature Medicine 2025 Personalized Medicine Paper
2:56 – Grapes Sky-Rocket Blood Sugar!
5:05 – “For Many People Rice is Worse than Ice Cream”
6:45 – People With High Blood Pressure Are “Bread-Spikers”
7:33 – The Brilliant Grape-to-Potato Ratio!
12:10 – Those With Insulin Resistance Have Worse Response to Fiber
14:40 – The (Second) Coolest Fiber Paper I Ever Read
17:00 – Professor Snyders Fiber Randomized Controlled Trial
20:03 – Nick and Professor Snyder Reveal Their Fiber Responses
24:48 – The Future of Personalized Medicine is Bright!

#nutritionscience #glucose #glycemicresponse #insulin #insulinresistance #prediabetes #type2diabetes #continuousglucosemonitor #cgm #wearabletech #metabolicflexibility #metabolomics #genomics #systemsbiology #biohacking #longevity #healthoptimization #fiber #inulin #psyllium #resistantstarch #betaglucan #cholesterol #inflammation #gutbrainaxis #precisionmedicine #stanfordmedicine #microbiome #bloodsugar #precisionnutrition #metabolichealth #metabolism #stanford #harvard #grapes #diabetes #obesity #guthealth #personalizedmedicine #educational #medicaleducation #staycurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 2158 no I Eat Fish Every Day. Here's Why... Chapters0:00 – Intro, 2 New Studies 1:02 -- Study 1: Fish and All Cause Mortality4:42 -- Study 2: Fish and Cognition7:20 – Limitations and ClosingPaper 1 (Feb 2024): https://www.sciencedirect.com/science/article/abs/pii/S0002916523663038 Paper 2 (April 2024): https://www.mayoclinicproceedings.org/article/S0025-6196(23)00603-1/fulltext Se/Hg Ratio in Fish: https://link.springer.com/article/10.1007/s12011-007-8004-8Brazil-Macadamia Butter: https://ketodietapp.com/Blog/lchf/macadamia-and-brazil-butter House of Macadamia: http://partner.houseofmacadamias.com/nick-norwitz-15% Off All Bundles -10% off any item (non-bundle) with code "NICK10"Benefits of Omega-7 in Macadamia: https://youtu.be/Vngn6i-rmZI Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 14 Aug 2026 22:46:00 -0000 full Nick Norwitz MD PhD Chapters0:00 – Intro, 2 New Studies 1:02 -- Study 1: Fish and All Cause Mortality4:42 -- Study 2: Fish and Cognition7:20 – Limitations and ClosingPaper 1 (Feb 2024): https://www.sciencedirect.com/science/article/abs/pii/S0002916523663038 Paper 2 (April 2024): https://www.mayoclinicproceedings.org/article/S0025-6196(23)00603-1/fulltext Se/Hg Ratio in Fish: https://link.springer.com/article/10.1007/s12011-007-8004-8Brazil-Macadamia Butter: https://ketodietapp.com/Blog/lchf/macadamia-and-brazil-butter House of Macadamia: http://partner.houseofmacadamias.com/nick-norwitz-15% Off All Bundles -10% off any item (non-bundle) with code "NICK10"Benefits of Omega-7 in Macadamia: https://youtu.be/Vngn6i-rmZI Learn more about your ad choices. Visit megaphone.fm/adchoices Chapters
0:00 – Intro, 2 New Studies
1:02 -- Study 1: Fish and All Cause Mortality
4:42 -- Study 2: Fish and Cognition
7:20 – Limitations and Closing

Paper 1 (Feb 2024): https://www.sciencedirect.com/science/article/abs/pii/S0002916523663038
Paper 2 (April 2024): https://www.mayoclinicproceedings.org/article/S0025-6196(23)00603-1/fulltext

Se/Hg Ratio in Fish: https://link.springer.com/article/10.1007/s12011-007-8004-8

Brazil-Macadamia Butter: https://ketodietapp.com/Blog/lchf/macadamia-and-brazil-butter

House of Macadamia: http://partner.houseofmacadamias.com/nick-norwitz
-15% Off All Bundles
-10% off any item (non-bundle) with code "NICK10"

Benefits of Omega-7 in Macadamia: https://youtu.be/Vngn6i-rmZI

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 786 no This Tiny Molecule Blocks Aging For extra nuances, references and early access to data like these, see the newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/aging-is-an-explosion-can-we-stop?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Hundred Health Link: https://go.hundred.com/nick-norwitzDiscount Code: StayCurious50(Disclaimer below)Berberine and Heart Health Letter: https://staycuriousmetabolism.substack.com/p/how-berberine-lowers-cholesterol?r=40ekz2 Description Aging is usually framed as slow, passive decay — but emerging research suggests something far more active is happening beneath the surface. In this video, we explore groundbreaking evidence showing that breakdown of the extracellular matrix (the structural scaffold of your tissues) releases bioactive fragments that actively trigger inflammation and biological aging.You’ll learn how specific matrix-derived fragments, called matrikines — especially elastin fragments — associate with aging and metabolic dysfunction in humans, and how animal studies in mice and pigs demonstrate a causal inflammatory cascade that accelerates fat gain, muscle loss, organ dysfunction, and even early death. Crucially, the research identifies a precise immune pathway responsible — and shows that blocking it can dramatically improve healthspan and lifespan in animal models. Finally, we translate these findings into practical insights you can apply today. Chapters0:00 – New Science: Aging is a Molecular Explosion1:30 – Nerdy Warning! 1:59 – A Concise Roadmap to This Video2:53 – Chapter 1: The Extracellular Matrix and Matrikines Explained4:18 – Chapter 2: The Human Evidence5:04 – Chapter 3: The Causal Mechanisms8:59 – Chapter 4: What You Can Do Today10:39 – Practical Biomarkers to Track 12:00 – Get Your GHOAT!Hundred Health DisclaimerAs a scientific advisor at Hundred Health, I candidly hold a small equity stake in the company, but I don’t receive any commission or kickback if you subscribe. The discount code is for your benefit. I’ve chosen to partner with Hundred Health because I genuinely believe it has the potential to be a disruptive force for good in personalized healthcare. It’s a tool unlike anything else currently on the market.Here’s how it works: Hundred Health’s AI integrates your biodata, questionnaire responses, health priorities, and medical records (aggregated from over 400 EMRs). It then uses this foundation to interrogate the scientific literature and generate a personalized health protocol. That protocol is stress-tested through multiple AI “judges” to ensure robustness, validity, and continued evolution. The entire rationale and referencing process is transparent—and we’re continually working to evolve this platform from a powerful tool into something that could transform the future of healthcare.That’s the audacious goal. And with this team, I believe it’s within reach. Whether you’re an early adopter or plan to join later, this is something I’d feel confident recommending to a loved one. I think it can truly help. (See below for a comparison with functional medicine and answers to common questions.)#aging #longevity #inflammation #extracellularmatrix #ECM #matrikines #elastin #biologicalaging #healthspan #lifespan #metabolichealth #immunology #systemsbiology #agingresearch #longevityscience #biomarkers #hsCRP #omega3 #precisionmedicine #personalizedhealth #antiaging #molecularbiology #inflammaging #healthoptimization #scientificresearch #medicalscience #metabolism #agingmechanisms #healthscience #translationalresearch #staycurious #biohacking #longevitymedicine #agingtheory #preventivedealth #humanhealth #animalmodels #systemsmedicine #agingprocess #chronicinflammation #healthresearch #modernmedicine #wellnessscience #lifescience #futureofmedicine #scienceexplained #deepbiology Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 14 Aug 2026 04:46:00 -0000 full Nick Norwitz MD PhD For extra nuances, references and early access to data like these, see the newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/aging-is-an-explosion-can-we-stop?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Hundred Health Link: https://go.hundred.com/nick-norwitzDiscount Code: StayCurious50(Disclaimer below)Berberine and Heart Health Letter: https://staycuriousmetabolism.substack.com/p/how-berberine-lowers-cholesterol?r=40ekz2 Description Aging is usually framed as slow, passive decay — but emerging research suggests something far more active is happening beneath the surface. In this video, we explore groundbreaking evidence showing that breakdown of the extracellular matrix (the structural scaffold of your tissues) releases bioactive fragments that actively trigger inflammation and biological aging.You’ll learn how specific matrix-derived fragments, called matrikines — especially elastin fragments — associate with aging and metabolic dysfunction in humans, and how animal studies in mice and pigs demonstrate a causal inflammatory cascade that accelerates fat gain, muscle loss, organ dysfunction, and even early death. Crucially, the research identifies a precise immune pathway responsible — and shows that blocking it can dramatically improve healthspan and lifespan in animal models. Finally, we translate these findings into practical insights you can apply today. Chapters0:00 – New Science: Aging is a Molecular Explosion1:30 – Nerdy Warning! 1:59 – A Concise Roadmap to This Video2:53 – Chapter 1: The Extracellular Matrix and Matrikines Explained4:18 – Chapter 2: The Human Evidence5:04 – Chapter 3: The Causal Mechanisms8:59 – Chapter 4: What You Can Do Today10:39 – Practical Biomarkers to Track 12:00 – Get Your GHOAT!Hundred Health DisclaimerAs a scientific advisor at Hundred Health, I candidly hold a small equity stake in the company, but I don’t receive any commission or kickback if you subscribe. The discount code is for your benefit. I’ve chosen to partner with Hundred Health because I genuinely believe it has the potential to be a disruptive force for good in personalized healthcare. It’s a tool unlike anything else currently on the market.Here’s how it works: Hundred Health’s AI integrates your biodata, questionnaire responses, health priorities, and medical records (aggregated from over 400 EMRs). It then uses this foundation to interrogate the scientific literature and generate a personalized health protocol. That protocol is stress-tested through multiple AI “judges” to ensure robustness, validity, and continued evolution. The entire rationale and referencing process is transparent—and we’re continually working to evolve this platform from a powerful tool into something that could transform the future of healthcare.That’s the audacious goal. And with this team, I believe it’s within reach. Whether you’re an early adopter or plan to join later, this is something I’d feel confident recommending to a loved one. I think it can truly help. (See below for a comparison with functional medicine and answers to common questions.)#aging #longevity #inflammation #extracellularmatrix #ECM #matrikines #elastin #biologicalaging #healthspan #lifespan #metabolichealth #immunology #systemsbiology #agingresearch #longevityscience #biomarkers #hsCRP #omega3 #precisionmedicine #personalizedhealth #antiaging #molecularbiology #inflammaging #healthoptimization #scientificresearch #medicalscience #metabolism #agingmechanisms #healthscience #translationalresearch #staycurious #biohacking #longevitymedicine #agingtheory #preventivedealth #humanhealth #animalmodels #systemsmedicine #agingprocess #chronicinflammation #healthresearch #modernmedicine #wellnessscience #lifescience #futureofmedicine #scienceexplained #deepbiology Learn more about your ad choices. Visit megaphone.fm/adchoices For extra nuances, references and early access to data like these, see the newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/aging-is-an-explosion-can-we-stop?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Hundred Health Link: https://go.hundred.com/nick-norwitz
Discount Code: StayCurious50

(Disclaimer below)

Berberine and Heart Health Letter: https://staycuriousmetabolism.substack.com/p/how-berberine-lowers-cholesterol?r=40ekz2

Description
Aging is usually framed as slow, passive decay — but emerging research suggests something far more active is happening beneath the surface. In this video, we explore groundbreaking evidence showing that breakdown of the extracellular matrix (the structural scaffold of your tissues) releases bioactive fragments that actively trigger inflammation and biological aging.

You’ll learn how specific matrix-derived fragments, called matrikines — especially elastin fragments — associate with aging and metabolic dysfunction in humans, and how animal studies in mice and pigs demonstrate a causal inflammatory cascade that accelerates fat gain, muscle loss, organ dysfunction, and even early death.

Crucially, the research identifies a precise immune pathway responsible — and shows that blocking it can dramatically improve healthspan and lifespan in animal models. Finally, we translate these findings into practical insights you can apply today.

Chapters
0:00 – New Science: Aging is a Molecular Explosion
1:30 – Nerdy Warning!
1:59 – A Concise Roadmap to This Video
2:53 – Chapter 1: The Extracellular Matrix and Matrikines Explained
4:18 – Chapter 2: The Human Evidence
5:04 – Chapter 3: The Causal Mechanisms
8:59 – Chapter 4: What You Can Do Today
10:39 – Practical Biomarkers to Track
12:00 – Get Your GHOAT!

Hundred Health Disclaimer
As a scientific advisor at Hundred Health, I candidly hold a small equity stake in the company, but I don’t receive any commission or kickback if you subscribe. The discount code is for your benefit. I’ve chosen to partner with Hundred Health because I genuinely believe it has the potential to be a disruptive force for good in personalized healthcare. It’s a tool unlike anything else currently on the market.

Here’s how it works: Hundred Health’s AI integrates your biodata, questionnaire responses, health priorities, and medical records (aggregated from over 400 EMRs). It then uses this foundation to interrogate the scientific literature and generate a personalized health protocol. That protocol is stress-tested through multiple AI “judges” to ensure robustness, validity, and continued evolution. The entire rationale and referencing process is transparent—and we’re continually working to evolve this platform from a powerful tool into something that could transform the future of healthcare.

That’s the audacious goal. And with this team, I believe it’s within reach. Whether you’re an early adopter or plan to join later, this is something I’d feel confident recommending to a loved one. I think it can truly help. (See below for a comparison with functional medicine and answers to common questions.)

#aging #longevity #inflammation #extracellularmatrix #ECM #matrikines #elastin #biologicalaging #healthspan #lifespan #metabolichealth #immunology #systemsbiology #agingresearch #longevityscience #biomarkers #hsCRP #omega3 #precisionmedicine #personalizedhealth #antiaging #molecularbiology #inflammaging #healthoptimization #scientificresearch #medicalscience #metabolism #agingmechanisms #healthscience #translationalresearch #staycurious #biohacking #longevitymedicine #agingtheory #preventivedealth #humanhealth #animalmodels #systemsmedicine #agingprocess #chronicinflammation #healthresearch #modernmedicine #wellnessscience #lifescience #futureofmedicine #scienceexplained #deepbiology

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1115 no The Satiety Per Calorie Scam: A Lesson in Unmasking Pseudoscience I WANT TO DELETE THIS VIDEO. HOPEFULLY, I WILL GET THE CHANCE...Chapters0:00 – Introduction: A Case Study in Marketing Pseudoscience1:14 – Call for concern among doctors1:26 – I WANT TO DELETE THIS VIDEO1:39 – Satiety Per Calorie, Steel Man Case2:44 – Decent Idea Turns to Deception3:24 – First 4 Reasons SPC is Pseudoscientific 5:00 – This is CRAZY7:10 – Playbook Point 1: Virtue Signaling 7:55 – Playbook Point 2: Directionally Correct? Logical Fallacy 8:31 – Playbook Point 3: Vague Appeal to Evidence9:00 – Playbook Point 4: Shifting the Burden of Proof10:43 – Playbook Point 5: Distraction Humor10:56 – Why should you care?11:59 – I WILL DELETE THE VIDEO WHEN…SPC company CEO had mentioned one study they use, which is problematic and inconsistent with their claims that their system would facilitate long-term optimal weight management or "metabolic health"JN reanalysis mentioned in the video: https://jn.nutrition.org/article/S0022-3166(23)72806-X/fulltextAn associated video: https://youtu.be/tIPX_TnUAWQ#satiety #calories #nutritiontips #educational #informative #metabolichealth #metabolism #factchecking #nutritiontips #satietypercalorie #wellness #healthylifestyle #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 13 Aug 2026 10:46:00 -0000 full Nick Norwitz MD PhD I WANT TO DELETE THIS VIDEO. HOPEFULLY, I WILL GET THE CHANCE...Chapters0:00 – Introduction: A Case Study in Marketing Pseudoscience1:14 – Call for concern among doctors1:26 – I WANT TO DELETE THIS VIDEO1:39 – Satiety Per Calorie, Steel Man Case2:44 – Decent Idea Turns to Deception3:24 – First 4 Reasons SPC is Pseudoscientific 5:00 – This is CRAZY7:10 – Playbook Point 1: Virtue Signaling 7:55 – Playbook Point 2: Directionally Correct? Logical Fallacy 8:31 – Playbook Point 3: Vague Appeal to Evidence9:00 – Playbook Point 4: Shifting the Burden of Proof10:43 – Playbook Point 5: Distraction Humor10:56 – Why should you care?11:59 – I WILL DELETE THE VIDEO WHEN…SPC company CEO had mentioned one study they use, which is problematic and inconsistent with their claims that their system would facilitate long-term optimal weight management or "metabolic health"JN reanalysis mentioned in the video: https://jn.nutrition.org/article/S0022-3166(23)72806-X/fulltextAn associated video: https://youtu.be/tIPX_TnUAWQ#satiety #calories #nutritiontips #educational #informative #metabolichealth #metabolism #factchecking #nutritiontips #satietypercalorie #wellness #healthylifestyle #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices I WANT TO DELETE THIS VIDEO. HOPEFULLY, I WILL GET THE CHANCE...

Chapters
0:00 – Introduction: A Case Study in Marketing Pseudoscience
1:14 – Call for concern among doctors
1:26 – I WANT TO DELETE THIS VIDEO
1:39 – Satiety Per Calorie, Steel Man Case
2:44 – Decent Idea Turns to Deception
3:24 – First 4 Reasons SPC is Pseudoscientific
5:00 – This is CRAZY
7:10 – Playbook Point 1: Virtue Signaling
7:55 – Playbook Point 2: Directionally Correct? Logical Fallacy
8:31 – Playbook Point 3: Vague Appeal to Evidence
9:00 – Playbook Point 4: Shifting the Burden of Proof
10:43 – Playbook Point 5: Distraction Humor
10:56 – Why should you care?
11:59 – I WILL DELETE THE VIDEO WHEN…

SPC company CEO had mentioned one study they use, which is problematic and inconsistent with their claims that their system would facilitate long-term optimal weight management or "metabolic health"

JN reanalysis mentioned in the video: https://jn.nutrition.org/article/S0022-3166(23)72806-X/fulltext

An associated video: https://youtu.be/tIPX_TnUAWQ

#satiety #calories #nutritiontips #educational #informative #metabolichealth #metabolism #factchecking #nutritiontips #satietypercalorie #wellness #healthylifestyle #staycurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1044 no I Bet My Life Against Cholesterol Dogma (And Won) If you appreciate nuanced science and learning about human metabolism, check out StayCurious Metabolism, now a Top Overall Best-Seller in Science globally: https://staycuriousmetabolism.com Start by checking out the Heart Health Archives. Papers:Seven Years of 700 Cholesterol Without Coronary Atherosclerosis: https://www.mdpi.com/2079-9721/14/5/168 Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/ Oreo vs Statin Paper: https://pubmed.ncbi.nlm.nih.gov/38276308/ Cholesterol Code Movie: https://cholesterolcodemovie.com Description For seven years, I’ve been living with cholesterol levels that most doctors would say should have killed me by now — not just high, but astronomical — and I did it intentionally because I believe there’s something fundamentally misunderstood about cholesterol, heart disease, and people like me that modern medicine doesn’t understand. If I’m right, the implications could challenge some of the biggest assumptions in cardiology; if I’m wrong, I could end up dead. Today, I finally found out the truth in a way that can’t be faked. This is, without question, the most important video I’ve ever made.Chapters0:00 – The 7-Year Experiment 1:43 – My Extremely High LDL Cholesterol Should Be Killing Me2:26 –My Advanced Coronary CT Angiography (CCTA) Heart Scan5:30 – Interpreting My Heart Scan results6:30 – What Does This Really Mean for the Patient?10:00 – Why I Took Bet on My Life and My Heart.11:15 – What the Critics Will Say12:15 – The Cholesterol Code Movie12:50 – The Second Bet and Our Future Together#cholesterol #atherosclerosis #LDL #ApoB # educational #CCTA #LMHR #coronarycalcium #inflammation #metabolicsyndrome #plaqueprogression #arterialhealth #insulinsensitivity #fastinginsulin #hearthealth #ketogenicdiet #metabolicflexibility #lipidprofile #coronaryarterydisease #lipids #heartscan #atherogenic #vascularhealth #metabolichealth #lowcarb #ketoscience #cardiometabolic #cholesterolmyths #insulinresistance #longevity #biomarkers #advancedlipids Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 12 Aug 2026 16:46:00 -0000 full Nick Norwitz MD PhD If you appreciate nuanced science and learning about human metabolism, check out StayCurious Metabolism, now a Top Overall Best-Seller in Science globally: https://staycuriousmetabolism.com Start by checking out the Heart Health Archives. Papers:Seven Years of 700 Cholesterol Without Coronary Atherosclerosis: https://www.mdpi.com/2079-9721/14/5/168 Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/ Oreo vs Statin Paper: https://pubmed.ncbi.nlm.nih.gov/38276308/ Cholesterol Code Movie: https://cholesterolcodemovie.com Description For seven years, I’ve been living with cholesterol levels that most doctors would say should have killed me by now — not just high, but astronomical — and I did it intentionally because I believe there’s something fundamentally misunderstood about cholesterol, heart disease, and people like me that modern medicine doesn’t understand. If I’m right, the implications could challenge some of the biggest assumptions in cardiology; if I’m wrong, I could end up dead. Today, I finally found out the truth in a way that can’t be faked. This is, without question, the most important video I’ve ever made.Chapters0:00 – The 7-Year Experiment 1:43 – My Extremely High LDL Cholesterol Should Be Killing Me2:26 –My Advanced Coronary CT Angiography (CCTA) Heart Scan5:30 – Interpreting My Heart Scan results6:30 – What Does This Really Mean for the Patient?10:00 – Why I Took Bet on My Life and My Heart.11:15 – What the Critics Will Say12:15 – The Cholesterol Code Movie12:50 – The Second Bet and Our Future Together#cholesterol #atherosclerosis #LDL #ApoB # educational #CCTA #LMHR #coronarycalcium #inflammation #metabolicsyndrome #plaqueprogression #arterialhealth #insulinsensitivity #fastinginsulin #hearthealth #ketogenicdiet #metabolicflexibility #lipidprofile #coronaryarterydisease #lipids #heartscan #atherogenic #vascularhealth #metabolichealth #lowcarb #ketoscience #cardiometabolic #cholesterolmyths #insulinresistance #longevity #biomarkers #advancedlipids Learn more about your ad choices. Visit megaphone.fm/adchoices If you appreciate nuanced science and learning about human metabolism, check out StayCurious Metabolism, now a Top Overall Best-Seller in Science globally: https://staycuriousmetabolism.com

Start by checking out the Heart Health Archives.

Papers:
Seven Years of 700 Cholesterol Without Coronary Atherosclerosis: https://www.mdpi.com/2079-9721/14/5/168

Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/

Oreo vs Statin Paper: https://pubmed.ncbi.nlm.nih.gov/38276308/

Cholesterol Code Movie: https://cholesterolcodemovie.com

Description
For seven years, I’ve been living with cholesterol levels that most doctors would say should have killed me by now — not just high, but astronomical — and I did it intentionally because I believe there’s something fundamentally misunderstood about cholesterol, heart disease, and people like me that modern medicine doesn’t understand.

If I’m right, the implications could challenge some of the biggest assumptions in cardiology; if I’m wrong, I could end up dead. Today, I finally found out the truth in a way that can’t be faked. This is, without question, the most important video I’ve ever made.

Chapters
0:00 – The 7-Year Experiment
1:43 – My Extremely High LDL Cholesterol Should Be Killing Me
2:26 –My Advanced Coronary CT Angiography (CCTA) Heart Scan
5:30 – Interpreting My Heart Scan results
6:30 – What Does This Really Mean for the Patient?
10:00 – Why I Took Bet on My Life and My Heart.
11:15 – What the Critics Will Say
12:15 – The Cholesterol Code Movie
12:50 – The Second Bet and Our Future Together

#cholesterol #atherosclerosis #LDL #ApoB # educational #CCTA #LMHR #coronarycalcium #inflammation #metabolicsyndrome #plaqueprogression #arterialhealth #insulinsensitivity #fastinginsulin #hearthealth #ketogenicdiet #metabolicflexibility #lipidprofile #coronaryarterydisease #lipids #heartscan #atherogenic #vascularhealth #metabolichealth #lowcarb #ketoscience #cardiometabolic #cholesterolmyths #insulinresistance #longevity #biomarkers #advancedlipids

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1136 no Sweet Surprise: The Science of Sucralose will leave your head Spinning Paper: https://www.cell.com/cell-metabolism/pdf/S1550-4131(20)30057-7.pdf Dosing used in primary experiment: 7 beverages over ~2 weeks each containing 0.06 g sucralose (0 Kcal) vs 30.38 g sucrose (120 Kcal) vs or 0.06 g sucralose and 31.83 g of the non-sweet carbohydrate maltodextrin (120Kcal). If there are 12 mg sucralose in a single packet of Splenda, then it's equivalent to ~2.5 Splenda packs per day (or 5 packs [5 * 0.012 = 0.06], every other day) for 2 weeks.Chapters0:00 – Introduction0:35 – Study: RCT on Sucralose (zero calorie sweetener) 1:26 – Researchers’ uncoupling hypothesis was wrong1:37 – So What? Real World Applications.2:40 – Caveats 2:58 – More SHOCKING Data!4:16 – Brain activity findings4:38 – Nick’s remaining questionsTwitter breakdown of the data: https://x.com/nicknorwitz/status/1807018727482737120 Prior video on Sucralose: https://youtu.be/44qM9VtNAjc Ketochow: https://ketochow.xyz I’m not a partner. But they have some good products, along with a CORE line without sucralose that uses stevia. I’ve used Ketchow infrequently during particularly busy clinical rotations in medical school when proper meals were difficult to obtain. No hospital pizza and cookies for me. And, to be honest, even hospital eggs kinda’ suck.) Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 11 Aug 2026 22:46:00 -0000 full Nick Norwitz MD PhD Paper: https://www.cell.com/cell-metabolism/pdf/S1550-4131(20)30057-7.pdf Dosing used in primary experiment: 7 beverages over ~2 weeks each containing 0.06 g sucralose (0 Kcal) vs 30.38 g sucrose (120 Kcal) vs or 0.06 g sucralose and 31.83 g of the non-sweet carbohydrate maltodextrin (120Kcal). If there are 12 mg sucralose in a single packet of Splenda, then it's equivalent to ~2.5 Splenda packs per day (or 5 packs [5 * 0.012 = 0.06], every other day) for 2 weeks.Chapters0:00 – Introduction0:35 – Study: RCT on Sucralose (zero calorie sweetener) 1:26 – Researchers’ uncoupling hypothesis was wrong1:37 – So What? Real World Applications.2:40 – Caveats 2:58 – More SHOCKING Data!4:16 – Brain activity findings4:38 – Nick’s remaining questionsTwitter breakdown of the data: https://x.com/nicknorwitz/status/1807018727482737120 Prior video on Sucralose: https://youtu.be/44qM9VtNAjc Ketochow: https://ketochow.xyz I’m not a partner. But they have some good products, along with a CORE line without sucralose that uses stevia. I’ve used Ketchow infrequently during particularly busy clinical rotations in medical school when proper meals were difficult to obtain. No hospital pizza and cookies for me. And, to be honest, even hospital eggs kinda’ suck.) Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://www.cell.com/cell-metabolism/pdf/S1550-4131(20)30057-7.pdf

Dosing used in primary experiment: 7 beverages over ~2 weeks each containing 0.06 g sucralose (0 Kcal) vs 30.38 g sucrose (120 Kcal) vs or 0.06 g sucralose and 31.83 g of the non-sweet carbohydrate maltodextrin (120Kcal). If there are 12 mg sucralose in a single packet of Splenda, then it's equivalent to ~2.5 Splenda packs per day (or 5 packs [5 * 0.012 = 0.06], every other day) for 2 weeks.

Chapters
0:00 – Introduction
0:35 – Study: RCT on Sucralose (zero calorie sweetener)
1:26 – Researchers’ uncoupling hypothesis was wrong
1:37 – So What? Real World Applications.
2:40 – Caveats
2:58 – More SHOCKING Data!
4:16 – Brain activity findings
4:38 – Nick’s remaining questions

Twitter breakdown of the data: https://x.com/nicknorwitz/status/1807018727482737120

Prior video on Sucralose: https://youtu.be/44qM9VtNAjc

Ketochow: https://ketochow.xyz
I’m not a partner. But they have some good products, along with a CORE line without sucralose that uses stevia. I’ve used Ketchow infrequently during particularly busy clinical rotations in medical school when proper meals were difficult to obtain. No hospital pizza and cookies for me. And, to be honest, even hospital eggs kinda’ suck.)

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 460 no How to Lose Visceral Fat in 8 Weeks (Proven in RCTs) For all references, extra nuances, and early access to breakdowns like this, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/shrink-visceral-fat-by-feeding-your?r=40ekz2 Winnow Microplastic Binding Probiotic: https://www.winnowlabs.com/STAYCURIOUS Use Discount Code “StayCurious” for 15% Off Microplastics and Heart Health, Letter https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Microplastics and Brain Health, Letter: https://staycuriousmetabolism.substack.com/p/this-graph-changed-how-i-think-about?r=40ekz2 Description:In this video we examine the scientific evidence behind resistant starch, including randomized controlled trials showing reductions in body weight, total fat mass, and visceral fat measured by MRI—even when calorie intake remains controlled. We also explore the biological mechanism, including how changes in the gut microbiome may drive these effects.But there’s an important twist: not everyone responds the same way. We’ll look at new research explaining why some people are “high responders” while others see little benefit, and what role specific gut bacteria play. Finally, we discuss practical ways to experiment with resistant starch yourself—from green bananas to high-amylose maize starch—and how to approach it carefully.Chapters0:00 – The Strange Science Inside a Green Banana1:30 – A Roadmap to This Video 3:08 – Chapter 1: What Resistant Starch Actually Is5:18 – Chapter 2: Human Trials Showing Fat and Visceral Fat Loss8:17 – Chapter 3: Mechanism of Action: Microbiome and Metabolism10:17 – Chapter 4: Why Some People Respond and Others Don’t14:14 – Chapter 5: Practical Ways to Use Resistant Starch18:04 – Big Picture: Personalized Nutrition and the MicrobiomeHashtags#ResistantStarch #GutMicrobiome #GutHealth #MetabolicHealth #VisceralFat #FatLossScience #NutritionResearch #NutritionScience #Microbiome #Microbiota #InsulinSensitivity #WeightLossScience #HealthScience #NutritionFacts #Digestion #GutBacteria #Prebiotics #HealthResearch #Biochemistry #Metabolism #HealthOptimization #GreenBananas #NutritionEducation #ScienceExplained #Healthspan #LongevityScience #DietScience #MicrobiomeResearch #HealthData #BodyFat #VisceralFatReduction #MetabolicFitness #FunctionalNutrition #NutritionTips #HealthyLifestyle #HealthInsights #DigestiveHealth #ScientificResearch #NutritionStudy #ClinicalTrial #NutritionNerd #StayCurious #HealthLearning #NutritionBiology #MicrobiomeHealth #PrebioticFiber #MetabolicScience #ScienceOfHealth #HealthBreakdown #NutritionExplained Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 11 Aug 2026 04:46:00 -0000 full Nick Norwitz MD PhD For all references, extra nuances, and early access to breakdowns like this, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/shrink-visceral-fat-by-feeding-your?r=40ekz2 Winnow Microplastic Binding Probiotic: https://www.winnowlabs.com/STAYCURIOUS Use Discount Code “StayCurious” for 15% Off Microplastics and Heart Health, Letter https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Microplastics and Brain Health, Letter: https://staycuriousmetabolism.substack.com/p/this-graph-changed-how-i-think-about?r=40ekz2 Description:In this video we examine the scientific evidence behind resistant starch, including randomized controlled trials showing reductions in body weight, total fat mass, and visceral fat measured by MRI—even when calorie intake remains controlled. We also explore the biological mechanism, including how changes in the gut microbiome may drive these effects.But there’s an important twist: not everyone responds the same way. We’ll look at new research explaining why some people are “high responders” while others see little benefit, and what role specific gut bacteria play. Finally, we discuss practical ways to experiment with resistant starch yourself—from green bananas to high-amylose maize starch—and how to approach it carefully.Chapters0:00 – The Strange Science Inside a Green Banana1:30 – A Roadmap to This Video 3:08 – Chapter 1: What Resistant Starch Actually Is5:18 – Chapter 2: Human Trials Showing Fat and Visceral Fat Loss8:17 – Chapter 3: Mechanism of Action: Microbiome and Metabolism10:17 – Chapter 4: Why Some People Respond and Others Don’t14:14 – Chapter 5: Practical Ways to Use Resistant Starch18:04 – Big Picture: Personalized Nutrition and the MicrobiomeHashtags#ResistantStarch #GutMicrobiome #GutHealth #MetabolicHealth #VisceralFat #FatLossScience #NutritionResearch #NutritionScience #Microbiome #Microbiota #InsulinSensitivity #WeightLossScience #HealthScience #NutritionFacts #Digestion #GutBacteria #Prebiotics #HealthResearch #Biochemistry #Metabolism #HealthOptimization #GreenBananas #NutritionEducation #ScienceExplained #Healthspan #LongevityScience #DietScience #MicrobiomeResearch #HealthData #BodyFat #VisceralFatReduction #MetabolicFitness #FunctionalNutrition #NutritionTips #HealthyLifestyle #HealthInsights #DigestiveHealth #ScientificResearch #NutritionStudy #ClinicalTrial #NutritionNerd #StayCurious #HealthLearning #NutritionBiology #MicrobiomeHealth #PrebioticFiber #MetabolicScience #ScienceOfHealth #HealthBreakdown #NutritionExplained Learn more about your ad choices. Visit megaphone.fm/adchoices For all references, extra nuances, and early access to breakdowns like this, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/shrink-visceral-fat-by-feeding-your?r=40ekz2

Winnow Microplastic Binding Probiotic: https://www.winnowlabs.com/STAYCURIOUS
Use Discount Code “StayCurious” for 15% Off

Microplastics and Heart Health, Letter https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2

Microplastics and Brain Health, Letter: https://staycuriousmetabolism.substack.com/p/this-graph-changed-how-i-think-about?r=40ekz2

Description:
In this video we examine the scientific evidence behind resistant starch, including randomized controlled trials showing reductions in body weight, total fat mass, and visceral fat measured by MRI—even when calorie intake remains controlled. We also explore the biological mechanism, including how changes in the gut microbiome may drive these effects.

But there’s an important twist: not everyone responds the same way. We’ll look at new research explaining why some people are “high responders” while others see little benefit, and what role specific gut bacteria play. Finally, we discuss practical ways to experiment with resistant starch yourself—from green bananas to high-amylose maize starch—and how to approach it carefully.

Chapters
0:00 – The Strange Science Inside a Green Banana
1:30 – A Roadmap to This Video
3:08 – Chapter 1: What Resistant Starch Actually Is
5:18 – Chapter 2: Human Trials Showing Fat and Visceral Fat Loss
8:17 – Chapter 3: Mechanism of Action: Microbiome and Metabolism
10:17 – Chapter 4: Why Some People Respond and Others Don’t
14:14 – Chapter 5: Practical Ways to Use Resistant Starch
18:04 – Big Picture: Personalized Nutrition and the Microbiome

Hashtags
#ResistantStarch #GutMicrobiome #GutHealth #MetabolicHealth #VisceralFat #FatLossScience #NutritionResearch #NutritionScience #Microbiome #Microbiota #InsulinSensitivity #WeightLossScience #HealthScience #NutritionFacts #Digestion #GutBacteria #Prebiotics #HealthResearch #Biochemistry #Metabolism #HealthOptimization #GreenBananas #NutritionEducation #ScienceExplained #Healthspan #LongevityScience #DietScience #MicrobiomeResearch #HealthData #BodyFat #VisceralFatReduction #MetabolicFitness #FunctionalNutrition #NutritionTips #HealthyLifestyle #HealthInsights #DigestiveHealth #ScientificResearch #NutritionStudy #ClinicalTrial #NutritionNerd #StayCurious #HealthLearning #NutritionBiology #MicrobiomeHealth #PrebioticFiber #MetabolicScience #ScienceOfHealth #HealthBreakdown #NutritionExplained

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1397 no Rethinking Obesity: Time to Stop Blaming Calories Chapters0:00 – Introduction: Fuel Partitioning 1:37 – Video Roadmap2:18 – 50,000-foot view of Fuel Partitioning Model3:28 – Interpretative Caution5:05 – Matches and Logs5:17 – Value of Animal Models and Limits of Human Studies 6:47 – Dominate Calories with Physiology7:15 – Actionable Takeaways Trapped Fat Paper: https://onlinelibrary.wiley.com/doi/10.1111/obr.13795Leptin Resistance Video: https://youtu.be/bmaKtDUwr8g Metabolic Ward Reanalysis Video: https://youtu.be/gKX2Bnii9C0 Re-analysis Paper: https://jn.nutrition.org/article/S0022-3166(23)72806-X/fulltext Associated Interview with Professor Walter Willett: https://youtu.be/tIPX_TnUAWQ Like my shirt? https://metabolismshirts.myspreadshop.com#fatloss #healthandfitness #metabolism Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 10 Aug 2026 10:46:00 -0000 full Nick Norwitz MD PhD Chapters0:00 – Introduction: Fuel Partitioning 1:37 – Video Roadmap2:18 – 50,000-foot view of Fuel Partitioning Model3:28 – Interpretative Caution5:05 – Matches and Logs5:17 – Value of Animal Models and Limits of Human Studies 6:47 – Dominate Calories with Physiology7:15 – Actionable Takeaways Trapped Fat Paper: https://onlinelibrary.wiley.com/doi/10.1111/obr.13795Leptin Resistance Video: https://youtu.be/bmaKtDUwr8g Metabolic Ward Reanalysis Video: https://youtu.be/gKX2Bnii9C0 Re-analysis Paper: https://jn.nutrition.org/article/S0022-3166(23)72806-X/fulltext Associated Interview with Professor Walter Willett: https://youtu.be/tIPX_TnUAWQ Like my shirt? https://metabolismshirts.myspreadshop.com#fatloss #healthandfitness #metabolism Learn more about your ad choices. Visit megaphone.fm/adchoices Chapters
0:00 – Introduction: Fuel Partitioning
1:37 – Video Roadmap
2:18 – 50,000-foot view of Fuel Partitioning Model
3:28 – Interpretative Caution
5:05 – Matches and Logs
5:17 – Value of Animal Models and Limits of Human Studies
6:47 – Dominate Calories with Physiology
7:15 – Actionable Takeaways

Trapped Fat Paper: https://onlinelibrary.wiley.com/doi/10.1111/obr.13795

Leptin Resistance Video: https://youtu.be/bmaKtDUwr8g

Metabolic Ward Reanalysis Video: https://youtu.be/gKX2Bnii9C0

Re-analysis Paper: https://jn.nutrition.org/article/S0022-3166(23)72806-X/fulltext

Associated Interview with Professor Walter Willett: https://youtu.be/tIPX_TnUAWQ

Like my shirt? https://metabolismshirts.myspreadshop.com

#fatloss #healthandfitness #metabolism

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 698 no The Sardine Diet Gave Me a Superpower (And a Very Unfortunate Side Effect) For the written breakdown, early access to information like this, and extra nuances, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/why-stinking-like-sardines-might?r=40ekz2 DescriptionI ran an experiment on myself where I ate 1,000 sardines in a month. What followed was something I didn’t expect. Along with a very real (and very noticeable) side effect, I developed what felt like a metabolic “superpower”: extreme cold resistance and increased energy. In this video, I break down the strange physiological changes I experienced and the cutting-edge 2026 science that may explain them. But this isn’t just about sardines. It’s about a deeper principle in biology: everything in the body is connected. When you change one pathway, others move with it. Understanding those connections may be the key to unlocking new ways to optimize metabolism. But as this experiment shows, every benefit comes with a trade-off.Chapters 0:00 – The 1,000 Sardine Experiment 1:50 – Roadmap to this Video3:52 – Part 1: The Superpower5:10 – The Omega-3 Heat Hormone (12-HEPE)7:37 – Part 2: The Breakthrough Study and Smelly Price9:08 – Part 3: The Connection Between the Power and the Price#sardines #nutrition #metabolism #health #science #diet #omega3 #fatloss #biohacking #fitness #healthscience #nutritiontips #weightloss #wellness #longevity #metabolichealth #keto #lowcarb #fishdiet #superfood #guthealth #hormones #biochemistry #humanbody #scientific #research #clinicalscience #healthtips #fitnessjourney #fatburning #thermogenesis #omega3fattyacids #brainhealth #hearthealth #dietexperiment #selfexperiment #n1experiment #medicalscience #staycurious #foodscience #energy #fatlossjourney #healthyfats #metabolicrate #bodycomposition #nutritionfacts #scienceexplained #biologymatters #coldexposure #performance Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 09 Aug 2026 16:46:00 -0000 full Nick Norwitz MD PhD For the written breakdown, early access to information like this, and extra nuances, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/why-stinking-like-sardines-might?r=40ekz2 DescriptionI ran an experiment on myself where I ate 1,000 sardines in a month. What followed was something I didn’t expect. Along with a very real (and very noticeable) side effect, I developed what felt like a metabolic “superpower”: extreme cold resistance and increased energy. In this video, I break down the strange physiological changes I experienced and the cutting-edge 2026 science that may explain them. But this isn’t just about sardines. It’s about a deeper principle in biology: everything in the body is connected. When you change one pathway, others move with it. Understanding those connections may be the key to unlocking new ways to optimize metabolism. But as this experiment shows, every benefit comes with a trade-off.Chapters 0:00 – The 1,000 Sardine Experiment 1:50 – Roadmap to this Video3:52 – Part 1: The Superpower5:10 – The Omega-3 Heat Hormone (12-HEPE)7:37 – Part 2: The Breakthrough Study and Smelly Price9:08 – Part 3: The Connection Between the Power and the Price#sardines #nutrition #metabolism #health #science #diet #omega3 #fatloss #biohacking #fitness #healthscience #nutritiontips #weightloss #wellness #longevity #metabolichealth #keto #lowcarb #fishdiet #superfood #guthealth #hormones #biochemistry #humanbody #scientific #research #clinicalscience #healthtips #fitnessjourney #fatburning #thermogenesis #omega3fattyacids #brainhealth #hearthealth #dietexperiment #selfexperiment #n1experiment #medicalscience #staycurious #foodscience #energy #fatlossjourney #healthyfats #metabolicrate #bodycomposition #nutritionfacts #scienceexplained #biologymatters #coldexposure #performance Learn more about your ad choices. Visit megaphone.fm/adchoices For the written breakdown, early access to information like this, and extra nuances, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/why-stinking-like-sardines-might?r=40ekz2

Description
I ran an experiment on myself where I ate 1,000 sardines in a month. What followed was something I didn’t expect. Along with a very real (and very noticeable) side effect, I developed what felt like a metabolic “superpower”: extreme cold resistance and increased energy. In this video, I break down the strange physiological changes I experienced and the cutting-edge 2026 science that may explain them.

But this isn’t just about sardines. It’s about a deeper principle in biology: everything in the body is connected. When you change one pathway, others move with it. Understanding those connections may be the key to unlocking new ways to optimize metabolism. But as this experiment shows, every benefit comes with a trade-off.

Chapters
0:00 – The 1,000 Sardine Experiment
1:50 – Roadmap to this Video
3:52 – Part 1: The Superpower
5:10 – The Omega-3 Heat Hormone (12-HEPE)
7:37 – Part 2: The Breakthrough Study and Smelly Price
9:08 – Part 3: The Connection Between the Power and the Price

#sardines #nutrition #metabolism #health #science #diet #omega3 #fatloss #biohacking #fitness #healthscience #nutritiontips #weightloss #wellness #longevity #metabolichealth #keto #lowcarb #fishdiet #superfood #guthealth #hormones #biochemistry #humanbody #scientific #research #clinicalscience #healthtips #fitnessjourney #fatburning #thermogenesis #omega3fattyacids #brainhealth #hearthealth #dietexperiment #selfexperiment #n1experiment #medicalscience #staycurious #foodscience #energy #fatlossjourney #healthyfats #metabolicrate #bodycomposition #nutritionfacts #scienceexplained #biologymatters #coldexposure #performance

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1034 no Sugar SPIKE: The Continuous Glucose Monitor Controversy BBC Article: https://www.bbc.com/news/articles/c1ddk1ddme5oLevels: https://levels.link/NICKNORWITZ Get 2 months off an annual membership to the application, along with a continuous glucose monitor, using the link above.Chapters0:00 – Continuous Glucose Monitors for Non-Diabetics 0:58 – CGM can Provide Powerful Biofeedback for Behavior Change2:03 – Counterpoint 1: Data Misuse4:02 – Eating Disorders6:48 – Absence of Evidence 8:19 – The Future, Beyond CGMs9:26 – Conclusion#metabolichealth #continuousglucosemonitor #staycurious #sugarfree #metabolichealth #insulin #insulinresistance #nutritiontips #educational #informational #bloodsugar #glycemicindex #personalizednutrition #n1science #healthdata #glucosemonitoring #foodexperiment #individualizedhealth #nutritionexperiment #sugarsensitivity #dietaryresponse #nutritionalbiology #insulinspike #bloodsugarcontrol #healthysugar #diabetesprevention #nutritionandbiology #curiositydriven #glucoseintolerance #testingnutrition #bloodsugarresponse #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 08 Aug 2026 22:46:00 -0000 full Nick Norwitz MD PhD BBC Article: https://www.bbc.com/news/articles/c1ddk1ddme5oLevels: https://levels.link/NICKNORWITZ Get 2 months off an annual membership to the application, along with a continuous glucose monitor, using the link above.Chapters0:00 – Continuous Glucose Monitors for Non-Diabetics 0:58 – CGM can Provide Powerful Biofeedback for Behavior Change2:03 – Counterpoint 1: Data Misuse4:02 – Eating Disorders6:48 – Absence of Evidence 8:19 – The Future, Beyond CGMs9:26 – Conclusion#metabolichealth #continuousglucosemonitor #staycurious #sugarfree #metabolichealth #insulin #insulinresistance #nutritiontips #educational #informational #bloodsugar #glycemicindex #personalizednutrition #n1science #healthdata #glucosemonitoring #foodexperiment #individualizedhealth #nutritionexperiment #sugarsensitivity #dietaryresponse #nutritionalbiology #insulinspike #bloodsugarcontrol #healthysugar #diabetesprevention #nutritionandbiology #curiositydriven #glucoseintolerance #testingnutrition #bloodsugarresponse #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices BBC Article: https://www.bbc.com/news/articles/c1ddk1ddme5o

Levels: https://levels.link/NICKNORWITZ
Get 2 months off an annual membership to the application, along with a continuous glucose monitor, using the link above.

Chapters
0:00 – Continuous Glucose Monitors for Non-Diabetics
0:58 – CGM can Provide Powerful Biofeedback for Behavior Change
2:03 – Counterpoint 1: Data Misuse
4:02 – Eating Disorders
6:48 – Absence of Evidence
8:19 – The Future, Beyond CGMs
9:26 – Conclusion

#metabolichealth #continuousglucosemonitor #staycurious #sugarfree #metabolichealth #insulin #insulinresistance #nutritiontips #educational #informational #bloodsugar #glycemicindex #personalizednutrition #n1science #healthdata #glucosemonitoring #foodexperiment #individualizedhealth #nutritionexperiment #sugarsensitivity #dietaryresponse #nutritionalbiology #insulinspike #bloodsugarcontrol #healthysugar #diabetesprevention #nutritionandbiology #curiositydriven #glucoseintolerance #testingnutrition #bloodsugarresponse #staycurious

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]]> 767 no I Changed My Mind on Cholesterol Medications (After 7 Years) For a written breakdown, more nuances and early access to content, see the associated newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/im-finally-lowering-my-cholesterol?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Statin RCT Video: https://youtu.be/d9LeDSoYOVc Ezetimibe Video: https://youtu.be/5idzP5ghT7A Bempedoic Acid Letter: https://staycuriousmetabolism.substack.com/p/beyond-cholesterol-the-unfolding?r=40ekz2 DescriptionFor the last seven years, despite extremely high cholesterol, I refused cholesterol-lowering medications. But I’ve just changed my mind…sort of. In this video, I walk through the full decision-making process: the risks, the uncertainty, the medical context, and the nuances that made this case unusually complicated. There are three plot twists.This is not medical advice. It’s a detailed look at an unusual case, and an invitation to stay curious, think critically, and keep an open mind in the face of medical dogma.Chapters 0:00 – My Cholesterol 2:50 – Roadmap for this video 4:10 – Part 1, 700 and Not a Lab Error 8:17 – Part 2, Why I Refused Cholesterol Meds for 7 Years 10:53 – Part 3, The First Plot Twist 12:00 – Proof in my LDL and ApoB, 56% Reductions18:22 – Part 4, How to Think When the Guidelines Don’t Fit 21:21 – The Final Plot Twist#cholesterol #LDL #hearthealth #statins #cardiology #lipids #healthscience #medicalcase #rareconditions #genetics #familialhypercholesterolemia #preventivemedicine #biomarkers #healthdebate #longevity #metabolichealth #doctorsadvice #patientstory #healthdata #clinicalresearch #case study #evidencebased #nutritiondebate #healthrisk #labresults #healthanalysis #scienceexplained #medicaldiscussion #healthjourney #cholesterollevels #statindebate #heartdisease #riskfactors #biochemistry #healthdecisions #medicalstory #researchreview #healthinsights #patientexperience #sciencecommunication #wellnessscience #healthfacts #doctorpatient #healthquestions #dataoverdogma #clinicalcases #healthperspective #curiositydriven #longtermhealth Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 08 Aug 2026 04:46:00 -0000 full Nick Norwitz MD PhD For a written breakdown, more nuances and early access to content, see the associated newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/im-finally-lowering-my-cholesterol?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Statin RCT Video: https://youtu.be/d9LeDSoYOVc Ezetimibe Video: https://youtu.be/5idzP5ghT7A Bempedoic Acid Letter: https://staycuriousmetabolism.substack.com/p/beyond-cholesterol-the-unfolding?r=40ekz2 DescriptionFor the last seven years, despite extremely high cholesterol, I refused cholesterol-lowering medications. But I’ve just changed my mind…sort of. In this video, I walk through the full decision-making process: the risks, the uncertainty, the medical context, and the nuances that made this case unusually complicated. There are three plot twists.This is not medical advice. It’s a detailed look at an unusual case, and an invitation to stay curious, think critically, and keep an open mind in the face of medical dogma.Chapters 0:00 – My Cholesterol 2:50 – Roadmap for this video 4:10 – Part 1, 700 and Not a Lab Error 8:17 – Part 2, Why I Refused Cholesterol Meds for 7 Years 10:53 – Part 3, The First Plot Twist 12:00 – Proof in my LDL and ApoB, 56% Reductions18:22 – Part 4, How to Think When the Guidelines Don’t Fit 21:21 – The Final Plot Twist#cholesterol #LDL #hearthealth #statins #cardiology #lipids #healthscience #medicalcase #rareconditions #genetics #familialhypercholesterolemia #preventivemedicine #biomarkers #healthdebate #longevity #metabolichealth #doctorsadvice #patientstory #healthdata #clinicalresearch #case study #evidencebased #nutritiondebate #healthrisk #labresults #healthanalysis #scienceexplained #medicaldiscussion #healthjourney #cholesterollevels #statindebate #heartdisease #riskfactors #biochemistry #healthdecisions #medicalstory #researchreview #healthinsights #patientexperience #sciencecommunication #wellnessscience #healthfacts #doctorpatient #healthquestions #dataoverdogma #clinicalcases #healthperspective #curiositydriven #longtermhealth Learn more about your ad choices. Visit megaphone.fm/adchoices For a written breakdown, more nuances and early access to content, see the associated newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/im-finally-lowering-my-cholesterol?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Statin RCT Video: https://youtu.be/d9LeDSoYOVc

Ezetimibe Video: https://youtu.be/5idzP5ghT7A

Bempedoic Acid Letter: https://staycuriousmetabolism.substack.com/p/beyond-cholesterol-the-unfolding?r=40ekz2

Description
For the last seven years, despite extremely high cholesterol, I refused cholesterol-lowering medications. But I’ve just changed my mind…sort of. In this video, I walk through the full decision-making process: the risks, the uncertainty, the medical context, and the nuances that made this case unusually complicated.

There are three plot twists.

This is not medical advice. It’s a detailed look at an unusual case, and an invitation to stay curious, think critically, and keep an open mind in the face of medical dogma.

Chapters
0:00 – My Cholesterol
2:50 – Roadmap for this video
4:10 – Part 1, 700 and Not a Lab Error
8:17 – Part 2, Why I Refused Cholesterol Meds for 7 Years
10:53 – Part 3, The First Plot Twist
12:00 – Proof in my LDL and ApoB, 56% Reductions
18:22 – Part 4, How to Think When the Guidelines Don’t Fit
21:21 – The Final Plot Twist

#cholesterol #LDL #hearthealth #statins #cardiology #lipids #healthscience #medicalcase #rareconditions #genetics #familialhypercholesterolemia #preventivemedicine #biomarkers #healthdebate #longevity #metabolichealth #doctorsadvice #patientstory #healthdata #clinicalresearch #case study #evidencebased #nutritiondebate #healthrisk #labresults #healthanalysis #scienceexplained #medicaldiscussion #healthjourney #cholesterollevels #statindebate #heartdisease #riskfactors #biochemistry #healthdecisions #medicalstory #researchreview #healthinsights #patientexperience #sciencecommunication #wellnessscience #healthfacts #doctorpatient #healthquestions #dataoverdogma #clinicalcases #healthperspective #curiositydriven #longtermhealth

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1681 no Become a MUSCLE Expert in 10 Minutes Chapters0:00 – Introduction0:45 – Lots of Muscle Does Not Equal Lots of Good Muscle2:04 – Muscle Contractions Sink Blood Glucose4:13 – Microbiome and Protein Bioavailability 6:09 – Exercise and Longevity 7:04 – Thermic Effect of Food9:08 – Closing Microbiome and Protein Bioavailability Video: https://youtu.be/uD4rbo1z-Lc Exercise and Longevity Video: https://youtu.be/lPjwIqDLC7E Andrew Huberman and Gabrielle Lyon Episode: https://youtu.be/WFcYF_pxLgA?si=viiVvi2zcRmT8Xd- Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 07 Aug 2026 10:46:00 -0000 full Nick Norwitz MD PhD Chapters0:00 – Introduction0:45 – Lots of Muscle Does Not Equal Lots of Good Muscle2:04 – Muscle Contractions Sink Blood Glucose4:13 – Microbiome and Protein Bioavailability 6:09 – Exercise and Longevity 7:04 – Thermic Effect of Food9:08 – Closing Microbiome and Protein Bioavailability Video: https://youtu.be/uD4rbo1z-Lc Exercise and Longevity Video: https://youtu.be/lPjwIqDLC7E Andrew Huberman and Gabrielle Lyon Episode: https://youtu.be/WFcYF_pxLgA?si=viiVvi2zcRmT8Xd- Learn more about your ad choices. Visit megaphone.fm/adchoices Chapters
0:00 – Introduction
0:45 – Lots of Muscle Does Not Equal Lots of Good Muscle
2:04 – Muscle Contractions Sink Blood Glucose
4:13 – Microbiome and Protein Bioavailability
6:09 – Exercise and Longevity
7:04 – Thermic Effect of Food
9:08 – Closing

Microbiome and Protein Bioavailability Video: https://youtu.be/uD4rbo1z-Lc

Exercise and Longevity Video: https://youtu.be/lPjwIqDLC7E

Andrew Huberman and Gabrielle Lyon Episode: https://youtu.be/WFcYF_pxLgA?si=viiVvi2zcRmT8Xd-

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 755 no How to Slow Aging for $0.06 a Day For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/how-to-legitimately-slow-aging-for?r=40ekz2Could you really improve healthspan, or lifespan, for 6.2 cents per day?In this video, we break down brand new 2026 research on vitamin C and cellular aging, focusing on a key pathway involving iron accumulation and an enzyme called ACSL4. Researchers found that vitamin C may directly inhibit this enzyme while also boosting antioxidant defenses, essentially launching a “two-pronged attack” against a specific form of biological aging.We then look at the real-world question: does this work in living organisms? In a long-term primate study, vitamin C was associated with reduced aging markers and even protection against age-related brain shrinkage. Finally, we translate the findings into a practical, low-cost protocol, while discussing important nuances around dosing, absorption, and metabolic context.Chapters1:30 – Roadmap to This Video2:00 – Part 1: A New Cause of Aging5:03 – Part 2: Proof It’s Happening in Me and You7:21 – Part 3: How to Slow Cellular Aging10:48 – Part 4: the $0.06 Protocol#vitaminc #aging #longevity #healthspan #brainhealth #antiaging #supplements #nutrition #biohacking #metabolism #mitochondria #oxidativestress #antioxidants #ironmetabolism #cellularaging #neuroscience #wellness #healthscience #medicalresearch #longevityscience #diet #supplementation #healthoptimization #functionalmedicine #preventivehealth #agingresearch #healthtips #brainaging #ferroptosis #biochemistry #vitamins #healthylifestyle #lifespan #agingprocess #healthhacks #nutritiontips #supplementstack #metabolichealth #longevitytips #scienceexplained #brainfunction #antiagingresearch #longevityhacks #healthspanextension #oxidativedamage #wellnessjourney #agingwell #longevitymedicine #sciencecommunication Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 06 Aug 2026 16:46:00 -0000 full Nick Norwitz MD PhD For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/how-to-legitimately-slow-aging-for?r=40ekz2Could you really improve healthspan, or lifespan, for 6.2 cents per day?In this video, we break down brand new 2026 research on vitamin C and cellular aging, focusing on a key pathway involving iron accumulation and an enzyme called ACSL4. Researchers found that vitamin C may directly inhibit this enzyme while also boosting antioxidant defenses, essentially launching a “two-pronged attack” against a specific form of biological aging.We then look at the real-world question: does this work in living organisms? In a long-term primate study, vitamin C was associated with reduced aging markers and even protection against age-related brain shrinkage. Finally, we translate the findings into a practical, low-cost protocol, while discussing important nuances around dosing, absorption, and metabolic context.Chapters1:30 – Roadmap to This Video2:00 – Part 1: A New Cause of Aging5:03 – Part 2: Proof It’s Happening in Me and You7:21 – Part 3: How to Slow Cellular Aging10:48 – Part 4: the $0.06 Protocol#vitaminc #aging #longevity #healthspan #brainhealth #antiaging #supplements #nutrition #biohacking #metabolism #mitochondria #oxidativestress #antioxidants #ironmetabolism #cellularaging #neuroscience #wellness #healthscience #medicalresearch #longevityscience #diet #supplementation #healthoptimization #functionalmedicine #preventivehealth #agingresearch #healthtips #brainaging #ferroptosis #biochemistry #vitamins #healthylifestyle #lifespan #agingprocess #healthhacks #nutritiontips #supplementstack #metabolichealth #longevitytips #scienceexplained #brainfunction #antiagingresearch #longevityhacks #healthspanextension #oxidativedamage #wellnessjourney #agingwell #longevitymedicine #sciencecommunication Learn more about your ad choices. Visit megaphone.fm/adchoices For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/how-to-legitimately-slow-aging-for?r=40ekz2

Could you really improve healthspan, or lifespan, for 6.2 cents per day?
In this video, we break down brand new 2026 research on vitamin C and cellular aging, focusing on a key pathway involving iron accumulation and an enzyme called ACSL4. Researchers found that vitamin C may directly inhibit this enzyme while also boosting antioxidant defenses, essentially launching a “two-pronged attack” against a specific form of biological aging.

We then look at the real-world question: does this work in living organisms? In a long-term primate study, vitamin C was associated with reduced aging markers and even protection against age-related brain shrinkage. Finally, we translate the findings into a practical, low-cost protocol, while discussing important nuances around dosing, absorption, and metabolic context.

Chapters
1:30 – Roadmap to This Video
2:00 – Part 1: A New Cause of Aging
5:03 – Part 2: Proof It’s Happening in Me and You
7:21 – Part 3: How to Slow Cellular Aging
10:48 – Part 4: the $0.06 Protocol

#vitaminc #aging #longevity #healthspan #brainhealth #antiaging #supplements #nutrition #biohacking #metabolism #mitochondria #oxidativestress #antioxidants #ironmetabolism #cellularaging #neuroscience #wellness #healthscience #medicalresearch #longevityscience #diet #supplementation #healthoptimization #functionalmedicine #preventivehealth #agingresearch #healthtips #brainaging #ferroptosis #biochemistry #vitamins #healthylifestyle #lifespan #agingprocess #healthhacks #nutritiontips #supplementstack #metabolichealth #longevitytips #scienceexplained #brainfunction #antiagingresearch #longevityhacks #healthspanextension #oxidativedamage #wellnessjourney #agingwell #longevitymedicine #sciencecommunication

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1037 no Defeat Your Culinary Kryptonite! New Science of GLP-1 and Satiety Paper: https://doi.org/10.1126%2Fscience.adj2537 Chapters0:00 – Culinary Kryptonite 1:06 – GLP-1 preingestive satiation 2:46 – DMH is the brain region involved in preingestive satiation 4:14 – Heterogeneity: Rainbows and Froot Loops 5:58 – Anti-Responder?7:13 – There’s always room for ice cream10:29 – My prescriptions Optogenetics breakdown (go to 3 min 19 sec) in this video: https://youtu.be/44qM9VtNAjc Video Sponsor(s) - House of Macadamia and RxSugarYes, I’m wearing a Mac Monster Macadamia Nut Shirt! I’ve been a heavy user of highly satiating macadamia nuts for over 5 years since I started a ketogenic diet. They’re delicious, versatile, high MUFA, high Omega-7/Palmitoleic Acid, low Omega-6/Linoleic acid, and low oxalate, phytate and lectin.To try product from my favorite nut company, HouseOfMacadamia, Go To:http://partner.houseofmacadamias.com/nick-norwitz- 15% Off All Bundles - 10% off any item (non-bundle) with code "NICK10"And for more information on macadamia nutrition and Omega-7: https://youtu.be/Vngn6i-rmZII'm also on the scientific advisory board at RxSugar, a company that specializes in allulose. Unlike macadamia - which I do consume regularly - I don't have much of a sweet tooth so don't find I have much of a need for allulose. However, I always try my best to separate my personal preferences from the science, which is why I'm happy and proud to support RxSugar and their mission to displace fructose and sugar in the food supply with allulose! Among allulose's interesting properties is that it induces the release of endogenous GLP-1, albeit at lower dose equivalencies than prescription medications. Still, there are data (clinical and preclinical) that allulose can have anti-obesogenic properties. And the precise mechanism is being explored actively! There are also clinical reports of people have loss of cravings and "food noise" with allulose products, which is interesting. I wonder if one could measure a change in DMH pre-ingestion satiation neurons after an allulose bolus... perhaps we will find out in time! You can use my discount code NICK20 for 20% off any products.https://rxsugar.comFor more scientific information on allulose, go here: https://youtu.be/pr93EsEV2bM Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 05 Aug 2026 22:46:00 -0000 full Nick Norwitz MD PhD Paper: https://doi.org/10.1126%2Fscience.adj2537 Chapters0:00 – Culinary Kryptonite 1:06 – GLP-1 preingestive satiation 2:46 – DMH is the brain region involved in preingestive satiation 4:14 – Heterogeneity: Rainbows and Froot Loops 5:58 – Anti-Responder?7:13 – There’s always room for ice cream10:29 – My prescriptions Optogenetics breakdown (go to 3 min 19 sec) in this video: https://youtu.be/44qM9VtNAjc Video Sponsor(s) - House of Macadamia and RxSugarYes, I’m wearing a Mac Monster Macadamia Nut Shirt! I’ve been a heavy user of highly satiating macadamia nuts for over 5 years since I started a ketogenic diet. They’re delicious, versatile, high MUFA, high Omega-7/Palmitoleic Acid, low Omega-6/Linoleic acid, and low oxalate, phytate and lectin.To try product from my favorite nut company, HouseOfMacadamia, Go To:http://partner.houseofmacadamias.com/nick-norwitz- 15% Off All Bundles - 10% off any item (non-bundle) with code "NICK10"And for more information on macadamia nutrition and Omega-7: https://youtu.be/Vngn6i-rmZII'm also on the scientific advisory board at RxSugar, a company that specializes in allulose. Unlike macadamia - which I do consume regularly - I don't have much of a sweet tooth so don't find I have much of a need for allulose. However, I always try my best to separate my personal preferences from the science, which is why I'm happy and proud to support RxSugar and their mission to displace fructose and sugar in the food supply with allulose! Among allulose's interesting properties is that it induces the release of endogenous GLP-1, albeit at lower dose equivalencies than prescription medications. Still, there are data (clinical and preclinical) that allulose can have anti-obesogenic properties. And the precise mechanism is being explored actively! There are also clinical reports of people have loss of cravings and "food noise" with allulose products, which is interesting. I wonder if one could measure a change in DMH pre-ingestion satiation neurons after an allulose bolus... perhaps we will find out in time! You can use my discount code NICK20 for 20% off any products.https://rxsugar.comFor more scientific information on allulose, go here: https://youtu.be/pr93EsEV2bM Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://doi.org/10.1126%2Fscience.adj2537

Chapters
0:00 – Culinary Kryptonite
1:06 – GLP-1 preingestive satiation
2:46 – DMH is the brain region involved in preingestive satiation
4:14 – Heterogeneity: Rainbows and Froot Loops
5:58 – Anti-Responder?
7:13 – There’s always room for ice cream
10:29 – My prescriptions

Optogenetics breakdown (go to 3 min 19 sec) in this video: https://youtu.be/44qM9VtNAjc

Video Sponsor(s) - House of Macadamia and RxSugar

Yes, I’m wearing a Mac Monster Macadamia Nut Shirt! I’ve been a heavy user of highly satiating macadamia nuts for over 5 years since I started a ketogenic diet. They’re delicious, versatile, high MUFA, high Omega-7/Palmitoleic Acid, low Omega-6/Linoleic acid, and low oxalate, phytate and lectin.

To try product from my favorite nut company, HouseOfMacadamia, Go To:
http://partner.houseofmacadamias.com/nick-norwitz
- 15% Off All Bundles
- 10% off any item (non-bundle) with code "NICK10"

And for more information on macadamia nutrition and Omega-7: https://youtu.be/Vngn6i-rmZI

I'm also on the scientific advisory board at RxSugar, a company that specializes in allulose. Unlike macadamia - which I do consume regularly - I don't have much of a sweet tooth so don't find I have much of a need for allulose. However, I always try my best to separate my personal preferences from the science, which is why I'm happy and proud to support RxSugar and their mission to displace fructose and sugar in the food supply with allulose! Among allulose's interesting properties is that it induces the release of endogenous GLP-1, albeit at lower dose equivalencies than prescription medications. Still, there are data (clinical and preclinical) that allulose can have anti-obesogenic properties. And the precise mechanism is being explored actively! There are also clinical reports of people have loss of cravings and "food noise" with allulose products, which is interesting. I wonder if one could measure a change in DMH pre-ingestion satiation neurons after an allulose bolus... perhaps we will find out in time!

You can use my discount code NICK20 for 20% off any products.
https://rxsugar.com

For more scientific information on allulose, go here: https://youtu.be/pr93EsEV2bM

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 844 no The Best Peptides for Longevity and Sleep (Human Studies) If you're interested in going deeper, check out our StayCurious Metabolism library on "Peptides and More" https://staycuriousmetabolism.substack.com/p/peptidesReferenced LettersRussian Longevity Peptides: https://staycuriousmetabolism.substack.com/p/can-these-longevity-peptides-be-real?r=40ekz2 Pinealon and Sleep: https://staycuriousmetabolism.substack.com/p/why-im-trying-this-peptide-for-sleep?r=40ekz2 To Try PinealonClick this link and use discount code "StayCurious" - Click here: https://yourprotocol.co?sca_ref=11108235.AADIX7EtofThymic Health and Longevity: https://open.substack.com/pub/staycuriousmetabolism/p/the-most-overlooked-organ-in-aging?utm_campaign=post-expanded-share&utm_medium=webChapters0:00 – Are These Russian Longevity Peptides Real?!1:57 – Part 1, All Roads Lead Back to Russia6:24 – Part 2, How These Peptides Work10:20 – Part 3, My Personal Experience 14:28 – Part 4, Looking Towards the FutureCan short peptides really influence aging, immunity, sleep, and even mortality? In this video, we examine the controversial longevity research surrounding peptides linked to Russian gerontology researcher Vladimir Khavinson. We break down the human clinical trials, telomerase activation data, thymus and pineal gland peptides, and the surprising claims of reduced mortality and improved health outcomes in elderly patients.Along the way, we explore the biology of telomeres, cellular senescence, immune aging, melatonin production, circadian rhythm regulation, and the cancer paradox of telomerase activation. The video also covers peptide sleep stacks like Pinealon + Epithalon, practical protocol discussions, and the important distinction between intriguing early evidence and definitive proof.This is not hype or blind skepticism—it’s a deep dive into the actual science, mechanisms, limitations, and unanswered questions behind some of the most fascinating anti-aging peptide research available today.#Longevity #AntiAging #Peptides #Epithalon #Epitalon #Thymalin #Telomerase #Telomeres #Biohacking #HealthyAging #LifeExtension #AgingResearch #PeptideTherapy #CellularAging #ImmuneSystem #Melatonin #SleepOptimization #CircadianRhythm #Senescence #HealthScience #Metabolism #LongevityScience #Gerontology #HumanOptimization #Biology #MolecularBiology #Healthspan #Lifespan #MedicalResearch #Wellness #BioRegulation #Khavinson #Neuroscience #FunctionalMedicine #Optimization #Supplements #SleepScience #TCells #Inflammaging #CellBiology #ScienceExplained #PreventiveHealth #GLP1 #MetabolicHealth #DeepDive #ScientificResearch #LongevityPeptides #Thymus #PinealGland #ScienceYouTube Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 05 Aug 2026 04:46:00 -0000 full Nick Norwitz MD PhD If you're interested in going deeper, check out our StayCurious Metabolism library on "Peptides and More" https://staycuriousmetabolism.substack.com/p/peptidesReferenced LettersRussian Longevity Peptides: https://staycuriousmetabolism.substack.com/p/can-these-longevity-peptides-be-real?r=40ekz2 Pinealon and Sleep: https://staycuriousmetabolism.substack.com/p/why-im-trying-this-peptide-for-sleep?r=40ekz2 To Try PinealonClick this link and use discount code "StayCurious" - Click here: https://yourprotocol.co?sca_ref=11108235.AADIX7EtofThymic Health and Longevity: https://open.substack.com/pub/staycuriousmetabolism/p/the-most-overlooked-organ-in-aging?utm_campaign=post-expanded-share&utm_medium=webChapters0:00 – Are These Russian Longevity Peptides Real?!1:57 – Part 1, All Roads Lead Back to Russia6:24 – Part 2, How These Peptides Work10:20 – Part 3, My Personal Experience 14:28 – Part 4, Looking Towards the FutureCan short peptides really influence aging, immunity, sleep, and even mortality? In this video, we examine the controversial longevity research surrounding peptides linked to Russian gerontology researcher Vladimir Khavinson. We break down the human clinical trials, telomerase activation data, thymus and pineal gland peptides, and the surprising claims of reduced mortality and improved health outcomes in elderly patients.Along the way, we explore the biology of telomeres, cellular senescence, immune aging, melatonin production, circadian rhythm regulation, and the cancer paradox of telomerase activation. The video also covers peptide sleep stacks like Pinealon + Epithalon, practical protocol discussions, and the important distinction between intriguing early evidence and definitive proof.This is not hype or blind skepticism—it’s a deep dive into the actual science, mechanisms, limitations, and unanswered questions behind some of the most fascinating anti-aging peptide research available today.#Longevity #AntiAging #Peptides #Epithalon #Epitalon #Thymalin #Telomerase #Telomeres #Biohacking #HealthyAging #LifeExtension #AgingResearch #PeptideTherapy #CellularAging #ImmuneSystem #Melatonin #SleepOptimization #CircadianRhythm #Senescence #HealthScience #Metabolism #LongevityScience #Gerontology #HumanOptimization #Biology #MolecularBiology #Healthspan #Lifespan #MedicalResearch #Wellness #BioRegulation #Khavinson #Neuroscience #FunctionalMedicine #Optimization #Supplements #SleepScience #TCells #Inflammaging #CellBiology #ScienceExplained #PreventiveHealth #GLP1 #MetabolicHealth #DeepDive #ScientificResearch #LongevityPeptides #Thymus #PinealGland #ScienceYouTube Learn more about your ad choices. Visit megaphone.fm/adchoices If you're interested in going deeper, check out our StayCurious Metabolism library on "Peptides and More" https://staycuriousmetabolism.substack.com/p/peptides

Referenced Letters

Russian Longevity Peptides: https://staycuriousmetabolism.substack.com/p/can-these-longevity-peptides-be-real?r=40ekz2

Pinealon and Sleep: https://staycuriousmetabolism.substack.com/p/why-im-trying-this-peptide-for-sleep?r=40ekz2

To Try Pinealon

Click this link and use discount code "StayCurious" - Click here: https://yourprotocol.co?sca_ref=11108235.AADIX7Etof

Thymic Health and Longevity: https://open.substack.com/pub/staycuriousmetabolism/p/the-most-overlooked-organ-in-aging?utm_campaign=post-expanded-share&utm_medium=web

Chapters
0:00 – Are These Russian Longevity Peptides Real?!
1:57 – Part 1, All Roads Lead Back to Russia
6:24 – Part 2, How These Peptides Work
10:20 – Part 3, My Personal Experience
14:28 – Part 4, Looking Towards the Future

Can short peptides really influence aging, immunity, sleep, and even mortality? In this video, we examine the controversial longevity research surrounding peptides linked to Russian gerontology researcher Vladimir Khavinson.

We break down the human clinical trials, telomerase activation data, thymus and pineal gland peptides, and the surprising claims of reduced mortality and improved health outcomes in elderly patients.

Along the way, we explore the biology of telomeres, cellular senescence, immune aging, melatonin production, circadian rhythm regulation, and the cancer paradox of telomerase activation.

The video also covers peptide sleep stacks like Pinealon + Epithalon, practical protocol discussions, and the important distinction between intriguing early evidence and definitive proof.

This is not hype or blind skepticism—it’s a deep dive into the actual science, mechanisms, limitations, and unanswered questions behind some of the most fascinating anti-aging peptide research available today.

#Longevity #AntiAging #Peptides #Epithalon #Epitalon #Thymalin #Telomerase #Telomeres #Biohacking #HealthyAging #LifeExtension #AgingResearch #PeptideTherapy #CellularAging #ImmuneSystem #Melatonin #SleepOptimization #CircadianRhythm #Senescence #HealthScience #Metabolism #LongevityScience #Gerontology #HumanOptimization #Biology #MolecularBiology #Healthspan #Lifespan #MedicalResearch #Wellness #BioRegulation #Khavinson #Neuroscience #FunctionalMedicine #Optimization #Supplements #SleepScience #TCells #Inflammaging #CellBiology #ScienceExplained #PreventiveHealth #GLP1 #MetabolicHealth #DeepDive #ScientificResearch #LongevityPeptides #Thymus #PinealGland #ScienceYouTube

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1167 no Make your Fat Flexible: This Can Do what Ozempic Never Could Fuel Partitioning video: https://youtu.be/9KbxdzPK8W0 Paper: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00186-4GLP-1, New Basic Science Newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/4-incredible-facts-about-glp-1s?r=40ekz2&utm_campaign=post&utm_medium=web Chapters0:00 – New Drug More Powerful than Ozempic1:42 – GLP-1 and GLP-1 + GIP receptor agonists2:31 – Tirzepatide binds to fat cells and alters their metabolism6:31 – Tirzepatide improves fuel partitioning in obesity Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 04 Aug 2026 10:46:00 -0000 full Nick Norwitz MD PhD Fuel Partitioning video: https://youtu.be/9KbxdzPK8W0 Paper: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00186-4GLP-1, New Basic Science Newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/4-incredible-facts-about-glp-1s?r=40ekz2&utm_campaign=post&utm_medium=web Chapters0:00 – New Drug More Powerful than Ozempic1:42 – GLP-1 and GLP-1 + GIP receptor agonists2:31 – Tirzepatide binds to fat cells and alters their metabolism6:31 – Tirzepatide improves fuel partitioning in obesity Learn more about your ad choices. Visit megaphone.fm/adchoices Fuel Partitioning video: https://youtu.be/9KbxdzPK8W0

Paper: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00186-4

GLP-1, New Basic Science Newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/4-incredible-facts-about-glp-1s?r=40ekz2&utm_campaign=post&utm_medium=web

Chapters
0:00 – New Drug More Powerful than Ozempic
1:42 – GLP-1 and GLP-1 + GIP receptor agonists
2:31 – Tirzepatide binds to fat cells and alters their metabolism
6:31 – Tirzepatide improves fuel partitioning in obesity

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 671 no Heart Rate Variability (And The Coffee that Almost Killed Me) For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/why-you-need-to-track-your-heart?r=40ekz2 If you want to try the omega supplement I use, Accentrate Omega Max, here’s the link: https://www.fenixhealthscience.com/staycurious Use Discount Code StayCurious for 20% OffHeart rate variability (HRV) is more than just a number, it’s a real-time window into how well your brain, heart, and nervous system are working together. In this video, we break down what HRV actually measures, why it’s such a powerful predictor of mortality and heart attack risk, and how it reflects something deeper: your body’s ability to adapt, recover, and respond to stress.We walk through landmark studies showing that low HRV is associated with significantly higher risk of death and first cardiac events—even after controlling for traditional risk factors. But this isn’t just about risk. HRV is something you can measure today and actively improve through exercise, nutrition, and targeted breathing strategies.Finally, we tie it all together with a personal story about how a simple cup of coffee (or tea) led to a severe physiological event that highlights just how dynamic and complex the nervous system can be. By the end, you’ll understand not just what HRV is, but how to use it as a practical tool for better health and performance.⁠Chapters0:00 – The Coffee that Almost Killed Me1:30 – Roadmap to this Video2:07 – Chapter 1: What is Heart Rate Variability (HRV)?5:30 – Chapter 2: Why Does HRV Matter?8:57 – Chapter 3: How to Measure and Improve HRV? (Exercise, Caffeine, Omega-3s, Biofeedback)18:38 – Chapter 4: The Craziest Coffee Story You’ll Ever Hear!#HeartRateVariability #HRV #HealthScience #Longevity #CardiovascularHealth #Biohacking #Wearables #Whoop #OuraRing #FitnessScience #Recovery #StressManagement #NervousSystem #VagusNerve #Omega3 #BreathingTechniques #Zone2 #HIIT #HealthOptimization #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 03 Aug 2026 16:46:00 -0000 full Nick Norwitz MD PhD For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/why-you-need-to-track-your-heart?r=40ekz2 If you want to try the omega supplement I use, Accentrate Omega Max, here’s the link: https://www.fenixhealthscience.com/staycurious Use Discount Code StayCurious for 20% OffHeart rate variability (HRV) is more than just a number, it’s a real-time window into how well your brain, heart, and nervous system are working together. In this video, we break down what HRV actually measures, why it’s such a powerful predictor of mortality and heart attack risk, and how it reflects something deeper: your body’s ability to adapt, recover, and respond to stress.We walk through landmark studies showing that low HRV is associated with significantly higher risk of death and first cardiac events—even after controlling for traditional risk factors. But this isn’t just about risk. HRV is something you can measure today and actively improve through exercise, nutrition, and targeted breathing strategies.Finally, we tie it all together with a personal story about how a simple cup of coffee (or tea) led to a severe physiological event that highlights just how dynamic and complex the nervous system can be. By the end, you’ll understand not just what HRV is, but how to use it as a practical tool for better health and performance.⁠Chapters0:00 – The Coffee that Almost Killed Me1:30 – Roadmap to this Video2:07 – Chapter 1: What is Heart Rate Variability (HRV)?5:30 – Chapter 2: Why Does HRV Matter?8:57 – Chapter 3: How to Measure and Improve HRV? (Exercise, Caffeine, Omega-3s, Biofeedback)18:38 – Chapter 4: The Craziest Coffee Story You’ll Ever Hear!#HeartRateVariability #HRV #HealthScience #Longevity #CardiovascularHealth #Biohacking #Wearables #Whoop #OuraRing #FitnessScience #Recovery #StressManagement #NervousSystem #VagusNerve #Omega3 #BreathingTechniques #Zone2 #HIIT #HealthOptimization #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/why-you-need-to-track-your-heart?r=40ekz2

If you want to try the omega supplement I use, Accentrate Omega Max, here’s the link: https://www.fenixhealthscience.com/staycurious

Use Discount Code StayCurious for 20% Off

Heart rate variability (HRV) is more than just a number, it’s a real-time window into how well your brain, heart, and nervous system are working together. In this video, we break down what HRV actually measures, why it’s such a powerful predictor of mortality and heart attack risk, and how it reflects something deeper: your body’s ability to adapt, recover, and respond to stress.

We walk through landmark studies showing that low HRV is associated with significantly higher risk of death and first cardiac events—even after controlling for traditional risk factors. But this isn’t just about risk. HRV is something you can measure today and actively improve through exercise, nutrition, and targeted breathing strategies.

Finally, we tie it all together with a personal story about how a simple cup of coffee (or tea) led to a severe physiological event that highlights just how dynamic and complex the nervous system can be. By the end, you’ll understand not just what HRV is, but how to use it as a practical tool for better health and performance.

⁠Chapters
0:00 – The Coffee that Almost Killed Me
1:30 – Roadmap to this Video
2:07 – Chapter 1: What is Heart Rate Variability (HRV)?
5:30 – Chapter 2: Why Does HRV Matter?
8:57 – Chapter 3: How to Measure and Improve HRV? (Exercise, Caffeine, Omega-3s, Biofeedback)
18:38 – Chapter 4: The Craziest Coffee Story You’ll Ever Hear!

#HeartRateVariability #HRV #HealthScience #Longevity #CardiovascularHealth #Biohacking #Wearables #Whoop #OuraRing #FitnessScience #Recovery #StressManagement #NervousSystem #VagusNerve #Omega3 #BreathingTechniques #Zone2 #HIIT #HealthOptimization #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1711 no Too Cool for Stool: NEW Metabolic Advantage of Ketogenic Diets Paper: https://www.nature.com/articles/s42255-024-01072-1 Chapters0:00 – Introduction0:46 – Ketogenic diets increase levels of taurine-conjugated bile acids1:44 – Weight loss and improved glucose tolerance2:24 – Changes to microbiome3:05 – Pooping Calories!4:17 – Is this relevant in humans? Yes!5:38 – A few take-aways and caveats Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 02 Aug 2026 22:46:00 -0000 full Nick Norwitz MD PhD Paper: https://www.nature.com/articles/s42255-024-01072-1 Chapters0:00 – Introduction0:46 – Ketogenic diets increase levels of taurine-conjugated bile acids1:44 – Weight loss and improved glucose tolerance2:24 – Changes to microbiome3:05 – Pooping Calories!4:17 – Is this relevant in humans? Yes!5:38 – A few take-aways and caveats Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://www.nature.com/articles/s42255-024-01072-1

Chapters
0:00 – Introduction
0:46 – Ketogenic diets increase levels of taurine-conjugated bile acids
1:44 – Weight loss and improved glucose tolerance
2:24 – Changes to microbiome
3:05 – Pooping Calories!
4:17 – Is this relevant in humans? Yes!
5:38 – A few take-aways and caveats

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 498 no Sunlight LooksMaxxing (Backed by Science) For extra nuances and all the references, please see the newsletter: https://staycuriousmetabolism.substack.com/p/how-i-hacked-my-girlfriends-brainwith?r=40ekz2&utm_campaign=post&utm_medium=web&triedRedirect=true Can light influence attraction, hormones, and even reproductive biology? In this video, we explore surprising research on light exposure, testosterone, estrogen, fertility signals, and behavioral changes observed in both animal models and human studies.From hormone cascades triggered through the skin to seasonal changes in reproductive biology, this is a fascinating look at how deeply light may shape human physiology. Along the way, I also test whether increasing my own sunlight exposure changes my testosterone levels and reveal how my girlfriend hacked my brain!For more nuance, mechanisms, protocols, and limitations behind these findings, check out the full deep dive linked above.Chapters0:00 – Light Can Make You More Attractive3:00 – The Dance Between Light and Human Evolution 6:37 – Some Crazy Experiments in Mice9:22 – Human Studies on Attraction and Hormones11:05 – Nick’s Funny Personal Diamond Necklace Story12:12 – Fertility and Reproductive Biology13:51 – The Science of Solar Angle14:53 – My Sunlight Testosterone Experiment15:20 – The Bigger Picture of Light and Hormones#Sunlight #Testosterone #UVB #Hormones #Metabolism #Fertility #HealthScience #Longevity #CircadianRhythm #Biohacking #MensHealth #WomensHealth #LightExposure #HumanBiology #Mitochondria #EvolutionaryBiology #HormoneHealth #Phototherapy #Science #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 02 Aug 2026 04:46:00 -0000 full Nick Norwitz MD PhD For extra nuances and all the references, please see the newsletter: https://staycuriousmetabolism.substack.com/p/how-i-hacked-my-girlfriends-brainwith?r=40ekz2&utm_campaign=post&utm_medium=web&triedRedirect=true Can light influence attraction, hormones, and even reproductive biology? In this video, we explore surprising research on light exposure, testosterone, estrogen, fertility signals, and behavioral changes observed in both animal models and human studies.From hormone cascades triggered through the skin to seasonal changes in reproductive biology, this is a fascinating look at how deeply light may shape human physiology. Along the way, I also test whether increasing my own sunlight exposure changes my testosterone levels and reveal how my girlfriend hacked my brain!For more nuance, mechanisms, protocols, and limitations behind these findings, check out the full deep dive linked above.Chapters0:00 – Light Can Make You More Attractive3:00 – The Dance Between Light and Human Evolution 6:37 – Some Crazy Experiments in Mice9:22 – Human Studies on Attraction and Hormones11:05 – Nick’s Funny Personal Diamond Necklace Story12:12 – Fertility and Reproductive Biology13:51 – The Science of Solar Angle14:53 – My Sunlight Testosterone Experiment15:20 – The Bigger Picture of Light and Hormones#Sunlight #Testosterone #UVB #Hormones #Metabolism #Fertility #HealthScience #Longevity #CircadianRhythm #Biohacking #MensHealth #WomensHealth #LightExposure #HumanBiology #Mitochondria #EvolutionaryBiology #HormoneHealth #Phototherapy #Science #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For extra nuances and all the references, please see the newsletter: https://staycuriousmetabolism.substack.com/p/how-i-hacked-my-girlfriends-brainwith?r=40ekz2&utm_campaign=post&utm_medium=web&triedRedirect=true

Can light influence attraction, hormones, and even reproductive biology?

In this video, we explore surprising research on light exposure, testosterone, estrogen, fertility signals, and behavioral changes observed in both animal models and human studies.

From hormone cascades triggered through the skin to seasonal changes in reproductive biology, this is a fascinating look at how deeply light may shape human physiology.

Along the way, I also test whether increasing my own sunlight exposure changes my testosterone levels and reveal how my girlfriend hacked my brain!

For more nuance, mechanisms, protocols, and limitations behind these findings, check out the full deep dive linked above.

Chapters
0:00 – Light Can Make You More Attractive
3:00 – The Dance Between Light and Human Evolution
6:37 – Some Crazy Experiments in Mice
9:22 – Human Studies on Attraction and Hormones
11:05 – Nick’s Funny Personal Diamond Necklace Story
12:12 – Fertility and Reproductive Biology
13:51 – The Science of Solar Angle
14:53 – My Sunlight Testosterone Experiment
15:20 – The Bigger Picture of Light and Hormones

#Sunlight #Testosterone #UVB #Hormones #Metabolism #Fertility #HealthScience #Longevity #CircadianRhythm #Biohacking #MensHealth #WomensHealth #LightExposure #HumanBiology #Mitochondria #EvolutionaryBiology #HormoneHealth #Phototherapy #Science #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1185 no Does Cereal Destroy Metabolic Health? Chapters0:00 – The Kelce Cereal Controversy1:54 – The perspective of a child3:20 – The perspective of a patient5:04 – The perspective of a scientist 7:49 – Concluding thoughts #metabolism #kelce #healthandwellness Want to check out the “Nitty Gritty” science? Here are some recent paper breakdown videos to check out"GLP-1 Quiets Foods Noise, and This is Howhttps://youtu.be/Lhx8hCj71fkKetogenic Diet Promotes Fecal Elimination of Calories https://youtu.be/d0WuCIZxPxUThe Fuel Partitioning Model of Obesityhttps://youtu.be/9KbxdzPK8W0The Artificial Sweetener Sucralose Causes Insulin Resistancehttps://youtu.be/fyERqDgSiMgNew Mechanism of Leptin Resistancehttps://youtu.be/bmaKtDUwr8gExercise Can Reverse a Metabolic Signature of Aging in Fathttps://youtu.be/lPjwIqDLC7E Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 01 Aug 2026 10:46:00 -0000 full Nick Norwitz MD PhD Chapters0:00 – The Kelce Cereal Controversy1:54 – The perspective of a child3:20 – The perspective of a patient5:04 – The perspective of a scientist 7:49 – Concluding thoughts #metabolism #kelce #healthandwellness Want to check out the “Nitty Gritty” science? Here are some recent paper breakdown videos to check out"GLP-1 Quiets Foods Noise, and This is Howhttps://youtu.be/Lhx8hCj71fkKetogenic Diet Promotes Fecal Elimination of Calories https://youtu.be/d0WuCIZxPxUThe Fuel Partitioning Model of Obesityhttps://youtu.be/9KbxdzPK8W0The Artificial Sweetener Sucralose Causes Insulin Resistancehttps://youtu.be/fyERqDgSiMgNew Mechanism of Leptin Resistancehttps://youtu.be/bmaKtDUwr8gExercise Can Reverse a Metabolic Signature of Aging in Fathttps://youtu.be/lPjwIqDLC7E Learn more about your ad choices. Visit megaphone.fm/adchoices Chapters
0:00 – The Kelce Cereal Controversy
1:54 – The perspective of a child
3:20 – The perspective of a patient
5:04 – The perspective of a scientist
7:49 – Concluding thoughts

#metabolism #kelce #healthandwellness
Want to check out the “Nitty Gritty” science? Here are some recent paper breakdown videos to check out"

GLP-1 Quiets Foods Noise, and This is How
https://youtu.be/Lhx8hCj71fk

Ketogenic Diet Promotes Fecal Elimination of Calories
https://youtu.be/d0WuCIZxPxU

The Fuel Partitioning Model of Obesity
https://youtu.be/9KbxdzPK8W0

The Artificial Sweetener Sucralose Causes Insulin Resistance
https://youtu.be/fyERqDgSiMg

New Mechanism of Leptin Resistance
https://youtu.be/bmaKtDUwr8g

Exercise Can Reverse a Metabolic Signature of Aging in Fat
https://youtu.be/lPjwIqDLC7E

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 737 no The Technology That Will Change Humans Forever For extra nuances and all the references, please see the newsletter: https://staycuriousmetabolism.substack.com/p/can-we-become-like-captain-america?r=40ekz2 The StayCurious Human Enhancement SeriesWe're launching a new series at StayCurious Metabolism called Peptides Plus, where we'll explore the most promising tools available today—and the innovations that may shape tomorrow. We have dozens of deep dives planned, covering everything from emerging therapeutics to cutting-edge performance and longevity interventions.GO HERE: https://staycuriousmetabolism.substack.com/p/peptidesChapters0:00 — Superhuman Biology Is Already Starting2:40 — Beyond GLP-1: Fat Loss Without Muscle Loss7:28 — Gene Editing, CRISPR, and the Future of Disease Cure14:57 — Cellular Reprogramming and Biological Age Reset18:49 — MicroRNAs, Mitochondria, and What Comes NextVideo DescriptionWhat if the idea of “superhuman biology” isn’t science fiction anymore—but early-stage reality? From drugs that selectively burn fat while preserving muscle, to gene editing technologies capable of correcting disease at the DNA level, the frontier of human bio-optimization is moving faster than most people realize.In this video, we explore how breakthroughs like myostatin inhibition, CRISPR and prime gene editing, prime editing, and cellular reprogramming are converging toward a future where biology itself can be engineered. Along the way, we examine real clinical data—from 100% fat loss outcomes in trials to gene therapies curing genetic diseases—and unpack what’s actually possible today versus what’s coming next.This is not about unearened hype or pure fantasy. It’s a grounded, evidence-based look at how modern science is beginning to close the gap between comic book imagination and real-world biology—and the implications that come with it.#GeneEditing #CRISPR #HealthScience #FutureOfMedicine #HumanOptimization #AntiAging #Metabolism #MuscleGrowth #FatLoss #Biotech #MedicalInnovation #Superhuman #LongevityScience #Neuroscience #AlzheimersResearch #Genetics #PrecisionMedicine #FitnessScience #HealthOptimization #CellularBiology #Epigenetics #YamanakaFactors #Mitochondria #MicroRNA #Biology #ScienceExplained #MedicalBreakthrough #LongevityResearch #FutureHealth #Bioengineering #HealthTech #WellnessScience #AgingResearch #ClinicalTrials #ObesityTreatment #MuscleScience #MetabolicHealth #ScientificResearch #HumanPerformance #NextGenMedicine #DNAEditing #StemCells #HealthFuture #StayCurious #ScienceContent #MedicalScience #Innovation #BiologyFacts Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 31 Jul 2026 16:46:00 -0000 full Nick Norwitz MD PhD For extra nuances and all the references, please see the newsletter: https://staycuriousmetabolism.substack.com/p/can-we-become-like-captain-america?r=40ekz2 The StayCurious Human Enhancement SeriesWe're launching a new series at StayCurious Metabolism called Peptides Plus, where we'll explore the most promising tools available today—and the innovations that may shape tomorrow. We have dozens of deep dives planned, covering everything from emerging therapeutics to cutting-edge performance and longevity interventions.GO HERE: https://staycuriousmetabolism.substack.com/p/peptidesChapters0:00 — Superhuman Biology Is Already Starting2:40 — Beyond GLP-1: Fat Loss Without Muscle Loss7:28 — Gene Editing, CRISPR, and the Future of Disease Cure14:57 — Cellular Reprogramming and Biological Age Reset18:49 — MicroRNAs, Mitochondria, and What Comes NextVideo DescriptionWhat if the idea of “superhuman biology” isn’t science fiction anymore—but early-stage reality? From drugs that selectively burn fat while preserving muscle, to gene editing technologies capable of correcting disease at the DNA level, the frontier of human bio-optimization is moving faster than most people realize.In this video, we explore how breakthroughs like myostatin inhibition, CRISPR and prime gene editing, prime editing, and cellular reprogramming are converging toward a future where biology itself can be engineered. Along the way, we examine real clinical data—from 100% fat loss outcomes in trials to gene therapies curing genetic diseases—and unpack what’s actually possible today versus what’s coming next.This is not about unearened hype or pure fantasy. It’s a grounded, evidence-based look at how modern science is beginning to close the gap between comic book imagination and real-world biology—and the implications that come with it.#GeneEditing #CRISPR #HealthScience #FutureOfMedicine #HumanOptimization #AntiAging #Metabolism #MuscleGrowth #FatLoss #Biotech #MedicalInnovation #Superhuman #LongevityScience #Neuroscience #AlzheimersResearch #Genetics #PrecisionMedicine #FitnessScience #HealthOptimization #CellularBiology #Epigenetics #YamanakaFactors #Mitochondria #MicroRNA #Biology #ScienceExplained #MedicalBreakthrough #LongevityResearch #FutureHealth #Bioengineering #HealthTech #WellnessScience #AgingResearch #ClinicalTrials #ObesityTreatment #MuscleScience #MetabolicHealth #ScientificResearch #HumanPerformance #NextGenMedicine #DNAEditing #StemCells #HealthFuture #StayCurious #ScienceContent #MedicalScience #Innovation #BiologyFacts Learn more about your ad choices. Visit megaphone.fm/adchoices For extra nuances and all the references, please see the newsletter: https://staycuriousmetabolism.substack.com/p/can-we-become-like-captain-america?r=40ekz2

The StayCurious Human Enhancement Series

We're launching a new series at StayCurious Metabolism called Peptides Plus, where we'll explore the most promising tools available today—and the innovations that may shape tomorrow. We have dozens of deep dives planned, covering everything from emerging therapeutics to cutting-edge performance and longevity interventions.

GO HERE: https://staycuriousmetabolism.substack.com/p/peptides

Chapters
0:00 — Superhuman Biology Is Already Starting
2:40 — Beyond GLP-1: Fat Loss Without Muscle Loss
7:28 — Gene Editing, CRISPR, and the Future of Disease Cure
14:57 — Cellular Reprogramming and Biological Age Reset
18:49 — MicroRNAs, Mitochondria, and What Comes Next

Video Description
What if the idea of “superhuman biology” isn’t science fiction anymore—but early-stage reality? From drugs that selectively burn fat while preserving muscle, to gene editing technologies capable of correcting disease at the DNA level, the frontier of human bio-optimization is moving faster than most people realize.

In this video, we explore how breakthroughs like myostatin inhibition, CRISPR and prime gene editing, prime editing, and cellular reprogramming are converging toward a future where biology itself can be engineered. Along the way, we examine real clinical data—from 100% fat loss outcomes in trials to gene therapies curing genetic diseases—and unpack what’s actually possible today versus what’s coming next.

This is not about unearened hype or pure fantasy. It’s a grounded, evidence-based look at how modern science is beginning to close the gap between comic book imagination and real-world biology—and the implications that come with it.

#GeneEditing #CRISPR #HealthScience #FutureOfMedicine #HumanOptimization #AntiAging #Metabolism #MuscleGrowth #FatLoss #Biotech #MedicalInnovation #Superhuman #LongevityScience #Neuroscience #AlzheimersResearch #Genetics #PrecisionMedicine #FitnessScience #HealthOptimization #CellularBiology #Epigenetics #YamanakaFactors #Mitochondria #MicroRNA #Biology #ScienceExplained #MedicalBreakthrough #LongevityResearch #FutureHealth #Bioengineering #HealthTech #WellnessScience #AgingResearch #ClinicalTrials #ObesityTreatment #MuscleScience #MetabolicHealth #ScientificResearch #HumanPerformance #NextGenMedicine #DNAEditing #StemCells #HealthFuture #StayCurious #ScienceContent #MedicalScience #Innovation #BiologyFacts

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1738 no Could This Common Item Really Treat Metabolic Syndrome? Levels of the ‘anti-obesity’ hormone, GLP-1, are reduced in insulin-resistance disorders, including obesity, PCOS, diabetes, metabolic syndrome, etc. Why? This is as question that’s been plaguing obesity medicine. But now, we have a mechanism. It’s not the whole picture (it hardly ever is). However, it’s a fascinating discovery that will blow your mind, if you take the time to contemplate it deeply.Paper, Nature Metabolism: https://www.nature.com/articles/s42255-024-01068-x 2015 Inulin RCT: https://pubmed.ncbi.nlm.nih.gov/26203099/ PCOS video: https://youtu.be/svLWvhW6G2g Chapters0:00 – Introduction, New Paper0:46 – New Paper in Nature Metabolism1:28 – Obesogenic diet Changes Microbiome to Decrease GLP-1 2:29 – Sulfur Metabolism in the Gut Poisons Gut Cells that Make GLP-13:07 – Unexpected Solution?!4:16 – Takeaways 4:52 – Fiber?This video contains no paid promotions, i.e. I am not sponsored by AG-1… yet (wink, wink, nudge, nudge, tease, tease) Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 30 Jul 2026 22:46:00 -0000 full Nick Norwitz MD PhD Levels of the ‘anti-obesity’ hormone, GLP-1, are reduced in insulin-resistance disorders, including obesity, PCOS, diabetes, metabolic syndrome, etc. Why? This is as question that’s been plaguing obesity medicine. But now, we have a mechanism. It’s not the whole picture (it hardly ever is). However, it’s a fascinating discovery that will blow your mind, if you take the time to contemplate it deeply.Paper, Nature Metabolism: https://www.nature.com/articles/s42255-024-01068-x 2015 Inulin RCT: https://pubmed.ncbi.nlm.nih.gov/26203099/ PCOS video: https://youtu.be/svLWvhW6G2g Chapters0:00 – Introduction, New Paper0:46 – New Paper in Nature Metabolism1:28 – Obesogenic diet Changes Microbiome to Decrease GLP-1 2:29 – Sulfur Metabolism in the Gut Poisons Gut Cells that Make GLP-13:07 – Unexpected Solution?!4:16 – Takeaways 4:52 – Fiber?This video contains no paid promotions, i.e. I am not sponsored by AG-1… yet (wink, wink, nudge, nudge, tease, tease) Learn more about your ad choices. Visit megaphone.fm/adchoices Levels of the ‘anti-obesity’ hormone, GLP-1, are reduced in insulin-resistance disorders, including obesity, PCOS, diabetes, metabolic syndrome, etc. Why? This is as question that’s been plaguing obesity medicine. But now, we have a mechanism. It’s not the whole picture (it hardly ever is). However, it’s a fascinating discovery that will blow your mind, if you take the time to contemplate it deeply.

Paper, Nature Metabolism: https://www.nature.com/articles/s42255-024-01068-x

2015 Inulin RCT: https://pubmed.ncbi.nlm.nih.gov/26203099/

PCOS video: https://youtu.be/svLWvhW6G2g

Chapters
0:00 – Introduction, New Paper
0:46 – New Paper in Nature Metabolism
1:28 – Obesogenic diet Changes Microbiome to Decrease GLP-1
2:29 – Sulfur Metabolism in the Gut Poisons Gut Cells that Make GLP-1
3:07 – Unexpected Solution?!
4:16 – Takeaways
4:52 – Fiber?

This video contains no paid promotions, i.e. I am not sponsored by AG-1… yet (wink, wink, nudge, nudge, tease, tease)

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 473 no The #1 Nutrient For Brain Health (It's Not Even Close) For a written breakdown and early access to content, see the letter: https://staycuriousmetabolism.substack.com/p/omega-3-across-the-lifespan-my-1?r=40ekz2If you want to try the Lyso-DHA omega supplement I use, Accentrate Omega Max, here’s the https://www.fenixhealthscience.com/staycurious Use Discount Code StayCurious for 20% Off LPC-DHA Video: https://youtu.be/B-kEn0FukXMLithium Video: https://youtu.be/Hcz0Eyp1LE4NAD Video: https://youtu.be/-R7sPPQTtcoInterview with Bill Harris Part 1: https://youtu.be/rZT4Y6T_0VcInterview with Bill Harris Part 2: https://youtu.be/fdBToTJ0jqsOmega QuantIf you want to get your Omega-3 via Omega Quant, click on this link: https://omegaquant.com/ref/864 Discount Code: NickNorwitz for 10% off In this video, I break down the science that matters most if you care about brain health, longevity, and preventing cognitive decline—starting with one molecule that may be more important than anything else: DHA.We’ll walk through how DHA supports your brain structurally, metabolically, and anti-inflammatorily—and why it may be especially critical for people at higher genetic risk. You’ll also learn about one of the earliest changes in Alzheimer’s disease (long before symptoms appear), how lipid metabolism shifts over time, and what that means for prevention. This isn’t about hype—it’s about understanding biology deeply enough to act early.Finally, I’ll share my personal protocol—what I actually do knowing my genetic risk—and how I think about diet, supplements, and lifestyle from a first-principles perspective. If you want to think like a neuroscientist and take control of your brain health, this is for you.Chapters0:00 – My No 1 Nutrient for Brain Health1:53 – Roadmap to this video2:58 – Part 1, Meet DHA4:33 – Part 2, Big Fat Metabolic Shift10:59 – Part 3, Biological Mechanisms14:46 – Part 4, My Personal Protocol #Alzheimers #BrainHealth #DHA #Omega3 #Neuroscience #Longevity #ApoE4 #CognitiveHealth #Memory #NutritionScience #PreventAlzheimers #Biohacking #HealthOptimization #Omega3Benefits #BrainFood #Neurodegeneration #LongevityScience #HealthyAging #Metabolism #Inflammation #BDNF #Neuroprotection #FishOil #Sardines #Nootropics #CognitiveFunction #BrainOptimization #StayCurious #ScienceBased #MedicalScience #FunctionalMedicine #Healthspan #Lifespan #DietAndHealth #BrainNutrition #Neurobiology #MindHealth #BrainRepair #BrainEnergy #Mitochondria #OxidativeStress #WellnessScience #PreventativeHealth #Biohacker #ClinicalResearch #MedicalEducation #ScienceExplained #HealthTips #BrainLongevity #MentalClarity Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 30 Jul 2026 04:46:00 -0000 full Nick Norwitz MD PhD For a written breakdown and early access to content, see the letter: https://staycuriousmetabolism.substack.com/p/omega-3-across-the-lifespan-my-1?r=40ekz2If you want to try the Lyso-DHA omega supplement I use, Accentrate Omega Max, here’s the https://www.fenixhealthscience.com/staycurious Use Discount Code StayCurious for 20% Off LPC-DHA Video: https://youtu.be/B-kEn0FukXMLithium Video: https://youtu.be/Hcz0Eyp1LE4NAD Video: https://youtu.be/-R7sPPQTtcoInterview with Bill Harris Part 1: https://youtu.be/rZT4Y6T_0VcInterview with Bill Harris Part 2: https://youtu.be/fdBToTJ0jqsOmega QuantIf you want to get your Omega-3 via Omega Quant, click on this link: https://omegaquant.com/ref/864 Discount Code: NickNorwitz for 10% off In this video, I break down the science that matters most if you care about brain health, longevity, and preventing cognitive decline—starting with one molecule that may be more important than anything else: DHA.We’ll walk through how DHA supports your brain structurally, metabolically, and anti-inflammatorily—and why it may be especially critical for people at higher genetic risk. You’ll also learn about one of the earliest changes in Alzheimer’s disease (long before symptoms appear), how lipid metabolism shifts over time, and what that means for prevention. This isn’t about hype—it’s about understanding biology deeply enough to act early.Finally, I’ll share my personal protocol—what I actually do knowing my genetic risk—and how I think about diet, supplements, and lifestyle from a first-principles perspective. If you want to think like a neuroscientist and take control of your brain health, this is for you.Chapters0:00 – My No 1 Nutrient for Brain Health1:53 – Roadmap to this video2:58 – Part 1, Meet DHA4:33 – Part 2, Big Fat Metabolic Shift10:59 – Part 3, Biological Mechanisms14:46 – Part 4, My Personal Protocol #Alzheimers #BrainHealth #DHA #Omega3 #Neuroscience #Longevity #ApoE4 #CognitiveHealth #Memory #NutritionScience #PreventAlzheimers #Biohacking #HealthOptimization #Omega3Benefits #BrainFood #Neurodegeneration #LongevityScience #HealthyAging #Metabolism #Inflammation #BDNF #Neuroprotection #FishOil #Sardines #Nootropics #CognitiveFunction #BrainOptimization #StayCurious #ScienceBased #MedicalScience #FunctionalMedicine #Healthspan #Lifespan #DietAndHealth #BrainNutrition #Neurobiology #MindHealth #BrainRepair #BrainEnergy #Mitochondria #OxidativeStress #WellnessScience #PreventativeHealth #Biohacker #ClinicalResearch #MedicalEducation #ScienceExplained #HealthTips #BrainLongevity #MentalClarity Learn more about your ad choices. Visit megaphone.fm/adchoices For a written breakdown and early access to content, see the letter: https://staycuriousmetabolism.substack.com/p/omega-3-across-the-lifespan-my-1?r=40ekz2

If you want to try the Lyso-DHA omega supplement I use, Accentrate Omega Max, here’s the https://www.fenixhealthscience.com/staycurious

Use Discount Code StayCurious for 20% Off

LPC-DHA Video: https://youtu.be/B-kEn0FukXM

Lithium Video: https://youtu.be/Hcz0Eyp1LE4

NAD Video: https://youtu.be/-R7sPPQTtco

Interview with Bill Harris Part 1: https://youtu.be/rZT4Y6T_0Vc

Interview with Bill Harris Part 2: https://youtu.be/fdBToTJ0jqs

Omega Quant

If you want to get your Omega-3 via Omega Quant, click on this link: https://omegaquant.com/ref/864 Discount Code: NickNorwitz for 10% off

In this video, I break down the science that matters most if you care about brain health, longevity, and preventing cognitive decline—starting with one molecule that may be more important than anything else: DHA.

We’ll walk through how DHA supports your brain structurally, metabolically, and anti-inflammatorily—and why it may be especially critical for people at higher genetic risk. You’ll also learn about one of the earliest changes in Alzheimer’s disease (long before symptoms appear), how lipid metabolism shifts over time, and what that means for prevention. This isn’t about hype—it’s about understanding biology deeply enough to act early.

Finally, I’ll share my personal protocol—what I actually do knowing my genetic risk—and how I think about diet, supplements, and lifestyle from a first-principles perspective. If you want to think like a neuroscientist and take control of your brain health, this is for you.

Chapters
0:00 – My No 1 Nutrient for Brain Health
1:53 – Roadmap to this video
2:58 – Part 1, Meet DHA
4:33 – Part 2, Big Fat Metabolic Shift
10:59 – Part 3, Biological Mechanisms
14:46 – Part 4, My Personal Protocol

#Alzheimers #BrainHealth #DHA #Omega3 #Neuroscience #Longevity #ApoE4 #CognitiveHealth #Memory #NutritionScience #PreventAlzheimers #Biohacking #HealthOptimization #Omega3Benefits #BrainFood #Neurodegeneration #LongevityScience #HealthyAging #Metabolism #Inflammation #BDNF #Neuroprotection #FishOil #Sardines #Nootropics #CognitiveFunction #BrainOptimization #StayCurious #ScienceBased #MedicalScience #FunctionalMedicine #Healthspan #Lifespan #DietAndHealth #BrainNutrition #Neurobiology #MindHealth #BrainRepair #BrainEnergy #Mitochondria #OxidativeStress #WellnessScience #PreventativeHealth #Biohacker #ClinicalResearch #MedicalEducation #ScienceExplained #HealthTips #BrainLongevity #MentalClarity

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1413 no The Next Medical Revolution: Why N of 1 Medicine is the Key to Your Healthier Future In this video, we explore the revolutionary shift towards N = 1 medicine—a personalized approach that challenges the traditional one-size-fits-all model in healthcare. Learn how harnessing your individual data can lead to more precise, effective treatments tailored specifically to you. We dive into the limitations of randomized controlled trials (RCTs) and why they may be holding back true medical innovation. Discover the future of medicine, where data-driven insights empower you to take control of your health. Chapters:0:00 – Vision of the Future0:53 – What is a Randomized Controlled Trial1:27 – Proof of Failure 1:45 – Specificity and Individuality 2:30 – The Future is N = 1 MedicineN of 1 company: https://enov.oneSnyder Lab, Stanford: https://snyderlab.stanford.eduPrior video on CGM: https://youtu.be/vLD_fWTi54Y Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 29 Jul 2026 10:46:00 -0000 full Nick Norwitz MD PhD In this video, we explore the revolutionary shift towards N = 1 medicine—a personalized approach that challenges the traditional one-size-fits-all model in healthcare. Learn how harnessing your individual data can lead to more precise, effective treatments tailored specifically to you. We dive into the limitations of randomized controlled trials (RCTs) and why they may be holding back true medical innovation. Discover the future of medicine, where data-driven insights empower you to take control of your health. Chapters:0:00 – Vision of the Future0:53 – What is a Randomized Controlled Trial1:27 – Proof of Failure 1:45 – Specificity and Individuality 2:30 – The Future is N = 1 MedicineN of 1 company: https://enov.oneSnyder Lab, Stanford: https://snyderlab.stanford.eduPrior video on CGM: https://youtu.be/vLD_fWTi54Y Learn more about your ad choices. Visit megaphone.fm/adchoices In this video, we explore the revolutionary shift towards N = 1 medicine—a personalized approach that challenges the traditional one-size-fits-all model in healthcare. Learn how harnessing your individual data can lead to more precise, effective treatments tailored specifically to you. We dive into the limitations of randomized controlled trials (RCTs) and why they may be holding back true medical innovation. Discover the future of medicine, where data-driven insights empower you to take control of your health.

Chapters:
0:00 – Vision of the Future
0:53 – What is a Randomized Controlled Trial
1:27 – Proof of Failure
1:45 – Specificity and Individuality
2:30 – The Future is N = 1 Medicine

N of 1 company: https://enov.one

Snyder Lab, Stanford: https://snyderlab.stanford.edu

Prior video on CGM: https://youtu.be/vLD_fWTi54Y

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 384 no Should Everyone Take GLP-1s? (What Changed My Mind) If you'd like an even more comprehensive written deep dive (with references, citations, and additional nuances) you can find it at Stay Curious Metabolism, the world's fast-growing Science Substack: https://staycuriousmetabolism.substack.com/p/should-everyone-take-glp-1s-what?r=40ekz2And if you're interested in the rapidly evolving world of peptides and human bioengineering, be sure to check out our companion library, Peptides and More: https://staycuriousmetabolism.substack.com/p/peptidesATX-304 Letter: https://open.substack.com/pub/staycuriousmetabolism/p/this-new-diabetes-drug-works-like?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=trueIf you want to try ATX-304, you can, but it's expensive. The company I trust is Wingspan and if you want to try it code 'StayCurious' will at least, get you 10% off. Click here: https://try.gotwingspan.com/norwitzatx-304 Bone Health Letter: https://open.substack.com/pub/staycuriousmetabolism/p/a-masterclass-on-building-stronger?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true My Reta Experiment, Video: https://youtu.be/9HaFrUmzpNE The Technology That Will Change Humans Forever, Video: https://youtu.be/eJTqiMsZP8Y Chapters0:00 – I Was a GLP-1 Skeptic1:32 – The Definitive Guide on GLP-13:46 – GLP-1s are Causing a Societal Shift5:52 – Common Concerns: Muscle, Bone, Eyes, and Thyroid13:58 – GLP-1 Generations19:01 – Weight-Independent Benefits: Brain and Joints25:42 – Combination Therapies 28:35 – Rapid-Fire Q and ADescription:My goal is simple: create the most comprehensive guide to GLP-1s on YouTube. Whether you're considering these medications yourself, already taking one, treating patients, or simply trying to understand where obesity medicine is headed, this video will give you a rigorous, evidence-based overview of the benefits, risks, effects on muscle, bone health, brain health, cardiovascular disease, addiction, and much more.#GLP1 #GLP1s #Ozempic #Wegovy #Mounjaro #Zepbound #Semaglutide #Tirzepatide #Retatrutide #WeightLoss #Obesity #MetabolicHealth #HealthScience #Longevity #Biohacking #Nutrition #Fitness #MuscleGain #MuscleLoss #FatLoss #BodyComposition #InsulinResistance #Diabetes #Type2Diabetes #Prediabetes #ApoB #LDL #Cholesterol #HeartHealth #CardiovascularHealth #BrainHealth #Alzheimers #Dementia #CognitiveHealth #Inflammation #JointHealth #Osteoarthritis #BoneHealth #Protein #ResistanceTraining #HealthyAging #MedicalResearch #EvidenceBased #ScienceExplained #Pharmacology #HealthOptimization #Metabolism #FoodNoise #AddictionScience #Orforglipron Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 28 Jul 2026 16:46:00 -0000 full Nick Norwitz MD PhD If you'd like an even more comprehensive written deep dive (with references, citations, and additional nuances) you can find it at Stay Curious Metabolism, the world's fast-growing Science Substack: https://staycuriousmetabolism.substack.com/p/should-everyone-take-glp-1s-what?r=40ekz2And if you're interested in the rapidly evolving world of peptides and human bioengineering, be sure to check out our companion library, Peptides and More: https://staycuriousmetabolism.substack.com/p/peptidesATX-304 Letter: https://open.substack.com/pub/staycuriousmetabolism/p/this-new-diabetes-drug-works-like?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=trueIf you want to try ATX-304, you can, but it's expensive. The company I trust is Wingspan and if you want to try it code 'StayCurious' will at least, get you 10% off. Click here: https://try.gotwingspan.com/norwitzatx-304 Bone Health Letter: https://open.substack.com/pub/staycuriousmetabolism/p/a-masterclass-on-building-stronger?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true My Reta Experiment, Video: https://youtu.be/9HaFrUmzpNE The Technology That Will Change Humans Forever, Video: https://youtu.be/eJTqiMsZP8Y Chapters0:00 – I Was a GLP-1 Skeptic1:32 – The Definitive Guide on GLP-13:46 – GLP-1s are Causing a Societal Shift5:52 – Common Concerns: Muscle, Bone, Eyes, and Thyroid13:58 – GLP-1 Generations19:01 – Weight-Independent Benefits: Brain and Joints25:42 – Combination Therapies 28:35 – Rapid-Fire Q and ADescription:My goal is simple: create the most comprehensive guide to GLP-1s on YouTube. Whether you're considering these medications yourself, already taking one, treating patients, or simply trying to understand where obesity medicine is headed, this video will give you a rigorous, evidence-based overview of the benefits, risks, effects on muscle, bone health, brain health, cardiovascular disease, addiction, and much more.#GLP1 #GLP1s #Ozempic #Wegovy #Mounjaro #Zepbound #Semaglutide #Tirzepatide #Retatrutide #WeightLoss #Obesity #MetabolicHealth #HealthScience #Longevity #Biohacking #Nutrition #Fitness #MuscleGain #MuscleLoss #FatLoss #BodyComposition #InsulinResistance #Diabetes #Type2Diabetes #Prediabetes #ApoB #LDL #Cholesterol #HeartHealth #CardiovascularHealth #BrainHealth #Alzheimers #Dementia #CognitiveHealth #Inflammation #JointHealth #Osteoarthritis #BoneHealth #Protein #ResistanceTraining #HealthyAging #MedicalResearch #EvidenceBased #ScienceExplained #Pharmacology #HealthOptimization #Metabolism #FoodNoise #AddictionScience #Orforglipron Learn more about your ad choices. Visit megaphone.fm/adchoices If you'd like an even more comprehensive written deep dive (with references, citations, and additional nuances) you can find it at Stay Curious Metabolism, the world's fast-growing Science Substack: https://staycuriousmetabolism.substack.com/p/should-everyone-take-glp-1s-what?r=40ekz2

And if you're interested in the rapidly evolving world of peptides and human bioengineering, be sure to check out our companion library, Peptides and More: https://staycuriousmetabolism.substack.com/p/peptides

ATX-304 Letter: https://open.substack.com/pub/staycuriousmetabolism/p/this-new-diabetes-drug-works-like?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

If you want to try ATX-304, you can, but it's expensive.

The company I trust is Wingspan and if you want to try it code 'StayCurious' will at least, get you 10% off. Click here: https://try.gotwingspan.com/norwitzatx-304

Bone Health Letter: https://open.substack.com/pub/staycuriousmetabolism/p/a-masterclass-on-building-stronger?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

My Reta Experiment, Video: https://youtu.be/9HaFrUmzpNE

The Technology That Will Change Humans Forever, Video: https://youtu.be/eJTqiMsZP8Y

Chapters
0:00 – I Was a GLP-1 Skeptic
1:32 – The Definitive Guide on GLP-1
3:46 – GLP-1s are Causing a Societal Shift
5:52 – Common Concerns: Muscle, Bone, Eyes, and Thyroid
13:58 – GLP-1 Generations
19:01 – Weight-Independent Benefits: Brain and Joints
25:42 – Combination Therapies
28:35 – Rapid-Fire Q and A

Description:
My goal is simple: create the most comprehensive guide to GLP-1s on YouTube. Whether you're considering these medications yourself, already taking one, treating patients, or simply trying to understand where obesity medicine is headed, this video will give you a rigorous, evidence-based overview of the benefits, risks, effects on muscle, bone health, brain health, cardiovascular disease, addiction, and much more.

#GLP1 #GLP1s #Ozempic #Wegovy #Mounjaro #Zepbound #Semaglutide #Tirzepatide #Retatrutide #WeightLoss #Obesity #MetabolicHealth #HealthScience #Longevity #Biohacking #Nutrition #Fitness #MuscleGain #MuscleLoss #FatLoss #BodyComposition #InsulinResistance #Diabetes #Type2Diabetes #Prediabetes #ApoB #LDL #Cholesterol #HeartHealth #CardiovascularHealth #BrainHealth #Alzheimers #Dementia #CognitiveHealth #Inflammation #JointHealth #Osteoarthritis #BoneHealth #Protein #ResistanceTraining #HealthyAging #MedicalResearch #EvidenceBased #ScienceExplained #Pharmacology #HealthOptimization #Metabolism #FoodNoise #AddictionScience #Orforglipron

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 2446 no Metabolic Health Saved My Life: Here’s Why It Should Matter to You From a young age, I was fascinated by the wonders of biology, but it was a personal health crisis that truly defined my mission: to Make Metabolic Health Mainstream. After battling severe inflammatory bowel disease and finding remission through a metabolic health intervention, I knew I had found my purpose.Now, I'm on a mission to inspire change, spark conversation, and shift the way we think about health at its core. But I can’t do it alone. I need an army of Metabolic Health Enthusiasts — people who are ready to invest in their own health and help change the world.I invite you to join me on this journey. Together, we can make metabolic health a movement that transforms lives.Website: https://www.nicknorwitz.com #MetabolicHealthMovement #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 27 Jul 2026 22:46:00 -0000 full Nick Norwitz MD PhD From a young age, I was fascinated by the wonders of biology, but it was a personal health crisis that truly defined my mission: to Make Metabolic Health Mainstream. After battling severe inflammatory bowel disease and finding remission through a metabolic health intervention, I knew I had found my purpose.Now, I'm on a mission to inspire change, spark conversation, and shift the way we think about health at its core. But I can’t do it alone. I need an army of Metabolic Health Enthusiasts — people who are ready to invest in their own health and help change the world.I invite you to join me on this journey. Together, we can make metabolic health a movement that transforms lives.Website: https://www.nicknorwitz.com #MetabolicHealthMovement #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices From a young age, I was fascinated by the wonders of biology, but it was a personal health crisis that truly defined my mission: to Make Metabolic Health Mainstream. After battling severe inflammatory bowel disease and finding remission through a metabolic health intervention, I knew I had found my purpose.

Now, I'm on a mission to inspire change, spark conversation, and shift the way we think about health at its core. But I can’t do it alone. I need an army of Metabolic Health Enthusiasts — people who are ready to invest in their own health and help change the world.

I invite you to join me on this journey. Together, we can make metabolic health a movement that transforms lives.

Website: https://www.nicknorwitz.com

#MetabolicHealthMovement #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 226 no How to Build "Superager" Mitochondria (3 Steps) For all the references, nuanced discussions, and early access to this type of content, check out the StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/how-to-reboot-your-bodys-batteries?r=40ekz2 If you'd like to dive even deeper, explore the StayCurious Metabolism archives: https://staycuriousmetabolism.substack.com Join the Best-Selling Science Newsletters on Substack. Members frequently describe it as “the best investments they've ever made in their health.”SS-31 Newsletter: https://staycuriousmetabolism.substack.com/p/the-fda-approved-peptide-for-mitochondrial?r=40ekz2 MOTS-C Newsletter: https://staycuriousmetabolism.substack.com/p/mots-c-the-mitochondrial-peptide?r=40ekz2 More information on the Nature Aging Study from 11:58 coming to the Substack soon! Subscribe there to stay up to date! https://staycuriousmetabolism.substack.com⁠DescriptionMitochondria are often called the “powerhouses of the cell,” but they’re far more than tiny energy factories. In this video, we explore how mitochondrial function influences energy, aging, metabolism, sleep, and overall health—and what current research suggests you can do to support these remarkable little life-support systems.We begin with practical, evidence-based lifestyle habits before moving into emerging areas of research, including the mitochondrial peptides, and the future possibility of mitochondrial transplantation. If you’re interested in longevity, metabolic health, exercise physiology, aging, or the latest mitochondrial research, this video provides a research-driven overview of one of the most fascinating areas in modern biology.Chapters 0:00 – Mitochondria are More Than You Think2:25 – Free and Foundational Tools for Better Mitochondria5:56 – Leaky Mitochondria and the Root Cause of Autoimmune Disease 8:45 – Ketogenic Diets and Mitochondrial Performance11:33 – What Exercise Does to Mitochondria 12:55 – SS-31, The Glue for Your Mitochondria 17:02 – MOTS-c, The Mitochondrial Hormone that Mimics Exercise 20:12 – The Future of Mitochondrial Medicine#Mitochondria #Longevity #HealthyAging #MetabolicHealth #Bioenergetics #ExerciseScience #NutritionScience #CircadianRhythm #KetogenicDiet #Peptides #MOTSc #SS31 #CellBiology #HealthScience #Metabolism #AgingResearch #Wellness #Science #HealthOptimization #MedicalResearch Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 27 Jul 2026 04:46:00 -0000 full Nick Norwitz MD PhD For all the references, nuanced discussions, and early access to this type of content, check out the StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/how-to-reboot-your-bodys-batteries?r=40ekz2 If you'd like to dive even deeper, explore the StayCurious Metabolism archives: https://staycuriousmetabolism.substack.com Join the Best-Selling Science Newsletters on Substack. Members frequently describe it as “the best investments they've ever made in their health.”SS-31 Newsletter: https://staycuriousmetabolism.substack.com/p/the-fda-approved-peptide-for-mitochondrial?r=40ekz2 MOTS-C Newsletter: https://staycuriousmetabolism.substack.com/p/mots-c-the-mitochondrial-peptide?r=40ekz2 More information on the Nature Aging Study from 11:58 coming to the Substack soon! Subscribe there to stay up to date! https://staycuriousmetabolism.substack.com⁠DescriptionMitochondria are often called the “powerhouses of the cell,” but they’re far more than tiny energy factories. In this video, we explore how mitochondrial function influences energy, aging, metabolism, sleep, and overall health—and what current research suggests you can do to support these remarkable little life-support systems.We begin with practical, evidence-based lifestyle habits before moving into emerging areas of research, including the mitochondrial peptides, and the future possibility of mitochondrial transplantation. If you’re interested in longevity, metabolic health, exercise physiology, aging, or the latest mitochondrial research, this video provides a research-driven overview of one of the most fascinating areas in modern biology.Chapters 0:00 – Mitochondria are More Than You Think2:25 – Free and Foundational Tools for Better Mitochondria5:56 – Leaky Mitochondria and the Root Cause of Autoimmune Disease 8:45 – Ketogenic Diets and Mitochondrial Performance11:33 – What Exercise Does to Mitochondria 12:55 – SS-31, The Glue for Your Mitochondria 17:02 – MOTS-c, The Mitochondrial Hormone that Mimics Exercise 20:12 – The Future of Mitochondrial Medicine#Mitochondria #Longevity #HealthyAging #MetabolicHealth #Bioenergetics #ExerciseScience #NutritionScience #CircadianRhythm #KetogenicDiet #Peptides #MOTSc #SS31 #CellBiology #HealthScience #Metabolism #AgingResearch #Wellness #Science #HealthOptimization #MedicalResearch Learn more about your ad choices. Visit megaphone.fm/adchoices For all the references, nuanced discussions, and early access to this type of content, check out the StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/how-to-reboot-your-bodys-batteries?r=40ekz2

If you'd like to dive even deeper, explore the StayCurious Metabolism archives: https://staycuriousmetabolism.substack.com

Join the Best-Selling Science Newsletters on Substack. Members frequently describe it as “the best investments they've ever made in their health.”

SS-31 Newsletter: https://staycuriousmetabolism.substack.com/p/the-fda-approved-peptide-for-mitochondrial?r=40ekz2

MOTS-C Newsletter: https://staycuriousmetabolism.substack.com/p/mots-c-the-mitochondrial-peptide?r=40ekz2

More information on the Nature Aging Study from 11:58 coming to the Substack soon! Subscribe there to stay up to date! https://staycuriousmetabolism.substack.com
⁠
Description
Mitochondria are often called the “powerhouses of the cell,” but they’re far more than tiny energy factories. In this video, we explore how mitochondrial function influences energy, aging, metabolism, sleep, and overall health—and what current research suggests you can do to support these remarkable little life-support systems.

We begin with practical, evidence-based lifestyle habits before moving into emerging areas of research, including the mitochondrial peptides, and the future possibility of mitochondrial transplantation.

If you’re interested in longevity, metabolic health, exercise physiology, aging, or the latest mitochondrial research, this video provides a research-driven overview of one of the most fascinating areas in modern biology.

Chapters
0:00 – Mitochondria are More Than You Think
2:25 – Free and Foundational Tools for Better Mitochondria
5:56 – Leaky Mitochondria and the Root Cause of Autoimmune Disease
8:45 – Ketogenic Diets and Mitochondrial Performance
11:33 – What Exercise Does to Mitochondria
12:55 – SS-31, The Glue for Your Mitochondria
17:02 – MOTS-c, The Mitochondrial Hormone that Mimics Exercise
20:12 – The Future of Mitochondrial Medicine

#Mitochondria #Longevity #HealthyAging #MetabolicHealth #Bioenergetics #ExerciseScience #NutritionScience #CircadianRhythm #KetogenicDiet #Peptides #MOTSc #SS31 #CellBiology #HealthScience #Metabolism #AgingResearch #Wellness #Science #HealthOptimization #MedicalResearch

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1574 no How to Age Better: New Science. New Solutions New research in a top science journal, Nature, reveals that the inflammatory molecule IL-11 contributes to aging processes and that blocking IL-11 improves function and molecular measures of healthspan, and extends lifespan by up to 25%, in animal studies. I review the data and offer you a potential solution.Nature Paper: https://www.nature.com/articles/s41586-024-07701-9 DoNotAge.com, IL-11 Bundle, Discount Code “STAYCURIOUS10”:https://donotage.org/august-bundle Chapters0:00 – You Can Choose How You Age1:05 – IL11 is a “Pro-Aging” Molecule3:47 – How to Inhibit IL-114:51 – Don’t Die Mom!#StayCurious #Longevity #HealthyAging Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 26 Jul 2026 10:46:00 -0000 full Nick Norwitz MD PhD New research in a top science journal, Nature, reveals that the inflammatory molecule IL-11 contributes to aging processes and that blocking IL-11 improves function and molecular measures of healthspan, and extends lifespan by up to 25%, in animal studies. I review the data and offer you a potential solution.Nature Paper: https://www.nature.com/articles/s41586-024-07701-9 DoNotAge.com, IL-11 Bundle, Discount Code “STAYCURIOUS10”:https://donotage.org/august-bundle Chapters0:00 – You Can Choose How You Age1:05 – IL11 is a “Pro-Aging” Molecule3:47 – How to Inhibit IL-114:51 – Don’t Die Mom!#StayCurious #Longevity #HealthyAging Learn more about your ad choices. Visit megaphone.fm/adchoices New research in a top science journal, Nature, reveals that the inflammatory molecule IL-11 contributes to aging processes and that blocking IL-11 improves function and molecular measures of healthspan, and extends lifespan by up to 25%, in animal studies. I review the data and offer you a potential solution.

Nature Paper: https://www.nature.com/articles/s41586-024-07701-9

DoNotAge.com, IL-11 Bundle, Discount Code “STAYCURIOUS10”:
https://donotage.org/august-bundle

Chapters
0:00 – You Can Choose How You Age
1:05 – IL11 is a “Pro-Aging” Molecule
3:47 – How to Inhibit IL-11
4:51 – Don’t Die Mom!

#StayCurious #Longevity #HealthyAging

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]]> 426 no Do This Every Day to Keep Your Arteries Healthy If you enjoyed this video and want access to all the references, deeper nuance, and additional context behind everything we discussed, consider joining StayCurious Metabolism, an overall top best-selling science newsletter: https://staycuriousmetabolism.comThe companion article for this video is here: https://staycuriousmetabolism.substack.com/p/the-heart-supplements-i-recommend?r=40ekz2Find out why Stay Curious Metabolism became one of the fastest-growing science publications on Substack and reached the top two globally in just one year.Referenced VideosHeart Rate Variability: https://youtu.be/bdxYexIpYjo Berberine: https://youtu.be/KMVsg9EnbcE Vitamin C: https://youtu.be/0p0cld4RmDo Chapters0:00 – 2,000 Hours of Heart Health in 20 Minutes 1:50 – Our Mystery Box of Heart Health Tools2:15 – The Scoop, Nattokinase5:12 – The Ice Pack, TUDCA 9:24 – The Charger, Heart Rate Variability 13:24 – The Straw, Berberine 16:00 – The Ducted Tape, Vitamin C DescriptionI spent seven years living with cholesterol levels higher than most doctors ever see in their entire careers. By conventional thinking, I should have been accumulating plaque at an alarming rate. But when I underwent advanced cardiovascular imaging, the result was shocking: zero plaque. No soft plaque. No calcified plaque. Nothing.After that story went viral, I received the same questions over and over again: How do you protect your heart? What supplements do you take? What's the secret? In this video, I break down five of the highest-yield tools I use to think about cardiovascular health, drawing on thousands of hours of research spanning metabolism, lipidology, vascular biology, and longevity science.We'll cover Nattokinase, TUDCA, heart rate variability, omega-3s, berberine, vitamin C, statins, blood sugar control, inflammation, LDL cholesterol, ApoB, Lp(a), and more. The goal isn't hype, it's understanding the biology well enough to make smarter decisions about protecting your heart over the long term.Brand Criteria and SuggestionsAfter the letter went live, I received several questions about which brands I would consider for Nattokinase, TUDCA, and berberine. Rather than specific endorsements, here are the main criteria I use when evaluating these products.More details can be found at the newsletter. Below is condensed version given the word limit for YouTube captions.NattokinaseLook for:• Potency listed in Fibrinolytic Units (FU), typically 2,000–4,000 FU per capsule • NSK-SD®, the most extensively studied nattokinase ingredient (a positive signal, but not required) • Third-party testing, a Certificate of Analysis (COA), and/or cGMP-compliant manufacturing Brands that stand out include:• Doctor's Best • Life Extension • Jarrow Formulas • A budget-friendly option is NOW Foods.TUDCALook for:• A transparent label showing 250–500 mg TUDCA per capsule • Avoidance of proprietary “bile support” blends • Third-party testing, COA, and/or cGMP manufacturing • A reputable manufacturer Companies often discussed include:• Double Wood • Nootropics Depot BerberineThe criteria are similar to TUDCA. Look for:• Clearly labeled berberine HCl, typically 500 mg per capsule • No proprietary blends • Third-party testing, COA, and/or cGMP manufacturing Manufacturers that stand out include:• Thorne • Life Extension • Nootropics Depot • Jarrow Formulas Some newer berberine formulations (e.g., phytosome or liposomal forms) may improve absorption, although most of the human evidence still comes from traditional berberine HCl.This content is for educational and informational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Please consult your healthcare provider regarding decisions about your health.#HeartHealth #CardiovascularHealth #HeartDisease #HeartAttack #Cholestero Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 25 Jul 2026 16:46:00 -0000 full Nick Norwitz MD PhD If you enjoyed this video and want access to all the references, deeper nuance, and additional context behind everything we discussed, consider joining StayCurious Metabolism, an overall top best-selling science newsletter: https://staycuriousmetabolism.comThe companion article for this video is here: https://staycuriousmetabolism.substack.com/p/the-heart-supplements-i-recommend?r=40ekz2Find out why Stay Curious Metabolism became one of the fastest-growing science publications on Substack and reached the top two globally in just one year.Referenced VideosHeart Rate Variability: https://youtu.be/bdxYexIpYjo Berberine: https://youtu.be/KMVsg9EnbcE Vitamin C: https://youtu.be/0p0cld4RmDo Chapters0:00 – 2,000 Hours of Heart Health in 20 Minutes 1:50 – Our Mystery Box of Heart Health Tools2:15 – The Scoop, Nattokinase5:12 – The Ice Pack, TUDCA 9:24 – The Charger, Heart Rate Variability 13:24 – The Straw, Berberine 16:00 – The Ducted Tape, Vitamin C DescriptionI spent seven years living with cholesterol levels higher than most doctors ever see in their entire careers. By conventional thinking, I should have been accumulating plaque at an alarming rate. But when I underwent advanced cardiovascular imaging, the result was shocking: zero plaque. No soft plaque. No calcified plaque. Nothing.After that story went viral, I received the same questions over and over again: How do you protect your heart? What supplements do you take? What's the secret? In this video, I break down five of the highest-yield tools I use to think about cardiovascular health, drawing on thousands of hours of research spanning metabolism, lipidology, vascular biology, and longevity science.We'll cover Nattokinase, TUDCA, heart rate variability, omega-3s, berberine, vitamin C, statins, blood sugar control, inflammation, LDL cholesterol, ApoB, Lp(a), and more. The goal isn't hype, it's understanding the biology well enough to make smarter decisions about protecting your heart over the long term.Brand Criteria and SuggestionsAfter the letter went live, I received several questions about which brands I would consider for Nattokinase, TUDCA, and berberine. Rather than specific endorsements, here are the main criteria I use when evaluating these products.More details can be found at the newsletter. Below is condensed version given the word limit for YouTube captions.NattokinaseLook for:• Potency listed in Fibrinolytic Units (FU), typically 2,000–4,000 FU per capsule • NSK-SD®, the most extensively studied nattokinase ingredient (a positive signal, but not required) • Third-party testing, a Certificate of Analysis (COA), and/or cGMP-compliant manufacturing Brands that stand out include:• Doctor's Best • Life Extension • Jarrow Formulas • A budget-friendly option is NOW Foods.TUDCALook for:• A transparent label showing 250–500 mg TUDCA per capsule • Avoidance of proprietary “bile support” blends • Third-party testing, COA, and/or cGMP manufacturing • A reputable manufacturer Companies often discussed include:• Double Wood • Nootropics Depot BerberineThe criteria are similar to TUDCA. Look for:• Clearly labeled berberine HCl, typically 500 mg per capsule • No proprietary blends • Third-party testing, COA, and/or cGMP manufacturing Manufacturers that stand out include:• Thorne • Life Extension • Nootropics Depot • Jarrow Formulas Some newer berberine formulations (e.g., phytosome or liposomal forms) may improve absorption, although most of the human evidence still comes from traditional berberine HCl.This content is for educational and informational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Please consult your healthcare provider regarding decisions about your health.#HeartHealth #CardiovascularHealth #HeartDisease #HeartAttack #Cholestero Learn more about your ad choices. Visit megaphone.fm/adchoices If you enjoyed this video and want access to all the references, deeper nuance, and additional context behind everything we discussed, consider joining StayCurious Metabolism, an overall top best-selling science newsletter: https://staycuriousmetabolism.com

The companion article for this video is here: https://staycuriousmetabolism.substack.com/p/the-heart-supplements-i-recommend?r=40ekz2

Find out why Stay Curious Metabolism became one of the fastest-growing science publications on Substack and reached the top two globally in just one year.

Referenced Videos
Heart Rate Variability: https://youtu.be/bdxYexIpYjo
Berberine: https://youtu.be/KMVsg9EnbcE
Vitamin C: https://youtu.be/0p0cld4RmDo

Chapters
0:00 – 2,000 Hours of Heart Health in 20 Minutes
1:50 – Our Mystery Box of Heart Health Tools
2:15 – The Scoop, Nattokinase
5:12 – The Ice Pack, TUDCA
9:24 – The Charger, Heart Rate Variability
13:24 – The Straw, Berberine
16:00 – The Ducted Tape, Vitamin C

Description

I spent seven years living with cholesterol levels higher than most doctors ever see in their entire careers. By conventional thinking, I should have been accumulating plaque at an alarming rate. But when I underwent advanced cardiovascular imaging, the result was shocking: zero plaque. No soft plaque. No calcified plaque. Nothing.

After that story went viral, I received the same questions over and over again: How do you protect your heart? What supplements do you take? What's the secret? In this video, I break down five of the highest-yield tools I use to think about cardiovascular health, drawing on thousands of hours of research spanning metabolism, lipidology, vascular biology, and longevity science.

We'll cover Nattokinase, TUDCA, heart rate variability, omega-3s, berberine, vitamin C, statins, blood sugar control, inflammation, LDL cholesterol, ApoB, Lp(a), and more. The goal isn't hype, it's understanding the biology well enough to make smarter decisions about protecting your heart over the long term.

Brand Criteria and Suggestions

After the letter went live, I received several questions about which brands I would consider for Nattokinase, TUDCA, and berberine. Rather than specific endorsements, here are the main criteria I use when evaluating these products.

More details can be found at the newsletter. Below is condensed version given the word limit for YouTube captions.

Nattokinase
Look for:
• Potency listed in Fibrinolytic Units (FU), typically 2,000–4,000 FU per capsule
• NSK-SD®, the most extensively studied nattokinase ingredient (a positive signal, but not required)
• Third-party testing, a Certificate of Analysis (COA), and/or cGMP-compliant manufacturing
Brands that stand out include:
• Doctor's Best
• Life Extension
• Jarrow Formulas
• A budget-friendly option is NOW Foods.

TUDCA
Look for:
• A transparent label showing 250–500 mg TUDCA per capsule
• Avoidance of proprietary “bile support” blends
• Third-party testing, COA, and/or cGMP manufacturing
• A reputable manufacturer
Companies often discussed include:
• Double Wood
• Nootropics Depot

Berberine
The criteria are similar to TUDCA. Look for:
• Clearly labeled berberine HCl, typically 500 mg per capsule
• No proprietary blends
• Third-party testing, COA, and/or cGMP manufacturing
Manufacturers that stand out include:
• Thorne
• Life Extension
• Nootropics Depot
• Jarrow Formulas

Some newer berberine formulations (e.g., phytosome or liposomal forms) may improve absorption, although most of the human evidence still comes from traditional berberine HCl.

This content is for educational and informational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Please consult your healthcare provider regarding decisions about your health.

#HeartHealth #CardiovascularHealth #HeartDisease #HeartAttack #Cholestero

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1523 no How Ketones Block Cancer Keto is more than just cutting carbs. It’s about entering a unique metabolic state where your body produces ketones, powerful molecules that can play a critical role in fighting cancer. Specifically, the ketone body beta-hydroxybutyrate has been shown to inhibit key enzymes and pathways that cancer cells rely on for growth. This isn’t just about removing carbs from your diet; it’s about adding a metabolic state that could reshape cancer metabolism. I will break down the science, concisely and in a way that’s easy to understand. #Cancer #Metabolism #Ketodiet #mTORPaper: https://www.nature.com/articles/s42255-024-01093-w Chapters0:00 – Keto is a Powerful Metabolic State1:33 – New Paper 2:49 – Ketone Bodies Block Cancer Metabolism3:50 – Conclusion Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 24 Jul 2026 22:46:00 -0000 full Nick Norwitz MD PhD Keto is more than just cutting carbs. It’s about entering a unique metabolic state where your body produces ketones, powerful molecules that can play a critical role in fighting cancer. Specifically, the ketone body beta-hydroxybutyrate has been shown to inhibit key enzymes and pathways that cancer cells rely on for growth. This isn’t just about removing carbs from your diet; it’s about adding a metabolic state that could reshape cancer metabolism. I will break down the science, concisely and in a way that’s easy to understand. #Cancer #Metabolism #Ketodiet #mTORPaper: https://www.nature.com/articles/s42255-024-01093-w Chapters0:00 – Keto is a Powerful Metabolic State1:33 – New Paper 2:49 – Ketone Bodies Block Cancer Metabolism3:50 – Conclusion Learn more about your ad choices. Visit megaphone.fm/adchoices Keto is more than just cutting carbs. It’s about entering a unique metabolic state where your body produces ketones, powerful molecules that can play a critical role in fighting cancer. Specifically, the ketone body beta-hydroxybutyrate has been shown to inhibit key enzymes and pathways that cancer cells rely on for growth. This isn’t just about removing carbs from your diet; it’s about adding a metabolic state that could reshape cancer metabolism. I will break down the science, concisely and in a way that’s easy to understand. #Cancer #Metabolism #Ketodiet #mTOR

Paper: https://www.nature.com/articles/s42255-024-01093-w

Chapters
0:00 – Keto is a Powerful Metabolic State
1:33 – New Paper
2:49 – Ketone Bodies Block Cancer Metabolism
3:50 – Conclusion

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 364 no Scientists Found A New Way to Boost Metabolism (2026 Science) For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/are-we-close-to-unlocking-the-secret?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Winnow Microplastic Binding Probiotic: https://www.winnowlabs.com/STAYCURIOUS25 Use Discount Code “StayCurious” for 15% Off Microplastics Heart Health, Letter https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Microplastics Brain Health, Letter: https://staycuriousmetabolism.substack.com/p/this-graph-changed-how-i-think-about?r=40ekz2 Nattokinase Video: https://youtu.be/LGQO227_MtoDescription:What if you could burn hundreds of extra calories per day, without changing your exercise routine or activity? It sounds impossible. But controlled human trials suggest that simply lowering protein intake might increase energy expenditure by up to 20%, even when total calories stay the same.In this video, I break down a bizarre and fascinating metabolic story: from human trials showing massive increases in calorie burn, to my own self-experiment where I deliberately overate and still lost weight, to a brand-new paper in Nature that may finally explain what’s going on. The answer leads us to the gut microbiome and reveals a mechanism involving fat “beiging,” thermogenesis, and a specific microbial cocktail that may control how much energy we burn.This is not a recommendation to follow a low-protein diet. It’s an exploration of a surprising scientific phenomenon that challenges how we think about metabolism, and a glimpse into a future where we might be able to engineer fat burning at the biological level.Chapters0:00 – How to Burn 600 More Calories Per Day2:48 – Chapter 1: The Most Surprising Study of 20255:00 – Chapter 2: My Fat Burning Self-Experiment 7:40 – Chapter 3: The Breakthrough Paper 10:54 – Chapter 4: The Fat-Burning Cocktail15:40 – Chapter 5: What This Means for Me and You18:42 – Do Ketogenic Diets Boost Metabolism Too?21:10 – My Principles of Gut Health#metabolism #fatloss #nutrition #weightloss #science #health #diet #calories #microbiome #guthealth #ketogenicdiet #keto #lowprotein #fatburning #thermogenesis #longevity #biohacking #healthscience #nutritionscience #fitness #metabolichealth #insulin #fatlossjourney #diettips #wellness #research #clinicaltrials #scienceexplained #humanmetabolism #microbiota #probiotics #gutmicrobiome #fasting #intermittentfasting #lowcarb #ketolife #nutritionfacts #healthtips #weightlosstips #fatburn #metabolicrate #energybalance #calorieburning #newscience #healthresearch #medicalscience #physiology #staycurious #n1experiment #biochemistry Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 24 Jul 2026 04:46:00 -0000 full Nick Norwitz MD PhD For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/are-we-close-to-unlocking-the-secret?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Winnow Microplastic Binding Probiotic: https://www.winnowlabs.com/STAYCURIOUS25 Use Discount Code “StayCurious” for 15% Off Microplastics Heart Health, Letter https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Microplastics Brain Health, Letter: https://staycuriousmetabolism.substack.com/p/this-graph-changed-how-i-think-about?r=40ekz2 Nattokinase Video: https://youtu.be/LGQO227_MtoDescription:What if you could burn hundreds of extra calories per day, without changing your exercise routine or activity? It sounds impossible. But controlled human trials suggest that simply lowering protein intake might increase energy expenditure by up to 20%, even when total calories stay the same.In this video, I break down a bizarre and fascinating metabolic story: from human trials showing massive increases in calorie burn, to my own self-experiment where I deliberately overate and still lost weight, to a brand-new paper in Nature that may finally explain what’s going on. The answer leads us to the gut microbiome and reveals a mechanism involving fat “beiging,” thermogenesis, and a specific microbial cocktail that may control how much energy we burn.This is not a recommendation to follow a low-protein diet. It’s an exploration of a surprising scientific phenomenon that challenges how we think about metabolism, and a glimpse into a future where we might be able to engineer fat burning at the biological level.Chapters0:00 – How to Burn 600 More Calories Per Day2:48 – Chapter 1: The Most Surprising Study of 20255:00 – Chapter 2: My Fat Burning Self-Experiment 7:40 – Chapter 3: The Breakthrough Paper 10:54 – Chapter 4: The Fat-Burning Cocktail15:40 – Chapter 5: What This Means for Me and You18:42 – Do Ketogenic Diets Boost Metabolism Too?21:10 – My Principles of Gut Health#metabolism #fatloss #nutrition #weightloss #science #health #diet #calories #microbiome #guthealth #ketogenicdiet #keto #lowprotein #fatburning #thermogenesis #longevity #biohacking #healthscience #nutritionscience #fitness #metabolichealth #insulin #fatlossjourney #diettips #wellness #research #clinicaltrials #scienceexplained #humanmetabolism #microbiota #probiotics #gutmicrobiome #fasting #intermittentfasting #lowcarb #ketolife #nutritionfacts #healthtips #weightlosstips #fatburn #metabolicrate #energybalance #calorieburning #newscience #healthresearch #medicalscience #physiology #staycurious #n1experiment #biochemistry Learn more about your ad choices. Visit megaphone.fm/adchoices For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/are-we-close-to-unlocking-the-secret?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Winnow Microplastic Binding Probiotic: https://www.winnowlabs.com/STAYCURIOUS25
Use Discount Code “StayCurious” for 15% Off

Microplastics Heart Health, Letter https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2

Microplastics Brain Health, Letter: https://staycuriousmetabolism.substack.com/p/this-graph-changed-how-i-think-about?r=40ekz2

Nattokinase Video: https://youtu.be/LGQO227_Mto

Description:

What if you could burn hundreds of extra calories per day, without changing your exercise routine or activity? It sounds impossible. But controlled human trials suggest that simply lowering protein intake might increase energy expenditure by up to 20%, even when total calories stay the same.

In this video, I break down a bizarre and fascinating metabolic story: from human trials showing massive increases in calorie burn, to my own self-experiment where I deliberately overate and still lost weight, to a brand-new paper in Nature that may finally explain what’s going on. The answer leads us to the gut microbiome and reveals a mechanism involving fat “beiging,” thermogenesis, and a specific microbial cocktail that may control how much energy we burn.

This is not a recommendation to follow a low-protein diet. It’s an exploration of a surprising scientific phenomenon that challenges how we think about metabolism, and a glimpse into a future where we might be able to engineer fat burning at the biological level.

Chapters
0:00 – How to Burn 600 More Calories Per Day
2:48 – Chapter 1: The Most Surprising Study of 2025
5:00 – Chapter 2: My Fat Burning Self-Experiment
7:40 – Chapter 3: The Breakthrough Paper
10:54 – Chapter 4: The Fat-Burning Cocktail
15:40 – Chapter 5: What This Means for Me and You
18:42 – Do Ketogenic Diets Boost Metabolism Too?
21:10 – My Principles of Gut Health

#metabolism #fatloss #nutrition #weightloss #science #health #diet #calories #microbiome #guthealth #ketogenicdiet #keto #lowprotein #fatburning #thermogenesis #longevity #biohacking #healthscience #nutritionscience #fitness #metabolichealth #insulin #fatlossjourney #diettips #wellness #research #clinicaltrials #scienceexplained #humanmetabolism #microbiota #probiotics #gutmicrobiome #fasting #intermittentfasting #lowcarb #ketolife #nutritionfacts #healthtips #weightlosstips #fatburn #metabolicrate #energybalance #calorieburning #newscience #healthresearch #medicalscience #physiology #staycurious #n1experiment #biochemistry

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1846 no Four New Research Findings about GLP-1 Medications This video reviews brand new research collect from across top science journals (Science, Nature, Cell Metabolism and Nature Metabolism) on the mechanisms and mysteries around GLP-1 receptor agonists and related topics. This is not a clinical lecture, but a fascinating physiology lesson. Leave your opinions at the door and immerse in interesting science!Chapters:0:00 – Introduction 1:39 – Ozempic without Nausea3:37 – GLP-1 and PCOS5:10 – Resisting You Culinary Kryptonite 7:20 – Better Than Ozempic 9:53 – Conclusions #healthandfitness #staycurious #metabolism GLP-1 and PCOS: https://youtu.be/svLWvhW6G2gGLP-1 and pre-ingestion satiety, i.e. Resisting Your Culinary Kryptonite: https://youtu.be/Lhx8hCj71fkBetter Than GLP-1: https://youtu.be/F8v6oRDVycI Trapped Fat and the Fuel Partitioning Model of Obesity: https://youtu.be/9KbxdzPK8W0Links to the papers are in the video notes of the respective video Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 23 Jul 2026 10:46:00 -0000 full Nick Norwitz MD PhD This video reviews brand new research collect from across top science journals (Science, Nature, Cell Metabolism and Nature Metabolism) on the mechanisms and mysteries around GLP-1 receptor agonists and related topics. This is not a clinical lecture, but a fascinating physiology lesson. Leave your opinions at the door and immerse in interesting science!Chapters:0:00 – Introduction 1:39 – Ozempic without Nausea3:37 – GLP-1 and PCOS5:10 – Resisting You Culinary Kryptonite 7:20 – Better Than Ozempic 9:53 – Conclusions #healthandfitness #staycurious #metabolism GLP-1 and PCOS: https://youtu.be/svLWvhW6G2gGLP-1 and pre-ingestion satiety, i.e. Resisting Your Culinary Kryptonite: https://youtu.be/Lhx8hCj71fkBetter Than GLP-1: https://youtu.be/F8v6oRDVycI Trapped Fat and the Fuel Partitioning Model of Obesity: https://youtu.be/9KbxdzPK8W0Links to the papers are in the video notes of the respective video Learn more about your ad choices. Visit megaphone.fm/adchoices This video reviews brand new research collect from across top science journals (Science, Nature, Cell Metabolism and Nature Metabolism) on the mechanisms and mysteries around GLP-1 receptor agonists and related topics. This is not a clinical lecture, but a fascinating physiology lesson. Leave your opinions at the door and immerse in interesting science!

Chapters:
0:00 – Introduction
1:39 – Ozempic without Nausea
3:37 – GLP-1 and PCOS
5:10 – Resisting You Culinary Kryptonite
7:20 – Better Than Ozempic
9:53 – Conclusions

#healthandfitness #staycurious #metabolism

GLP-1 and PCOS: https://youtu.be/svLWvhW6G2g

GLP-1 and pre-ingestion satiety, i.e. Resisting Your Culinary Kryptonite: https://youtu.be/Lhx8hCj71fk

Better Than GLP-1: https://youtu.be/F8v6oRDVycI

Trapped Fat and the Fuel Partitioning Model of Obesity: https://youtu.be/9KbxdzPK8W0

Links to the papers are in the video notes of the respective video

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 830 no This Peptide Could Solve $163 Billion Aging Problem If you'd ever like to go deeper with me, join our globally bestselling science newsletter, StayCurious Metabolism: https://staycuriousmetabolism.substack.com NOHO Labs: My Peptide and Longevity Clinicians If you're looking for comprehensive support with peptides, I've spent a lot of time searching and vetting providers, and I'm happy to recommend the thoughtful clinicians at NOHO Labs, which is the service my family and I use.Link: https://noholabs.com/nick/ We negotiated the best arrangement we could for the StayCurious community, including concierge care, personalized peptide protocols, prescriptions when appropriate, and ongoing individualized oversight. Of course, you know I'm a big believer in N = 1 experimentation, but it's important to do that safely. These are clinicians who can provide thoughtful, individualized guidance, and I've been consistently impressed by their expertise, curiosity, and commitment to lifelong learning.If you have any questions, I'll do my best to answer them. And if you decide to work with them, I'd genuinely appreciate any feedback about your experience.This Copper Elixir is skin product my family uses formulated with GHK-Cu and rh-Oligopeptide-1 (EGF)Link: https://mymirrorskin.com/products/copper-elixir?sca_ref=11747127.sMNmVN7hTx GHK-Cu letter: https://staycuriousmetabolism.substack.com/p/ghk-cu-the-strange-science-of-the?r=40ekz2 Wolverine Stack Letter: https://staycuriousmetabolism.substack.com/p/can-peptides-regrow-the-heart-the?r=40ekz2 BPC-157 Letter: https://staycuriousmetabolism.substack.com/p/bpc-157-bro-science-or-breakthrough?r=40ekz2 KPV Letter: https://staycuriousmetabolism.substack.com/p/the-gut-healing-peptide-i-wish-i?r=40ekz2 DescriptionIn this video, we explore the biology of the copper peptide (GHK-Cu)—how your body naturally produces it, why levels decline with age, and what randomized controlled trials suggest about skin health and wound healing. Along the way, we'll dive into copper biology, collagen production, mitochondrial function, gene expression, and why this small blue peptide has become one of the most fascinating molecules I've researched.Finally, I'll explain why I decided to experiment with GHK-Cu myself, what I've observed so far, and where the current science ends and speculation begins. Whether you're interested in longevity, regenerative medicine, wound healing, peptides, or simply understanding the biology behind healthy aging, I think you'll enjoy this rabbit hole.Chapters 0:00 – Why I Injected This Blue Copper Peptide2:47 – GHK-Cu Explained: What Is the Copper Peptide?3:38 – Why GHK-Cu Declines with Age4:31 – Copper Biology: How GHK-Cu Delivers Copper Safely7:26 – How GHK-Cu Repairs Skin and Boosts Collagen8:28 – The Science That Changed My Mind10:43 – The #1 Mistake When Using Copper Peptides11:21 – GHK-Cu for Wound Healing (Human Trial)12:23 – What Happens When You Inject GHK-Cu?14:58 – My GHK-Cu Healing ExperimentDisclaimer and Disclosures: The opinions expressed herein are our own. This video is for general informational purposes only and is not medical advice; talk to your own clinician before starting, stopping, or changing any treatment. Research Use Only (RUO) products have not been cleared or approved by the FDA for clinical diagnostic use. RUO products are intended solely for laboratory research and are not intended to be used for diagnosing, treating, or preventing disease in humans. Any discussion of specific RUO products is for research purposes only and does not constitute a claim of clinical efficacy. NOHO Labs is a paid partner. You can find out more about our selection criteria at the partners page at nicknorwitz.com. Nothing on this page is medical advice — always consult your own clinician before starting any new therapy.#GHKCu #CopperPeptide #Peptides #Longevity #SkinHealth #WoundHealing #Regene Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 22 Jul 2026 16:46:00 -0000 full Nick Norwitz MD PhD If you'd ever like to go deeper with me, join our globally bestselling science newsletter, StayCurious Metabolism: https://staycuriousmetabolism.substack.com NOHO Labs: My Peptide and Longevity Clinicians If you're looking for comprehensive support with peptides, I've spent a lot of time searching and vetting providers, and I'm happy to recommend the thoughtful clinicians at NOHO Labs, which is the service my family and I use.Link: https://noholabs.com/nick/ We negotiated the best arrangement we could for the StayCurious community, including concierge care, personalized peptide protocols, prescriptions when appropriate, and ongoing individualized oversight. Of course, you know I'm a big believer in N = 1 experimentation, but it's important to do that safely. These are clinicians who can provide thoughtful, individualized guidance, and I've been consistently impressed by their expertise, curiosity, and commitment to lifelong learning.If you have any questions, I'll do my best to answer them. And if you decide to work with them, I'd genuinely appreciate any feedback about your experience.This Copper Elixir is skin product my family uses formulated with GHK-Cu and rh-Oligopeptide-1 (EGF)Link: https://mymirrorskin.com/products/copper-elixir?sca_ref=11747127.sMNmVN7hTx GHK-Cu letter: https://staycuriousmetabolism.substack.com/p/ghk-cu-the-strange-science-of-the?r=40ekz2 Wolverine Stack Letter: https://staycuriousmetabolism.substack.com/p/can-peptides-regrow-the-heart-the?r=40ekz2 BPC-157 Letter: https://staycuriousmetabolism.substack.com/p/bpc-157-bro-science-or-breakthrough?r=40ekz2 KPV Letter: https://staycuriousmetabolism.substack.com/p/the-gut-healing-peptide-i-wish-i?r=40ekz2 DescriptionIn this video, we explore the biology of the copper peptide (GHK-Cu)—how your body naturally produces it, why levels decline with age, and what randomized controlled trials suggest about skin health and wound healing. Along the way, we'll dive into copper biology, collagen production, mitochondrial function, gene expression, and why this small blue peptide has become one of the most fascinating molecules I've researched.Finally, I'll explain why I decided to experiment with GHK-Cu myself, what I've observed so far, and where the current science ends and speculation begins. Whether you're interested in longevity, regenerative medicine, wound healing, peptides, or simply understanding the biology behind healthy aging, I think you'll enjoy this rabbit hole.Chapters 0:00 – Why I Injected This Blue Copper Peptide2:47 – GHK-Cu Explained: What Is the Copper Peptide?3:38 – Why GHK-Cu Declines with Age4:31 – Copper Biology: How GHK-Cu Delivers Copper Safely7:26 – How GHK-Cu Repairs Skin and Boosts Collagen8:28 – The Science That Changed My Mind10:43 – The #1 Mistake When Using Copper Peptides11:21 – GHK-Cu for Wound Healing (Human Trial)12:23 – What Happens When You Inject GHK-Cu?14:58 – My GHK-Cu Healing ExperimentDisclaimer and Disclosures: The opinions expressed herein are our own. This video is for general informational purposes only and is not medical advice; talk to your own clinician before starting, stopping, or changing any treatment. Research Use Only (RUO) products have not been cleared or approved by the FDA for clinical diagnostic use. RUO products are intended solely for laboratory research and are not intended to be used for diagnosing, treating, or preventing disease in humans. Any discussion of specific RUO products is for research purposes only and does not constitute a claim of clinical efficacy. NOHO Labs is a paid partner. You can find out more about our selection criteria at the partners page at nicknorwitz.com. Nothing on this page is medical advice — always consult your own clinician before starting any new therapy.#GHKCu #CopperPeptide #Peptides #Longevity #SkinHealth #WoundHealing #Regene Learn more about your ad choices. Visit megaphone.fm/adchoices If you'd ever like to go deeper with me, join our globally bestselling science newsletter, StayCurious Metabolism: https://staycuriousmetabolism.substack.com

NOHO Labs: My Peptide and Longevity Clinicians

If you're looking for comprehensive support with peptides, I've spent a lot of time searching and vetting providers, and I'm happy to recommend the thoughtful clinicians at NOHO Labs, which is the service my family and I use.

Link: https://noholabs.com/nick/

We negotiated the best arrangement we could for the StayCurious community, including concierge care, personalized peptide protocols, prescriptions when appropriate, and ongoing individualized oversight. Of course, you know I'm a big believer in N = 1 experimentation, but it's important to do that safely. These are clinicians who can provide thoughtful, individualized guidance, and I've been consistently impressed by their expertise, curiosity, and commitment to lifelong learning.

If you have any questions, I'll do my best to answer them.
And if you decide to work with them, I'd genuinely appreciate any feedback about your experience.

This Copper Elixir is skin product my family uses formulated with GHK-Cu and rh-Oligopeptide-1 (EGF)

Link: https://mymirrorskin.com/products/copper-elixir?sca_ref=11747127.sMNmVN7hTx

GHK-Cu letter: https://staycuriousmetabolism.substack.com/p/ghk-cu-the-strange-science-of-the?r=40ekz2

Wolverine Stack Letter: https://staycuriousmetabolism.substack.com/p/can-peptides-regrow-the-heart-the?r=40ekz2

BPC-157 Letter: https://staycuriousmetabolism.substack.com/p/bpc-157-bro-science-or-breakthrough?r=40ekz2

KPV Letter: https://staycuriousmetabolism.substack.com/p/the-gut-healing-peptide-i-wish-i?r=40ekz2

Description
In this video, we explore the biology of the copper peptide (GHK-Cu)—how your body naturally produces it, why levels decline with age, and what randomized controlled trials suggest about skin health and wound healing. Along the way, we'll dive into copper biology, collagen production, mitochondrial function, gene expression, and why this small blue peptide has become one of the most fascinating molecules I've researched.

Finally, I'll explain why I decided to experiment with GHK-Cu myself, what I've observed so far, and where the current science ends and speculation begins. Whether you're interested in longevity, regenerative medicine, wound healing, peptides, or simply understanding the biology behind healthy aging, I think you'll enjoy this rabbit hole.

Chapters
0:00 – Why I Injected This Blue Copper Peptide
2:47 – GHK-Cu Explained: What Is the Copper Peptide?
3:38 – Why GHK-Cu Declines with Age
4:31 – Copper Biology: How GHK-Cu Delivers Copper Safely
7:26 – How GHK-Cu Repairs Skin and Boosts Collagen
8:28 – The Science That Changed My Mind
10:43 – The #1 Mistake When Using Copper Peptides
11:21 – GHK-Cu for Wound Healing (Human Trial)
12:23 – What Happens When You Inject GHK-Cu?
14:58 – My GHK-Cu Healing Experiment

Disclaimer and Disclosures: The opinions expressed herein are our own. This video is for general informational purposes only and is not medical advice; talk to your own clinician before starting, stopping, or changing any treatment. Research Use Only (RUO) products have not been cleared or approved by the FDA for clinical diagnostic use. RUO products are intended solely for laboratory research and are not intended to be used for diagnosing, treating, or preventing disease in humans. Any discussion of specific RUO products is for research purposes only and does not constitute a claim of clinical efficacy. NOHO Labs is a paid partner. You can find out more about our selection criteria at the partners page at nicknorwitz.com. Nothing on this page is medical advice — always consult your own clinician before starting any new therapy.

#GHKCu #CopperPeptide #Peptides #Longevity #SkinHealth #WoundHealing #Regene

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1519 no Heart of the Matter: Higher LDL on Keto Does NOT Mean More Plaque. JACC Advances Paper: https://www.jacc.org/doi/10.1016/j.jacadv.2024.101109Chapters0:00 – Introduction0:49 – New Publication! LMHR CCTA study2:58 – Main Findings7:00 – Perspectives: Clinical Competencies and Translational Outlook9:51 – Caveats 11:48 – Counter-caveats Some Other PapersLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/ Meta Analysis of 41 RCTs: https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltext OreoVsStatin: https://pubmed.ncbi.nlm.nih.gov/38276308/ Select Prior videosApoB and All-Cause Mortality: https://youtu.be/sAjDjLJUlQQ Not all LDL is Equal: https://youtu.be/UiGEHgGEN-M Why is there LMHR Confusion: https://youtu.be/4_9UFPopl2g Like my Lipid Nerd shirt? https://metabolismshirts.myspreadshop.com Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 21 Jul 2026 22:46:00 -0000 full Nick Norwitz MD PhD JACC Advances Paper: https://www.jacc.org/doi/10.1016/j.jacadv.2024.101109Chapters0:00 – Introduction0:49 – New Publication! LMHR CCTA study2:58 – Main Findings7:00 – Perspectives: Clinical Competencies and Translational Outlook9:51 – Caveats 11:48 – Counter-caveats Some Other PapersLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/ Meta Analysis of 41 RCTs: https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltext OreoVsStatin: https://pubmed.ncbi.nlm.nih.gov/38276308/ Select Prior videosApoB and All-Cause Mortality: https://youtu.be/sAjDjLJUlQQ Not all LDL is Equal: https://youtu.be/UiGEHgGEN-M Why is there LMHR Confusion: https://youtu.be/4_9UFPopl2g Like my Lipid Nerd shirt? https://metabolismshirts.myspreadshop.com Learn more about your ad choices. Visit megaphone.fm/adchoices JACC Advances Paper: https://www.jacc.org/doi/10.1016/j.jacadv.2024.101109

Chapters
0:00 – Introduction
0:49 – New Publication! LMHR CCTA study
2:58 – Main Findings
7:00 – Perspectives: Clinical Competencies and Translational Outlook
9:51 – Caveats
11:48 – Counter-caveats

Some Other Papers
Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/

Meta Analysis of 41 RCTs: https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltext

OreoVsStatin: https://pubmed.ncbi.nlm.nih.gov/38276308/

Select Prior videos
ApoB and All-Cause Mortality: https://youtu.be/sAjDjLJUlQQ

Not all LDL is Equal: https://youtu.be/UiGEHgGEN-M

Why is there LMHR Confusion: https://youtu.be/4_9UFPopl2g


Like my Lipid Nerd shirt?
https://metabolismshirts.myspreadshop.com

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1162 no Why I Never Skip Leg Day (as a Neuroscientist) For additional nuances, all the references and early access to content like this, see the associated newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/how-to-quietly-grow-your-brain-in?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true 5-Amino-1-MQ Letter: https://staycuriousmetabolism.substack.com/p/the-metabolic-leak-that-might-be?r=40ekz2 Dihexa Letter: https://open.substack.com/pub/staycuriousmetabolism/p/dihexa-the-brain-boosting-peptide?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true If you want to try either 5-Amino-1-MQ or Dihexa, the company I personally use for these is Wingspan. I’ve vetted them and the meet all my criteria, including having high regulatory standards, cGMP certification, and they came recommended by a trusted colleague.Try 5-Amino-1MQ → try.gotwingspan.com/norwitz5Amino1MQTry Dihexa → try.gotwingspan.com/norwitzDihexaDiscount code is “StayCurious”Warning: These aren’t cheap products. I mention them for those who have the means and enjoy responsible self-experimentation.Chapters 0:00 – Grow Your Brain in 30 Minutes Per Day?2:03 – The Twin Study That Made Me Rethink Leg Day6:23 – The BDNF-Irisin Axis9:52 – How Muscles Maintain Healthy Blood Sugar11:47 – Muscles, Brain, and Brain Blood Flow12:13 – The Muscle-NAD-Brain Axis13:17 – Practical Protocols17:00 – 5-Amino-1-MQ: Plugging the Metabolic Leak17:47 – Dihexa: 10,000,000 Times Stronger Than BDNF?DescriptionCould your next leg workout do more than build muscle? In this video, we explore fascinating research showing that greater leg strength is associated with better cognitive aging, larger brain volume, and reduced cognitive decline—even among identical twins. You'll learn how your muscles act as endocrine organs, releasing signaling molecules that directly influence brain health, memory, metabolism, and resilience.We'll unpack the science behind BDNF, irisin, insulin sensitivity, blood flow, and NAD+, then translate the research into practical training recommendations you can start using today. Finally, we'll discuss evidence-based supplements including creatine, 5-amino-1MQ, and Dihexa, and where they fit (and don't fit) alongside the fundamentals of exercise, sleep, and metabolic health.For additional nuance, scientific references, and deeper dives into the mechanisms discussed in this video, check out the accompanying StayCurious letter linked above.#BrainHealth #LegDay #Exercise #StrengthTraining #Longevity #HealthyAging #Neuroscience #Brain #Cognition #Memory #BDNF #Irisin #Muscle #MuscleHealth #Fitness #ResistanceTraining #Aging #Alzheimers #DementiaPrevention #MetabolicHealth #InsulinSensitivity #BloodSugar #NAD #Mitochondria #Creatine #Biohacking #HealthOptimization #FunctionalFitness #ExerciseScience #Science #MedicalResearch #EvidenceBased #Wellness #Health #HealthyLifestyle #Lifting #Gym #Squats #Deadlifts #LongevityScience #BrainFunction #Neuroplasticity #Learning #CognitiveHealth #VO2Max #Metabolism #Strength #PreventiveHealth #ExerciseMedicine #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 21 Jul 2026 04:46:00 -0000 full Nick Norwitz MD PhD For additional nuances, all the references and early access to content like this, see the associated newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/how-to-quietly-grow-your-brain-in?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true 5-Amino-1-MQ Letter: https://staycuriousmetabolism.substack.com/p/the-metabolic-leak-that-might-be?r=40ekz2 Dihexa Letter: https://open.substack.com/pub/staycuriousmetabolism/p/dihexa-the-brain-boosting-peptide?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true If you want to try either 5-Amino-1-MQ or Dihexa, the company I personally use for these is Wingspan. I’ve vetted them and the meet all my criteria, including having high regulatory standards, cGMP certification, and they came recommended by a trusted colleague.Try 5-Amino-1MQ → try.gotwingspan.com/norwitz5Amino1MQTry Dihexa → try.gotwingspan.com/norwitzDihexaDiscount code is “StayCurious”Warning: These aren’t cheap products. I mention them for those who have the means and enjoy responsible self-experimentation.Chapters 0:00 – Grow Your Brain in 30 Minutes Per Day?2:03 – The Twin Study That Made Me Rethink Leg Day6:23 – The BDNF-Irisin Axis9:52 – How Muscles Maintain Healthy Blood Sugar11:47 – Muscles, Brain, and Brain Blood Flow12:13 – The Muscle-NAD-Brain Axis13:17 – Practical Protocols17:00 – 5-Amino-1-MQ: Plugging the Metabolic Leak17:47 – Dihexa: 10,000,000 Times Stronger Than BDNF?DescriptionCould your next leg workout do more than build muscle? In this video, we explore fascinating research showing that greater leg strength is associated with better cognitive aging, larger brain volume, and reduced cognitive decline—even among identical twins. You'll learn how your muscles act as endocrine organs, releasing signaling molecules that directly influence brain health, memory, metabolism, and resilience.We'll unpack the science behind BDNF, irisin, insulin sensitivity, blood flow, and NAD+, then translate the research into practical training recommendations you can start using today. Finally, we'll discuss evidence-based supplements including creatine, 5-amino-1MQ, and Dihexa, and where they fit (and don't fit) alongside the fundamentals of exercise, sleep, and metabolic health.For additional nuance, scientific references, and deeper dives into the mechanisms discussed in this video, check out the accompanying StayCurious letter linked above.#BrainHealth #LegDay #Exercise #StrengthTraining #Longevity #HealthyAging #Neuroscience #Brain #Cognition #Memory #BDNF #Irisin #Muscle #MuscleHealth #Fitness #ResistanceTraining #Aging #Alzheimers #DementiaPrevention #MetabolicHealth #InsulinSensitivity #BloodSugar #NAD #Mitochondria #Creatine #Biohacking #HealthOptimization #FunctionalFitness #ExerciseScience #Science #MedicalResearch #EvidenceBased #Wellness #Health #HealthyLifestyle #Lifting #Gym #Squats #Deadlifts #LongevityScience #BrainFunction #Neuroplasticity #Learning #CognitiveHealth #VO2Max #Metabolism #Strength #PreventiveHealth #ExerciseMedicine #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices For additional nuances, all the references and early access to content like this, see the associated newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/how-to-quietly-grow-your-brain-in?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

5-Amino-1-MQ Letter: https://staycuriousmetabolism.substack.com/p/the-metabolic-leak-that-might-be?r=40ekz2

Dihexa Letter: https://open.substack.com/pub/staycuriousmetabolism/p/dihexa-the-brain-boosting-peptide?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

If you want to try either 5-Amino-1-MQ or Dihexa, the company I personally use for these is Wingspan. I’ve vetted them and the meet all my criteria, including having high regulatory standards, cGMP certification, and they came recommended by a trusted colleague.

Try 5-Amino-1MQ → try.gotwingspan.com/norwitz5Amino1MQ

Try Dihexa → try.gotwingspan.com/norwitzDihexa
Discount code is “StayCurious”

Warning: These aren’t cheap products. I mention them for those who have the means and enjoy responsible self-experimentation.

Chapters
0:00 – Grow Your Brain in 30 Minutes Per Day?
2:03 – The Twin Study That Made Me Rethink Leg Day
6:23 – The BDNF-Irisin Axis
9:52 – How Muscles Maintain Healthy Blood Sugar
11:47 – Muscles, Brain, and Brain Blood Flow
12:13 – The Muscle-NAD-Brain Axis
13:17 – Practical Protocols
17:00 – 5-Amino-1-MQ: Plugging the Metabolic Leak
17:47 – Dihexa: 10,000,000 Times Stronger Than BDNF?

Description

Could your next leg workout do more than build muscle? In this video, we explore fascinating research showing that greater leg strength is associated with better cognitive aging, larger brain volume, and reduced cognitive decline—even among identical twins. You'll learn how your muscles act as endocrine organs, releasing signaling molecules that directly influence brain health, memory, metabolism, and resilience.

We'll unpack the science behind BDNF, irisin, insulin sensitivity, blood flow, and NAD+, then translate the research into practical training recommendations you can start using today. Finally, we'll discuss evidence-based supplements including creatine, 5-amino-1MQ, and Dihexa, and where they fit (and don't fit) alongside the fundamentals of exercise, sleep, and metabolic health.

For additional nuance, scientific references, and deeper dives into the mechanisms discussed in this video, check out the accompanying StayCurious letter linked above.

#BrainHealth #LegDay #Exercise #StrengthTraining #Longevity #HealthyAging #Neuroscience #Brain #Cognition #Memory #BDNF #Irisin #Muscle #MuscleHealth #Fitness #ResistanceTraining #Aging #Alzheimers #DementiaPrevention #MetabolicHealth #InsulinSensitivity #BloodSugar #NAD #Mitochondria #Creatine #Biohacking #HealthOptimization #FunctionalFitness #ExerciseScience #Science #MedicalResearch #EvidenceBased #Wellness #Health #HealthyLifestyle #Lifting #Gym #Squats #Deadlifts #LongevityScience #BrainFunction #Neuroplasticity #Learning #CognitiveHealth #VO2Max #Metabolism #Strength #PreventiveHealth #ExerciseMedicine #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1412 no Could the Carnivore Diet Revolutionize Inflammatory Bowel Disease Treatment? Paper, Carnivore for Inflammatory Bowel Disease: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1467475/fullKetogenic and carnivore diets, are gaining popularity for the experimental treatment of a wide range of disorders, including inflammatory bowel disease (IBD). We report on 10 cases of biopsy-confirmed IBD responsive to carnivore-ketogenic diets. Clinical presentations were diverse, including six cases of ulcerative colitis and of four of Crohn’s disease. Clinical improvements were substantial and universal. Patients’ diets comprised mostly meat, eggs and animal fats. Patients report their diets are pleasurable, sustainable, and unequivocally enhance their quality of life. Chapters:0:00 – Diet for Inflammatory Bowel Disease 2:02 – Research Questions and Biological Background3:03 – NEW STUDY: Carnivore for IBD4:12 – Patients Achieved Incredible Remission 5:47 – Patients’ Stories and Quotes 7:23 – Caveats and Limitations 8:06 – This is a Call to Action for Science to Step Up Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 20 Jul 2026 10:46:00 -0000 full Nick Norwitz MD PhD Paper, Carnivore for Inflammatory Bowel Disease: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1467475/fullKetogenic and carnivore diets, are gaining popularity for the experimental treatment of a wide range of disorders, including inflammatory bowel disease (IBD). We report on 10 cases of biopsy-confirmed IBD responsive to carnivore-ketogenic diets. Clinical presentations were diverse, including six cases of ulcerative colitis and of four of Crohn’s disease. Clinical improvements were substantial and universal. Patients’ diets comprised mostly meat, eggs and animal fats. Patients report their diets are pleasurable, sustainable, and unequivocally enhance their quality of life. Chapters:0:00 – Diet for Inflammatory Bowel Disease 2:02 – Research Questions and Biological Background3:03 – NEW STUDY: Carnivore for IBD4:12 – Patients Achieved Incredible Remission 5:47 – Patients’ Stories and Quotes 7:23 – Caveats and Limitations 8:06 – This is a Call to Action for Science to Step Up Learn more about your ad choices. Visit megaphone.fm/adchoices Paper, Carnivore for Inflammatory Bowel Disease: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1467475/full

Ketogenic and carnivore diets, are gaining popularity for the experimental treatment of a wide range of disorders, including inflammatory bowel disease (IBD). We report on 10 cases of biopsy-confirmed IBD responsive to carnivore-ketogenic diets. Clinical presentations were diverse, including six cases of ulcerative colitis and of four of Crohn’s disease. Clinical improvements were substantial and universal. Patients’ diets comprised mostly meat, eggs and animal fats. Patients report their diets are pleasurable, sustainable, and unequivocally enhance their quality of life.

Chapters:
0:00 – Diet for Inflammatory Bowel Disease
2:02 – Research Questions and Biological Background
3:03 – NEW STUDY: Carnivore for IBD
4:12 – Patients Achieved Incredible Remission
5:47 – Patients’ Stories and Quotes
7:23 – Caveats and Limitations
8:06 – This is a Call to Action for Science to Step Up

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 735 no How Much Sleep Do You Really Need? For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/stop-chasing-8-hours-of-sleep?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Pinealon Letter: https://staycuriousmetabolism.substack.com/p/why-im-trying-this-peptide-for-sleep?r=40ekz2 To Try Pinealon Click this link and use discount code "StayCurious" - Click here: https://yourprotocol.co?sca_ref=11108235.AADIX7Etof No Sleep Letter: https://staycuriousmetabolism.substack.com/p/what-if-you-didnt-need-to-sleep-this?r=40ekz2 Deep Sleep Masterclass: https://staycuriousmetabolism.substack.com/p/how-to-help-your-brain-clean-itself?r=40ekz2 I review several gamma entrainment devices in the Deep Sleep letter, along with the evidence supporting this tool. The only device I have personal experience with is Gamma Light Therapy, which was developed based on some of the early Nature research and is also one of the more affordable options. I believe this link should still provide a discount. https://gammalighttherapy.com/?dt_id=2318686&utm_source=NICKNORWITZ DescriptionIn this video, I break down the neuroscience of sleep and sleep efficiency and review why deep practical strategies that may you improve sleep quality—even when you can't always sleep longer. We'll explore everything from the glymphatic system (your brain's nightly cleaning cycle) to magnesium L-threonate, peptides, side sleeping, 40 Hz light and sound therapy, and emerging research on REM optimization.Whether you're trying to improve cognition, protect long-term brain health, reduce Alzheimer's risk, or simply wake up feeling more refreshed, this video dives into both the established science and the exciting frontier of sleep research. Chapters0:00 – Stop Chasing 8 Hours of Sleep2:07 – Why We Sleep in The First Place?4:08 – What If We Didn’t Need to Sleep at All?4:40 – Stages of Sleep and Why They Matters7:21 – The New “No Sleep” Study8:20 – Tools for Optimizing Deep Sleep15:21 – Tools for Optimizing REM Sleep#sleep #bettersleep #deepsleep #remsleep #sleepscience #sleephealth #brainhealth #neuroscience #brain #alzheimers #dementia #memory #learning #longevity #health #wellness #biohacking #optimization #metabolism #circadianrhythm #sleephygiene #glymphaticsystem #magnesium #magnesiumthreonate #peptides #pinealon #tesamorelin #sermorelin #cjc1295 #mk677 #dsip #growthhormone #gaba #brainoptimization #healthyaging #preventivemedicine #science #medicalresearch #cellbiology #productivity #focus #mentalhealth #brainfog #oura #ouraring #exercise #sleeptips #harvard #mit #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 19 Jul 2026 16:46:00 -0000 full Nick Norwitz MD PhD For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/stop-chasing-8-hours-of-sleep?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Pinealon Letter: https://staycuriousmetabolism.substack.com/p/why-im-trying-this-peptide-for-sleep?r=40ekz2 To Try Pinealon Click this link and use discount code "StayCurious" - Click here: https://yourprotocol.co?sca_ref=11108235.AADIX7Etof No Sleep Letter: https://staycuriousmetabolism.substack.com/p/what-if-you-didnt-need-to-sleep-this?r=40ekz2 Deep Sleep Masterclass: https://staycuriousmetabolism.substack.com/p/how-to-help-your-brain-clean-itself?r=40ekz2 I review several gamma entrainment devices in the Deep Sleep letter, along with the evidence supporting this tool. The only device I have personal experience with is Gamma Light Therapy, which was developed based on some of the early Nature research and is also one of the more affordable options. I believe this link should still provide a discount. https://gammalighttherapy.com/?dt_id=2318686&utm_source=NICKNORWITZ DescriptionIn this video, I break down the neuroscience of sleep and sleep efficiency and review why deep practical strategies that may you improve sleep quality—even when you can't always sleep longer. We'll explore everything from the glymphatic system (your brain's nightly cleaning cycle) to magnesium L-threonate, peptides, side sleeping, 40 Hz light and sound therapy, and emerging research on REM optimization.Whether you're trying to improve cognition, protect long-term brain health, reduce Alzheimer's risk, or simply wake up feeling more refreshed, this video dives into both the established science and the exciting frontier of sleep research. Chapters0:00 – Stop Chasing 8 Hours of Sleep2:07 – Why We Sleep in The First Place?4:08 – What If We Didn’t Need to Sleep at All?4:40 – Stages of Sleep and Why They Matters7:21 – The New “No Sleep” Study8:20 – Tools for Optimizing Deep Sleep15:21 – Tools for Optimizing REM Sleep#sleep #bettersleep #deepsleep #remsleep #sleepscience #sleephealth #brainhealth #neuroscience #brain #alzheimers #dementia #memory #learning #longevity #health #wellness #biohacking #optimization #metabolism #circadianrhythm #sleephygiene #glymphaticsystem #magnesium #magnesiumthreonate #peptides #pinealon #tesamorelin #sermorelin #cjc1295 #mk677 #dsip #growthhormone #gaba #brainoptimization #healthyaging #preventivemedicine #science #medicalresearch #cellbiology #productivity #focus #mentalhealth #brainfog #oura #ouraring #exercise #sleeptips #harvard #mit #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/stop-chasing-8-hours-of-sleep?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Pinealon Letter: https://staycuriousmetabolism.substack.com/p/why-im-trying-this-peptide-for-sleep?r=40ekz2

To Try Pinealon Click this link and use discount code "StayCurious" - Click here: https://yourprotocol.co?sca_ref=11108235.AADIX7Etof

No Sleep Letter: https://staycuriousmetabolism.substack.com/p/what-if-you-didnt-need-to-sleep-this?r=40ekz2

Deep Sleep Masterclass: https://staycuriousmetabolism.substack.com/p/how-to-help-your-brain-clean-itself?r=40ekz2

I review several gamma entrainment devices in the Deep Sleep letter, along with the evidence supporting this tool. The only device I have personal experience with is Gamma Light Therapy, which was developed based on some of the early Nature research and is also one of the more affordable options. I believe this link should still provide a discount. https://gammalighttherapy.com/?dt_id=2318686&utm_source=NICKNORWITZ

Description

In this video, I break down the neuroscience of sleep and sleep efficiency and review why deep practical strategies that may you improve sleep quality—even when you can't always sleep longer. We'll explore everything from the glymphatic system (your brain's nightly cleaning cycle) to magnesium L-threonate, peptides, side sleeping, 40 Hz light and sound therapy, and emerging research on REM optimization.

Whether you're trying to improve cognition, protect long-term brain health, reduce Alzheimer's risk, or simply wake up feeling more refreshed, this video dives into both the established science and the exciting frontier of sleep research.

Chapters
0:00 – Stop Chasing 8 Hours of Sleep
2:07 – Why We Sleep in The First Place?
4:08 – What If We Didn’t Need to Sleep at All?
4:40 – Stages of Sleep and Why They Matters
7:21 – The New “No Sleep” Study
8:20 – Tools for Optimizing Deep Sleep
15:21 – Tools for Optimizing REM Sleep

#sleep #bettersleep #deepsleep #remsleep #sleepscience #sleephealth #brainhealth #neuroscience #brain #alzheimers #dementia #memory #learning #longevity #health #wellness #biohacking #optimization #metabolism #circadianrhythm #sleephygiene #glymphaticsystem #magnesium #magnesiumthreonate #peptides #pinealon #tesamorelin #sermorelin #cjc1295 #mk677 #dsip #growthhormone #gaba #brainoptimization #healthyaging #preventivemedicine #science #medicalresearch #cellbiology #productivity #focus #mentalhealth #brainfog #oura #ouraring #exercise #sleeptips #harvard #mit #staycurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1384 no Meat the Facts: Red Meat Causes Diabetes? Two major papers have recently made headlines, claiming a link between red meat intake and Type 2 Diabetes. The media has been grilling the story, cooking up conflict and confusion. In this video, I break down the serious limitations in those studies and explain why giving up red meat to prevent diabetes is not a fruitful endeavor.Paper 1: Wang et al. Integration of epidemiological and blood biomarker analysis links haem iron intake to increased type 2 diabetes risk. Nature Metabolism; August 2024.Paper 2: Li et al. Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries. Lancet Diabetes and Endocrinology; Sept 2024.Carnivore Diet for Inflammatory Bowel DiseasePaper: https://doi.org/10.3389/fnut.2024.1467475Video: https://youtu.be/JJQCwsy_yM8 Chapters0:00 – Red Meat Linked to Type 2 Diabetes?1:09 – Paper 1: Heme Iron and Diabetes2:50 – Is this Relevant to You?4:08 – Summary of Paper 15:00 – Paper 2: Meta-Analysis of 31 Cohorts8:14 – Summary of Paper 29:38 – Why do I care?10:53 – Carnivore diet for Inflammatory Bowel Disease#RedMeat #type2diabetes #DietMyth #HealthResearch #carnivorediet Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 18 Jul 2026 22:46:00 -0000 full Nick Norwitz MD PhD Two major papers have recently made headlines, claiming a link between red meat intake and Type 2 Diabetes. The media has been grilling the story, cooking up conflict and confusion. In this video, I break down the serious limitations in those studies and explain why giving up red meat to prevent diabetes is not a fruitful endeavor.Paper 1: Wang et al. Integration of epidemiological and blood biomarker analysis links haem iron intake to increased type 2 diabetes risk. Nature Metabolism; August 2024.Paper 2: Li et al. Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries. Lancet Diabetes and Endocrinology; Sept 2024.Carnivore Diet for Inflammatory Bowel DiseasePaper: https://doi.org/10.3389/fnut.2024.1467475Video: https://youtu.be/JJQCwsy_yM8 Chapters0:00 – Red Meat Linked to Type 2 Diabetes?1:09 – Paper 1: Heme Iron and Diabetes2:50 – Is this Relevant to You?4:08 – Summary of Paper 15:00 – Paper 2: Meta-Analysis of 31 Cohorts8:14 – Summary of Paper 29:38 – Why do I care?10:53 – Carnivore diet for Inflammatory Bowel Disease#RedMeat #type2diabetes #DietMyth #HealthResearch #carnivorediet Learn more about your ad choices. Visit megaphone.fm/adchoices Two major papers have recently made headlines, claiming a link between red meat intake and Type 2 Diabetes. The media has been grilling the story, cooking up conflict and confusion. In this video, I break down the serious limitations in those studies and explain why giving up red meat to prevent diabetes is not a fruitful endeavor.

Paper 1: Wang et al. Integration of epidemiological and blood biomarker analysis links haem iron intake to increased type 2 diabetes risk. Nature Metabolism; August 2024.

Paper 2: Li et al. Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries. Lancet Diabetes and Endocrinology; Sept 2024.

Carnivore Diet for Inflammatory Bowel Disease
Paper: https://doi.org/10.3389/fnut.2024.1467475
Video: https://youtu.be/JJQCwsy_yM8

Chapters
0:00 – Red Meat Linked to Type 2 Diabetes?
1:09 – Paper 1: Heme Iron and Diabetes
2:50 – Is this Relevant to You?
4:08 – Summary of Paper 1
5:00 – Paper 2: Meta-Analysis of 31 Cohorts
8:14 – Summary of Paper 2
9:38 – Why do I care?
10:53 – Carnivore diet for Inflammatory Bowel Disease

#RedMeat #type2diabetes #DietMyth #HealthResearch #carnivorediet

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 932 no How to Hack a 7 Day Fast in 24 Hours For all the references, nuanced discussions, and early access to this type of content, check out the StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/what-happens-to-your-body-during?r=40ekz2 If you'd like to dive even deeper, explore the StayCurious Metabolism archives: https://staycuriousmetabolism.substack.com Join the Best-Selling Science Newsletters on Substack. Members frequently describe it as “the best investments they've ever made in their health.”Kenetik Ketones If you'd like to try Kenetik, click the link below or use the discount code STAYCURIOUS for 15% off.Link: https://drinkkenetik.com/STAYCURIOUS?q=nick-norwitzAs a bit of behind-the-scenes news, they've also asked me to help design a clinical trial aimed at developing a diagnostic rubric to identify the people most likely to benefit from exogenous ketones. If you have ideas for biomarkers, clinical characteristics, or other factors that should be included, I'd love to hear them. Feel free to share your thoughts in the comments—I genuinely enjoy crowdsourcing ideas from this community.Resistant Starch Visceral Fat Video: https://youtu.be/wnEApLnKDRI DescriptionA remarkable study published in Nature Metabolism tracked nearly 3,000 circulating proteins while healthy volunteers completed a medically supervised 7-day water-only fast. The findings suggest that prolonged fasting isn't simply about burning fat—it may trigger coordinated biological changes affecting metabolism, inflammation, cardiovascular health, brain biology, and immune function. In this video, I break down exactly what happens on days 1–2, days 3–5, days 5–7, and during refeeding, while explaining why the 72-hour mark may represent a critical metabolic threshold. I also explore an important practical question: can you reproduce these fasting-related changes without completing a full week-long fast? Chapters0:00 – What Happens When You Fast for 7 Days?2:30 – The Study Design and Methodology 4:30 – The Fasting Timeline: Days 1 to 107:34 – What Happened to Lean Mass vs Fat Mass9:39 – The Big Twist: Day 3 Threshold16:23 – How to Hack a 7 Day Fast with Exogenous Ketones21:00 – The Favorite Exogenous Ketones22:07 – Different People Appear to Have Different Ketone Thresholds24:12 – How to Break a Prolonged Fast25:52 – A HUGE THANK YOU… And What’s Next…#fasting #prolongedfasting #waterfast #ketosis #ketones #ketogenicdiet #keto #metabolism #metabolichealth #nutrition #health #science #longevity #proteomics #NatureMetabolism #insulin #fatloss #weightloss #autophagy #brainhealth #cardiovascularhealth #inflammation #immunology #neuroscience #mitochondria #biohacking #exogenousketones #ketoneesters #BHB #metabolicflexibility #timerestrictedeating #intermittentfasting #fastingtips #fastingbenefits #research #clinicalresearch #medicalscience #healthscience #wellness #epilepsy #Alzheimers #autoimmunedisease #glucose #fatburning #lowcarb #staycurious #nutritionresearch #evidencebased #lifescience #healthyaging Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 18 Jul 2026 04:46:00 -0000 full Nick Norwitz MD PhD For all the references, nuanced discussions, and early access to this type of content, check out the StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/what-happens-to-your-body-during?r=40ekz2 If you'd like to dive even deeper, explore the StayCurious Metabolism archives: https://staycuriousmetabolism.substack.com Join the Best-Selling Science Newsletters on Substack. Members frequently describe it as “the best investments they've ever made in their health.”Kenetik Ketones If you'd like to try Kenetik, click the link below or use the discount code STAYCURIOUS for 15% off.Link: https://drinkkenetik.com/STAYCURIOUS?q=nick-norwitzAs a bit of behind-the-scenes news, they've also asked me to help design a clinical trial aimed at developing a diagnostic rubric to identify the people most likely to benefit from exogenous ketones. If you have ideas for biomarkers, clinical characteristics, or other factors that should be included, I'd love to hear them. Feel free to share your thoughts in the comments—I genuinely enjoy crowdsourcing ideas from this community.Resistant Starch Visceral Fat Video: https://youtu.be/wnEApLnKDRI DescriptionA remarkable study published in Nature Metabolism tracked nearly 3,000 circulating proteins while healthy volunteers completed a medically supervised 7-day water-only fast. The findings suggest that prolonged fasting isn't simply about burning fat—it may trigger coordinated biological changes affecting metabolism, inflammation, cardiovascular health, brain biology, and immune function. In this video, I break down exactly what happens on days 1–2, days 3–5, days 5–7, and during refeeding, while explaining why the 72-hour mark may represent a critical metabolic threshold. I also explore an important practical question: can you reproduce these fasting-related changes without completing a full week-long fast? Chapters0:00 – What Happens When You Fast for 7 Days?2:30 – The Study Design and Methodology 4:30 – The Fasting Timeline: Days 1 to 107:34 – What Happened to Lean Mass vs Fat Mass9:39 – The Big Twist: Day 3 Threshold16:23 – How to Hack a 7 Day Fast with Exogenous Ketones21:00 – The Favorite Exogenous Ketones22:07 – Different People Appear to Have Different Ketone Thresholds24:12 – How to Break a Prolonged Fast25:52 – A HUGE THANK YOU… And What’s Next…#fasting #prolongedfasting #waterfast #ketosis #ketones #ketogenicdiet #keto #metabolism #metabolichealth #nutrition #health #science #longevity #proteomics #NatureMetabolism #insulin #fatloss #weightloss #autophagy #brainhealth #cardiovascularhealth #inflammation #immunology #neuroscience #mitochondria #biohacking #exogenousketones #ketoneesters #BHB #metabolicflexibility #timerestrictedeating #intermittentfasting #fastingtips #fastingbenefits #research #clinicalresearch #medicalscience #healthscience #wellness #epilepsy #Alzheimers #autoimmunedisease #glucose #fatburning #lowcarb #staycurious #nutritionresearch #evidencebased #lifescience #healthyaging Learn more about your ad choices. Visit megaphone.fm/adchoices For all the references, nuanced discussions, and early access to this type of content, check out the StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/what-happens-to-your-body-during?r=40ekz2

If you'd like to dive even deeper, explore the StayCurious Metabolism archives: https://staycuriousmetabolism.substack.com

Join the Best-Selling Science Newsletters on Substack. Members frequently describe it as “the best investments they've ever made in their health.”

Kenetik Ketones
If you'd like to try Kenetik, click the link below or use the discount code STAYCURIOUS for 15% off.

Link: https://drinkkenetik.com/STAYCURIOUS?q=nick-norwitz

As a bit of behind-the-scenes news, they've also asked me to help design a clinical trial aimed at developing a diagnostic rubric to identify the people most likely to benefit from exogenous ketones. If you have ideas for biomarkers, clinical characteristics, or other factors that should be included, I'd love to hear them.

Feel free to share your thoughts in the comments—I genuinely enjoy crowdsourcing ideas from this community.

Resistant Starch Visceral Fat Video: https://youtu.be/wnEApLnKDRI

Description
A remarkable study published in Nature Metabolism tracked nearly 3,000 circulating proteins while healthy volunteers completed a medically supervised 7-day water-only fast. The findings suggest that prolonged fasting isn't simply about burning fat—it may trigger coordinated biological changes affecting metabolism, inflammation, cardiovascular health, brain biology, and immune function. In this video, I break down exactly what happens on days 1–2, days 3–5, days 5–7, and during refeeding, while explaining why the 72-hour mark may represent a critical metabolic threshold. I also explore an important practical question: can you reproduce these fasting-related changes without completing a full week-long fast?

Chapters
0:00 – What Happens When You Fast for 7 Days?
2:30 – The Study Design and Methodology
4:30 – The Fasting Timeline: Days 1 to 10
7:34 – What Happened to Lean Mass vs Fat Mass
9:39 – The Big Twist: Day 3 Threshold
16:23 – How to Hack a 7 Day Fast with Exogenous Ketones
21:00 – The Favorite Exogenous Ketones
22:07 – Different People Appear to Have Different Ketone Thresholds
24:12 – How to Break a Prolonged Fast
25:52 – A HUGE THANK YOU… And What’s Next…

#fasting #prolongedfasting #waterfast #ketosis #ketones #ketogenicdiet #keto #metabolism #metabolichealth #nutrition #health #science #longevity #proteomics #NatureMetabolism #insulin #fatloss #weightloss #autophagy #brainhealth #cardiovascularhealth #inflammation #immunology #neuroscience #mitochondria #biohacking #exogenousketones #ketoneesters #BHB #metabolicflexibility #timerestrictedeating #intermittentfasting #fastingtips #fastingbenefits #research #clinicalresearch #medicalscience #healthscience #wellness #epilepsy #Alzheimers #autoimmunedisease #glucose #fatburning #lowcarb #staycurious #nutritionresearch #evidencebased #lifescience #healthyaging

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 2026 no I Ate 720 Eggs in 1 Month. Here's What Happened to my Cholesterol In a month-long challenge, I devoured 720 eggs—yes, that’s one egg every hour on average, totaling over 133,000 mg of dietary cholesterol. Beyond the egg-citing puns, stick around to uncover the jaw-dropping results and the deeper ‘why’ behind this yolk-filled experiment. Prepare to be shell-shocked!#eggs #metabolism #nutritionfacts #lmhr Chapters0:00 – I ate 720 eggs in one month1:01 – What Happened to my LDL cholesterol?1:13 – Why Dietary Cholesterol Doesn’t Increase Cholesterol 2:05 – Eggs, Berries and Lipid Energy Model5:20 – Why did I make this video? A commentary on social mediaCholesin video: https://youtu.be/Q00wHV2tcy4 OreoVsStatin video: https://youtu.be/L1mMnnyJrgk Lipid Energy Model Paper: https://pubmed.ncbi.nlm.nih.gov/35629964/ Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 17 Jul 2026 10:46:00 -0000 full Nick Norwitz MD PhD In a month-long challenge, I devoured 720 eggs—yes, that’s one egg every hour on average, totaling over 133,000 mg of dietary cholesterol. Beyond the egg-citing puns, stick around to uncover the jaw-dropping results and the deeper ‘why’ behind this yolk-filled experiment. Prepare to be shell-shocked!#eggs #metabolism #nutritionfacts #lmhr Chapters0:00 – I ate 720 eggs in one month1:01 – What Happened to my LDL cholesterol?1:13 – Why Dietary Cholesterol Doesn’t Increase Cholesterol 2:05 – Eggs, Berries and Lipid Energy Model5:20 – Why did I make this video? A commentary on social mediaCholesin video: https://youtu.be/Q00wHV2tcy4 OreoVsStatin video: https://youtu.be/L1mMnnyJrgk Lipid Energy Model Paper: https://pubmed.ncbi.nlm.nih.gov/35629964/ Learn more about your ad choices. Visit megaphone.fm/adchoices In a month-long challenge, I devoured 720 eggs—yes, that’s one egg every hour on average, totaling over 133,000 mg of dietary cholesterol. Beyond the egg-citing puns, stick around to uncover the jaw-dropping results and the deeper ‘why’ behind this yolk-filled experiment. Prepare to be shell-shocked!

#eggs #metabolism #nutritionfacts #lmhr

Chapters
0:00 – I ate 720 eggs in one month
1:01 – What Happened to my LDL cholesterol?
1:13 – Why Dietary Cholesterol Doesn’t Increase Cholesterol
2:05 – Eggs, Berries and Lipid Energy Model
5:20 – Why did I make this video? A commentary on social media

Cholesin video: https://youtu.be/Q00wHV2tcy4

OreoVsStatin video: https://youtu.be/L1mMnnyJrgk

Lipid Energy Model Paper: https://pubmed.ncbi.nlm.nih.gov/35629964/

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 627 no How To Heal 20 Years of Gut Damage in 30 Days If you'd like to dive deeper into any of the individual topics we discussed, including BPC-157, Larazotide, and KPV, you can find dedicated deep dives in our Peptides and More library, here: https://staycuriousmetabolism.substack.com/p/peptides For the written companion to this video—including all the references and extra nuances—check out the letter at StayCurious Metabolism, here: https://open.substack.com/pub/staycuriousmetabolism/p/how-to-heal-20-years-of-gut-damage?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=trueIf you'd like to try the Winnow Labs microplastic-binding probiotic, use the link below and the discount code STAYCURIOUS for 15% off.https://www.winnowlabs.com/STAYCURIOUS25 And if you'd like to try any of the three peptides we discussed from the WINGSPAN, use the link below and the code STAYCURIOUS for 10% off.try.gotwingspan.com/norwitzChapters0:00 – My Gut Health Recovery Story1:55 – Free Foundational Tools for Gut Health7:32 – Dietary Principles for a Healthy Gut12:57 – The Ultimate Peptide Stack for Gut RecoveryDescriptionWhat would I do if I could go back to the day, I was diagnosed with inflammatory bowel disease and start over with everything I know now?In this video, I break down the gut-health framework I wish I had when my intestines were inflamed, ulcerated, and on the verge of requiring major surgery. We cover surprising science on the gut-brain axis, vagus nerve signaling, breathwork, stress reduction, time-restricted feeding, fermented foods, probiotics, microplastics…Then we dive into what I consider the ultimate peptide stack for gut health: BPC-157, Larazotide, and KPV. You'll learn how each works, what role it may play in supporting gut barrier integrity, inflammation, and tissue repair, and how I think about combining them. Whether you're dealing with inflammatory bowel disease, leaky gut, digestive symptoms, or simply want a deeper understanding of gut biology, this video is designed to give you practical tools backed by science.Disclaimer: The content presented in this video is for informational and educational purposes only and should not be construed as medical advice. Any decisions regarding your health should be made in consultation with your personal healthcare provider, who can consider your individual circumstances and medical history. This content contains a partnership message. As with all of my partnerships, I only work with companies that meet a strict set of criteria. Specifically, the product or service must provide a genuine solution to a real problem faced by my audience, operate to the highest standards of quality and ethics, and be something that I personally use or would feel comfortable recommending to family and close friends. While I am compensated for certain partnerships, my opinions remain my own, and I strive to maintain the same standards of honesty, transparency, and scientific rigor regardless of whether content is sponsored or unsponsored. You can learn more about all partnerships at nicknorwitz.com.#GutHealth #LeakyGut #InflammatoryBowelDisease #IBD #CrohnsDisease #UlcerativeColitis #DigestiveHealth #Microbiome #GutMicrobiome #BPC157 #Larazotide #KPV #Peptides #PeptideTherapy #FunctionalMedicine #MetabolicHealth #Longevity #HealthOptimization #Inflammation #ChronicInflammation #AutoimmuneDisease #GutBrainAxis #VagusNerve #Breathwork #PhysiologicalSigh #StressReduction #FermentedFoods #Sauerkraut #Kefir #Probiotics #Microplastics #TimeRestrictedFeeding #IntermittentFasting #NutritionScience #EvidenceBasedMedicine #HealthScience #Biohacking #HumanBiology #Gastroenterology #ColonHealth #IntestinalPermeability #TightJunctions #Zonulin #Crohns #UlcerativeColitisAwareness #ScientificWellness #PreventiveHealth #HealthyGut #ScienceCommunication #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 16 Jul 2026 16:46:00 -0000 full Nick Norwitz MD PhD If you'd like to dive deeper into any of the individual topics we discussed, including BPC-157, Larazotide, and KPV, you can find dedicated deep dives in our Peptides and More library, here: https://staycuriousmetabolism.substack.com/p/peptides For the written companion to this video—including all the references and extra nuances—check out the letter at StayCurious Metabolism, here: https://open.substack.com/pub/staycuriousmetabolism/p/how-to-heal-20-years-of-gut-damage?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=trueIf you'd like to try the Winnow Labs microplastic-binding probiotic, use the link below and the discount code STAYCURIOUS for 15% off.https://www.winnowlabs.com/STAYCURIOUS25 And if you'd like to try any of the three peptides we discussed from the WINGSPAN, use the link below and the code STAYCURIOUS for 10% off.try.gotwingspan.com/norwitzChapters0:00 – My Gut Health Recovery Story1:55 – Free Foundational Tools for Gut Health7:32 – Dietary Principles for a Healthy Gut12:57 – The Ultimate Peptide Stack for Gut RecoveryDescriptionWhat would I do if I could go back to the day, I was diagnosed with inflammatory bowel disease and start over with everything I know now?In this video, I break down the gut-health framework I wish I had when my intestines were inflamed, ulcerated, and on the verge of requiring major surgery. We cover surprising science on the gut-brain axis, vagus nerve signaling, breathwork, stress reduction, time-restricted feeding, fermented foods, probiotics, microplastics…Then we dive into what I consider the ultimate peptide stack for gut health: BPC-157, Larazotide, and KPV. You'll learn how each works, what role it may play in supporting gut barrier integrity, inflammation, and tissue repair, and how I think about combining them. Whether you're dealing with inflammatory bowel disease, leaky gut, digestive symptoms, or simply want a deeper understanding of gut biology, this video is designed to give you practical tools backed by science.Disclaimer: The content presented in this video is for informational and educational purposes only and should not be construed as medical advice. Any decisions regarding your health should be made in consultation with your personal healthcare provider, who can consider your individual circumstances and medical history. This content contains a partnership message. As with all of my partnerships, I only work with companies that meet a strict set of criteria. Specifically, the product or service must provide a genuine solution to a real problem faced by my audience, operate to the highest standards of quality and ethics, and be something that I personally use or would feel comfortable recommending to family and close friends. While I am compensated for certain partnerships, my opinions remain my own, and I strive to maintain the same standards of honesty, transparency, and scientific rigor regardless of whether content is sponsored or unsponsored. You can learn more about all partnerships at nicknorwitz.com.#GutHealth #LeakyGut #InflammatoryBowelDisease #IBD #CrohnsDisease #UlcerativeColitis #DigestiveHealth #Microbiome #GutMicrobiome #BPC157 #Larazotide #KPV #Peptides #PeptideTherapy #FunctionalMedicine #MetabolicHealth #Longevity #HealthOptimization #Inflammation #ChronicInflammation #AutoimmuneDisease #GutBrainAxis #VagusNerve #Breathwork #PhysiologicalSigh #StressReduction #FermentedFoods #Sauerkraut #Kefir #Probiotics #Microplastics #TimeRestrictedFeeding #IntermittentFasting #NutritionScience #EvidenceBasedMedicine #HealthScience #Biohacking #HumanBiology #Gastroenterology #ColonHealth #IntestinalPermeability #TightJunctions #Zonulin #Crohns #UlcerativeColitisAwareness #ScientificWellness #PreventiveHealth #HealthyGut #ScienceCommunication #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices If you'd like to dive deeper into any of the individual topics we discussed, including BPC-157, Larazotide, and KPV, you can find dedicated deep dives in our Peptides and More library, here: https://staycuriousmetabolism.substack.com/p/peptides

For the written companion to this video—including all the references and extra nuances—check out the letter at StayCurious Metabolism, here: https://open.substack.com/pub/staycuriousmetabolism/p/how-to-heal-20-years-of-gut-damage?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

If you'd like to try the Winnow Labs microplastic-binding probiotic, use the link below and the discount code STAYCURIOUS for 15% off.
https://www.winnowlabs.com/STAYCURIOUS25

And if you'd like to try any of the three peptides we discussed from the WINGSPAN, use the link below and the code STAYCURIOUS for 10% off.
try.gotwingspan.com/norwitz

Chapters
0:00 – My Gut Health Recovery Story
1:55 – Free Foundational Tools for Gut Health
7:32 – Dietary Principles for a Healthy Gut
12:57 – The Ultimate Peptide Stack for Gut Recovery

Description

What would I do if I could go back to the day, I was diagnosed with inflammatory bowel disease and start over with everything I know now?

In this video, I break down the gut-health framework I wish I had when my intestines were inflamed, ulcerated, and on the verge of requiring major surgery. We cover surprising science on the gut-brain axis, vagus nerve signaling, breathwork, stress reduction, time-restricted feeding, fermented foods, probiotics, microplastics…

Then we dive into what I consider the ultimate peptide stack for gut health: BPC-157, Larazotide, and KPV. You'll learn how each works, what role it may play in supporting gut barrier integrity, inflammation, and tissue repair, and how I think about combining them.

Whether you're dealing with inflammatory bowel disease, leaky gut, digestive symptoms, or simply want a deeper understanding of gut biology, this video is designed to give you practical tools backed by science.

Disclaimer: The content presented in this video is for informational and educational purposes only and should not be construed as medical advice. Any decisions regarding your health should be made in consultation with your personal healthcare provider, who can consider your individual circumstances and medical history. This content contains a partnership message. As with all of my partnerships, I only work with companies that meet a strict set of criteria. Specifically, the product or service must provide a genuine solution to a real problem faced by my audience, operate to the highest standards of quality and ethics, and be something that I personally use or would feel comfortable recommending to family and close friends. While I am compensated for certain partnerships, my opinions remain my own, and I strive to maintain the same standards of honesty, transparency, and scientific rigor regardless of whether content is sponsored or unsponsored. You can learn more about all partnerships at nicknorwitz.com.

#GutHealth #LeakyGut #InflammatoryBowelDisease #IBD #CrohnsDisease #UlcerativeColitis #DigestiveHealth #Microbiome #GutMicrobiome #BPC157 #Larazotide #KPV #Peptides #PeptideTherapy #FunctionalMedicine #MetabolicHealth #Longevity #HealthOptimization #Inflammation #ChronicInflammation #AutoimmuneDisease #GutBrainAxis #VagusNerve #Breathwork #PhysiologicalSigh #StressReduction #FermentedFoods #Sauerkraut #Kefir #Probiotics #Microplastics #TimeRestrictedFeeding #IntermittentFasting #NutritionScience #EvidenceBasedMedicine #HealthScience #Biohacking #HumanBiology #Gastroenterology #ColonHealth #IntestinalPermeability #TightJunctions #Zonulin #Crohns #UlcerativeColitisAwareness #ScientificWellness #PreventiveHealth #HealthyGut #ScienceCommunication #StayCurious

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1368 no Joe Rogan Is A Therapist?! The Not So "Bro" Science of Exercise and Stress Exercise is good for mental health, or so some say. But is it just psychology or associated healthy habits? No! New research in Cell Metabolism sheds light on HOW exercise improves resilience to psychological stress and exerts its anti-anxiety effects on the brain and mind. The biological story is beautiful and centers on how lactate, produced during exercise, can modify a key protein, SNAP91, that controls how brain cells talk to one another. In this video, I breakdown the data and provide practical takeaways for you to bring to the gym… and you may even save money on therapy too.Chapters0:00 – Joe Rogan Wisdom0:39 – New paper on Exercise, Lactate, and Anxiety 1:19 – Lactylation in the Brain1:50 – Brain Lactate from Exercise Reduces Anxiety 2:49 – Lactate attaches to SNAP91 to Change Brain Metabolism5:32 – Practical Takeaway Paper: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00289-4#AnxietyRelief #BrainHealth #WorkoutMotivation Exercise #muscles #lactate #brainhealth #neuroscience #brainenergy #mitochondrialhealth #metabolism #educational #sleep #staycurious #neuroprotection #neurons #mitochondria #brainmetabolism #agingbrain #scientificbreakthrough #neuroplasticity #brainaging #healthysleep #mentalclarity #neurohealth #brainresearch #neurotoxins #dementiaprevention #healthylifestyle #memoryhealth #mitochondrialfunction #neurosciencebreakthrough #brainmaintenance #agingwell #cellularhealth #metabolichealth #wellness Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 15 Jul 2026 22:46:00 -0000 full Nick Norwitz MD PhD Exercise is good for mental health, or so some say. But is it just psychology or associated healthy habits? No! New research in Cell Metabolism sheds light on HOW exercise improves resilience to psychological stress and exerts its anti-anxiety effects on the brain and mind. The biological story is beautiful and centers on how lactate, produced during exercise, can modify a key protein, SNAP91, that controls how brain cells talk to one another. In this video, I breakdown the data and provide practical takeaways for you to bring to the gym… and you may even save money on therapy too.Chapters0:00 – Joe Rogan Wisdom0:39 – New paper on Exercise, Lactate, and Anxiety 1:19 – Lactylation in the Brain1:50 – Brain Lactate from Exercise Reduces Anxiety 2:49 – Lactate attaches to SNAP91 to Change Brain Metabolism5:32 – Practical Takeaway Paper: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00289-4#AnxietyRelief #BrainHealth #WorkoutMotivation Exercise #muscles #lactate #brainhealth #neuroscience #brainenergy #mitochondrialhealth #metabolism #educational #sleep #staycurious #neuroprotection #neurons #mitochondria #brainmetabolism #agingbrain #scientificbreakthrough #neuroplasticity #brainaging #healthysleep #mentalclarity #neurohealth #brainresearch #neurotoxins #dementiaprevention #healthylifestyle #memoryhealth #mitochondrialfunction #neurosciencebreakthrough #brainmaintenance #agingwell #cellularhealth #metabolichealth #wellness Learn more about your ad choices. Visit megaphone.fm/adchoices Exercise is good for mental health, or so some say. But is it just psychology or associated healthy habits? No! New research in Cell Metabolism sheds light on HOW exercise improves resilience to psychological stress and exerts its anti-anxiety effects on the brain and mind. The biological story is beautiful and centers on how lactate, produced during exercise, can modify a key protein, SNAP91, that controls how brain cells talk to one another. In this video, I breakdown the data and provide practical takeaways for you to bring to the gym… and you may even save money on therapy too.

Chapters
0:00 – Joe Rogan Wisdom
0:39 – New paper on Exercise, Lactate, and Anxiety
1:19 – Lactylation in the Brain
1:50 – Brain Lactate from Exercise Reduces Anxiety
2:49 – Lactate attaches to SNAP91 to Change Brain Metabolism
5:32 – Practical Takeaway

Paper: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00289-4

#AnxietyRelief #BrainHealth #WorkoutMotivation Exercise #muscles #lactate #brainhealth #neuroscience #brainenergy #mitochondrialhealth #metabolism #educational #sleep #staycurious #neuroprotection #neurons #mitochondria #brainmetabolism #agingbrain #scientificbreakthrough #neuroplasticity #brainaging #healthysleep #mentalclarity #neurohealth #brainresearch #neurotoxins #dementiaprevention #healthylifestyle #memoryhealth #mitochondrialfunction #neurosciencebreakthrough #brainmaintenance #agingwell #cellularhealth #metabolichealth #wellness

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 505 no Reverse Heart Disease in 1 Year (Proven in RCT) For the written companion, including references and extra nuances, check out StayCurious Metabolism: https://staycuriousmetabolism.substack.com/p/how-to-reverse-atherosclerosis-in?r=40ekz2 If you'd like to try the Winnow Labs microplastic-binding probiotic, use the link below and the discount code STAYCURIOUS for 15% off.Link: https://www.winnowlabs.com/STAYCURIOUS25 Microplastics and Heart Health Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Microplastics and Brain Health Letter: https://staycuriousmetabolism.substack.com/p/this-graph-changed-how-i-think-about?r=40ekz2 Sleep Video: https://youtu.be/cgnfJtLc_pY GLP-1 Masterclass Letter: https://youtu.be/a_vJYkb_Rjk Exercise for the Brain Video: https://youtu.be/b7jss3R5E50 Pinealon Letter: https://staycuriousmetabolism.substack.com/p/why-im-trying-this-peptide-for-sleep?r=40ekz2 Nattokinase Letter: https://staycuriousmetabolism.substack.com/p/nattokinase-the-heart-health-supplement?r=40ekz2 TUDCA Letter: https://staycuriousmetabolism.substack.com/p/can-tudca-protect-from-atherosclerosis?r=40ekz2 Chapters0:00 – Two Things I Do Every Day to Protect My Arteries1:51 – Part 1, Clones in Your Bones5:36 – Part 2, Don’t Sleep on Exercise8:43 – Delving Deep into the Mechanisms of Sleep and Exercise10:23 – Direct Evidence of the Impact of Sleep and Exercise on Atherosclerosis 11:12 – Part 3, How to Reverse Atherosclerosis for Free14:40 – Part 4, Bonus Tools to Protect Your ArteriesIn today’s video, we'll explore fascinating new research on clonal hematopoiesis, mutant inflammatory blood cell clones that originate in the bone marrow and may contribute to atherosclerosis. You'll learn how sleep and exercise appear to suppress these inflammatory clones, reduce arterial inflammation, and potentially protect cardiovascular health in ways most people have never heard about. We'll also review data from a 90,000-person study, examine a randomized controlled trial showing exercise-associated plaque regression, discuss why inflammation matters as much as cholesterol, and cover additional tools that may support arterial health. Disclaimer: The content presented in this video is for informational and educational purposes only and should not be construed as medical advice. Any decisions regarding your health should be made in consultation with your personal healthcare provider, who can consider your individual circumstances and medical history. This content contains a partnership message. As with all of my partnerships, I only work with companies that meet a strict set of criteria. Specifically, the product or service must provide a genuine solution to a real problem faced by my audience, operate to the highest standards of quality and ethics, and be something that I personally use or would feel comfortable recommending to family and close friends. While I am compensated for certain partnerships, my opinions remain my own, and I strive to maintain the same standards of honesty, transparency, and scientific rigor regardless of whether content is sponsored or unsponsored. You can learn more about all partnerships at nicknorwitz.com #HeartHealth #CardiovascularHealth #Atherosclerosis #Plaque #Arteries #Cholesterol #LDL #Inflammation #Sleep #Exercise #Longevity #Health #Wellness #PreventiveMedicine #MetabolicHealth #Biohacking #Science #MedicalResearch #Neuroscience #Fitness #SleepHealth #HeartDisease #CoronaryArteryDisease #CACScore #Cardiology #HealthyAging #ExerciseScience #SleepScience #ImmuneSystem #ClonalHematopoiesis #UKBiobank #GLP1 #Nattokinase #TUDCA #Microplastics #InflammationResearch #PlaqueRegression #HealthyLifestyle #DiseasePrevention #PublicHealth #EvidenceBasedMedicine #HealthOptimization #FitnessMotivation #ResistanceTraining #Zone2 #HeartAttackPrevention #BrainHealth #HealthEducation #StayCurious #Me Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 15 Jul 2026 04:46:00 -0000 full Nick Norwitz MD PhD For the written companion, including references and extra nuances, check out StayCurious Metabolism: https://staycuriousmetabolism.substack.com/p/how-to-reverse-atherosclerosis-in?r=40ekz2 If you'd like to try the Winnow Labs microplastic-binding probiotic, use the link below and the discount code STAYCURIOUS for 15% off.Link: https://www.winnowlabs.com/STAYCURIOUS25 Microplastics and Heart Health Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Microplastics and Brain Health Letter: https://staycuriousmetabolism.substack.com/p/this-graph-changed-how-i-think-about?r=40ekz2 Sleep Video: https://youtu.be/cgnfJtLc_pY GLP-1 Masterclass Letter: https://youtu.be/a_vJYkb_Rjk Exercise for the Brain Video: https://youtu.be/b7jss3R5E50 Pinealon Letter: https://staycuriousmetabolism.substack.com/p/why-im-trying-this-peptide-for-sleep?r=40ekz2 Nattokinase Letter: https://staycuriousmetabolism.substack.com/p/nattokinase-the-heart-health-supplement?r=40ekz2 TUDCA Letter: https://staycuriousmetabolism.substack.com/p/can-tudca-protect-from-atherosclerosis?r=40ekz2 Chapters0:00 – Two Things I Do Every Day to Protect My Arteries1:51 – Part 1, Clones in Your Bones5:36 – Part 2, Don’t Sleep on Exercise8:43 – Delving Deep into the Mechanisms of Sleep and Exercise10:23 – Direct Evidence of the Impact of Sleep and Exercise on Atherosclerosis 11:12 – Part 3, How to Reverse Atherosclerosis for Free14:40 – Part 4, Bonus Tools to Protect Your ArteriesIn today’s video, we'll explore fascinating new research on clonal hematopoiesis, mutant inflammatory blood cell clones that originate in the bone marrow and may contribute to atherosclerosis. You'll learn how sleep and exercise appear to suppress these inflammatory clones, reduce arterial inflammation, and potentially protect cardiovascular health in ways most people have never heard about. We'll also review data from a 90,000-person study, examine a randomized controlled trial showing exercise-associated plaque regression, discuss why inflammation matters as much as cholesterol, and cover additional tools that may support arterial health. Disclaimer: The content presented in this video is for informational and educational purposes only and should not be construed as medical advice. Any decisions regarding your health should be made in consultation with your personal healthcare provider, who can consider your individual circumstances and medical history. This content contains a partnership message. As with all of my partnerships, I only work with companies that meet a strict set of criteria. Specifically, the product or service must provide a genuine solution to a real problem faced by my audience, operate to the highest standards of quality and ethics, and be something that I personally use or would feel comfortable recommending to family and close friends. While I am compensated for certain partnerships, my opinions remain my own, and I strive to maintain the same standards of honesty, transparency, and scientific rigor regardless of whether content is sponsored or unsponsored. You can learn more about all partnerships at nicknorwitz.com #HeartHealth #CardiovascularHealth #Atherosclerosis #Plaque #Arteries #Cholesterol #LDL #Inflammation #Sleep #Exercise #Longevity #Health #Wellness #PreventiveMedicine #MetabolicHealth #Biohacking #Science #MedicalResearch #Neuroscience #Fitness #SleepHealth #HeartDisease #CoronaryArteryDisease #CACScore #Cardiology #HealthyAging #ExerciseScience #SleepScience #ImmuneSystem #ClonalHematopoiesis #UKBiobank #GLP1 #Nattokinase #TUDCA #Microplastics #InflammationResearch #PlaqueRegression #HealthyLifestyle #DiseasePrevention #PublicHealth #EvidenceBasedMedicine #HealthOptimization #FitnessMotivation #ResistanceTraining #Zone2 #HeartAttackPrevention #BrainHealth #HealthEducation #StayCurious #Me Learn more about your ad choices. Visit megaphone.fm/adchoices For the written companion, including references and extra nuances, check out StayCurious Metabolism: https://staycuriousmetabolism.substack.com/p/how-to-reverse-atherosclerosis-in?r=40ekz2

If you'd like to try the Winnow Labs microplastic-binding probiotic, use the link below and the discount code STAYCURIOUS for 15% off.
Link: https://www.winnowlabs.com/STAYCURIOUS25

Microplastics and Heart Health Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2

Microplastics and Brain Health Letter: https://staycuriousmetabolism.substack.com/p/this-graph-changed-how-i-think-about?r=40ekz2

Sleep Video: https://youtu.be/cgnfJtLc_pY

GLP-1 Masterclass Letter: https://youtu.be/a_vJYkb_Rjk

Exercise for the Brain Video: https://youtu.be/b7jss3R5E50

Pinealon Letter: https://staycuriousmetabolism.substack.com/p/why-im-trying-this-peptide-for-sleep?r=40ekz2

Nattokinase Letter: https://staycuriousmetabolism.substack.com/p/nattokinase-the-heart-health-supplement?r=40ekz2

TUDCA Letter: https://staycuriousmetabolism.substack.com/p/can-tudca-protect-from-atherosclerosis?r=40ekz2

Chapters
0:00 – Two Things I Do Every Day to Protect My Arteries
1:51 – Part 1, Clones in Your Bones
5:36 – Part 2, Don’t Sleep on Exercise
8:43 – Delving Deep into the Mechanisms of Sleep and Exercise
10:23 – Direct Evidence of the Impact of Sleep and Exercise on Atherosclerosis
11:12 – Part 3, How to Reverse Atherosclerosis for Free
14:40 – Part 4, Bonus Tools to Protect Your Arteries

In today’s video, we'll explore fascinating new research on clonal hematopoiesis, mutant inflammatory blood cell clones that originate in the bone marrow and may contribute to atherosclerosis. You'll learn how sleep and exercise appear to suppress these inflammatory clones, reduce arterial inflammation, and potentially protect cardiovascular health in ways most people have never heard about. We'll also review data from a 90,000-person study, examine a randomized controlled trial showing exercise-associated plaque regression, discuss why inflammation matters as much as cholesterol, and cover additional tools that may support arterial health.

Disclaimer: The content presented in this video is for informational and educational purposes only and should not be construed as medical advice. Any decisions regarding your health should be made in consultation with your personal healthcare provider, who can consider your individual circumstances and medical history. This content contains a partnership message. As with all of my partnerships, I only work with companies that meet a strict set of criteria. Specifically, the product or service must provide a genuine solution to a real problem faced by my audience, operate to the highest standards of quality and ethics, and be something that I personally use or would feel comfortable recommending to family and close friends. While I am compensated for certain partnerships, my opinions remain my own, and I strive to maintain the same standards of honesty, transparency, and scientific rigor regardless of whether content is sponsored or unsponsored. You can learn more about all partnerships at nicknorwitz.com

#HeartHealth #CardiovascularHealth #Atherosclerosis #Plaque #Arteries #Cholesterol #LDL #Inflammation #Sleep #Exercise #Longevity #Health #Wellness #PreventiveMedicine #MetabolicHealth #Biohacking #Science #MedicalResearch #Neuroscience #Fitness #SleepHealth #HeartDisease #CoronaryArteryDisease #CACScore #Cardiology #HealthyAging #ExerciseScience #SleepScience #ImmuneSystem #ClonalHematopoiesis #UKBiobank #GLP1 #Nattokinase #TUDCA #Microplastics #InflammationResearch #PlaqueRegression #HealthyLifestyle #DiseasePrevention #PublicHealth #EvidenceBasedMedicine #HealthOptimization #FitnessMotivation #ResistanceTraining #Zone2 #HeartAttackPrevention #BrainHealth #HealthEducation #StayCurious #Me

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1405 no How Diet Can Treat Depression: The Metabolic Marvel of Bile Acids Metabolic health is the foundation for mental health. We are only beginning to unravel the mechanistic mysteries around the ways in which how we eat and live as physical beings impacts our mind. These new data add an interesting piece to the puzzle and demonstrate how bile acid molecules act as endogenous anti-depressants. Watch all the way through, and you’ll be astonished at the biological elegance of our bodies. And you’re in for a surprise. Chapters0:00 – Metabolic Psychiatry is Booming 0:47 – Bile Acids Can Improve Depression 4:51 – How this relates to Your Mental Health6:07 – What Fuels Metabolic Psychiatry?6:47 – People Don’t Fake Depression, They Fake Being Okay7:22 – Words from Zach WilliamsPrior Keto and Bile Acids video: https://youtu.be/d0WuCIZxPxU Optogenetics is covered in this video shortly after the 3-minute mark: https://youtu.be/44qM9VtNAjc Danan et al. paper: https://pubmed.ncbi.nlm.nih.gov/35873236/Sethi el al. paper: https://pubmed.ncbi.nlm.nih.gov/38547601/ Sethi et al. video review: https://youtu.be/Gpz_uOHluWo#mentalhealth #depression #metabolism #ketodiet #anxietyrelief Learn more about your ad choices. Visit megaphone.fm/adchoices Tue, 14 Jul 2026 10:46:00 -0000 full Nick Norwitz MD PhD Metabolic health is the foundation for mental health. We are only beginning to unravel the mechanistic mysteries around the ways in which how we eat and live as physical beings impacts our mind. These new data add an interesting piece to the puzzle and demonstrate how bile acid molecules act as endogenous anti-depressants. Watch all the way through, and you’ll be astonished at the biological elegance of our bodies. And you’re in for a surprise. Chapters0:00 – Metabolic Psychiatry is Booming 0:47 – Bile Acids Can Improve Depression 4:51 – How this relates to Your Mental Health6:07 – What Fuels Metabolic Psychiatry?6:47 – People Don’t Fake Depression, They Fake Being Okay7:22 – Words from Zach WilliamsPrior Keto and Bile Acids video: https://youtu.be/d0WuCIZxPxU Optogenetics is covered in this video shortly after the 3-minute mark: https://youtu.be/44qM9VtNAjc Danan et al. paper: https://pubmed.ncbi.nlm.nih.gov/35873236/Sethi el al. paper: https://pubmed.ncbi.nlm.nih.gov/38547601/ Sethi et al. video review: https://youtu.be/Gpz_uOHluWo#mentalhealth #depression #metabolism #ketodiet #anxietyrelief Learn more about your ad choices. Visit megaphone.fm/adchoices Metabolic health is the foundation for mental health. We are only beginning to unravel the mechanistic mysteries around the ways in which how we eat and live as physical beings impacts our mind. These new data add an interesting piece to the puzzle and demonstrate how bile acid molecules act as endogenous anti-depressants. Watch all the way through, and you’ll be astonished at the biological elegance of our bodies. And you’re in for a surprise.

Chapters
0:00 – Metabolic Psychiatry is Booming
0:47 – Bile Acids Can Improve Depression
4:51 – How this relates to Your Mental Health
6:07 – What Fuels Metabolic Psychiatry?
6:47 – People Don’t Fake Depression, They Fake Being Okay
7:22 – Words from Zach Williams

Prior Keto and Bile Acids video: https://youtu.be/d0WuCIZxPxU

Optogenetics is covered in this video shortly after the 3-minute mark: https://youtu.be/44qM9VtNAjc

Danan et al. paper: https://pubmed.ncbi.nlm.nih.gov/35873236/

Sethi el al. paper: https://pubmed.ncbi.nlm.nih.gov/38547601/

Sethi et al. video review: https://youtu.be/Gpz_uOHluWo

#mentalhealth #depression #metabolism #ketodiet #anxietyrelief

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 744 no Exercise Erases 57% of Muscle Aging For all the references, additional nuances, and early access to content like this, check out the associated StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/scientists-just-discovered-how-exercise?r=40ekz2 Exercise Non-Responder Letter: https://staycuriousmetabolism.substack.com/p/why-your-workouts-arent-working-its?r=40ekz2 Sleep Masterclass Video: https://youtu.be/cgnfJtLc_pY SS-31 Letter: https://staycuriousmetabolism.substack.com/p/the-fda-approved-peptide-for-mitochondrial?r=40ekz2 MOTS-C Letter: https://staycuriousmetabolism.substack.com/p/mots-c-the-mitochondrial-peptide?r=40ekz2 Wolverine Stack Letter: https://staycuriousmetabolism.substack.com/p/can-peptides-regrow-the-heart-the?r=40ekz2 Thymus and Longevity Letter: https://staycuriousmetabolism.substack.com/p/the-most-overlooked-organ-in-aging?r=40ekz2 5-Amino-1MQ Letter: https://staycuriousmetabolism.substack.com/p/the-metabolic-leak-that-might-be?r=40ekz2 If you want to try 5-Amino-1MQ, here’s the link: try.gotwingspan.com/norwitz5Amino1MQ. Discount code “StayCurious”Chapters0:00 – A Big New Studies Looked Inside Aging Muscle4:13 – What Actually Breaks During Aging6:33 – The Muscle that Refused to Age10:20 – Foundational Tools to Preserve Healthy Muscle13:45 – The Exercise Non-Responder Phenomenon 15:24 – Advanced Tools to Preserve Healthy Muscle16:35 – The Mitochondrial Peptides (SS-31 and MOTS-c)20:37 – Plugging the Leak in the System (5-Amino-1MQ)21:50 – The Growth Hormone Peptides 24:00 – Aging is More of a Choice Than Ever BeforeDescription:What if aging isn’t as inevitable as we think? A new Nature Aging study looked deep inside human muscle and found something remarkable: in highly trained older adults, more than half of the gene-expression changes normally associated with aging were absent. Not merely slowed—absent.In this video, I break down what actually changes inside aging muscle, why mitochondria and NAD+ matter, and what exercise appears to preserve at the molecular level. Then we move from the fundamentals—resistance training, aerobic fitness, nutrition, sleep, and daily movement—to more advanced tools being explored for healthy aging, including SS-31, MOTS-c, 5-Amino-1MQ, tesamorelin, and other growth-hormone-axis therapies.The big question is simple: how much of aging is really happening to us, and how much can we influence? The answer may be far more encouraging than most people realize.#Aging #Longevity #HealthyAging #Exercise #Muscle #MuscleHealth #Mitochondria #NAD #NADPlus #Metabolism #MetabolicHealth #StrengthTraining #ResistanceTraining #Cardio #AerobicExercise #VO2Max #Fitness #Healthspan #Lifespan #AntiAging #BiologicalAge #MuscleAging #MitochondrialHealth #ExerciseScience #LongevityScience #NatureAging #HealthyMuscle #Sarcopenia #Strength #Mobility #Sleep #Nutrition #BloodSugar #InsulinSensitivity #SS31 #MOTSc #5Amino1MQ #Tesamorelin #Peptides #LongevityPeptides #GrowthHormone #VisceralFat #Thymus #BrainHealth #HeartHealth #ExerciseMimetic #Biohacking #HumanPerformance #StayCurious #science Disclaimer: This video is for general informational purposes only and is not medical advice; talk to your own clinician before starting, stopping, or changing any treatment. Research Use Only (RUO) products have not been cleared or approved by the FDA for clinical diagnostic use. RUO products are intended solely for laboratory research and are not intended to be used for diagnosing, treating, or preventing disease in humans. Any discussion of specific RUO products is for research purposes only and does not constitute a claim of clinical efficacy. Nothing on this page is medical advice — always consult your own clinician before starting any new therapy. Learn more about your ad choices. Visit megaphone.fm/adchoices Mon, 13 Jul 2026 16:46:00 -0000 full Nick Norwitz MD PhD For all the references, additional nuances, and early access to content like this, check out the associated StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/scientists-just-discovered-how-exercise?r=40ekz2 Exercise Non-Responder Letter: https://staycuriousmetabolism.substack.com/p/why-your-workouts-arent-working-its?r=40ekz2 Sleep Masterclass Video: https://youtu.be/cgnfJtLc_pY SS-31 Letter: https://staycuriousmetabolism.substack.com/p/the-fda-approved-peptide-for-mitochondrial?r=40ekz2 MOTS-C Letter: https://staycuriousmetabolism.substack.com/p/mots-c-the-mitochondrial-peptide?r=40ekz2 Wolverine Stack Letter: https://staycuriousmetabolism.substack.com/p/can-peptides-regrow-the-heart-the?r=40ekz2 Thymus and Longevity Letter: https://staycuriousmetabolism.substack.com/p/the-most-overlooked-organ-in-aging?r=40ekz2 5-Amino-1MQ Letter: https://staycuriousmetabolism.substack.com/p/the-metabolic-leak-that-might-be?r=40ekz2 If you want to try 5-Amino-1MQ, here’s the link: try.gotwingspan.com/norwitz5Amino1MQ. Discount code “StayCurious”Chapters0:00 – A Big New Studies Looked Inside Aging Muscle4:13 – What Actually Breaks During Aging6:33 – The Muscle that Refused to Age10:20 – Foundational Tools to Preserve Healthy Muscle13:45 – The Exercise Non-Responder Phenomenon 15:24 – Advanced Tools to Preserve Healthy Muscle16:35 – The Mitochondrial Peptides (SS-31 and MOTS-c)20:37 – Plugging the Leak in the System (5-Amino-1MQ)21:50 – The Growth Hormone Peptides 24:00 – Aging is More of a Choice Than Ever BeforeDescription:What if aging isn’t as inevitable as we think? A new Nature Aging study looked deep inside human muscle and found something remarkable: in highly trained older adults, more than half of the gene-expression changes normally associated with aging were absent. Not merely slowed—absent.In this video, I break down what actually changes inside aging muscle, why mitochondria and NAD+ matter, and what exercise appears to preserve at the molecular level. Then we move from the fundamentals—resistance training, aerobic fitness, nutrition, sleep, and daily movement—to more advanced tools being explored for healthy aging, including SS-31, MOTS-c, 5-Amino-1MQ, tesamorelin, and other growth-hormone-axis therapies.The big question is simple: how much of aging is really happening to us, and how much can we influence? The answer may be far more encouraging than most people realize.#Aging #Longevity #HealthyAging #Exercise #Muscle #MuscleHealth #Mitochondria #NAD #NADPlus #Metabolism #MetabolicHealth #StrengthTraining #ResistanceTraining #Cardio #AerobicExercise #VO2Max #Fitness #Healthspan #Lifespan #AntiAging #BiologicalAge #MuscleAging #MitochondrialHealth #ExerciseScience #LongevityScience #NatureAging #HealthyMuscle #Sarcopenia #Strength #Mobility #Sleep #Nutrition #BloodSugar #InsulinSensitivity #SS31 #MOTSc #5Amino1MQ #Tesamorelin #Peptides #LongevityPeptides #GrowthHormone #VisceralFat #Thymus #BrainHealth #HeartHealth #ExerciseMimetic #Biohacking #HumanPerformance #StayCurious #science Disclaimer: This video is for general informational purposes only and is not medical advice; talk to your own clinician before starting, stopping, or changing any treatment. Research Use Only (RUO) products have not been cleared or approved by the FDA for clinical diagnostic use. RUO products are intended solely for laboratory research and are not intended to be used for diagnosing, treating, or preventing disease in humans. Any discussion of specific RUO products is for research purposes only and does not constitute a claim of clinical efficacy. Nothing on this page is medical advice — always consult your own clinician before starting any new therapy. Learn more about your ad choices. Visit megaphone.fm/adchoices For all the references, additional nuances, and early access to content like this, check out the associated StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/scientists-just-discovered-how-exercise?r=40ekz2

Exercise Non-Responder Letter: https://staycuriousmetabolism.substack.com/p/why-your-workouts-arent-working-its?r=40ekz2

Sleep Masterclass Video: https://youtu.be/cgnfJtLc_pY

SS-31 Letter: https://staycuriousmetabolism.substack.com/p/the-fda-approved-peptide-for-mitochondrial?r=40ekz2

MOTS-C Letter: https://staycuriousmetabolism.substack.com/p/mots-c-the-mitochondrial-peptide?r=40ekz2

Wolverine Stack Letter: https://staycuriousmetabolism.substack.com/p/can-peptides-regrow-the-heart-the?r=40ekz2

Thymus and Longevity Letter: https://staycuriousmetabolism.substack.com/p/the-most-overlooked-organ-in-aging?r=40ekz2

5-Amino-1MQ Letter: https://staycuriousmetabolism.substack.com/p/the-metabolic-leak-that-might-be?r=40ekz2

If you want to try 5-Amino-1MQ, here’s the link: try.gotwingspan.com/norwitz5Amino1MQ. Discount code “StayCurious”

Chapters
0:00 – A Big New Studies Looked Inside Aging Muscle
4:13 – What Actually Breaks During Aging
6:33 – The Muscle that Refused to Age
10:20 – Foundational Tools to Preserve Healthy Muscle
13:45 – The Exercise Non-Responder Phenomenon
15:24 – Advanced Tools to Preserve Healthy Muscle
16:35 – The Mitochondrial Peptides (SS-31 and MOTS-c)
20:37 – Plugging the Leak in the System (5-Amino-1MQ)
21:50 – The Growth Hormone Peptides
24:00 – Aging is More of a Choice Than Ever Before

Description:

What if aging isn’t as inevitable as we think? A new Nature Aging study looked deep inside human muscle and found something remarkable: in highly trained older adults, more than half of the gene-expression changes normally associated with aging were absent. Not merely slowed—absent.

In this video, I break down what actually changes inside aging muscle, why mitochondria and NAD+ matter, and what exercise appears to preserve at the molecular level. Then we move from the fundamentals—resistance training, aerobic fitness, nutrition, sleep, and daily movement—to more advanced tools being explored for healthy aging, including SS-31, MOTS-c, 5-Amino-1MQ, tesamorelin, and other growth-hormone-axis therapies.

The big question is simple: how much of aging is really happening to us, and how much can we influence? The answer may be far more encouraging than most people realize.


#Aging #Longevity #HealthyAging #Exercise #Muscle #MuscleHealth #Mitochondria #NAD #NADPlus #Metabolism #MetabolicHealth #StrengthTraining #ResistanceTraining #Cardio #AerobicExercise #VO2Max #Fitness #Healthspan #Lifespan #AntiAging #BiologicalAge #MuscleAging #MitochondrialHealth #ExerciseScience #LongevityScience #NatureAging #HealthyMuscle #Sarcopenia #Strength #Mobility #Sleep #Nutrition #BloodSugar #InsulinSensitivity #SS31 #MOTSc #5Amino1MQ #Tesamorelin #Peptides #LongevityPeptides #GrowthHormone #VisceralFat #Thymus #BrainHealth #HeartHealth #ExerciseMimetic #Biohacking #HumanPerformance #StayCurious #science

Disclaimer: This video is for general informational purposes only and is not medical advice; talk to your own clinician before starting, stopping, or changing any treatment. Research Use Only (RUO) products have not been cleared or approved by the FDA for clinical diagnostic use. RUO products are intended solely for laboratory research and are not intended to be used for diagnosing, treating, or preventing disease in humans. Any discussion of specific RUO products is for research purposes only and does not constitute a claim of clinical efficacy. Nothing on this page is medical advice — always consult your own clinician before starting any new therapy.

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1822 no How To Lower Your Blood Sugar with Brownies! Would you like to ‘Have your Brownie and Eat it Too?’ Well, maybe you can do even better. In this video, I speak about some of the science framing the invention of a new Anti-Sugar Brownie, which can reproducibly drop my blood glucose (and insulin), and do the same in friends and colleagues, including those with diabetes. This is a sales pitch for science and curiosity. If you don’t need this tool in your life, good on you and you’ll still learn. For those looking for such a tool for friends and loved ones, well, let’s get innovative and fight Big Food in their own domain. Chapters0:00 – An Anti-Sugar Brownie0:53 – I Won’t Eat Sucralose and Aspartame3:17 – I am Curious about Allulose 5:59 – Adding an unexpected Member to the Metabolic Health ArmyBrownie Discount Code, NICK20 for 20% off the Anti-Sugar Brownie https://rxsugar.com/products/rxsugar-keto-brownie-mixLevels Affiliate Link, 2 Free Months (Copy and Paste): https://levels.link/nicknorwitzMetabolic Loophole: https://youtu.be/fyERqDgSiMg Cure Metabolic Syndrome: https://youtu.be/hiCxpHDAlbs Continuous Glucose Monitors: https://youtu.be/vLD_fWTi54Y Allulose breakdown: https://youtu.be/pr93EsEV2bMReferenced studiesSucralose, Human RCT: PMID: 32130881Aspartame, Transgenerational Anxiety: PMID: 36459641Allulose, Human RCT, PMCID: PMC9193293Allulose vs Stevia, PMID: 38931176#metabolism #nutritiontips #brownies #sugarfreediet #metabolichealth #healthandfitness #allulose #artificialsweeteners #obesityepidemic Special thanks to my friends Thomas DeLauer, Steve Hanley, Dominic D’Agostino, Ben Bikman, Richard Johnson, Andrew Koutnik, and my other colleagues on the Scientific Advisory Board. Group of good people with an authentic purpose Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 12 Jul 2026 22:46:00 -0000 full Nick Norwitz MD PhD Would you like to ‘Have your Brownie and Eat it Too?’ Well, maybe you can do even better. In this video, I speak about some of the science framing the invention of a new Anti-Sugar Brownie, which can reproducibly drop my blood glucose (and insulin), and do the same in friends and colleagues, including those with diabetes. This is a sales pitch for science and curiosity. If you don’t need this tool in your life, good on you and you’ll still learn. For those looking for such a tool for friends and loved ones, well, let’s get innovative and fight Big Food in their own domain. Chapters0:00 – An Anti-Sugar Brownie0:53 – I Won’t Eat Sucralose and Aspartame3:17 – I am Curious about Allulose 5:59 – Adding an unexpected Member to the Metabolic Health ArmyBrownie Discount Code, NICK20 for 20% off the Anti-Sugar Brownie https://rxsugar.com/products/rxsugar-keto-brownie-mixLevels Affiliate Link, 2 Free Months (Copy and Paste): https://levels.link/nicknorwitzMetabolic Loophole: https://youtu.be/fyERqDgSiMg Cure Metabolic Syndrome: https://youtu.be/hiCxpHDAlbs Continuous Glucose Monitors: https://youtu.be/vLD_fWTi54Y Allulose breakdown: https://youtu.be/pr93EsEV2bMReferenced studiesSucralose, Human RCT: PMID: 32130881Aspartame, Transgenerational Anxiety: PMID: 36459641Allulose, Human RCT, PMCID: PMC9193293Allulose vs Stevia, PMID: 38931176#metabolism #nutritiontips #brownies #sugarfreediet #metabolichealth #healthandfitness #allulose #artificialsweeteners #obesityepidemic Special thanks to my friends Thomas DeLauer, Steve Hanley, Dominic D’Agostino, Ben Bikman, Richard Johnson, Andrew Koutnik, and my other colleagues on the Scientific Advisory Board. Group of good people with an authentic purpose Learn more about your ad choices. Visit megaphone.fm/adchoices Would you like to ‘Have your Brownie and Eat it Too?’ Well, maybe you can do even better. In this video, I speak about some of the science framing the invention of a new Anti-Sugar Brownie, which can reproducibly drop my blood glucose (and insulin), and do the same in friends and colleagues, including those with diabetes. This is a sales pitch for science and curiosity. If you don’t need this tool in your life, good on you and you’ll still learn. For those looking for such a tool for friends and loved ones, well, let’s get innovative and fight Big Food in their own domain.

Chapters
0:00 – An Anti-Sugar Brownie
0:53 – I Won’t Eat Sucralose and Aspartame
3:17 – I am Curious about Allulose
5:59 – Adding an unexpected Member to the Metabolic Health Army

Brownie Discount Code, NICK20 for 20% off the Anti-Sugar Brownie https://rxsugar.com/products/rxsugar-keto-brownie-mix

Levels Affiliate Link, 2 Free Months (Copy and Paste): https://levels.link/nicknorwitz

Metabolic Loophole: https://youtu.be/fyERqDgSiMg
Cure Metabolic Syndrome: https://youtu.be/hiCxpHDAlbs
Continuous Glucose Monitors: https://youtu.be/vLD_fWTi54Y
Allulose breakdown: https://youtu.be/pr93EsEV2bM

Referenced studies
Sucralose, Human RCT: PMID: 32130881
Aspartame, Transgenerational Anxiety: PMID: 36459641
Allulose, Human RCT, PMCID: PMC9193293
Allulose vs Stevia, PMID: 38931176

#metabolism #nutritiontips #brownies #sugarfreediet #metabolichealth #healthandfitness #allulose #artificialsweeteners #obesityepidemic

Special thanks to my friends Thomas DeLauer, Steve Hanley, Dominic D’Agostino, Ben Bikman, Richard Johnson, Andrew Koutnik, and my other colleagues on the Scientific Advisory Board. Group of good people with an authentic purpose

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 752 no The Strange Science of Eating Only Meat For all the references, additional nuances, and early access to content like this, check out the associated StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/i-tried-the-most-extreme-version?r=40ekz2Carnivore for Inflammatory Bowel Disease Paper (open access): https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1467475/full Masterclass on Gut Health Video: https://youtu.be/ndEfyeoq95w Chapters 0:00 – Why I Ate 100 Pounds of Meat in 30 Days3:07 – All Matters Gut Health5:23 – What Patients with Inflammatory Bowel Disease Say5:48 – How Mechanistically Carnivore Can Health the Gut8:18 – What About Microbiome Diversity?9:15 – The Nutrient Deficiency Problem10:17 – Omega-3: Beef vs Fish12:02 – The Vitamin C Paradox15:37 – Carnivore for Autoimmune and Inflammatory Conditions16:56 – Carnivore for Mental HealthDescriptionI ate more than 100 pounds of meat in 30 days while following the Lion Diet: no dairy, eggs, seafood, coffee, supplements, or plant foods—just ruminant meat, salt, and water. In this video, I break down what actually happened to my digestion, bloodwork, omega-3 levels, cholesterol, and overall health, while separating the carnivore diet’s legitimate strengths from the hype.We also dive into the science of carnivore diets, fiber, IBS, inflammatory bowel disease, microbiome diversity, vitamin C, calcium, omega-3s, ketosis, autoimmune disease, and mental health. The goal here isn’t to convince you to become carnivore. It’s to ask a better question: Is carnivore a diet everyone should follow, or a therapeutic tool that may be unusually useful for the right person at the right time?Medical Disclaimer: This content is provided for educational and informational purposes only and does not constitute medical advice. It is not intended to diagnose, treat, cure, or prevent any disease, nor is it a substitute for individualized medical advice from a qualified healthcare professional. Always consult your healthcare provider before making changes to medications, supplements, diet, or other aspects of your healthcare.#CarnivoreDiet #LionDiet #Carnivore #MeatDiet #30DayChallenge #Nutrition #NutritionScience #MetabolicHealth #GutHealth #IBS #IBD #CrohnsDisease #UlcerativeColitis #Fiber #LowFiberDiet #Microbiome #GutMicrobiome #KetogenicDiet #Keto #Ketosis #AutoimmuneDisease #Inflammation #EliminationDiet #VitaminC #Scurvy #Omega3 #Calcium #NutrientDeficiency #BloodWork #Cholesterol #Metabolism #MetabolicHealth #HealthyEating #DietExperiment #Biohacking #HealthExperiment #NutritionalKetosis #MentalHealth #Anorexia #EatingDisorders #BrainMetabolism #FoodScience #Beef #RedMeat #RuminantMeat #CarnivoreResearch #DietScience #StayCurious #HealthScience #Longevity Learn more about your ad choices. Visit megaphone.fm/adchoices Sun, 12 Jul 2026 04:46:00 -0000 full Nick Norwitz MD PhD For all the references, additional nuances, and early access to content like this, check out the associated StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/i-tried-the-most-extreme-version?r=40ekz2Carnivore for Inflammatory Bowel Disease Paper (open access): https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1467475/full Masterclass on Gut Health Video: https://youtu.be/ndEfyeoq95w Chapters 0:00 – Why I Ate 100 Pounds of Meat in 30 Days3:07 – All Matters Gut Health5:23 – What Patients with Inflammatory Bowel Disease Say5:48 – How Mechanistically Carnivore Can Health the Gut8:18 – What About Microbiome Diversity?9:15 – The Nutrient Deficiency Problem10:17 – Omega-3: Beef vs Fish12:02 – The Vitamin C Paradox15:37 – Carnivore for Autoimmune and Inflammatory Conditions16:56 – Carnivore for Mental HealthDescriptionI ate more than 100 pounds of meat in 30 days while following the Lion Diet: no dairy, eggs, seafood, coffee, supplements, or plant foods—just ruminant meat, salt, and water. In this video, I break down what actually happened to my digestion, bloodwork, omega-3 levels, cholesterol, and overall health, while separating the carnivore diet’s legitimate strengths from the hype.We also dive into the science of carnivore diets, fiber, IBS, inflammatory bowel disease, microbiome diversity, vitamin C, calcium, omega-3s, ketosis, autoimmune disease, and mental health. The goal here isn’t to convince you to become carnivore. It’s to ask a better question: Is carnivore a diet everyone should follow, or a therapeutic tool that may be unusually useful for the right person at the right time?Medical Disclaimer: This content is provided for educational and informational purposes only and does not constitute medical advice. It is not intended to diagnose, treat, cure, or prevent any disease, nor is it a substitute for individualized medical advice from a qualified healthcare professional. Always consult your healthcare provider before making changes to medications, supplements, diet, or other aspects of your healthcare.#CarnivoreDiet #LionDiet #Carnivore #MeatDiet #30DayChallenge #Nutrition #NutritionScience #MetabolicHealth #GutHealth #IBS #IBD #CrohnsDisease #UlcerativeColitis #Fiber #LowFiberDiet #Microbiome #GutMicrobiome #KetogenicDiet #Keto #Ketosis #AutoimmuneDisease #Inflammation #EliminationDiet #VitaminC #Scurvy #Omega3 #Calcium #NutrientDeficiency #BloodWork #Cholesterol #Metabolism #MetabolicHealth #HealthyEating #DietExperiment #Biohacking #HealthExperiment #NutritionalKetosis #MentalHealth #Anorexia #EatingDisorders #BrainMetabolism #FoodScience #Beef #RedMeat #RuminantMeat #CarnivoreResearch #DietScience #StayCurious #HealthScience #Longevity Learn more about your ad choices. Visit megaphone.fm/adchoices For all the references, additional nuances, and early access to content like this, check out the associated StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/i-tried-the-most-extreme-version?r=40ekz2

Carnivore for Inflammatory Bowel Disease Paper (open access): https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1467475/full

Masterclass on Gut Health Video: https://youtu.be/ndEfyeoq95w

Chapters
0:00 – Why I Ate 100 Pounds of Meat in 30 Days
3:07 – All Matters Gut Health
5:23 – What Patients with Inflammatory Bowel Disease Say
5:48 – How Mechanistically Carnivore Can Health the Gut
8:18 – What About Microbiome Diversity?
9:15 – The Nutrient Deficiency Problem
10:17 – Omega-3: Beef vs Fish
12:02 – The Vitamin C Paradox
15:37 – Carnivore for Autoimmune and Inflammatory Conditions
16:56 – Carnivore for Mental Health

Description
I ate more than 100 pounds of meat in 30 days while following the Lion Diet: no dairy, eggs, seafood, coffee, supplements, or plant foods—just ruminant meat, salt, and water. In this video, I break down what actually happened to my digestion, bloodwork, omega-3 levels, cholesterol, and overall health, while separating the carnivore diet’s legitimate strengths from the hype.

We also dive into the science of carnivore diets, fiber, IBS, inflammatory bowel disease, microbiome diversity, vitamin C, calcium, omega-3s, ketosis, autoimmune disease, and mental health. The goal here isn’t to convince you to become carnivore. It’s to ask a better question: Is carnivore a diet everyone should follow, or a therapeutic tool that may be unusually useful for the right person at the right time?

Medical Disclaimer: This content is provided for educational and informational purposes only and does not constitute medical advice. It is not intended to diagnose, treat, cure, or prevent any disease, nor is it a substitute for individualized medical advice from a qualified healthcare professional. Always consult your healthcare provider before making changes to medications, supplements, diet, or other aspects of your healthcare.

#CarnivoreDiet #LionDiet #Carnivore #MeatDiet #30DayChallenge #Nutrition #NutritionScience #MetabolicHealth #GutHealth #IBS #IBD #CrohnsDisease #UlcerativeColitis #Fiber #LowFiberDiet #Microbiome #GutMicrobiome #KetogenicDiet #Keto #Ketosis #AutoimmuneDisease #Inflammation #EliminationDiet #VitaminC #Scurvy #Omega3 #Calcium #NutrientDeficiency #BloodWork #Cholesterol #Metabolism #MetabolicHealth #HealthyEating #DietExperiment #Biohacking #HealthExperiment #NutritionalKetosis #MentalHealth #Anorexia #EatingDisorders #BrainMetabolism #FoodScience #Beef #RedMeat #RuminantMeat #CarnivoreResearch #DietScience #StayCurious #HealthScience #Longevity

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1523 no The Link Between Stress and the Microbiome: New Research Explained Paper: https://www.cell.com/cell/fulltext/S0092-8674(24)00779-7How does stress impact gut health? New science reveals a pathway whereby an emotion regulation center in the brain, the amygdala, signals to intestinal glands in the gut that feed particular good gut bacteria to improve gut health. Stress inhibits this pathway, leading to changes in the microbiome and “tummy troubles.” These new data provide mechanistic insights into how certain stress reduction practices, including those reviewed in this video, may help to improve gut health and reduce unpleasant symptoms – bloating, diarrhea, and constipation – plagues many of us. What’s good for the mind is good for the gut, and what good for the gut is good for the brain.#guthealth #mentalhealth #anxietyrelief Chapters0:00 – How Does Stress Impact Gut Health?0:57 – New Paper in Cell2:40 – Lactobacillus are Fed by Brunner’s Glands3:29 – Vagus Nerve Controls Brunner’s Glands4:35 – Bloating. Yikes!5:04 – The Amygdala controls the Microbiome 6:10 – Relevance to Humans7:40 – Summary of the Mechanism8:22 – A Nuance Note8:58 – Actionable Takeaways Learn more about your ad choices. Visit megaphone.fm/adchoices Sat, 11 Jul 2026 10:46:00 -0000 full Nick Norwitz MD PhD Paper: https://www.cell.com/cell/fulltext/S0092-8674(24)00779-7How does stress impact gut health? New science reveals a pathway whereby an emotion regulation center in the brain, the amygdala, signals to intestinal glands in the gut that feed particular good gut bacteria to improve gut health. Stress inhibits this pathway, leading to changes in the microbiome and “tummy troubles.” These new data provide mechanistic insights into how certain stress reduction practices, including those reviewed in this video, may help to improve gut health and reduce unpleasant symptoms – bloating, diarrhea, and constipation – plagues many of us. What’s good for the mind is good for the gut, and what good for the gut is good for the brain.#guthealth #mentalhealth #anxietyrelief Chapters0:00 – How Does Stress Impact Gut Health?0:57 – New Paper in Cell2:40 – Lactobacillus are Fed by Brunner’s Glands3:29 – Vagus Nerve Controls Brunner’s Glands4:35 – Bloating. Yikes!5:04 – The Amygdala controls the Microbiome 6:10 – Relevance to Humans7:40 – Summary of the Mechanism8:22 – A Nuance Note8:58 – Actionable Takeaways Learn more about your ad choices. Visit megaphone.fm/adchoices Paper: https://www.cell.com/cell/fulltext/S0092-8674(24)00779-7

How does stress impact gut health? New science reveals a pathway whereby an emotion regulation center in the brain, the amygdala, signals to intestinal glands in the gut that feed particular good gut bacteria to improve gut health. Stress inhibits this pathway, leading to changes in the microbiome and “tummy troubles.” These new data provide mechanistic insights into how certain stress reduction practices, including those reviewed in this video, may help to improve gut health and reduce unpleasant symptoms – bloating, diarrhea, and constipation – plagues many of us. What’s good for the mind is good for the gut, and what good for the gut is good for the brain.

#guthealth #mentalhealth #anxietyrelief

Chapters
0:00 – How Does Stress Impact Gut Health?
0:57 – New Paper in Cell
2:40 – Lactobacillus are Fed by Brunner’s Glands
3:29 – Vagus Nerve Controls Brunner’s Glands
4:35 – Bloating. Yikes!
5:04 – The Amygdala controls the Microbiome
6:10 – Relevance to Humans
7:40 – Summary of the Mechanism
8:22 – A Nuance Note
8:58 – Actionable Takeaways

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 838 no Why I Quit Being a Doctor If this spoke to you and you want to keep learning with me, subscribe here and join me at https://staycuriousmetabolism.com, our #1 top-rising science newsletter. #StayCurious. I hope to see you there.DescriptionI spent most of my life preparing to become a practicing doctor. I was valedictorian at Dartmouth, completed my PhD at Oxford, earned my MD at Harvard Medical School, and grew up in a family where medicine was practically the family business. But I was also a patient. In my early twenties, severe inflammatory bowel disease took me from the laboratory to hospital beds, intensive care, and some of the darkest moments of my life. An unconventional dietary intervention ultimately healed me and changed how I thought about medicine. This is the most personal story I’ve shared here. It’s about why I stepped away from the traditional medical path, what chronic illness taught me about the gap between evidence and individual experience, and why I chose a career in metabolic health and science communication. More than anything, it’s the story behind StayCurious.Chapters0:00 – From an MD PhD to… YouTube?1:18 – Growing Up in a Family of Doctors2:05 – Why I Walked Away from Medicine3:33 – My Double Life as a Patient6:00 – Trying Something Outside the Mainstream7:49 – The Evidence-Based Medicine Paradox7:49 – The Healing Power of Curiosity #Medicine #Doctor #MedicalSchool #HarvardMedicalSchool #PhD #Oxford #Health #MetabolicHealth #StayCurious #StayCuriousMetabolism #ChronicIllness #InflammatoryBowelDisease #IBD #UlcerativeColitis #CrohnsDisease #KetogenicDiet #Keto #LowCarb #Nutrition #NutritionScience #Metabolism #HealthScience #Science #EvidenceBasedMedicine #PersonalizedMedicine #PrecisionMedicine #MedicalResearch #Healthcare #PatientStory #ChronicDisease #AutoimmuneDisease #Inflammation #GutHealth #MentalHealth #HealthJourney #Recovery #Hope #Curiosity #ScienceCommunication #MedicalEducation #LifestyleMedicine #Diet #HealthOptimization #SelfExperimentation #Nof1 #Biohacking #Resilience #DoctorStory #CareerChange #PatientExperience Learn more about your ad choices. Visit megaphone.fm/adchoices Fri, 10 Jul 2026 16:46:00 -0000 full Nick Norwitz MD PhD If this spoke to you and you want to keep learning with me, subscribe here and join me at https://staycuriousmetabolism.com, our #1 top-rising science newsletter. #StayCurious. I hope to see you there.DescriptionI spent most of my life preparing to become a practicing doctor. I was valedictorian at Dartmouth, completed my PhD at Oxford, earned my MD at Harvard Medical School, and grew up in a family where medicine was practically the family business. But I was also a patient. In my early twenties, severe inflammatory bowel disease took me from the laboratory to hospital beds, intensive care, and some of the darkest moments of my life. An unconventional dietary intervention ultimately healed me and changed how I thought about medicine. This is the most personal story I’ve shared here. It’s about why I stepped away from the traditional medical path, what chronic illness taught me about the gap between evidence and individual experience, and why I chose a career in metabolic health and science communication. More than anything, it’s the story behind StayCurious.Chapters0:00 – From an MD PhD to… YouTube?1:18 – Growing Up in a Family of Doctors2:05 – Why I Walked Away from Medicine3:33 – My Double Life as a Patient6:00 – Trying Something Outside the Mainstream7:49 – The Evidence-Based Medicine Paradox7:49 – The Healing Power of Curiosity #Medicine #Doctor #MedicalSchool #HarvardMedicalSchool #PhD #Oxford #Health #MetabolicHealth #StayCurious #StayCuriousMetabolism #ChronicIllness #InflammatoryBowelDisease #IBD #UlcerativeColitis #CrohnsDisease #KetogenicDiet #Keto #LowCarb #Nutrition #NutritionScience #Metabolism #HealthScience #Science #EvidenceBasedMedicine #PersonalizedMedicine #PrecisionMedicine #MedicalResearch #Healthcare #PatientStory #ChronicDisease #AutoimmuneDisease #Inflammation #GutHealth #MentalHealth #HealthJourney #Recovery #Hope #Curiosity #ScienceCommunication #MedicalEducation #LifestyleMedicine #Diet #HealthOptimization #SelfExperimentation #Nof1 #Biohacking #Resilience #DoctorStory #CareerChange #PatientExperience Learn more about your ad choices. Visit megaphone.fm/adchoices If this spoke to you and you want to keep learning with me, subscribe here and join me at https://staycuriousmetabolism.com, our #1 top-rising science newsletter. #StayCurious. I hope to see you there.

Description

I spent most of my life preparing to become a practicing doctor. I was valedictorian at Dartmouth, completed my PhD at Oxford, earned my MD at Harvard Medical School, and grew up in a family where medicine was practically the family business. But I was also a patient. In my early twenties, severe inflammatory bowel disease took me from the laboratory to hospital beds, intensive care, and some of the darkest moments of my life. An unconventional dietary intervention ultimately healed me and changed how I thought about medicine. This is the most personal story I’ve shared here. It’s about why I stepped away from the traditional medical path, what chronic illness taught me about the gap between evidence and individual experience, and why I chose a career in metabolic health and science communication. More than anything, it’s the story behind StayCurious.

Chapters
0:00 – From an MD PhD to… YouTube?
1:18 – Growing Up in a Family of Doctors
2:05 – Why I Walked Away from Medicine
3:33 – My Double Life as a Patient
6:00 – Trying Something Outside the Mainstream
7:49 – The Evidence-Based Medicine Paradox
7:49 – The Healing Power of Curiosity

#Medicine #Doctor #MedicalSchool #HarvardMedicalSchool #PhD #Oxford #Health #MetabolicHealth #StayCurious #StayCuriousMetabolism #ChronicIllness #InflammatoryBowelDisease #IBD #UlcerativeColitis #CrohnsDisease #KetogenicDiet #Keto #LowCarb #Nutrition #NutritionScience #Metabolism #HealthScience #Science #EvidenceBasedMedicine #PersonalizedMedicine #PrecisionMedicine #MedicalResearch #Healthcare #PatientStory #ChronicDisease #AutoimmuneDisease #Inflammation #GutHealth #MentalHealth #HealthJourney #Recovery #Hope #Curiosity #ScienceCommunication #MedicalEducation #LifestyleMedicine #Diet #HealthOptimization #SelfExperimentation #Nof1 #Biohacking #Resilience #DoctorStory #CareerChange #PatientExperience

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]]> 782 no Nick Norwitz's Food as Medicine Journey This is my story and why I'm driven to make Metabolic Medicine mainstream. Food is the most powerful tool we have to transform health. Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 09 Jul 2026 22:46:00 -0000 full Nick Norwitz MD PhD This is my story and why I'm driven to make Metabolic Medicine mainstream. Food is the most powerful tool we have to transform health. Learn more about your ad choices. Visit megaphone.fm/adchoices This is my story and why I'm driven to make Metabolic Medicine mainstream. Food is the most powerful tool we have to transform health.

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 396 no The Gut Health Trick I Wish I Knew 10 Year Ago For early access, all references, and additional nuances, check out the associated StayCurious Metabolism newsletter https://staycuriousmetabolism.substack.com/p/reset-your-vagus-nerve-to-control?r=40ekz2Get 10% off your Pulsetto FIT here: https://pulsetto.tech/pages/StayCurious or use my coupon code: StayCurious. It’s completely risk-free with a 30-day money-back guarantee, so you can test it and see how your body responds.Chapters0:00 – Reset Your Vagus Nerve to Control Gut Inflammation 1:38 – The Takes Are Greater Than I Realized 3:06 – The Gut Health Study That Hit Close to Home5:52 – What The SUMOylation?6:54 – Quick Summary of Main Points So Far8:18 –Stimulating the Vagus Nerve Lowers Inflammation in Humans11:04 – The Wiring Diagram 13:13 – Levers and Tools You Can Use TodayDescriptionWhat if stress isn’t merely “in your head,” but is physically wired into inflammation? In this video, I explore the emerging science of the vagus nerve, inflammation, gut health, and autoimmune disease. We start with research showing how stress worsened experimental colitis in mice, and how electrical vagus nerve stimulation reversed inflammatory changes. But this isn’t only mouse biology. We examine a randomized, double-blind human trial of vagus nerve stimulation in rheumatoid arthritis, including evidence of clinical improvement and a signal for reduced bone erosion. Finally, we get practical: slow exhale-focused breathing, stress reduction, and non-invasive transcutaneous vagus nerve stimulation, including my personal experience with a cervical vagus nerve stimulation device. The larger lesson is that the nervous and immune systems aren’t separate worlds, they’re in constant communication. #VagusNerve #VagusNerveStimulation #Inflammation #ChronicInflammation #GutHealth #GutBrainAxis #BrainGutConnection #NervousSystem #ParasympatheticNervousSystem #AutonomicNervousSystem #AutoimmuneDisease #Autoimmunity #UlcerativeColitis #CrohnsDisease #IBD #InflammatoryBowelDisease #RheumatoidArthritis #Stress #StressManagement #StressRelief #Breathwork #BreathingExercises #CyclicSighing #HRV #HeartRateVariability #tVNS #BioelectronicMedicine #Neuromodulation #Immunology #ImmuneSystem #GutInflammation #BrainHealth #MentalHealth #Anxiety #Sleep #Insomnia #Cortisol #HealthScience #MedicalResearch #Science #MetabolicHealth #Longevity #Healthspan #Biohacking #WellnessScience #MindBodyConnection #StayCurious #StayCuriousMetabolism #Pulsetto #vagaltone Disclaimer: The content presented in this video is for informational and educational purposes only and should not be construed as medical advice. Any decisions regarding your health should be made in consultation with your personal healthcare provider, who can consider your individual circumstances and medical history. This content contains a partnership message from Pulsetto. Pulsetto is a general wellness product intended to support a healthy lifestyle. It is not intended to diagnose, treat, cure, or prevent any disease or medical condition. As with all of my partnerships, I only work with companies that meet a strict set of criteria. Specifically, the product or service must provide a genuine solution to a real problem faced by my audience, operate to the highest standards of quality and ethics, and be something that I personally use or would feel comfortable recommending to family and close friends. While I am compensated for partnerships, my opinions remain my own, and I strive to maintain the same standards of honesty, transparency, and scientific rigor regardless of whether content is sponsored or unsponsored. You can learn more about all partnerships at nicknorwitz.com. Learn more about your ad choices. Visit megaphone.fm/adchoices Thu, 09 Jul 2026 04:46:00 -0000 full Nick Norwitz MD PhD For early access, all references, and additional nuances, check out the associated StayCurious Metabolism newsletter https://staycuriousmetabolism.substack.com/p/reset-your-vagus-nerve-to-control?r=40ekz2Get 10% off your Pulsetto FIT here: https://pulsetto.tech/pages/StayCurious or use my coupon code: StayCurious. It’s completely risk-free with a 30-day money-back guarantee, so you can test it and see how your body responds.Chapters0:00 – Reset Your Vagus Nerve to Control Gut Inflammation 1:38 – The Takes Are Greater Than I Realized 3:06 – The Gut Health Study That Hit Close to Home5:52 – What The SUMOylation?6:54 – Quick Summary of Main Points So Far8:18 –Stimulating the Vagus Nerve Lowers Inflammation in Humans11:04 – The Wiring Diagram 13:13 – Levers and Tools You Can Use TodayDescriptionWhat if stress isn’t merely “in your head,” but is physically wired into inflammation? In this video, I explore the emerging science of the vagus nerve, inflammation, gut health, and autoimmune disease. We start with research showing how stress worsened experimental colitis in mice, and how electrical vagus nerve stimulation reversed inflammatory changes. But this isn’t only mouse biology. We examine a randomized, double-blind human trial of vagus nerve stimulation in rheumatoid arthritis, including evidence of clinical improvement and a signal for reduced bone erosion. Finally, we get practical: slow exhale-focused breathing, stress reduction, and non-invasive transcutaneous vagus nerve stimulation, including my personal experience with a cervical vagus nerve stimulation device. The larger lesson is that the nervous and immune systems aren’t separate worlds, they’re in constant communication. #VagusNerve #VagusNerveStimulation #Inflammation #ChronicInflammation #GutHealth #GutBrainAxis #BrainGutConnection #NervousSystem #ParasympatheticNervousSystem #AutonomicNervousSystem #AutoimmuneDisease #Autoimmunity #UlcerativeColitis #CrohnsDisease #IBD #InflammatoryBowelDisease #RheumatoidArthritis #Stress #StressManagement #StressRelief #Breathwork #BreathingExercises #CyclicSighing #HRV #HeartRateVariability #tVNS #BioelectronicMedicine #Neuromodulation #Immunology #ImmuneSystem #GutInflammation #BrainHealth #MentalHealth #Anxiety #Sleep #Insomnia #Cortisol #HealthScience #MedicalResearch #Science #MetabolicHealth #Longevity #Healthspan #Biohacking #WellnessScience #MindBodyConnection #StayCurious #StayCuriousMetabolism #Pulsetto #vagaltone Disclaimer: The content presented in this video is for informational and educational purposes only and should not be construed as medical advice. Any decisions regarding your health should be made in consultation with your personal healthcare provider, who can consider your individual circumstances and medical history. This content contains a partnership message from Pulsetto. Pulsetto is a general wellness product intended to support a healthy lifestyle. It is not intended to diagnose, treat, cure, or prevent any disease or medical condition. As with all of my partnerships, I only work with companies that meet a strict set of criteria. Specifically, the product or service must provide a genuine solution to a real problem faced by my audience, operate to the highest standards of quality and ethics, and be something that I personally use or would feel comfortable recommending to family and close friends. While I am compensated for partnerships, my opinions remain my own, and I strive to maintain the same standards of honesty, transparency, and scientific rigor regardless of whether content is sponsored or unsponsored. You can learn more about all partnerships at nicknorwitz.com. Learn more about your ad choices. Visit megaphone.fm/adchoices For early access, all references, and additional nuances, check out the associated StayCurious Metabolism newsletter https://staycuriousmetabolism.substack.com/p/reset-your-vagus-nerve-to-control?r=40ekz2

Get 10% off your Pulsetto FIT here: https://pulsetto.tech/pages/StayCurious or use my coupon code: StayCurious.

It’s completely risk-free with a 30-day money-back guarantee, so you can test it and see how your body responds.

Chapters
0:00 – Reset Your Vagus Nerve to Control Gut Inflammation
1:38 – The Takes Are Greater Than I Realized
3:06 – The Gut Health Study That Hit Close to Home
5:52 – What The SUMOylation?
6:54 – Quick Summary of Main Points So Far
8:18 –Stimulating the Vagus Nerve Lowers Inflammation in Humans
11:04 – The Wiring Diagram
13:13 – Levers and Tools You Can Use Today

Description
What if stress isn’t merely “in your head,” but is physically wired into inflammation? In this video, I explore the emerging science of the vagus nerve, inflammation, gut health, and autoimmune disease. We start with research showing how stress worsened experimental colitis in mice, and how electrical vagus nerve stimulation reversed inflammatory changes.

But this isn’t only mouse biology. We examine a randomized, double-blind human trial of vagus nerve stimulation in rheumatoid arthritis, including evidence of clinical improvement and a signal for reduced bone erosion.

Finally, we get practical: slow exhale-focused breathing, stress reduction, and non-invasive transcutaneous vagus nerve stimulation, including my personal experience with a cervical vagus nerve stimulation device. The larger lesson is that the nervous and immune systems aren’t separate worlds, they’re in constant communication.

#VagusNerve #VagusNerveStimulation #Inflammation #ChronicInflammation #GutHealth #GutBrainAxis #BrainGutConnection #NervousSystem #ParasympatheticNervousSystem #AutonomicNervousSystem #AutoimmuneDisease #Autoimmunity #UlcerativeColitis #CrohnsDisease #IBD #InflammatoryBowelDisease #RheumatoidArthritis #Stress #StressManagement #StressRelief #Breathwork #BreathingExercises #CyclicSighing #HRV #HeartRateVariability #tVNS #BioelectronicMedicine #Neuromodulation #Immunology #ImmuneSystem #GutInflammation #BrainHealth #MentalHealth #Anxiety #Sleep #Insomnia #Cortisol #HealthScience #MedicalResearch #Science #MetabolicHealth #Longevity #Healthspan #Biohacking #WellnessScience #MindBodyConnection #StayCurious #StayCuriousMetabolism #Pulsetto #vagaltone

Disclaimer: The content presented in this video is for informational and educational purposes only and should not be construed as medical advice. Any decisions regarding your health should be made in consultation with your personal healthcare provider, who can consider your individual circumstances and medical history. This content contains a partnership message from Pulsetto. Pulsetto is a general wellness product intended to support a healthy lifestyle. It is not intended to diagnose, treat, cure, or prevent any disease or medical condition. As with all of my partnerships, I only work with companies that meet a strict set of criteria. Specifically, the product or service must provide a genuine solution to a real problem faced by my audience, operate to the highest standards of quality and ethics, and be something that I personally use or would feel comfortable recommending to family and close friends. While I am compensated for partnerships, my opinions remain my own, and I strive to maintain the same standards of honesty, transparency, and scientific rigor regardless of whether content is sponsored or unsponsored. You can learn more about all partnerships at nicknorwitz.com.

Learn more about your ad choices. Visit megaphone.fm/adchoices

]]> 1464 no Precision Nutrition for Alzheimer's Prevention in ApoE4 carriers - Video Abstract Here is a video abstract for my new paper about preventing Alzheimer's disease with nutrition!https://www.mdpi.com/2072-6643/13/4/1362# Learn more about your ad choices. Visit megaphone.fm/adchoices Wed, 08 Jul 2026 10:46:00 -0000 full Nick Norwitz MD PhD Here is a video abstract for my new paper about preventing Alzheimer's disease with nutrition!https://www.mdpi.com/2072-6643/13/4/1362# Learn more about your ad choices. Visit megaphone.fm/adchoices Here is a video abstract for my new paper about preventing Alzheimer's disease with nutrition!
https://www.mdpi.com/2072-6643/13/4/1362#

Learn more about your ad choices. Visit megaphone.fm/adchoices

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